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| 1 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Modulation of matrix metalloproteinase-9 activity by hyaluronan is dependent on NF-kappaB activity in lymphoma cell lines with dissimilar invasive behavior显示文摘 | Alaniz L Garcia M Cabrera P | 2004 | Biochem Biophys Res Commun2004，324，2： | 1 |
| 4 | Aggregate-protected and unprotected organic matter pools in conventional and no-tillage soils 显示文摘 | BEARE M H HENDRIX P F CABRERA M L | 1994 | Soil Science Society of America Journal1994，58，3： | 1 |
| 5 | Aggregate-protected and unprotected organic matter pools in conventional-tillage and no-tillage soils显示文摘 | Beate M H Cabrera M L Hendrix P F | 1994 | Soil Sci Soc Am J1994，58，： | 1 |
| 6 | Horizontal and vertical variability of soil properties in a trace element contaminated area显示文摘 | Pilar Burgos Engracia Madejón Alfredo Pérez-de-Mora Francisco Cabrera | 2007 | International Journal of Applied Earth Observations and Geoinformation2007，，1： | 1 |
| 7 | Sorption characteristics of heavy metal ions by a natural zeolite 显示文摘 | Cabrera C Gabaldon C Marzal P | 2005 | Journal of Chemical Technology and Biotechnology2005，80，4： | 1 |
| 8 | The effect of treatment with omalizumab, an anti - IgE an- tibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma 显示文摘 | Bousquet J Cabrera P Berkman N | 2004 | Allergy2004，60，3： | 1 |
| 9 | Interhospital transport of children requiring extracorporeal membrane oxygenation support for cardiac dysfunction显示文摘 | Cabrera AG Prodhan P Cleves MA | | 0，，03： | 1 |
| 10 | The treat- ment of open tibial fractures and of tibial non - union with a novel external fixator 显示文摘 | Ong C T Choon D S K Cabrera N P | 2002 | Injur2002，33，9： | 1 |
| 11 | “In Situ” Amendments and Revegetation Reduce Trace Element Leaching in a Contaminated Soil显示文摘 | Alfredo Pérez-de-Mora Pilar Burgos Francisco Cabrera Engracia Madejón | 2007 | Water Air and Soil Pollution (-)2007，，1： | 1 |
| 12 | Aggregate-protected and unprotected organic matter pools in conventional and no-tillage soils显示文摘 | BEAR M H CABRERA M L HENDRIX P F | 1994 | Soil Science Society of America Journal1994，，58： | 1 |
| 13 | The effects of repetition, comprehension checks and gestures on primary school children in an EFL situation 显示文摘 | Cabrera M P & Martinez P B | 2001 | ELT Journal2001，，53： | 1 |
| 14 | Obstetric antiphospholipid syndrome显示文摘 | Claudio Galarza-Maldonado Maria R. Kourilovitch Oscar M. Pérez-Fernández Mariana Gaybor Christian Cordero Sonia Cabrera Nikolai F. Soroka | 2011 | Autoimmunity Reviews2011，，4： | 1 |
| 15 | The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma显示文摘 | Bousquet J Cabrera P Berkman N | 2005 | Allergy2005，60，3： | 1 |
| 16 | Risk factors for hepatocellular carcinoma in patients with liver cirrhosis显示文摘 | Macias Rodriguez MA Rendon Unceta P Tejada Cabrera M | 2000 | Rev Esp Enferm Dig2000，92，7： | 1 |
| 17 | Studies on the zoonotic cycle of Taenia saginata taeniasis and cysticercosis in the Philippines显示文摘 | Arambulo P V Cabrera B D Tongson M S | 1976 | Int J Zoonoses1976，3，： | 1 |
| 18 | Rapid verification of wheat-Hordeum introgressions by direct staining of SCAR,STS,and SSR amplicons显示文摘 | HERNANDEZ P DORADO G CABRERA A LAURIE D A SNAPE J W MARTIN A | 2002 | Genome2002，45，： | 1 |
| 19 | Training Practices and Organizational Learning Capability : Relationship and Implica- tions 显示文摘 | Gomez P J Lorente J J C Cabrera R V | 2004 | Journal of European Industrial Training2004，28，23： | 1 |
| 20 | Phase transformation analysis throughout an anhydrous fluorinebasod sol -gel YBCO processing route显示文摘 | Finlayson A P Mouganie T Cordero- Cabrera M C | 2007 | Materials Chemistry and Physics2007，105，： | 1 |
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