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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Evolution of the social network of scientific collaborations显示文摘 | A.L Barabási H Jeong Z Néda E Ravasz A Schubert T Vicsek | 2002 | Physica A: Statistical Mechanics and its Applications2002，，3： | 3 |
| 3 | Embryonal rhabdomyosarcoma in the maxillary sinus with orbital involvement in a pediatric patient:Case report显示文摘This report presents a case of embryonal rhabdomyosarcoma(e RMS) located in the left maxillary sinus and invading the orbital cavity in a ten-year-old male patient who was treated at a referral hospital.The images provided from the computed tomography showed a heterogeneous mass with soft-tissue density,occupying part of the left half of the face inside the maxillary sinus,and infiltrating and destroying the bone structure of the maxillary sinus,left orbit,ethmoidal cells,nasal cavity,and sphenoid sinus.An analysis of the histological sections revealed an undifferentiated malignant neoplasm infiltrating the skeletal muscle tissue.The immunohistochemical analysis was positive for the antigens:MyoD 1,myogenin,desmin,and Ki67(100% positivity in neoplastic cells),allowing the identification of the tumour as an eR MS.The treatment protocol included initial chemotherapy followed by radiotherapy and finally surgery.The total time of the treatment was nine months,and in 18-mo of follow-up period did not show no local recurrences and a lack of visual impairment. | Ana Carolina Rodrigues de Melo Tácio Candeia Lyra Isabella Lima Arrais Ribeiro Alexandre Rolim da Paz Paulo Rogério Ferreti Bonan Ricardo Dias de Castro Ana Maria Gondim Valen?a | 2017 | World Journal of Clinical Cases2017，5，12： | 3 |
| 4 | 顽固性高血压与由心内容积决定的血管内液体潴留无关显示文摘顽固性高血压(refractory hypertension,RfHTN)是一种极端的抗高血压治疗失败的表现形式,定义为使用了包括长效噻嗪类和盐皮质激素受体拮抗剂在内的≥5种药时血压仍控制欠佳。RfHTN是难治性高血压(resistant hypertension,RHTN)的一个亚组,RHTN定义为使用≥3种降压药(包括利尿剂)后血压仍〉135/85mm Hg(1mm Hg=0.133kPa)。 | 刘青 叶鹏 Velasco A Siddiqui M Kreps E Kolakalapudi P Dudenbostel T Arora G Judd EK Prabhu SD Lloyd SG Oparil S Calhoun DA | 2018 | 中华高血压杂志2018，26，7： | 2 |
| 5 | Tumor necrosis factor alpha prevents tumor necrosis factor receptormediated mouse hepatocyte apoptosis, but not fasmediated apoptosis: role of nuclear factor-kappaB 显示文摘 | Nagaki M Naiki T Brenner DA | 2000 | Hepatology2000，32，6： | 2 |
| 6 | SiC/C薄膜的制备及其力学性能显示文摘 以SiC超细粉为原料、采用热等离子体物理气相沉积(TPPVD)技术快速制备出了高质量SiC/C薄膜,最大沉积速度达到225nm/s,高于常规物理气相沉积(PVD)和化学气相沉积(CVD)法两个数量级。用扫描电子显微镜、高分辨透射电子显微镜和X射线光电子谱对薄膜的形貌和微结构进行了观察和分析,并用纳牛力学探针测定了薄膜的力学性能。研究结果表明,向等离子体中导入CH4,SiC/C薄膜沉积速度增大,薄膜中C含量增加,薄膜断面呈现柱状结构。薄膜硬度和弹性模量随薄膜中C含量增加而降低,在接触深度为40nm时由纳牛力学探针测得沉积薄膜的最大硬度达到38GPa。 | 王新华 YOSHI DA T | 2005 | 复合材料学报2005，22，1： | 2 |
| 7 | 年龄对高血压患者血压评估的影响显示文摘 | 张玲玉 叶鹏 Lima NK Duarte PO da Freiria MG Almeida EF Rezende T Machado JV | 2010 | 中华高血压杂志2010，18，11： | 2 |
| 8 | Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer:results from a multicenter study in China显示文摘To evaluate whether prostate volume(PV)would provide additional predictive utility to the prostate health index(phi)for predicting prostate cancer(PCa)or clinically significant prostate cancer,we designed a prospective,observational multicenter study in two prostate biopsy cohorts.Cohort 1 included 595 patients from three medical centers from 2012 to 2013,and Cohort 2 included 1025 patients from four medical centers from 2013 to 2014.Area under the receiver operating characteristic curves(AUC)and logistic regression models were used to evaluate the predictive performance of PV-based derivatives and models.Linear regression analysis showed that both total prostate-specific antigen(tPSA)and free PSA(fPSA)were significantly correlated with PV(all P<0.05).[-2]proPSA(p2PSA)was significantly correlated with PV in Cohort 2(P<0.001)but not in Cohort 1(P=0.309),while no significant association was observed between phi and PV.When combining phi with PV,phi density(PHID)and another phi derivative(PHIV,calculated as phi/PV°5)did not outperform phi for predicting PCa or clinically significant PCa in either Cohort 1 or Cohort 2.Logistic regression analysis also showed that phi and PV were independent predictors for both PCa and clinically significant PCa(all P<0.05);however,PV did not provide additional predictive value to phi when combining these derivatives in a regression model(all models vs phi were not statistically significant,all P>0.05).In conclusion,PV-based derivatives(both PHIV and PHID)and models incorporating PV did not improve the predictive abilities of phi for either PCa or clinically significant PCa. | Da Huang Yi-Shuo Wu Ding-Wei Ye Jun Qi Fang Liu Brian T Helfand Siqun L Zheng Qiang Ding Dan-Feng Xu Rong Na Jian-Feng Xu Ying-Hao Sun | 2020 | Asian Journal of Andrology2020，22，5： | 2 |
| 9 | Comparative study of propylene polymerization using Me2Si(Rind)2ZrCl2/SiO2-SMAO/AlR3 and Me2Si(RInd)2ZrCl2/MAO(R=Me, H)显示文摘 | Franceschini F C da R Tavares T T dos Santos J H Z | 2007 | Polymer2007，48，7： | 1 |
| 10 | SLICC/ ACR damage index is valid and renal and pulmonary organ scores are predictors of severe outcome in patients with systemic lupus erythematosus显示文摘 | Seifert B Isenberg DA | 1996 | Br J Rheumatol1996，35，2： | 1 |
| 11 | Soil dehydrogenase activity显示文摘 | CASIDA LC KLEIN DA SANTORO T | 1964 | Soil Science1964，98，： | 1 |
| 12 | Cystosarcoma phyllodes:mastecotomy,lumpectorma,or lumpectomy puls irradiation显示文摘 | August DA Keamey T | 2000 | Surg Onco2000，9，2： | 1 |
| 13 | Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors显示文摘 | Kafri T Blomer U Peterson DA | 1997 | Nat Genet1997，17，2： | 1 |
| 14 | Serum unconjugated bile acids as a test for intestinal bacterial overgrowth in dogs显示文摘 | Melgarejo T Williams DA O' Connell NC | 2000 | Dig Dis Sci2000，45，2： | 1 |
| 15 | The effect of time,temperature and storage device on umbilical cord blood gas and lactate measurement: a randomized controlled trial显示文摘 | White CR Mok T Doherty DA | 2012 | J Matern Fetal Neonatal Med2012，25，6： | 1 |
| 16 | Measuring quality of life in cleft lip and palate patients: currently available patient-reported out- comes measures显示文摘 | Eckstein DA Wu RL Akinbiyi T | 2011 | Plastic Reconstr Surg2011，128，5： | 1 |
| 17 | Diagnostic value of the left atrial electrical potentials detected by body surface potential mapping in the prediction of coronary artery disease显示文摘 | Bauernfeind T Préda I Szakolczai K | 2011 | Int J Cardiol2011，150，3： | 1 |
| 18 | The essential oil of Eucalyptus tereticornis and its constituents, α-and β-pinene, show accelerative properties on rat gastrointestinal transit 显示文摘 | Juca D M Da Silva M T Junior RC Jr | 2011 | Planta Med2011，77，1： | 1 |
| 19 | Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients显示文摘 | Yauch RL Januario T Eberhard DA | 2005 | Clin Cancer Res2005，11，241： | 1 |
| 20 | Subconjunetival gas bub- ble formation during LASIK flap creation using femtoseeond laser 显示文摘 | Ide T Kymionis GD Goldman DA | 2008 | J Refract Surg2008，24，： | 1 |
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