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| 1 | Inflammation and colorectal cancer, when microbiota-host mutualism breaks显示文摘Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal cancer.In this review we discuss recent hypotheses on the mechanisms involved in the bacteria-mediated carcinogenesis,as well as the triggering factors favoring the shift of the gut microbiota from a mutualistic to a pro-carcinogenic configuration.The possible role of inflammation,bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically discussed.On the other hand,the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is suggested.As a common outcome of different environmental and endogenous triggers,such as diet,aging,pathogen infection or genetic predisposition,inflammation can compromise the microbiota-host mutualism,forcing the increase of pathobionts at the expense of health-promoting groups,and allowing the microbiota to acquire an overall pro-inflammatory configuration.Consolidating inflammation in the gut,and favoring the bloom of toxigenic bacterial drivers,these changes in the gut microbial ecosystem have been suggested as pivotal in promoting carcinogenesis.In this context,it will become of primary importance to implement dietary or probiotics-based interventions aimed at preserving the microbiota-host mutualism along aging,counteracting deviations that favor a pro-carcinogenic microbiota asset. | Marco Candela Silvia Turroni Elena Biagi Franck Carbonero Simone Rampelli Carla Fiorentini Patrizia Brigidi | 2014 | World Journal of Gastroenterology2014，20，4： | 13 |
| 2 | 非选择性β受体阻滞剂对肝硬化难治性腹水患者整体循环稳态和肾功能的影响显示文摘【据《J Hepatol》2020年3月报道】题:非选择性β受体阻滞剂对肝硬化难治性腹水患者整体循环稳态和肾功能的影响(作者Luis T等)非选择性β受体阻滞剂(NSBB)在难治性腹水(RA)中应用的安全性一直有待考证。本研究旨在探索NSBB对利尿剂应答性腹水和难治性腹水患者的心脏收缩能力、全身血流动力学、肾灌注压力和肾脏功能的影响。 | 张明媛 牛俊奇 LUIS T LUIS IS CANDELAS PéREZ DV | 2020 | 临床肝胆病杂志2020，36，6： | 3 |
| 3 | Antibiotics and probiotics in chronic pouchitis:A comparative proteomic approach显示文摘AIM:To profile protein expression in mucosal biopsies from patients with chronic refractory pouchitis following antibiotic or probiotic treatment,using a comparative proteomic approach. METHODS:Two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ ionization-time of flight mass spectrometry were used to characterize the changes related to antibiotic therapy in the protein expression profiles of biopsy samples from patients with chronic refractory pouchitis.The same proteomic approach was applied to identify differentially expressed proteins in the non-inflamed pouch before and after probiotic administration. RESULTS:In the first set of 2D gels,26 different proteins with at least 2-fold changes in their expression levels between the pouchitis condition and antibiotic-induced remission were identified.In the second set of analysis,the comparison between mucosal biopsy proteomes in the normal and probiotic-treated pouch resulted in 17 significantly differently expressed proteins.Of these,8 exhibited the same pattern of deregulation as in the pouchitis/pouch remission group. CONCLUSION:For the first time,2D protein maps of mucosal biopsies from patients with ileal pouch-anal anastomosis were provided,and differentially expressed proteins following antibiotic/probiotic treatment were identified. | Silvia Turroni Beatrice Vitali Marco Candela Paolo Gionchetti Fernando Rizzello Massimo Campieri Patrizia Brigidi | 2010 | World Journal of Gastroenterology2010，16，1： | 3 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | Ageing and gut microbes: Perspectives for health maintenance and longevity显示文摘 | Elena Biagi Marco Candela Silvia Turroni Paolo Garagnani Claudio Franceschi Patrizia Brigidi | 2012 | Pharmacological Research2012，，： | 2 |
| 6 | PD Recognition by Means of Statistical and Fractal Parameters and a Neural Network显示文摘 | CANDELA R MIRELLI G SCHIFANI R | 2000 | IEEE Transactions on Dielectrics and Electrical Insulation2000，7，1： | 1 |
| 7 | Magnetic properties and hyperfine interactions in the β″ phase of potassium ferrite 显示文摘 | Romanov V P Candela G A Roth R S | 1979 | J Appl Phys1979，50，： | 1 |
| 8 | Intron 22 factor Ⅷ gene inversion in Argentine families with severe haemophilia A显示文摘 | De Brasi C Candela M Cermel JM | 2000 | Haemophilia2000，6，1： | 1 |
| 9 | Early ICU energy deficit is a risk factor for Staphylococcus aureus ventilator-asso- ciatedpneumonia 显示文摘 | Faisy C Candela LM Savalle M | 2011 | Chest2011，140，5： | 1 |
| 10 | Dennal fillers:Types,indications,and complications 显示文摘 | Sanche-Carpintero Candelas D Ruiz-Rodriguez R | 2010 | Actas Dermosifiliogr2010，101，5： | 1 |
| 11 | Effect of growth hormone on bacterial translocation in experimental short-bowel syndrome显示文摘 | I. Eizaguirre P. Aldazabal M. J. Barrena J. M. Garcia-Arenzana C. Ariz S. Candelas J. A. Tovar | 1999 | Pediatric Surgery International (-)1999，，3： | 1 |
| 12 | Hy- drogen generation by aluminum corrosion in seawater promoted by suspensions of aluminum hydroxide 显示文摘 | SOLER L CANDELA AM MACANAS J | 2009 | International Journal of Hydrogen Energy2009，34，20： | 1 |
| 13 | The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity 显示文摘 | Shah JP Candela FC Poddar AK | 1990 | Cancer1990，66，1： | 1 |
| 14 | Thrombolytio therapy in patients requiring cardio pulmooary resusoitation显示文摘 | Tenaglia AN Califf RM Candela RT | 1991 | Am J Cardiol1991，68，： | 1 |
| 15 | Funetional se- quelae of tuberculous pleurisy in patients correetly treat- ed 显示文摘 | Candela A Andujar J HernOndez L et a/ | 2003 | Chest2003，123，6： | 1 |
| 16 | In Search of Stylized Facts on Art Market Prices: Evidence from the Secondary Market for Prints and Drawings in Italy显示文摘 | Candela G Scorcu A E | 2001 | Journal of Cultural Economics2001，25，3： | 1 |
| 17 | Estimation of flood inundation probabilities using global hazard indexes based on hydrodynamic variables显示文摘 | Aronica G T Candela A Fabio P | 2012 | Physics and Chemistry of the Earth 42-442012，，： | 1 |
| 18 | Rapid gaschromatographic method for the determination of diacetyl in milk,fermented milk and butter显示文摘 | Macciola V Candela G De Leonardis A | 2008 | Food Control2008，19，9： | 1 |
| 19 | A mass transfer model for copper and molybdenum in magmatic hydrothermal system: The origin of porphyry-type ore deposits显示文摘 | CANDELA P A HOLLAND H D | 1986 | Economic Geology1986，81，： | 1 |
| 20 | PD recognition by means of statistical and fractal parameters and a neural network显示文摘 | Candela R Mirelli G Schilanl R | 2000 | IEEE Trans on Diel and Elec Insual2000，7，： | 1 |
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