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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Principles of assessment and effective feedback显示文摘The highly competitive offer of medical training programs and schools,globalization and constant mobility of physicians and medical students(MS),and the commitment to society to deliver competent physicians,demands the definition of performance standards.This would allow to make their performances comparable no matter where they studied or which textbook did they used as reference,to have evaluation mechanisms that guarantee mastery of the integral evaluation of the performance.Assessment has been the key in the teaching-learning process as this obtains a formative and summative element,at different moments,from the extent to which the students have acquired knowledge,skills and attitudes.The progress of the learner must be enhanced with effective feedback on their performance and self-direction of the results obtained in each of the mechanisms established.If,traditionally,this has been considered as the accreditation of compliance with a standard,the evaluation also functions in an integral way as a formative process that identifies advances and deficiencies in the training of residents that allows the definition of actions and strategies for improving the operation of the programs.Different assessment mechanisms are associated with the areas of competence domain,some of the most common tools are:theoretical exams,checklists and rubrics,portfolio,projects and challenges.However,the importance of defining standards which are perceived as fair and designed according to the learning objectives remains a priority to guarantee the credibility of the evaluation agencies and institutions.Some strategies to assure credibility include the involvement of expert and trained evaluators,allowing the process to be carried out with transparency and diligence,and the principles employed should be supported by educational research. | Jorge Eugenio Valdez-García Mildred Vanessa López Cabrera Elena Ríos Barrientos | 2017 | Annals of Eye Science2017，，1： | 2 |
| 3 | Diels-Alder cycloaddition approach to puupehenone-related metabolites: synthesis of the potent angiogenesis inhibitor 8-epipuupehedione显示文摘 | Alvarez-Manzaneda EJ Chahboun R Cabrera E | 2007 | J Org Chem2007，72，9： | 1 |
| 4 | Performance of a broad-band acoustic doppler current profiler显示文摘 | BRUMLEY CABRERA R G | 1991 | IEEE Journal of Oceanic Engineering1991，16，4： | 1 |
| 5 | Hepatocellular carcinomacell supematants increase expansion and function of CD4 +、CE^s+ regulatory T cells显示文摘 | Cao M Cabrera R Xu Y | 2007 | Lab Invest2007，87，6： | 1 |
| 6 | Beneficial effects ofgreen tea-a review 显示文摘 | Cabrera C Artacho R Giménez R | 2006 | Journal of the American College ofNutrition2006，25，2： | 1 |
| 7 | Hepatocellular carcinoma: Current trends in worldwide epidemiology,risk factors, diagnosis, and therapeutics显示文摘 | Dhanasekaran R Limaye A Cabrera R | 2012 | Hepat Med2012，4，： | 1 |
| 8 | Usefulness of anorectal manometry in the neonatal diagnosis of Hirschsprung disease显示文摘 | Nunez R Cabrera R Moreno C | | 0，，01： | 1 |
| 9 | Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics显示文摘 | DHANASEKARAN R LIMAYE A CABRERA R | 2012 | Hepat Med2012，4，： | 1 |
| 10 | Circulating DNA is a useful prognostic factor in patients with adranced nou-small cell lung cancer显示文摘 | Sirera R Bremnes RM Cabrera A | 2011 | J Thorac Oncol2011，6，2： | 1 |
| 11 | Anti -idiotypic vaccination in the treatment of low-grade B-cell lymphoma显示文摘 | Barrios Y Cabrera R Yanez R | 2002 | Haematologica2002，87，4： | 1 |
| 12 | Early hematopoietic recovery after single unit unrelated cord blood transplantation in adults supported by co-infusion of mobilized stem cells from a third party donor显示文摘 | Magro E Regidor C Cabrera R | 2006 | Haematologica2006，91，5： | 1 |
| 13 | Electrochemical and surface analysis study of copper corrosion protection by 1 & hyphen;propanethiol and propyltrimethoxysilane & colon; A comparison with 3 & hyphen; mercaptopropyltrimethoxysilane 显示文摘 | Tremont R Cabrera C R | 2002 | Journal of Applied Electrochemistry2002，32，7： | 1 |
| 14 | Circulating DNA is a useful prognostic factor in patients with adrancednou small cell lung cancer 显示文摘 | Sirera R Bremnes RM Cabrera A | 2011 | J Thorac Oncol2011，6，2： | 1 |
| 15 | An immunomodulatory role for CD4 ^+ CD25^ + regulatory T lymphocytes in hepatitis C virus infection 显示文摘 | Cabrera R Tu Z Xu Y | 2004 | Hepatology2004，40，5： | 1 |
| 16 | Performance of a broad-band acoustic doppler current profiler显示文摘 | BLAIR H BR UMLEY R AMONG CABRERA KENT L DEINES | 1991 | Journal of Oceanic Engineering1991，16，4： | 1 |
| 17 | Lab-on-a-chip for drug development 显示文摘 | WEIGL B H BARDELL R L CABRERA C R | 2003 | Advanced Drug Delivery Reviews2003，55，3： | 1 |
| 18 | Tradescantia micronucleus biossay显示文摘 | Cabrera G L Chen R | 1994 | Mutat Res1994，310，： | 1 |
| 19 | Nitrogen-form and endophyte-infection effects on growth, nitrogen uptake, and alkaloid content of chewings fescue turfgrass显示文摘 | Richardson M D Cabrera R I Murphy J A | 1999 | J Plant Nutrition1999，22，1： | 1 |
| 20 | An immunomodulatory role for CD4( + ) CD25 ( + ) regulatory T lymphoeytes in hepatitis C virus infection 显示文摘 | Cabrera R Tu Z Xu Y | 2004 | Hepatology2004，40，5： | 1 |
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