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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 2 | Research on Service Life Prediction Model of Concrete Structure of Sea-crossing Bridge显示文摘According to the chloride corrosion environment,service life prediction model of concrete structure of sea-crossing bridge was built using modified Fick's second law and the whole probability calculation method,which was suitable for China. Furthermore,a visual service life prediction program of concrete structure was developed by optimized Monte Carlo method. Meanwhile,Life 365 program was compared,indicating reliability of the prediction program. Finally,the validity of prediction model was verified in JinTang Bridge of Zhoushan Island Mainland Linkage Project. | WANG C J ZHANG G Z LIU K X TU L Q LI J H QIN M Q | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 3 | Numerical modelling and validation of gas-particle flow in an in-line tube bank显示文摘 | Tian Z F Tu J Y Yeoh G H | 2007 | Computers & Chemical Engineering2007，31，9： | 1 |
| 4 | Nonylphenol induced apoptosis in rat testis through the Fas/FasL pathway显示文摘 | HAN X TU Z WANG X | 2004 | Bull Environ Contam Toxicol2004，73，4： | 1 |
| 5 | 显示文摘 | Tu Y F Fu Z Q Chen H Y | 2001 | Sensors and Actuators B2001，80，： | 1 |
| 6 | Genomic amplification of the human telomerase RNA gene for differential diagnosis of cervical disorders 显示文摘 | Tu Z Zhang A Wu R | 2009 | Cancer Genet Cytogenet2009，191，1： | 1 |
| 7 | Distribution Characteristics of Vehicle Specific Power on Urban Restricted Access Roadways 显示文摘 | Song G L Yu Z Tu | 2012 | Journal of Transportation Engineering (S0733-947X) ASCE2012，138，： | 1 |
| 8 | Baicalin inhibits TLR2/4 signa- ling pathway in rat brain following permanent cerebral ischemia 显示文摘 | Tu X K Yang W Z Shi S S | 2011 | Inflammation2011，34，5： | 1 |
| 9 | Material research for planar SOFC stack显示文摘 | T.-L Wen D Wang M Chen H Tu Z Lu Z Zhang H Nie W Huang | 2002 | Solid State Ionics2002，，3： | 1 |
| 10 | Synthesis of Bi6Mo2015sub-microwires via a molten salt method and enhancing thephotocatalytic reduction of CO2 into solar fuel through tuning the surface oxide vacancies by simple post-heating treatment显示文摘 | Li P Zhou Y Tu W Wang R Zhang C Liu Q Li H Li Z Dai H Wang J Yan S Zou Z | 2013 | CrystEngComm2013，15，46： | 1 |
| 11 | Th e I m p act s of En e rgy Pric e son En ergy I nte n sity:Evid e n ce fro m Chin a显示文摘 | HAN G L M TU M Z | 2007 | En ergyPolicy2007，35，5： | 1 |
| 12 | In vitro induction of differentia- tion by ginsenoside in SMMC-7721 hepatocarcinoma cell line显示文摘 | ZENG X L TU Z G | 2003 | Pharmacol Toxico2003，93，： | 1 |
| 13 | Microstructure,chemical and tribological investigations of MoxW1-xSy co-sputtered composite films显示文摘 | YIN G L HUANG P H YU Z HE D N TU J P | 2006 | Tribology Letters2006，22，1： | 1 |
| 14 | An efficient asymmetric epoxidation method for trans-olefins mediated by a fructose-derived keton显示文摘 | Tu Y Wang Z X Shi Y | 1996 | J Am Chem Soc1996，118，： | 1 |
| 15 | Cathode polarization in trivalent chromium plating 显示文摘 | Tu Z M Yang Z L | 1993 | Plating and Surface Finishing1993，80，9： | 1 |
| 16 | Dauriciane suppressed CsCl - indused early afterdepolarizations and triggered arrhythmias in rabbit in vivo显示文摘 | Xia J Tu H Li Z | 1999 | Acta Pharmacol Sin1999，20，6： | 1 |
| 17 | Lipid membranes with free edges显示文摘 | Z C Tu Z Cou-Yang | 2003 | Phys Rev E2003，68，06： | 1 |
| 18 | Analysis of dynamic response of concrete using a mesoscale model incorporating 3D effects 显示文摘 | Lu Y Song Z H Tu Z G | 2010 | International Journal of Protective Structures2010，1，2： | 1 |
| 19 | Intensification of biodiesel synthesis using zigzag micro-channel reactors显示文摘 | Wen Z Yu X Tu S-T | 2009 | Bioresource Technology2009，100，12： | 1 |
| 20 | An immunomod?latory role for CD4^+CD25^+ regμlatory T lymphecytes in hepatitis C virus infection显示文摘 | Cabrem R Tu Z Xu Y | 2004 | Hepatology2004，40，： | 1 |
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