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| 1 | Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China显示文摘In order to evaluate the performance of a molecular Hain line probe assay(Hain LPA)for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China。 | LI Qiang DONG Hai Yan PANG Yu XIA Hui OU Xi Chao ZHANG Zhi Ying LI Jun Chen ZHANG Jian Kang HUAN Shi Tong CHIN Daniel P KAM Kai Man ZHAO Yan Lin | 2015 | Biomedical and Environmental Sciences2015，28，6： | 13 |
| 2 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 3 | Effect of fiber supplementation on the microbiota in critically ill patients显示文摘AIM:To determine tolerance to fiber supplementation of semi-elemental tube feeds in critically ill patients and measure its effect on colonic microbiota and fermentation.METHODS:Thirteen intensive care unit patients receiving jejunal feeding with a semi-elemental diet for predominantly necrotizing pancreatitis were studied.The study was divided into 2 parts:first,short-term (3-9 d)clinical tolerance and colonic fermentation as assessed by fecal short chain fatty acid(SCFA)concentrations and breath hydrogen and methane was measured in response to progressive fiber supplementation increasing from 4 g tid up to normal requirement levels of 8 g tid;second,4 patients with diarrhea were studied for 2-5 wk with maximal supplementation to additionally assess its influence on fecal microbiota quantitated by quantitative polymerase chain reaction (qPCR)of microbial 16S rRNA genes and Human Intestinal Tract Chip(HITChip)microarray analysis.Nearly all patients were receiving antibiotics(10/13)and acid suppressants(11/13)at some stage during the studies.RESULTS:In group 1,tolerance to progressive fiber supplementation was good with breath hydrogen and methane evidence(P=0.008 and P<0.0001,respectively)of increased fermentation with no exacerbation of abdominal symptoms and resolution of diarrhea in 2 of 4 patients.In group 2 before supplementation,fecal microbiota mass and their metabolites,SCFA,were dramatically lower in patients compared to healthy volunteers.From qPCR and HITChip analyses we calculated that there was a 97%reduction in the predominant potential butyrate producers and starch degraders.Following 2-5 wk of fiber supplementation there was a significant increase in fecal SCFA(acetate 28.4±4.1μmol/g to 42.5±3.1μmol/g dry weight,P=0.01;propionate 1.6±0.5 vs 6.22±1.1,P=0.006 and butyrate 2.5±0.6 vs 5.9±1.1,P=0.04)and microbial counts of specific butyrate producers,with resolution of diarrhea in 3 of 4 patients.CONCLUSION:Conventional management of critically ill patients,which includes the use of elemental diets and broad-spectrum antibiotics,was associated with gross suppression of the colonic microbiota and their production of essential colonic fuels,i.e.,SCFA.Our investigations show that fiber supplementation of the feeds has the potential to improve microbiota mass and function,thereby reducing the risks of diarrhea due to dysbiosis. | Stephen JD O'Keefe Junhai Ou James P DeLany Scott Curry Erwin Zoetendal H Rex Gaskins Scott Gunn | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 4 | A study on mechanical and pressure- sensitive properties of cement mortar with nanophase materials 显示文摘 | Li H Xiao H G Ou J P | 2004 | Cem Concr Res2004，34，： | 1 |
| 5 | Large-scale experi- mental study of precast segmental unbonded posttensioned concrete bridge columns for seismic regions显示文摘 | OU Y C WANG P H TSAI M S | 2010 | Journal of Structural Engineering2010，136，3： | 1 |
| 6 | Prevalence rate of osteoporosis inthe mid-aged and elderly in selected parts of China显示文摘 | Li N Ou P Zhu H | 2011 | Chin Med J2011，18，13： | 1 |
| 7 | The E-eadherinn (CDH1) -C160A polymorphism and caloreetal cancer suseeptibillty: a meta-analysis 显示文摘 | Geng P Chen Y Ou J | 2012 | DNA Cell Bi012012，31，6： | 1 |
| 8 | Effect of axial compression on shear behavior of high-strength reinforced concrete columns 显示文摘 | OU Y C KURNIAWAN D P | 2015 | ACI Structural Journal2015，112，2： | 1 |
| 9 | Seismic response analysis of structures with velocity-dependent dampers 显示文摘 | OU J P LONG X LI Q S | 2007 | Journal of ConstructionalSteel Research2007，63，： | 1 |
| 10 | The management of psychiatric emerencies显示文摘 | Mavrogiorgou ou P Bru ne M Juckel G | 2011 | Dtsch Arztebl Int2011，108，13： | 1 |
| 11 | Characteristics of ground surface settlement during excavation 显示文摘 | Ou C Y Hsieh P G Chiou D C | 1993 | Canadian Geotechnical Journal1993，30，5： | 1 |
| 12 | Syntrophin gamma 2 regulates SCN5A gating by a PDZ domain-mediated interaction显示文摘 | Ou Y Strege P Miller SM | 2003 | J Biol Chem2003，278，3： | 1 |
| 13 | Prevalence rate og osteoporosis in the mid-aged and elderly in selected parts of China显示文摘 | Li N Ou P Zhu H | 2002 | China Med J (En- gl)2002，115，5： | 1 |
| 14 | Laminar drag reduction in microchannels using ultrahydrophobic surfaces 显示文摘 | Ou J Perot B Rothstein J P | 2004 | Physics of Fluids (S1070-6631)2004，16，12： | 1 |
| 15 | Mycoplasma pneumoniae myopericarditis in children 显示文摘 | Duthoit G Ou P Sidi D | 2006 | Arch Mal Coeur Vaiss2006，99，5： | 1 |
| 16 | 显示文摘 | Guan X H Dong X F Ou J P | 2007 | Proc of SPIE2007，6526，65： | 1 |
| 17 | Prevalence of cardiovascular disease risk factor clustering among the adult population of China:results from the International Collaborative Study of Cardiovascular Disease in Asia (InterAsia)显示文摘 | Ou D Gupta A Muntner P | 2005 | Circulation2005，112，5： | 1 |
| 18 | Three-dimensional CT scanning: a new diagnostic modality in congenital heart disease显示文摘 | Ou P Celermajer DS Calcagni G | 2007 | Heart2007，93，8： | 1 |
| 19 | Characteristics of ground surface settlement during excavation 显示文摘 | OU C Y HSIEN P G CHIOU D C | 1993 | Canadian Geoteehnical Journal1993，30，5： | 1 |
| 20 | DRAMMS:Deformable registration via attribute matching and mutual-saliency weighting 显示文摘 | Ou YM Aristeidis S Nikos P | 2011 | Medical Image Analysis2011，15，14： | 1 |
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