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| 1 | Cancer stem cell plasticity and tumor hierarchy显示文摘The origins of the complex process of intratumoral heterogeneity have been highly debated and different cellular mechanisms have been hypothesized to account for the diversity within a tumor. The clonal evolution and cancer stem cell(CSC) models have been proposed as drivers of this heterogeneity. However, the concept of cancer stem cell plasticity and bidirectional conversion between stem and non-stem cells has added additional complexity to these highly studied paradigms and may help explain the tumor heterogeneity observed in solid tumors. The process of cancer stem cell plasticity in which cancer cel s harbor the dynamic ability of shifting from a non-CSC state to a CSC state and vice versa may be modulated by specific microenvironmental signals and cellular interactions arising in the tumor niche. In addition to promoting CSC plasticity, these interactions may contribute to the cellular transformation of tumor cells and affect response to chemotherapeutic and radiation treatments by providing CSCs protection from these agents. Herein, we review the literature in support of this dynamic CSC state, discuss the effectors of plasticity, and examine their role in the development and treatment of cancer. | Marina Carla Cabrera Robert E Hollingsworth Elaine M Hurt | 2015 | World Journal of Stem Cells2015，7，1： | 8 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Influence of birth order, birth weight, colostrum and serum immunoglobulin G on neonatal piglet survival显示文摘Background: Intake of colostrum after birth is essential to stimulate intestinal growth and function, and to provide systemic immunological protection via absorption of Immunoglobulin G (IgG). The birth order and weight of 745 piglets (from 75 litters) were recorded during a one-week period of farrowing. Only pigs weighing greater than 0.68 kg birth weight were chosen for the trial. Sow colostrum was collected during parturition, and piglets were bled between 48 and 72 hours post-birth. Piglet serum IgG and colostral IgG concentrations were determined by radial immunodiffusion. Results: Sow parity had a significant (P < 0.001) effect on sow colostral IgG concentration, being 5% higher in multiparous females. Sow colostral IgG concentration explained 6% and piglet birth order accounted for another 4% of the variation observed in piglet serum IgG concentration (P < 0.05); however, birth weight had no detectable effect. Piglet serum IgG concentration had both a linear (P < 0.05) and quadratic effect (P < 0.05) on % survival. Piglets with 1,000 mg/dl serum IgG or less (n=24) had a 67% survival; whereas, piglets with IgG concentrations between 2250 to 2500 mg/dl (n=247) had a 91% survival. Birth order had no detectable effect on survival, but birth weight had a positive linear effect (P < 0.05). Piglets weighing 0.9 kg (n = 107) at birth had a 68% survival rate, and those weighing 1.6 kg (n = 158) had an 89% survival. Conclusion: We found that the combination of sow colostrum IgG concentration and birth order can account for 10% of the variation of piglet serum IgG concentration and that piglets with less than 1,000 mg/dl IgG serum concentration and weight of 0.9 kg at birth had low survival rate when compared to their larger siblings. The effective management of colostrum uptake in neonatal piglets in the first 24 hrs post-birth may potentially improve survival from birth to weaning. | Rafael A Cabrera Xi Lin Joy M Campbell Adam J Moeser Jack Odle | 2013 | Journal of Animal Science and Biotechnology2013，4，2： | 2 |
| 4 | 晶粒细化对TWIP钢力学性能与织构的影响(英文)显示文摘奥氏体高锰钢(15%-30%)呈现出孪晶诱导塑性变形机制,并在拉伸试验中表现出很好的强度-塑性性能,因此在汽车工业结构件应用中有很大潜力。最近几年,对于TWIP钢不同方面的研究受到了高度重视。之前一些综述文章关注于TWIP钢的基本知识,而非晶粒细化方法的影响。本文主要综述了通过冷轧以及强塑性变形方法引起的力学性能改善以及织构变化。基于之前的研究,通过冷轧以及强塑性变形方法,平均晶粒尺度可以急剧地减小,同时屈服强度和极限抗拉强度将会大幅升高。这个现象可以归因于变形过程引起的孪晶演化。另一方面,在冷轧变形后,Goss和Brass织构会逐步形成。 | 王雷 BENITO J A CALVO J CABRERA J M | 2016 | 材料热处理学报2016，37，8： | 2 |
| 5 | High temperature deformation of Inconel 718显示文摘 | Thomas A EI -Wahabi M Cabrera J M | 2006 | Journal of Materials Processing Technology2006，177，13： | 1 |
| 6 | The effect of removal of seminal plasma, egg yolk level and season on sperm freezabili- ty of Canary buck (Capra hircus) 显示文摘 | Cabrera F Gonzfdez F Batista M | 2005 | Reprod Dom Anim2005，40，3： | 1 |
| 7 | Evaluation of the hot ductility of a C-Mn steel produced from scrap recycling显示文摘 | CALVO J CABRERA J M REZAEIAN A | 2007 | ISIJ International2007，47，10： | 1 |
| 8 | Modulation of matrix metalloproteinase-9 activity by hyaluronan is dependent on NF-kappaB activity in lymphoma cell lines with dissimilar invasive behavior显示文摘 | Alaniz L Garcia M Cabrera P | 2004 | Biochem Biophys Res Commun2004，324，2： | 1 |
| 9 | Phytoplankton and Zooplankton Response to Ultraviolet Radiation in a High-Altitude Andean Lake:Short-Versus Long-Term Effects显示文摘 | Cabrera S Lopez M Tartarotti B | 1997 | Journal of Plankton Research1997，19，： | 1 |
| 10 | Effects of drying and rewetting on carbon and nitrogen mineralization in soils and incorporated residues显示文摘 | Kruse J S Kissel D E Cabrera M L | 2004 | Nutr Cycl Agroeco- sys2004，69，： | 1 |
| 11 | Hepatocellular carcinomacell supematants increase expansion and function of CD4 +、CE^s+ regulatory T cells显示文摘 | Cao M Cabrera R Xu Y | 2007 | Lab Invest2007，87，6： | 1 |
| 12 | Mapping sugar beet pectin acetylation B pattern 显示文摘 | Ralet M C Cabrera J C Bonnin E | 2005 | Phytochernistry2005，66，15： | 1 |
| 13 | Mitochondrial genome variation in eastern Asia and the peopling of Japan 显示文摘 | Tanaka M Cabrera VM Gonzalez AM et a1 | 2004 | Genome Res2004，，： | 1 |
| 14 | Tuning the stator resistance of induction motors using the artificial neural network 显示文摘 | Cabrera L A Elbuluk M E Husain I | 1997 | IEEE Trans on PE1997，12，5： | 1 |
| 15 | The essential oil of Senecio graveolens(Compositae) : Chemical composition and antimicrobial activity tests 显示文摘 | PEREZ C AGNESE A M CABRERA J L | 1999 | Journal of Ethnopharmacology1999，66，2： | 1 |
| 16 | Mitochondrialgenome variation in eastern Asia and the peopling of Japan显示文摘 | Tanaka M Cabrera VM Gonzalez AM | 2004 | Genome Res2004，14，10： | 1 |
| 17 | Comparison of the electro-optic coefficient r33 in well-defined phases of proton exchanged LiNbO3 waveguides显示文摘 | A. Méndez G. de la Paliza A. García-Caba?es J.M. Cabrera | 2001 | Applied Physics B Lasers and Optics (-)2001，，5： | 1 |
| 18 | Ammonia volatilization from urea, ammonium sulfate and NutraSweet sludge in bare and straw-cov- ered soils显示文摘 | Shahandeh H Cabrera M L Sumner M E | 1992 | Communications in Soil Science and Plant A nolysis1992，23，78： | 1 |
| 19 | Aggregate-protected and unprotected organic matter pools in conventional and no-tillage soils 显示文摘 | BEARE M H HENDRIX P F CABRERA M L | 1994 | Soil Science Society of America Journal1994，58，3： | 1 |
| 20 | Acute exercise activates nuclear factor (NF)-kappaB signaling pathway in rat skeletal muscle 显示文摘 | JI L L GOMEZ CABRERA M C STEINHAFEL N | 2004 | FASEB J2004，18，13： | 1 |
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