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| 1 | Internal ribosome entry site-based vectors for combined gene therapy显示文摘Gene therapy appears as a promising strategy to treatincurable diseases. In particular, combined gene therapy has shown improved therapeutic efficiency. Internal ribosome entry sites(IRESs), RNA elements naturally present in the 5' untranslated regions of a few m RNAs, constitute a powerful tool to co-express several genes of interest. IRESs are translational enhancers allowing the translational machinery to start protein synthesis by internal initiation. This feature allowed the design of multi-cistronic vectors expressing several genes from a single m RNA. IRESs exhibit tissue specificity, and drive translation in stress conditions when the global cell translation is blocked, which renders them useful for gene transfer in hypoxic conditions occurring in ischemic diseases and cancer. IRES-based viral and non viral vectors have been used successfully in preclinical and clinical assays of combined gene therapy and resulted in therapeutic benefits for various pathologies including cancers, cardiovascular diseases and degenerative diseases. | Edith Renaud-Gabardos Fransky Hantelys Florent Morfoisse Xavier Chaufour Barbara Garmy-Susini Anne-Catherine Prats | 2015 | World Journal of Experimental Medicine2015，5，1： | 4 |
| 2 | Transient accumulation, phosphorylation and changes in the oligomerization of Hsp27 during retinoic acid -induced differentiation of HL - 60 cells: possible role in the control of cellular growth and differentiation 显示文摘 | Chaufour S Mehlen P Arrigo AP | 1996 | Cell Stress and Chaperones1996，1，4： | 1 |
| 3 | Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels 显示文摘 | Arrigo AP Virot S Chaufour S | 2005 | Antioxid Redox Signal2005，7，： | 1 |
| 4 | Evaluation of disinfection and sterilization of reusable angioscopes with the duck hepatitis B model显示文摘 | Xavier Chaufour Anand K. Deva Karen Vickery Jean Zou Priya Kumaradeva Geoff H. White Yvonne E. Cossart | 1999 | Journal of Vascular Surgery1999，，2： | 1 |
| 5 | Comparative wheal and flare study of mizolastine vs terfenadine, cetirizine,loratadine and placebo in healthy volunteers 显示文摘 | Rosenzweig P Caplain H Chaufour S | 1995 | Br J Clin Pharmacol1995，40，5： | 1 |
| 6 | Apoptosis of vascular smooth muscle cells induced by cholesterol and its oxides in vitro and in vivo显示文摘 | Yin J Chaufour X McLachlan C | 2000 | Atherosclerosis2000，148，2： | 1 |
| 7 | Study of cardiac repolarization in healthy volunteers performed with mizolastine, a new H-receptor antagonist显示文摘 | Caplain H Lilienthal N | 1999 | Br J Clin Parmacol1999，47，： | 1 |
| 8 | Comparative wheal and flare study of mizolastine vs terfenadine,cetirizine, loratadine and placeboinheahhy volunteers显示文摘 | Rosenzweig P Caplain H Chaufour S | 1995 | BR J Clin Pharmacol1995，40，5： | 1 |
| 9 | Comparative wheal and flare study of mizolastine vs terfenadine,cetirizine,loratadine and placebo in healthy volunteers显示文摘 | Rosenzweig P Caplain H Chaufour S | 1995 | Br J Clin Pharmacol1995，40，5： | 1 |
| 10 | Study of cardiac repolarization in healthy volunteers performed with mizolastine, a new HI-receptor antagonist显示文摘 | Chaufour S Caplain H Lilienthal N | 1999 | Br J Clin Pharmacol1999，47，5： | 1 |
| 11 | Hsp27consolidates intracellular redoxhomeostasis by upholdingglutathione in its reduced form and by decreasingironintracellular levels显示文摘 | Arrigo A P Virot S Chaufour S | 2005 | Antioxid Redox Signal2005，7，34： | 1 |
| 12 | QT interval monitoring during clinical studies with mizolastine, a new Hi antihistamine显示文摘 | Delauche-Cavallier MC Chaufour S Guerault E | 1999 | Clin Exp Allergy1999，29，3： | 1 |
| 13 | Drive and automatic control of ropeways with to and fro movement 显示文摘 | Chaufour J M | 1976 | Rescue Generale de l''Electricite1976，85，12： | 1 |
| 14 | Transient accumulation,phosp horylation and changes in the oligomerization of Hsp27 during retinoic acid-ind uced differentiation of HL?60 cells:possible role in the control of cellular gr owth and differentiation 显示文摘 | Mehlen P Arrigo AP | 1996 | Cell Stress Chaper1996，1，： | 1 |
| 15 | Apoptosis of vascular smooth muscle cells induced by cholesterol and its oxides in vitro and in vivo显示文摘 | CHAUFOUR X MCLACHLAN C | 2000 | Atherosclerosis2000，148，： | 1 |
| 16 | HSP27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels 显示文摘 | ARRIGO AP VIROT S CHAUFOUR S | 2005 | Antioxid Redox Signal2005，7，34： | 1 |
| 17 | Comparative wheal and flare study mizolastine vs terfenadine, cetirizine, loratadine and placebo in healthy volunteers 显示文摘 | Rosenzweig P Caplain H Chaufour S | 1995 | Br J Clin Pharmacol1995，40，5： | 1 |
| 18 | QT interval monitoring during clinical studies with mizolastine, a new H1 Antihistamine显示文摘 | Delauche-Cavallier MC Chaufour S Guerault E | 1999 | Clin Exp Allergy1999，293，： | 1 |
| 19 | Comparative uhelal and flare study of mizolastine vs terfenadine,cetirizine,loratadine and placebo in healthy volunteers显示文摘 | Rosenzweig P Caplain H Chaufour S | 1995 | Bv J Clin Pharmacol1995，40，15： | 1 |
| 20 | Mammalian Small Stress Proteins Protect against Oxidative Stress through Their Ability to Increase Glucose-6-phosphate Dehydrogenase Activity and by Maintaining Optimal Cellular Detoxifying Machinery显示文摘 | Xavier Préville Francesca Salvemini Stéphane Giraud Sylvain Chaufour Catherine Paul Georges Stepien Matilde Valeria Ursini André-Patrick Arrigo | 1999 | Experimental Cell Research1999，，1： | 1 |
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