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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Profiling cellular bioenergetics, glutathione levels, and caspase activities in stomach biopsies of patients with upper gastrointestinal symptoms显示文摘AIM: To measure biochemical parameters in stomach biopsies and test their suitability as diagnostic biomarkers for gastritis and precancerous lesions.METHODS: Biopsies were obtained from the stomachs of two groups of patients(n = 40) undergoing fiberoptic endoscopy due to upper gastrointestinal symptoms. In the first group(n = 17), only the corpus region was examined. Biopsies were processed for microscopic examination and measurement of mitochondrial O2 consumption(cellular respiration), cellular adenosine triphosphate(ATP), glutathione(GSH), and caspase activity. In the second group of patients(n = 23), both corpus and antral regions were studied. Some biopsies were processed for microscopic examination, while the others were used for measurements of cellular respiration and GSH level.RESULTS: Microscopic examinations of gastric corpus biopsies from 17 patients revealed normal mucosae in 8 patients, superficial gastritis in 7 patients, and chronic atrophic gastritis in 1 patient. In patients with normal histology, the rate(mean ± SD) of cellular respiration was 0.17 ± 0.02 μmol/L O2 min-1 mg-1, ATP content was 487 ± 493 pmol/mg, and GSH was 469 ± 98 pmol/mg. Caspase activity was detected in 3 out of 8 specimens. The values of ATP and caspase activity were highly variable. The presence of superficial gastritis had insignificant effects on the measured biomarkers. In the patient with atrophic gastritis, cellular respiration was high andATP was relatively low, suggesting uncoupling oxidative phosphorylation. In the second cohort of patients, the examined biopsies showed either normal or superficial gastritis. The rate of cellular respiration(O2. μmol/L min-1 mg-1) was slightly higher in the corpus than the antrum(0.18 ± 0.05 vs 0.15 ± 0.04, P = 0.019). The value of GSH was about the same in both tissues(310 ± 135 vs 322 ± 155, P = 0.692).CONCLUSION: The corpus mucosa was metabolically more active than the antrum tissue. The data in this study will help in understanding the pathophysiology of gastric mucosa. | Ali S Alfazari Bayan Al-Dabbagh Wafa Al-Dhaheri Mazen S Taha Ahmad A Chebli Eva M Fontagnier Zaher Koutoubi Jose Kochiyi Sherif M Karam Abdul-Kader Souid | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 3 | Oral refeeding in mild acute pancreatitis:An old challenge显示文摘Although the idea that pancreas rest has long been considered as a very relevant topic in acute pancreatitis (AP)therapy,the right time and type of diet to be offered to patients recovering from an acute attack are a great challenge to clinicians who treat this condition.Fortunately,the last decade was noted for several trials looking for the best answer to the question:'when and how to start oral refeeding in AP?'It is well known that 80%of patients present with mild disease characterized by usually uncomplicated clinical course are managed with pancreatic rest through nil per oral;while the use of specific nutritional intervention is an exception.Therefore,mild AP has been the most investigated form of AP and researchers have tried different kind of meals to offer calories and reduce costs by shortening hospitalization time.Usually in mild AP,the oral refeeding is introduced between the first 3 d and 7 d after hospitalization but,the type of diet and patients’tolerance have been scrutinized in detail with mixed results.Although 20%to 25%have pain recurrence requiring nutritional support and greater time of hospitalization,most patients seem to tolerate oral refeeding well.We propose analyzing the most recent investigations of this matter and their conclusions to develop a better understanding of the management of AP. | Júlio Maria F Chebli Pedro D Gaburri Liliana A Chebli | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 2 |
| 4 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 5 | A numerical model for ground-borne vibrations from underground railway traffic based on a periodic finite element–boundary element formulation显示文摘 | G. Degrande D. Clouteau R. Othman M. Arnst H. Chebli R. Klein P. Chatterjee B. Janssens | 2006 | Journal of Sound and Vibration2006，，3： | 2 |
| 6 | Transport Logistics in Pollen Tubes显示文摘细胞的体积和结果的效果拖的在内的细胞的细胞器行动在 cytosol 在液体原因 bulkmovement 上强迫。细胞器和 cytosol 的运动导致称为 cytoplasmicstreaming 或胞质环流的一个全面运动模式。这流启用在 cellularcompartments 之间的分子和细胞器的活跃、被动的运输。而且,熔化并且泡与并且从血浆膜(exo/endocytosis ) 开始发育允许在里面和房间的外面之间的材料的 fortransport。在花粉试管,细胞质的流和很活跃的 exo/endocytosisare 并且完成几不同功能。在这评论,我们象他们的生物物理的 underpinnings 一样集中于细胞内部的 motionand 运输过程的后勤。我们讨论是 performedto 的各种各样的当模特儿的尝试理解长途的 shuttling 并且细胞器的短距离的指向。我们显示出怎么 mechanicaland 的联合与生物途径贡献了我们理解细胞内部的 transportlogistics.Key 词的房间的数学建模: | Youssef Chebli Jens Kroeger Anja Geitmann | 2013 | Molecular Plant2013，6，4： | 2 |
| 7 | Mood swings in patients with Crohn's disease: incidence and associat ed factors显示文摘 | Lima F D Ribeiro T C Chebli L A | 2012 | Rev Assoc Med Bras2012，58，4： | 1 |
| 8 | Strongyloides hyper-infection causing life-threatening gastrointestinal bleeding显示文摘A 55-year old male patient was diagnosed with strongy- loides hyper-infection with stool analysis and intestinal biopsy shortly after his chemotherapy for myeloma. He was commenced on albendazole anthelmintic therapy. After initiation of the treatment he suffered life- threatening gastrointestinal (GI) bleeding. Repeated endoscopies showed diffuse multi-focal intestinal bleeding. The patient required huge amounts of red blood cells and plasma transfusions and correction of haemostasis with recombinant activated factor Ⅶ. Abdominal aorto-angiography showed numerous micro- aneurysms (‘berry aneurysms’) in the superior and inferior mesenteric arteries’ territories. While the biopsy taken prior to the treatment with albendazole did not show evidence of vasculitis, the biopsy taken after initiation of therapy revealed leukoclastic aggregations around the vessels. These findings suggest that, in addition to direct destruction of the mucosa, vasculitis could be an important additive factor causing the massive GI bleeding during the anthelmintic treatment. This might result from substances released by the worms that have been killed with anthelmintic therapy. Current guidelines advise steroids to be tapered and stopped in case of systematic parasitic infections as they might reduce immunity and precipitate parasitic hyper-infection. In our opinion, steroid therapy might be of value in the management of strongyloides hyper- infection related vasculitis, in addition to the anthelmintic treatment. Indeed, steroid therapy of vasculitis with other means of supportive care resulted in cessation of the bleeding and recovery of the patient. | Lajos Csermely Hassan Jaafar Jorgen Kristensen Antonio Castella Waldemar Gorka Ahmed Ali Chebli Fawaz Trab Hussain Alizadeh Béla Hunyady | 2006 | World Journal of Gastroenterology2006，12，39： | 1 |
| 9 | Integrated front-end receiver for a portable ultrasonic system显示文摘 | Sawan M Chebli R Kassem A | 2003 | Analog Integrated Circuits and Signal Processing2003，36，12： | 1 |
| 10 | Effects of scape-injured 1-aminocyclopropane1-carboxylic acid(ACC)on the vase life of ‘Testarossa' cut gerbera显示文摘 | Gersopoulos D Chebli B | 1998 | J Amer Soc Hort Sci1998，123，5： | 1 |
| 11 | Prevalence and Pathogenesis of Duodenal Ulcer in Chronic Alcoholic Pancreatitis显示文摘 | Julio Maria Fonseca Chebli Aécio Flávio Meirelles de Souza Pedro Duarte Gaburri Kátia Valeria Bastos Tarsila Campanha Rocha Ribeiro Roberto José Carvalho Filho Liliana Andrade Chebli Lincoln Eduardo V.V. Castro Ferreira | 2002 | Journal of Clinical Gastroenterology2002，，1： | 1 |
| 12 | Fracture incidence in polyostotic fibrous dysplasia and the McCune-Albright syndrome 显示文摘 | Leet AI Chebli C Kushner H | 2004 | J Bone Miner Res2004，19，4： | 1 |
| 13 | Spontaneous bacterial peritonitis: How to deal with this life-threatening cirrhosis complication显示文摘 | Ribeiro TC Chebli JM Kondo M | 2008 | Therapeutics and Clinical Risk Management2008，4，5： | 1 |
| 14 | The RasGAP-associated endoribonuclease G3BP assembles stress granules 显示文摘 | Tourriere H Chebli K Zekri L | 2003 | J Cell Bi- ol2003，160，6： | 1 |
| 15 | Rasgap-associated endoribonuclease G3BP: selective RNA degradation and phosphorylation- dependent localisation 显示文摘 | Tourriere H Gallouzi I Chebli K | 2001 | Mol Cell Biol2001，21，22： | 1 |
| 16 | 3D periodic BE-FE model for various transportation structures interacting with soil显示文摘 | Chebli H Othman R Clouteau D Amst M Degrande G | | 0，，01： | 1 |
| 17 | Fracture incidence in polyostotic fibrous dysplasia and the McCune-Albright syndrome显示文摘 | Leet A I Chebli C Kushner H | 2004 | J Bone Miner Res2004，19，4： | 1 |
| 18 | Calpain 2 expression pattern and sub - cellular localization during mouse embryogenesis 显示文摘 | Raynaud F Marcilhac A Chebli K | 2008 | The Inter- national Journal of Developmental Biology2008，52，4： | 1 |
| 19 | RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation- dependent localization 显示文摘 | Tourrier H Gallouzi I E Chebli K | 2001 | Mol Cell Biol2001，21，22： | 1 |
| 20 | Control of fetal growth and neonatal survival by the RasGAP-associated endoribonuclease G3BP 显示文摘 | Zekri L Chebli K Tomxiere H | 2005 | Mol Cell Bio12005，25，19： | 1 |
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