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| 1 | PIKA as an Adjuvant Enhances Specific Humoral and Cellular Immune Responses Following the Vaccination of Mice with HBsAg plus PIKA显示文摘An adjuvant is usually used to enhance the immune response induced by vaccines. The choice of adjuvant or immune enhancer determines the effectiveness of the immune response. Currently, aluminium (Alum, a generic term for salts of aluminium) is the only FDA-approved adjuvant. Alum predominantly induces the differentiation of Th2 cells and thus mediates an antibody immune response. Therefore, there is an urgent need for new adjuvants that enhance not only humoral but also cellular immune responses. In the present study, we demonstrates that PIKA (a stabilized dsRNA) as an adjuvant directly induces the activation and the proliferation of both B and NK cells in vitro. Injection of PIKA into mice results in the production of cytokines in vivo. In addition, the study demonstrates that PIKA promotes the maturation of bone marrow-derived dendritic cells (BMDCs) including up-regulation of the co-stimulatory molecules CD80, CD86 and CD40, and the induction of cytokines such as IL-12p70, IL-12p40 and IL-6. Importantly, after immunization of mice with HBsAg plus PIKA, the presence of PIKA enhances the titers of HBsAg-specific IgG and HBsAg-specific IFN-γ production. These results demonstrate that PIKA as an adjuvant can promote both humoral and cellular immune responses. These might have an implication in applying PIKA as an adjuvant to be used in the design and development of both therapeutic and preventive vaccines, and used in the clinical study. | Erxia Shen Li Li Lietao Li Lianqiang Feng Lin Lu Ziliang Yao Haixiang Lin Changyou Wu | 2007 | Cellular & Molecular Immunology2007，4，2： | 13 |
| 2 | Dexamethasone-loaded ROS-responsive poly(thioketal)nanoparticles suppress inflammation and oxidative stress of acute lung injury显示文摘Acute lung injury(ALI)is associated with excessive inflammatory response,leading to acute respiratory distress syndrome(ARDS)without timely treatment.A fewer effective drugs are available currently to treat the ALI/ARDS.Herein,a therapeutic nanoplatform with reactive oxygen species(ROS)-responsiveness was developed for the regulation of inflammation.Dexamethasone acetate(Dex)was encapsulated into poly(thioketal)polymers to form polymeric nanoparticles(NPs)(PTKNPs@Dex).The NPs were composed of poly(1,4-phenyleneacetonedimethylene thioketal)(PPADT)and polythioketal urethane(PTKU),in which the thioketal bonds could be cleaved by the high level of ROS at the ALI site.The PTKNPs@Dex could accumulate in the pulmonary inflammatory sites and release the encapsulated payloads rapidly,leading to the decreased ROS level,less generation of pro-inflammatory cytokines,and reduced lung injury and mortality of mice.RNA sequencing(RNA-seq)analysis showed that the therapeutic efficacy of the NPs was associated with the modulation of many immune and inflammation-linked pathways.These findings provide a newly developed nanoplatform for the efficient treatment of ALI/ARDS. | Zihe Zhai Wei Ouyang Yuejun Yao Yuqi Zhang Haolan Zhang Feng Xu Changyou Gao | 2022 | Bioactive Materials2022，7，8： | 5 |
| 3 | Data-driven Transient Stability Assessment Based on Kernel Regression and Distance Metric Learning显示文摘Transient stability assessment(TSA) is of great importance in power systems. For a given contingency, one of the most widely-used transient stability indices is the critical clearing time(CCT), which is a function of the pre-fault power flow.TSA can be regarded as the fitting of this function with the prefault power flow as the input and the CCT as the output. In this paper, a data-driven TSA model is proposed to estimate the CCT. The model is based on Mahalanobis-kernel regression,which employs the Mahalanobis distance in the kernel regression method to formulate a better regressor. A distance metric learning approach is developed to determine the problem-specific distance for TSA, which describes the dissimilarity between two power flow scenarios. The proposed model is more accurate compared to other data-driven methods, and its accuracy can be further improved by supplementing more training samples.Moreover, the model provides the probability density function of the CCT, and different estimations of CCT at different conservativeness levels. Test results verify the validity and the merits of the method. | Xianzhuang Liu Yong Min Lei Chen Xiaohua Zhang Changyou Feng | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，1： | 4 |
| 4 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 5 | A Pragmatic Method to Determine Transient Stability Constrained with Interface Real Power Flow Limits via Power System Scenario Similarity显示文摘In practical power systems,operators generally keep interface flowing under the transient stability constrained with interface real power flow limits(TS-IRPFL)to guarantee transient stability of the system.Many methods of computing TS-IRPFL have been proposed.However,in practice,the method widely used to determine TS-IRPFL is based on selection and analysis of typical scenarios as well as scenario matching.First,typical scenarios are selected and analyzed to obtain accurate limits,then the scenario to be analyzed is matched with a certain typical scenario,whose limit is adopted as the forecast limit.In this paper,following the steps described above,a pragmatic method to determine TS-IRPFL is proposed.The proposed method utilizes data-driven tools to improve the steps of scenario selection and matching.First of all,we formulate a clear model of power system scenario similarity.Based on the similarity model,we develop a typical scenario selector by clustering and a scenario matcher by nearest neighbor algorithm.The proposed method is pragmatic because it does not change the existing procedure.Moreover,it is much more reasonable than the traditional method.Test results verify the validity of the method. | Xianzhuang Liu Yong Min Lei Chen Xiaohua Zhang Changyou Feng Wei Hu | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 1 |
| 6 | A comparative study on the bleeding显示文摘 | Wang Changyou Wang Feng | 2009 | Jo urnal of Qiqihar Medical School ulcer omeprazole and pantoprazole in treatment of upper gastrointestinal2009，36，08： | 1 |
| 7 | PRINCIPLES FOR OPTIMUM DESIGN OF OPEN PIT MINES显示文摘PRINCIPLESFOROPTIMUMDESIGNOFOPENPITMINESShiZhongmin,FengZhongren,XuChangyouDepartmentofMineralResourceandEnvironmentEngineeri... | Shi, Zhongmin Feng, Zhongren Xu, Changyou Zhang, Youdi | 1997 | 中国有色金属学会会刊:英文版1997，7，1： | 1 |
| 8 | Surface wettability of compressed polyelectrolyte multilayers显示文摘 | Bo Wang Jie Feng Changyou Gao | 2005 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2005，，1： | 1 |
| 9 | Biological hydrogel synthesized from hyaluronic acid, gelatin and chondroitin sulfate by click chemistry显示文摘 | Xiaohong Hu Dan Li Feng Zhou Changyou Gao | 2010 | Acta Biomaterialia2010，，4： | 1 |
| 10 | A tarsus construct of a novel branched polyethylene with good elasticity for eyelid reconstruction in vivo显示文摘Branched polyethylene(B-PE)elastomer was investigated for its potential medical application as a tarsus construct.The in vitro results showed that the B-PE and processed B-PE films or scaffolds did not exhibit noticeable cytotoxicity to the NIH3T3 fibroblasts and human vascular endothelial cells(ECs).The B-PE scaffolds with a pore size of 280–480 mm were prepared by using a gelatin porogen-leaching method.The porous scaffolds implanted subcutaneously in rats exhibited mild inflammatory response,collagen deposition and fast fibrovascularization,suggesting their good biocompatibility.Quantitative real-time PCR analysis showed low expression of pro-inflammatory genes and up-regulated expressions of collagen deposition and vascularization-related genes,validating the results of historical evaluation in a molecular level.The B-PE scaffolds and Medpor controls were transplanted in rabbits with eyelid defects.The B-PE scaffolds exhibited a similar elastic modulus and provided desirable repair effects with mild fibrous capsulation,less eyelid deformities,and were well integrated with the fibrovascular tissue compared with the Medpor controls. | Peifang Xu Xue Feng Honghao Zheng Zhongwei Feng Zhisheng Fu Changyou Gao Juan Ye | 2020 | Regenerative Biomaterials2020，7，3： | 1 |
| 11 | Functionalizing of polyurethane surfaces by photografting with hydrophilic monomers 显示文摘 | Guan Jianjun Gao Changyou Feng Linxiang Shen Jiacong | 2000 | Journal of Applied Polymer Science2000，77，11： | 1 |
| 12 | A Competitive Mechanism of Unit Maintenance Scheduling in a Deregulated Environment显示文摘 | FENG Changyou WANG Xifan | 2010 | IEEE Transactions on Power Systems2010，25，1： | 1 |
| 13 | Co-delivery of TRAIL gene enhances the anti-glioblastoma effect of paclitaxel in vitro and in vivo显示文摘 | Changyou Zhan Xiaoli Wei Jun Qian Linglin Feng Jianhua Zhu Weiyue Lu | 2012 | Journal of Controlled Release2012，，3： | 1 |
| 14 | A competitive mechanism of unit maintenance scheduling in a deregulated environment显示文摘 | FENG Changyou WANG Xifan | 2010 | IEEE Transactions on Power Systems2010，25，1： | 1 |
| 15 | Micelle‐Based Brain‐Targeted Drug Delivery Enabled by a Nicotine Acetylcholine Receptor Ligand显示文摘 | Changyou Zhan Bian Li Luojuan Hu Xiaoli Wei Linyin Feng Wei Fu Weiyue Lu | 2011 | Angew Chem Int Ed2011，，24： | 1 |
| 16 | Low Temperature Hydrothermal Synthesis of Ultra-light and Superelastic Graphene Oxide/Cellulose Aerogels for Absorption of Organic Liquids显示文摘Two-dimensional(2 D) graphene oxide(GO) nanosheets and 1 D2,2,6,6-tetramethylpiperidin-1-oxyl(TEMPO)-oxidized cellulose nanofibers(TOCN) were assembled into GO/TOCN aerogels via a low temperature hydrothermal and freeze-drying process. The as-prepared GO/TOCN aerogels exhibited interconnected 3 D network microstructures, a low density of 6.8 mg/cm^3, a high porosity up to 99.2% and excellent mechanical flexibility.The high porosity in conjunction with their hydrophobicity(contact angle of 121.5°), allowed the aerogels to absorb different organic liquids with absorption capacities up to 240 times of their own weight, depending on the density of the liquids. These results indicated that the aerogels were excellent candidates as sorbent materials for the clean-up of organic liquids. After five absorption-desorption cycles, the absorption capacity of the TOCN carbon aerogels could be regenerated up to 97% of the initial absorption capability,which demonstrated their excellent recyclability. | Meng Wang ChangYou Shao SuKun Zhou Jun Yang Feng Xu | 2018 | Paper And Biomaterials2018，3，1： | 0 |
| 17 | Advances Toward Sustainable Lignin-based Gel for Energy Storage and Smart Sensing显示文摘Polymers obtained from biomass are promising alternatives to petrobased polymers owing to their low cost,biocompatibility,and biodegradability.Lignin,a complex aromatic polymer containing several functional hydrophilic and active groups including hydroxyls,carbonyls,and methoxyls,is the second most abundant biopolymer in plants.In particular,sustainable ligninbased gels are emerging as an appealing material platform for developing energy-and sensing-related applications owing to their attractive and tailorable physiochemical properties.This study describes the preparation strategies of lignin-based gels according to previously reported methods,with significant attention on the diverse performance of lignin-derived gel materials.Additionally,a detailed review of lignin-based gels utilized as an important resource in diverse fields is provided.Finally,a future vision on challenges and their possible solutions is presented. | Yufan Feng Jie Yu Changyou Shao Runcang Sun | 2023 | Paper And Biomaterials2023，8，2： | 0 |
| 18 | Design spherical particles of potassium peroxymonosulfate compound salt with high stability and good powder properties via an agglomeration-dissolution mechanism显示文摘With the outbreak of COVID-19,disinfection protection has become a necessary measure to prevent infection.As a new type of disinfectant,potassium peroxymonosulfate compound salt(PMS)has the advantages of good bactericidal effect,non-toxicity,high safety and stability.However,the current PMS products with irregular particle shapes lead to poor flowability,high hygroscopicity,poor stability of reactive oxygen species(ROS)and serious caking problems.In this work,an agglomeration-dissolution mechanism was designed to prepare spherical PMS particles with large size(>300μm)and high sphericity(up to 90%),effectively addressing the above problems.Shaping(dissolution and abrasion)is the key to improving sphericity,which is mainly controlled by the design of the heating mode,residence time and stirring rate.Compared with the irregular PMS particles,the large spherical particles present better flowability(angle of repose decreased by 35.80%,Carr's index decreased by 64.29%,Hausner's ratio decreased by 19.14%),lower hygroscopicity(decreased by 38.0%),lower caking ratio(decreased by 84.50%),and higher stability(the monthly loss of ROS was reduced by 61.68%).The agglomeration-dissolution mechanism demonstrates the crystallization,agglomeration,dissolution and abrasion process of inorganic salt crystals,providing an opportunity to prepare high-end inorganic crystal materials with high-quality morphologies. | Shanshan Feng Changyou Yu Shilin Guo Jinbo Ouyang Fei Yin Xiaodong Zhang Yongjian Zhang Mingyang Chen Dandan Han Junbo Gong Jingkang Wang | 2023 | Particuology2023，，9： | 0 |
| 19 | Improving the fretting biocorrosion of Ti6Al4V alloy bone screw by decorating structure optimised TiO2 nanotubes layer显示文摘TiO2 nanotubes(NT)has been demonstrated its potential in orthopaedic applications due to its enhanced surface wettability and bio-osteointegration.However,the fretting biocorrosion is the main concern that limited its successfully application in orthopaedic application.In this study,a structure optimised thin TiO2 nanotube(SONT)layer was successfully created on Ti6Al4V bone screw,and its fretting corrosion performance was investigated and compared to the pristine Ti6Al4V bone screws and NT decorated screw in a bone-screw fretting simulation rig.The results have shown that the debonding TiO2 nanotube from the bone screw reduced significantly,as a result of structure optimisation.The SONT layer also exhibited enhanced bio-corrosion resistance compared pristine bone screw and conventionally NT modified bone screw.It is postulated that interfacial layer between TiO2 nanotube and Ti6Al4V substrate,generated during structure optimisation process,enhanced bonding of TiO2 nanotube layer to the Ti6Al4V bone screws that leading to the improvement in fretting corrosion resistance.The results highlighted the potential SONT in orthopaedic application as bone fracture fixation devices. | Jiajun Luo Maryam Tamaddon Changyou Yan Shuanhong Ma Xiaolong Wang Feng Zhou Chaozong Liu | 2020 | Journal of Materials Science & Technology2020，47，14： | 0 |
| 20 | Protein corona mediated liposomal drug delivery for bacterial infection management显示文摘Liposomes have been widely investigated as a class of promising antibiotic delivery systems for the treatment of life-threatening bacterial infections.However,the inevitable formation of protein corona on the liposomal surface can heavily impact in vivo performance.A better understanding of the effects of protein corona on liposomal behavior can significantly improve antibacterial liposomal drug development.Here,the critical role of protein corona in mediating liposome-bacteria interactions was elucidated.Adsorption of negatively charged protein on cationic liposome weakened electrostatic attractionenhanced liposomal binding to the bacteria.Cumulative complement deposition on anionic liposome composed of phosphatidylglycerol(DSPG s Lip)contributed to a superior binding affinity of DSPG s Lip to planktonic bacteria and biofilms,which was exploited to enhance bacteria-targeted drug delivery.In both S.aureus-related osteomyelitis and pneumonia mice models,DSPG s Lip was demonstrated as a promising antibiotic nanocarrier for managing MRSA infection,indicating the benefits of lipid composition-based protein corona modulation in liposomal antibiotic delivery for bacterial infection treatment. | Qianwen Shao Tianhao Ding Feng Pan Guanghui Li Shun Shen Jun Qian Changyou Zhan Xiaoli Wei | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，6： | 0 |
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