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| 1 | 医学领域一次研究和二次研究的方法学质量(偏倚风险)评价工具显示文摘方法学质量(偏倚风险)评估是医学研究开始前的重要步骤。因此,准确判断研究类型是前提,选择合适的评价工具也很重要。本综述介绍了用于随机对照试验(包括个体和整群)、动物实验、非随机干预性研究(包括随访研究、有对照组的前后对照研究、前后对照研究、非对照纵向研究、间断时间序列研究)、队列研究、病例-对照研究、横断面研究(包括分析和描述性研究)、观察性病例系列和病例报告、比较效果研究、诊断性研究、卫生经济学评价、预测研究(包括预测变量研究、预测模型影响研究、预后预测模型研究)、质性研究、结果测量工具(包括患者-报告的结果测量发展、内容真实性、结构真实性、内部一致性、跨文化真实性/测量不变性、信度、测量误差、校标真实性、结构真实性假设检验、反应度)、系统评价与Meta分析,以及临床实践指南的方法学质量评价工具。通过本综述,读者可以区分医学研究的类型并选择适当的工具。全面掌握相关知识并多加练习是正确评估方法学质量的基本要求。 | 李柄辉 訾豪 李路遥 王朝阳 任学群 郭毅(译) Ma LL Wang YY Yang ZH | 2021 | 医学新知2021，31，1： | 37 |
| 2 | Partial sequencing of 5' non-coding region of 7 HGV strains isolated from different areas of China显示文摘 | WANG Xing-Tai ZHUANG Hui SONG Hai-Bo Ll He-Min ZHANG Hua-Yuan and YU Yang(National Institute for the Control of bormceutical and BiologicalPriducts, Beijing 100050, China)(Department of Microbiology, Beijing Medical University, Beijing100083, China)(L | 1999 | World Journal of Gastroenterology1999，5，5： | 7 |
| 3 | Efficacies of β-L-D4A against Hepatitis B virus in 2.2.15 cells显示文摘AIM:To investigate the antiviral effect of beta-L-enantiomer of 2',3'-didehydro-2',3'-dideoxyadenosine (β-L-D4A) on 2.2.15 cells transfected with the hepatitis B virus (HBV) genome. METHODS:Lamivudine (3TC) as a positive control. Then, HBV DNA in treated 2.2.15 cells and the Hepatitis B surface antigen (HBsAg) in the culture supernatants were detected to determine the inhibitory effect of β-L-D4A. At the same time, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was used to detect the survival ratio of 2.2.15 cells. RESULTS:β-L-D4A has a dose-dependent inhibitory effect on HBV DNA replication;this effect was apparent when the concentration was above 1 mol/L. When β-L-D4A was at the highest concentration, 100 mol/L, the HBsAg inhibition ratio was above 50%. The Therapeutic index (TI) of β-L-D4A was above 2.1. CONCLUSION:β-L-D4A has a dose-dependent inhibitory effect on the replication of HBV DNA and the secretion of HBsAg at low toxicity. | Lin-Lin Gao, Xiao-Yan Wang, Ju-Sheng Lin, Ying-Hui Zhang, Yan Li, Institute of Liver Diseases, Tongji Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Author contributions:Gao LL and Wang XY contributed equally to this work Gao LL, Wang XY, Lin JS, Zhang YH, Li Y designed the research Gao LL and Wang XY performed the research Gao LL wrote the paper | 2008 | World Journal of Gastroenterology2008，14，8： | 7 |
| 4 | GSPAC water movement in extremely dry area显示文摘Under an extremely arid condition,a PVC greenhouse was built on the top of Mogao Grottoes in gobi area.The results of 235-day constant extraction of condensed water on the greenhouse film and soil water content showed that 2.1 g/(m2·d) groundwater moved up and exported into the soil,and a phreatic water evaporation existed in the extreme dry area where the groundwater is buried deeper than 200 m.After a prolonged export,the soil water content in the greenhouse was not lower but obviously higher than the original control ones.According to the monitored parameters including relative humidity and absolute humidity of soil,and temperature outside and inside the greenhouse,it was found that there is the available condition and mechanism for the upward movement of groundwater,and also it can be sure that the exported water was not from the soil and atmosphere outside the greenhouse.Phreatic water,an important source for soil water,interacts with atmosphere moisture via soil respiration.Soil salinity also has important effects on soil water movement and spatial-temporal heterogeneity.The extremely dry climate,terrestrial heat and change of upper soil temperature are the fundamental driving forces of water transportation and phreatic water evaporation in the Groundwater-Soil-Plant-Atmosphere Continuum(GSPAC) system. | HongShou Ll WanFu WANG GuoBin ZHANG ZhengMo ZHANG XiaoWei WANG | 2011 | Journal of Arid Land2011，3，2： | 4 |
| 5 | SYNTHESIS OF N-ARYL-4-METHYLPHENOXYACETAMIDES BY MEANS OF LIQUID-LIQUID PHASE TRANSFER CATALYSIS显示文摘SYNTHESIS OF N-ARYL-4-METHYLPHENOXYACETAMIDES BY MEANS OF LIQUID-LIQUID PHASE TRANSFER CATALYSIS￥TaiBaoWEI;JiChouCHEN;YouMing... | Wei, TB Chen, JC Zhang, YM Wang, LL | 1995 | Chinese Chemical Letters1995，6，3： | 4 |
| 6 | Genotypic variation in spatiotemporal distribution of canopy light interception in relation to yield formation in cotton显示文摘Background: Within-canopy interception of photosynthetically active radiation(PAR) impacts yield and other agronomic traits in cotton(Gossypium hirsutum L.). Field experiments were conducted to investigate the influence of 6 cotton varieties(they belong to 3 different plant types) on yield, yield distribution, light interception(LI), LI distribution and the relationship between yield formation and LI in Anyang, Henan, in 2014 and 2015.Result: The results showed that cotton cultivars with long branches(loose-type) intercepted more LI than did cultivars with short branches(compact-type), due to increased LI in the middle and upper canopy. Although loose-type varieties had greater LI, they did not yield significantly higher than compact-type varieties, due to decreased harvest index. Therefore, improving the harvest index by adjusting the source-to-sink relationship may further increase cotton yield for loose-type cotton. In addition, there was a positive relationship between reproductive organ biomass accumulation and canopy-accumulated LI, indicating that enhancing LI is important for yield improvement for each cultivar. Furthermore, yield distribution within the canopy was significantly linearly related to vertical LI distribution.Conclusion: Therefore, optimizing canopy structure of different plant type and subsequently optimizing LI distribution within the cotton canopy can effectively enhance the yield. | XING Fangfang HAN Yingchun FENG Lu ZHI Xiaoyu WANG Guoping YANG Beifang FAN Zhengyi LEI Yaping DU Wenli WANG Zhanbiao XIONG Shiwu LI Xiaofei Ll Yabing | 2018 | Journal of Cotton Research2018，1，3： | 3 |
| 7 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 8 | Infiuence of admission body temperature on stroke mortality显示文摘 | Lim LL Levi C | 2000 | Stroke2000，31，2： | 1 |
| 9 | Role of PKC in the late phase of microvascular protection induced by preconditioning显示文摘 | Wang WZ Stepheson LL Anderson GL | 2002 | J Surg Res2002，106，1： | 1 |
| 10 | Accumulation of advanced oxidation protein products induces podocyte apoptosis and deletion through NADPH-dependent mechanisms显示文摘 | Zhou LL Hou FF Wang GB | 2009 | Kidney Int2009，76，11： | 1 |
| 11 | Preparation and characteristics of nanostroctured lipid carriers for control-releasing progesterone by meh-emulsiflcation 显示文摘 | Yuan H Wang LL Du YZ | 2007 | Colloid Surface B2007，60，2： | 1 |
| 12 | Metabolomic analysis of the pos- itive effects on Ketogulonigenium vulgare growth and 2-keto-L- gulonic acid production by reduced glutathione 显示文摘 | Zhou J Yi H Wang LL | 2012 | OMICS A journal of Integrative Biology2012，16，7： | 1 |
| 13 | A hybrid model for predicting the prevalence of schistosomiasis in humans of qianjiang city, China 显示文摘 | ZHOU LL YU LJ WANG Y e~ al | 2014 | PLoS One2014，9，10： | 1 |
| 14 | The pivotal role ofc-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells 显示文摘 | Li DD Wang LL Deng R | 2009 | Oncogene2009，28，6： | 1 |
| 15 | Trachea relaxing effects and beta2-selectivity of SPFF,a newly developed bronchodilating agent,in guinea pigs and rabbits显示文摘 | Gan LL Wang MW Cheng MS | 2003 | Biol Pharm Bull2003，26，3： | 1 |
| 16 | The adolescent and young a-dult with cancer:state of the art-bone tumors显示文摘 | Rainusso N Wang LL Yustein JT | 2013 | Curr OncolRep2013，15，： | 1 |
| 17 | Overexpression of SKP2 promotes the radiation resistance of esophageal squamous cell carcinoma显示文摘 | Wang XC Tian LL Tian J | 2012 | Radiat Res2012，177，1： | 1 |
| 18 | Fibroblast PER2 circadian rhythmicity depends on cell density显示文摘 | Noguchi T Wang LL Welsh DK | 2013 | J Biol Rhythms2013，28，3： | 1 |
| 19 | Decreased expression of auto- phagy-related proteins in malignant epithelial ovarian cancer显示文摘 | Shen Y Li DD Wang LL | 2008 | Autophagy2008，4，8： | 1 |
| 20 | Sa!inomycin selectively targets 'CD 133+' cell subpopulations and decreases malignant traits in colorectal cancer lines显示文摘 | Dong Tl? Zhou HM Wang LL | 2011 | Ann Surg Oncol2011，18，6： | 1 |
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