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| 1 | Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual显示文摘Osteoblasts,which are the bone-forming cells,operate in a hypoxic environment.The transcription factors hypoxia-inducible factor-1α(HIF1)and HIF2 are key mediators of the cellular response to hypoxia.Both are expressed in osteoblasts.HIF1 is known to be a positive regulator of bone formation.Conversely,the role of HIF2 in the control osteoblast biology is still poorly understood.In this study,we used mouse genetics to demonstrate that HIF2 is an inhibitor of osteoblastogenesis and bone mass accrual.Moreover,we provided evidence that HIF2 impairs osteoblast differentiation at least in part,by upregulating the transcription factor Sox9.Our findings constitute a paradigm shift,as activation of the hypoxia-signaling pathway has traditionally been associated with increased bone formation through HIF1.Inhibiting HIF2 could thus represent a therapeutic approach for the treatment of the low bone mass observed in chronic diseases,osteoporosis,or aging. | Christophe Merceron Kavitha Ranganathan Elizabeth Wang Zachary Tata Shreya Makkapati Mohd Parvez Khan Laura Mangiavini Angela Qing Yao Laura Castellini Benjamin Levi Amato J.Giaccia Ernestina Schipani | 2019 | Bone Research2019，7，1： | 7 |
| 2 | The HEPD particle detector of the CSES satellite mission for investigating seismo-associated perturbations of the Van Allen belts显示文摘CSES(China Seismo-Electromagnetic Satellite) is a mission developed by CNSA(Chinese National Space Administration) and ASI(Italian Space Agency), to investigate the near-Earth electromagnetic, plasma and particle environment, for studying the seismo-associated disturbances in the ionosphere-magnetosphere transition zone. The anthropogenic and electromagnetic noise,as well as the natural non-seismic electromagnetic emissions is mainly due to tropospheric activity. In particular, the mission aims to confirming the existence of possible temporal correlations between the occurrence of earthquakes for medium and strong magnitude and the observation in space of electromagnetic perturbations, plasma variations and precipitation of bursts with highenergy charged particles from the inner Van Allen belt. In this framework, the high energy particle detector(HEPD) of the CSES mission has been developed by the Italian LIMADOU Collaboration. HEPD is an advanced detector based on a tower of scintillators and a silicon tracker that provides good energy and angular resolution and a wide angular acceptance, for electrons of 3–100 Me V, protons of 30–200 Me V and light nuclei up to the oxygen. CSES satellite has been launched on February 2^(nd), 2018 from the Jiuquan Satellite Launch Center(China). | AMBROSI Giovanni BARTOCCI Simona BASARA Laurent BATTISTON Roberto BURGER William J. CARFORA Luca CASTELLINI Guido CIPOLLONE Piero CONTI Livio CONTIN Andrea DE DONATO Cinzia DE SANTIS Cristian FOLLEGA Francesco M. GUANDALINI Cristina IONICA Maria IUPPA Roberto LAURENTI Giuliano LAZZIZZERA Ignazio LOLLI Mauro MANEA Christian MARCELLI Laura MASCIANTONIO Giuseppe MERGE Matteo OSTERIA Giuseppe PACINI Lorenzo PALMA Francesco PALMONARI Federico PANICO Beatrice PATRIZII Laura PERFETTO Francesco PICOZZA Piergiorgio POZZATO Michele PUEL Matteo RASHEVSKAYA Irina RICCI Ester RICCI Marco RICCIARINI Sergio Bruno SCOTTI Valentina SOTGIU Alessando SPARVOLI Roberta SPATARO Bruno VITALE Vincenzo | 2018 | Science China(Technological Sciences)2018，61，5： | 6 |
| 3 | Adiponectin affects the mechanical responses in strips from the mouse gastric fundus显示文摘AIM To investigate whether the adipocytes derived hormone adiponectin(ADPN) affects the mechanical responses in strips from the mouse gastric fundus. METHODS For functional experiments, gastric strips from the fundal region were cut in the direction of the longitudinal muscle layer and placed in organ baths containing KrebsHenseleit solution. Mechanical responses were recorded via force-displacement transducers, which were coupled to a polygraph for continuous recording of isometric tension. Electrical field stimulation(EFS) was applied via two platinum wire rings through which the preparation was threaded. The effects of ADPN were investigated on the neurally-induced contractile and relaxant responses elicited by EFS. The expression of ADPN receptors, Adipo-R1 and Adipo-R2, was also evaluated by touchdown-PCR analysis. RESULTS In the functional experiments, EFS(4-16 Hz) elicited tetrodotoxin(TTX)-sensitive contractile responses. Addition of ADPN to the bath medium caused a reduction in amplitude of the neurally-induced contractile responses(P < 0.05). The effects of ADPN were no longer observed in the presence of the nitric oxide(NO) synthesis inhibitor L-NG-nitro arginine(L-NNA)(P > 0.05). The direct smooth muscle response to methacholine was not influenced by ADPN(P > 0.05). In carbachol precontracted strips and in the presence of guanethidine, EFS induced relaxant responses. Addition of ADPN to the bath medium, other than causing a slight and progressive decay of the basal tension, increased the amplitude of the neurally-induced relaxant responses(P < 0.05). Touchdown-PCR analysis revealed the expression of both Adipo-R1 and Adipo-R2 in the gastric fundus.CONCLUSION The results indicate for the first time that ADPN is able to influence the mechanical responses in strips from the mouse gastric fundus. | Eglantina Idrizaj Rachele Garella Giovanni Castellini Hermine Mohr Natalia S Pellegata Fabio Francini Valdo Ricca Roberta Squecco Maria Caterina Baccari | 2018 | World Journal of Gastroenterology2018，24，35： | 2 |
| 4 | E ect of organic pro- duction system on broiler carcass and meat quality 显示文摘 | Castellini C Mugnai C Dal B A | 2002 | Meat Sci2002，60，： | 1 |
| 5 | The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxiainducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells显示文摘 | Razorenova OV Castellini L Colavitti R | 2014 | Mol Cell Biol2014，34，： | 1 |
| 6 | Feeding fresh chicory (Chicoria intybus) to young rabbits: performance, development of gastro-intestinal tract and immune functions of appendix and Peyer's patch显示文摘 | Castellini C Cardinali R Rebollar P | 2007 | Aninaml Feed Science and Technology2007，134，12： | 1 |
| 7 | Effect of organic produc-tion system on broiler carcass and meat quality显示文摘 | Castellini C M ugnai C Dal Bosco A | 2002 | Meat Sci2002，60，3： | 1 |
| 8 | Surface EMG in Advanced Hand Prosthetics显示文摘 | Castellini C Smagt P | 2009 | Biological Cybernetics2009，100，： | 1 |
| 9 | Human psyche and head- ache: tension-type headache 显示文摘 | Torelli P Abrignani G Castellini P | 2008 | Neurol Scl2008，29，1： | 1 |
| 10 | Sustainability of poultry production using the emergy approach: Comparison of conventional and organic rearing systems显示文摘 | Castellini C Bastianoni S Granai C | 2005 | Agriculture Ecosystems and Environment2005，114，： | 1 |
| 11 | Dissociation in eating disorders:relationship between dissociative experiences and binge-eating episodes显示文摘 | La Mela C Maglietta M Castellini G | 2010 | Compr Psychiat2010，51，： | 1 |
| 12 | Effect of dietary α- linolenic acid and vitamin E on the fatty acid composition, storage stability and sensory traits of rabbit meat显示文摘 | Dal Bosco A Castellini C Bianchl L | 2004 | Meat Sci2004，66，： | 1 |
| 13 | Effect of a bacterial lipopolysaccharide treatment on rabbit testis and ejaculated sperm显示文摘 | Collodel G Castellini C del Vecchio MT | | 0，，03： | 1 |
| 14 | Categorical closure operators显示文摘 | Castellini G | 2001 | Trends inMathematics2001，49，2： | 1 |
| 15 | Interior operators in a category: idempoten-cy and heredity 显示文摘 | Castellini G | 2011 | Topology and its Applications2011，158，17： | 1 |
| 16 | Improvement of lipid stability of rabbit meat by vitamin E and C administration显示文摘 | CASTELLINI C BOSCO A BERNARDINI M | 2001 | Journal of the Science of Food and Agricultnre2001，81，1： | 1 |
| 17 | Effect of dietary a-linolenic acid and vitamin E on the fatty acid composition, storage stability and sensory traits of rabbit meat显示文摘 | dal BOSCO A CASTELLINI C BIANCHI L | 2004 | Meat Science2004，66，2： | 1 |
| 18 | Environmental impact e- valuation of conventional, organic and organic-plus poultry produc- tion systems 'using life cycle assessment 显示文摘 | Boggia A Paolotti L Castellini C | 2010 | World Poultry Science Journal2010，66，1： | 1 |
| 19 | Desmosterol, the main sterol in rabbit semen: distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility显示文摘甾醇是细胞膜类脂化合物 bilayer 的必要部件包括象胆固醇和 desmosterol 那样的分子,它显著地在几动物种的精子被发现。然而,在兔子精液的 desmosterol 的存在从来没被调查过。这研究的目的是描绘呼喊的兔子精液的 subfractions 的甾醇作文并且评估在里面精子 acrosome 反应和活动性上的甾醇的 vitro 效果。二甾醇,在免费形式(94.3%) 流行地发生,在从 10 只肥沃的新西兰白兔子收集的整个精液被识别,明确地 desmosterol (58.5% 全部的甾醇) 和胆固醇(35.9% 全部的甾醇) 。Desmosterol 是在兔子精液的所有 subfractions 发现的占优势的甾醇,从 56.7% 变化(在 prostatic 能分泌的小粒, PSG ) 到 63.8%( 在精液的血浆) 。精子包含了 desmosterol (59.8%) 的一个中间的比例,它在头(甾醇的 52.0% 全部的内容) 和尾巴(81.8%) 之间是不均匀地分布式的。结果证明 desmosterol 和胆固醇能从 PSG 被转移到精子并且在比 1 mg L 高在集中在 vitro 精子 capacitation 禁止是同等地有效的 ? 1。相反,既不 desmosterol 也不胆固醇在精子活动性上有重要效果。因此,这被结束,兔子精液的各种各样的部分在甾醇作文和数量不同于对方,可以可能由于他们的不同功能的性质,和这些部分经历取决于精子 capacitation 的舞台的重要甾醇变化。 | Evangelia Mourvaki Raffaella Cardinali Rita Roberti Alessandro Dal Bosco Cesare Castellini | 2010 | Asian Journal of Andrology2010，12，6： | 1 |
| 20 | Effect of organic productionsystem on broiler carcass and meat quality显示文摘 | CASTELLINI C MUGNAI C DAL BOSCO A | 2002 | Meat Sci2002，60，： | 1 |
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