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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | An unusual complication of silastic dural substitute case report显示文摘 | Thomas H K Chan K H Leung SY | 1990 | Neurosurgery1990，27，3： | 1 |
| 3 | A report of two families with sarcosinaemia in Hong Kong and revisiting the pathogenetic potential of hypersarcosinaemia 显示文摘 | Lee SY Chan KY Chan AY | 2006 | Ann Acad Med Singapore2006，35，8： | 1 |
| 4 | Diagnostic clues tomegalobastic anae- mia without macrocytosis 显示文摘 | Chan CW Eiu SY Kho CS | 2007 | Int J Lab-Hematol2007，29，3： | 1 |
| 5 | Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation显示文摘 | Chan YC Leung FP Wong WT Tian XY Yung LM Lau CW Tsang SY Yao X Chen ZY Huang Y | | 0，，： | 1 |
| 6 | miR-210:The master hypoxamir显示文摘 | Chan YC Banerjee J Choi SY | 2012 | Microcirculation2012，19，： | 1 |
| 7 | Motivational In- terviewing: A useful approach to imporving cadiovascular health显示文摘 | Thompson DR Chair SY Chan SW | 2011 | J Clin Nuts2011，20，910： | 1 |
| 8 | Endoscopic-assisted subcutaneous mastectomy and axillary dissection with immediate mammary prosthesis reconstruction for early breast cancer显示文摘 | Ho WS Ying SY Chan AC | 2002 | Surg Endosc2002，16，2： | 1 |
| 9 | A study to explore nurses' knowledge in using the Glasgow Coma Scale in an acute care hospital显示文摘 | Mattar I Liaw SY Chan MF | 2013 | J Neurosci Nurs2013，45，5： | 1 |
| 10 | A randomized trial on addition of concurrent adjuvant chemotherapy and/or ac- celerated fractionation for locally-advanced nasopharyn- geal carcinoma 显示文摘 | Lee AW Tung SY Chan AT | 2011 | Radiother oncol2011，98，1： | 1 |
| 11 | Treatment of port wine stainswith intense pulsed light:a prospective study显示文摘 | HoWS Ying SY Chan PC | 2004 | DermatolSurg2004，30，6： | 1 |
| 12 | Short - form Tai Chi improves standing balance of people with chronic stroke显示文摘 | Au- Yeung Stephanie SY Hui- Chan Christina WY Tang Jervis CS | 2009 | NeuroFehabilitation and Neural Repair2009，23，5： | 1 |
| 13 | Expression of vascular endothelial growth factor in von Hippel-Lindau syndrome-associated papillary cystadenoma of the epididymis 显示文摘 | Leung SY Chan AS Wong MP | 1998 | Hum Pathol1998，29，11： | 1 |
| 14 | Pathogenic mechanisms of pulmonary arterial hypertension显示文摘 | Chan SY Loscalzo J | 2008 | J Mol Cell Cardiol2008，44，1： | 1 |
| 15 | The genetic drift of human pa- pillomavirus type 16 is a means of reconstructing prehistoric viral spread and movement of ancient populations 显示文摘 | He I Chan SY Burk RD | 1993 | J Virol1993，67，11： | 1 |
| 16 | Suppression of Transforming Growth Factor Beta/Smad Signaling in Keloid-Derived fibroblasts by Quercetin:Implications for the Treatment of Excessive Scars显示文摘 | Phan TT Lim IJ Chan SY | 2004 | J Trauma2004，57，： | 1 |
| 17 | MicroRNA- 210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/ 2 显示文摘 | Chan SY Zhang Ying-Yi Hemann C | 2009 | Cell Metab2009，10，4： | 1 |
| 18 | Expression of vascular endothelial growth factor in von Hippel-Lindau syndromeassociated papillary cystadenoma of the epididymis显示文摘 | Leung SY Chan AS Wong MP | 1998 | Hum Pathol1998，29，11： | 1 |
| 19 | Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars 显示文摘 | Phan TT Lim I J Chan SY | 2004 | J Trauma2004，57，5： | 1 |
| 20 | Expression of vascular endothelial growth factor and its receptors in the anaplastic progression of astrocytoma,oligodendroglioma,and ependymoma显示文摘 | Chan AS Leung SY Wong MP | 1998 | Am J Surg Pathol1998，22，7： | 1 |
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