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| 1 | A candidate targeting molecule of insulin-like growth factor-Ⅰ receptor for gastrointestinal cancers显示文摘Advances in molecular research in cancer have brought new therapeutic strategies into clinical usage.One new group of targets is tyrosine kinase receptors,which can be treated by several strategies,including small molecule tyrosine kinase inhibitors(TKIs) and monoclonal antibodies(mAbs).Aberrant activation of growth factors/receptors and their signal pathways are required for malignant transformation and progression in gastrointestinal(GI) carcinomas.The concept of targeting specif ic carcinogenic receptors has been validated by successful clinical application of many new drugs.Type I insulin-like growth factor(IGF) receptor(IGF-IR) signaling potently stimulates tumor progression and cellular differentiation,and is a promising new molecular target in human malignancies.In this review,we focus on this promising therapeutic target,IGF-IR.The IGF/IGF-IR axis is an important modifier of tumor cell proliferation,survival,growth,and treatment sensitivity in many malignant diseases,including human GI cancers.Preclinical studies demonstrated that downregulation of IGF-IR signals reversed the neoplastic phenotype and sensitized cells to anticancer treatments.These results were mainly obtained through our strategy of adenoviruses expressing dominant negative IGF-IR(IGF-IR/dn) against gastrointestinal cancers,including esophagus,stomach,colon,and pancreas.We also summarize a variety of strategies to interrupt the IGFs/IGF-IR axis and their preclinical experiences.Several mAbs and TKIs targeting IGF-IR have entered clinical trials,and early results have suggested that these agents have generally acceptable safety profiles as single agents.We summarize the advantages and disadvantages of each strategy and discuss the merits/demerits of dual targeting of IGF-IR and other growth factor receptors,including Her2 and the insulin receptor,as well as other alternatives and possible drug combinations.Thus,IGF-IR might be a candidate for a molecular therapeutic target in human GI carcinomas. | Yasushi Adachi Hiroyuki Yamamoto Hirokazu Ohashi Takao Endo David P Carbone Kohzoh Imai Yasuhisa Shinomura | 2010 | World Journal of Gastroenterology2010，16，46： | 14 |
| 2 | TNFalpha and its receptors in psoriatic skin,before and after treatment with etanercept显示文摘 | Caldarola G De Simone C Carbone A Tulli A Amerio P Feliciani C | 2009 | Int J Immunopathol Pharmacol2009，22，4： | 1 |
| 3 | Fluoroscopically assisted pedicle screw fixation for thoracic and thoracolumbar injuries显示文摘 | John J Carbone M D Justin P | 2003 | SPINE2003，28，1： | 1 |
| 4 | Agroforestry as sequestration 显示文摘 | Nair P K R Kumar B M a strategyfor carbon Nair V D | 2009 | Journal of Plant Nutrition and Soil Science2009，172，： | 1 |
| 5 | The Receptor for Urokinase-type Fibroblasts显示文摘 | ELIZABETH M VERTMAN G CARBON W P | 2004 | J Biol Chem2004，279，2： | 1 |
| 6 | BDNF,NT-3 and NGF induce distinct new Ca2+ channel synthesis in developing hippocampal neurons显示文摘 | Baldelli P Forni PE Carbone E | 2000 | Eur J Neurosci2000，12，11： | 1 |
| 7 | Coexistence of multiple silicene phases in silicon grown on Ag(1 1 1)显示文摘 | P Moras T O Mentes P M Sheverdyaeva A Locatelli C Carbone | 2014 | Journal of Physics: Condensed Matter2014，，： | 1 |
| 8 | A phase I/II A trial of continuous five-day infusion of squalamine lactate (MSI-1256F) plus carboplatin and paclitaxel in patients with advanced non-small cell lung cancer 显示文摘 | Herbst R S Hammond L A Carbone D P etal | 2003 | Clin Cancer Res2003，9，11： | 1 |
| 9 | A general secondary-structure model for procaryotic and eucaryotic RNAsfrom the small ribosomal subunits显示文摘 | STIEGLER P CARBON P EBEL J P | 1981 | Eur J Biochem1981，120，： | 1 |
| 10 | HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells显示文摘 | Carbone E Neri P Mesuraca M | 2005 | Blood2005，105，1： | 1 |
| 11 | Supercritical of peppermint and spearmint 显示文摘 | Barton P Hunghes R E carbon dioxide extraction Hussein M M | 1992 | Journal of supercritical Fluids1992，5，3： | 1 |
| 12 | Estrogen binding sites in peripheral biood mononuclear cells and thymocytes from 2 myasthenia gavis patients显示文摘 | Carbone A Piantelli M Musiani P | 1986 | Clin Lab Immunol1986，21，： | 1 |
| 13 | Dose/dense metro- nomic chemotherapy with fractioned cisplatin and oral daily etopo- side enhances the anti-angiogenic effects of bevacizumab and has strong antitumor activity in advanced non-small-cell-lung cancer patients显示文摘 | Correale P Remondo C Carbone SF | 2010 | Cancer Biol Ther2010，9，9： | 1 |
| 14 | Endocrine disrupting chem- icals and testicular cancer:a case-control study显示文摘 | Nori F Carbone P Giordano F | 2006 | Arch En- viron Occup Health2006，61，2： | 1 |
| 15 | Bone density of elite female athletes with stress fractures显示文摘 | CARBON R SAMBROOK P N DEAKIN V | 1990 | Med J Au1990，153，7： | 1 |
| 16 | Fluoroscopically assisted pedicle screw fixation for thoracic and thoracolumbar injuries显示文摘 | Carbone J J Tortolani P J Quartararo L G | 2003 | Spine2003，28，1： | 1 |
| 17 | Arrangement and fine structure of collagen fibrils in the decidualized mouse endometrium 显示文摘 | CARBONE K PINTO N M ABRAHAMSOHN P A | 2006 | Microsc Res Technol2006，69，1： | 1 |
| 18 | Noise Sensitivity of the ADC Histogram Test 显示文摘 | Carbone P Petri D | 1998 | IEEE Transactions on Instrumentation and Measurement1998，47，4： | 1 |
| 19 | Managing the Total Customer Experience显示文摘 | L L Berry L P Carbone H Haeckel | | 0，，03： | 1 |
| 20 | Dose/dense metro- nomic chemotherapy with fractioned cisplatin and oral daily e- toposide enhances the antiangiogenic effects of bevacizumab and has strong antitumor activity in advanced nonsmall-cell-lung cancer patients显示文摘 | Correale P Remondo C Carbone S F | 2010 | Cancer Biol Ther2010，9，9： | 1 |
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