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| 1 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 2 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 3 | Groundwater Flow Simulation and its Application in Groundwater Resource Evaluation in the North China Plain,China显示文摘这研究的目的是为评估北方中国的地下水资源建立 3D 地下水流动建模平凡的。首先,北方中国平原通过 hydrogeological 条件的描述垂直地被划分成三含水土层。地下水模型软件公克被用于当模特儿把模拟的区域划分成 164 排和 148 根线的一个常规网络。这个模型通过适合被验证观察并且模仿的地下水流动在 64 口典型观察井在在观察并且模仿的自记水位计之间的深、浅的层和比较删除。而且,水预算分析也在模拟时期(20022003 ) 期间被执行。确定的地下水流动模型的结果证明平均年度地下水在 1991 ~ 2003 期间北方中国平原再装 256.68 是慭档湩 e ??辸 吗?? | SHAO Jingli LI Ling CUI Yali ZHANG Zhaoji | 2013 | Acta Geologica Sinica(English Edition)2013，87，1： | 9 |
| 4 | Formaldehyde induces toxic effects and regulates the expression of damage response genes in BM-MSCs显示文摘在这研究,我们在老鼠骨头髓上估计了甲醛(FA ) 的有毒的效果间充质的干细胞(BM-MSCs ) 。Cytotoxicity 被使用 MTT 试金测量。DNA 海滨破裂被与朊酶 K (PK ) 修改的标准碱的彗星试金和彗星试金检测。DNAprotein 交叉连接(DPC ) 被 KCl-SDS 降水试金检测。我们发现在从 75 ~ 200 M 的集中的 FA 禁止了房间幸存并且在 125 M 上导致了 DPC。修改 PK 的彗星试金证明那导致 FA 的 DNA 海滨破裂从 75 ~ 200 M 以一种剂量依赖者方式被增加。在另一方面,标准碱的彗星试金证明那 DNA 海滨破裂在 125 M 上与 FA 集中被减少。我们由使用在 DPC 和幸存率之间有否定线性关联的皮尔森关联证实了(r = 0.987, P < 0.01 ) 并且在 DPC 和(i) 姐妹染色单体交换之间的积极线性关系并且(ii ) micronucleus (r = 0.995, P < 0.01;r = 0.968, P < 0.01 ) 。DNA 损坏 RT2 剖析程序聚合酶链反应数组被用来在损坏反应基因的表达式调查变化。相应再结合小径的核苷酸切除修理小径和 Brca2, Rad51,和 Xrcc2 的 Xpa 和 Xpc 都在 75 和 125 M FA 是起来调整的。然而,一样的基因与 175 M FA 是下面调整的。Chek1 和 Hus1 的表情,涉及房间周期规定,与 75, 125,和 175 M FA 以一样的方式被改变。这些结果显示 Xpa, Xpc, Brca2, Rad51, Xrcc2, Chek1,和 Hus1 是必要的让 BM-MSCs 抵抗 FA 的效果。 | Yali She Yi Li Yongqi Liu Guli Asai Shaobo Sun Jianxin He Zheng Pan Yan Cui | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 8 |
| 5 | Fe3O4/Au composite nano-particles and their optical properties显示文摘Fe3O4/Au composite particles with core/shell structure were prepared by reduction of Au3+ with hydroxylamine in the presence of an excess of Fe3O4 as seeds.The resultant col-loids,with an average diameter of less than 100 nm,were obtained;the remaining non-reacted Fe3O4 seeds can be removed by treatment with diluted HCl solution.The Fe3O4/Au colloids ex-hibit a characteristic peak of UV-visible spectra,which largely depend on the size of the particle and the suspension medium.The localized surface plasmon resonance peaks red shift and broaden with increased nanoparticle diameter or increased solvent ionic strength.The optical property is very important in the establishment of means for the detection of biomolecules. | CUI Yali HUI Wenli SU Jing WANG Yani CHEN Chao | 2005 | Science China Chemistry2005，48，4： | 8 |
| 6 | Study on the Estimation of Groundwater Withdrawals Based on Groundwater Flow Modeling and Its Application in the North China Plain显示文摘The amount of water withdrawn by wells is one of the quantitative variables that can be applied to estimate groundwater resources and further evaluate the human influence on groundwater systems. The accuracy for the calculation of the amount of water withdrawal significantly influences the regional groundwater resource evaluation and management. However, the decentralized groundwater pumping, inefficient management, measurement errors and uncertainties have resulted in considerable errors in the groundwater withdrawal estimation. In this study, to improve the estimation of the groundwater withdrawal, an innovative approach was proposed using an inversion method based on a regional groundwater flow numerical model, and this method was then applied in the North China Plain. The principle of the method was matching the simulated water levels with the observation ones by adjusting the amount of groundwater withdrawal. In addition, uncertainty analysis of hydraulic conductivity and specific yield for the estimation of the groundwater withdrawal was conducted. By using the proposed inversion method, the estimated annual average groundwater withdrawal was approximately 24.92×109 m3 in the North China Plain from 2002 to 2008. The inversion method also significantly improved the simulation results for both hydrograph and the flow field. Results of the uncertainty analysis showed that the hydraulic conductivity was more sensitive to the inversion results than the specific yield. | Jingli Shao Yali Cui Qichen Hao Zhong Han Tangpei Cheng | 2014 | Journal of Earth Science2014，25，6： | 6 |
| 7 | Preparation and characterization of Fe_(3)O_(4)/Au composite particles显示文摘Using Fe3O4 nano-particles as seeds, a new type of Fe3O4/Au composite particles with core/shell structure and diameter of about 170 nm was prepared by reduction of Au3+ with hydroxylamine in an aqueous solution. Particle size analyzer and transmission electron micro-scope were used to analyze the size distribution and microstructure of the particles in different conditions. The result showed that the magnetically responsive property and suspension stability of Fe3O4 seeds as well as reduction conditions of Au3+ to Au0 are the main factors which are crucial for obtaining a colloid of the Fe3O4/Au composite particles with uniform particle dispersion, excellent stability, homogeneity in particle sizes, and effective response to an external magnet in aqueous suspension solutions. UV-Vis analysis revealed that there is a characteristic peak of Fe3O4/Au fluid. For particles with d(0.5)=168 nm, the lmax is 625 nm. | CUI Yali HUI Wenli WANG Huirong WANG Lijun CHEN Chao | 2004 | Science China Chemistry2004，47，2： | 5 |
| 8 | Applicability of Artificial Recharge of Groundwater in the Yongding River Alluvial Fan in Beijing through Numerical Simulation显示文摘A groundwater transient flow model was developed to evaluate the applicability and effectiveness of artificial recharge scenarios in the middle-upper part of the Yongding River alluvial fan in Beijing. These scenarios were designed by taking into account different types of recharge facilities and their infiltration rate with the Middle Route Project for South-to-North Water Transfer(MRP) as the recharge water source. The simulation results suggest that:(1) the maximum amount of artificial recharge water, for scenario I, would be 127.42×106 m3 with surface infiltration facilities; and would be243.48×106 m3 for scenario II with surface infiltration and recharge wells under the constraint of the upper limit of groundwater;(2) with preferred pattern of recharge facilities, groundwater levels in both optimized recharge scenarios would not exceed the upper limit within the given recharge period; and(3implementation of the recharge scenarios would efficiently increase the aquifer replenishment and the groundwater budget will change from-54.11×106 to 70.89×104 and 183.36×104 m3, respectively. In addition, under these two scenarios groundwater level would rise up to 30 and 34 m, respectively, without increasing the amount of evaporation. The simulation results indicate that the proposed recharge scenarios are practically feasible, and artificial recharge can also contribute to an efficient recovery of groundwater storage in Beijing. | Qichen Hao Jingli Shao Yali Cui Zhenhua Xie | 2014 | Journal of Earth Science2014，25，3： | 4 |
| 9 | Microbial population dynamics and changes in main nutrients during the acidification process of pig manures显示文摘This study evaluated the impact of pig manure acidification on anaerobic treatment and composition of the fecal microbial community.According to the different chemical oxygen demand (COD) in the anaerobic treatment processes,pig manure was diluted 4 times (×4),16 times (×16),or 64 times (×64) and subjected to acidification.During the acidification process,pH,soluble chemical oxygen demand (SCOD),volatile fatty acids (VFAs),nitrogen (N),phosphorus (P) and potassium (K) were determined along with microbial population dynamics.The pH of the three dilutions first declined,and then slowly increased.The total VFAs of ×4 and ×16 dilutions peaked on day 15 and 20,respectively.The content of acetic acid,propanoic acid,butanoic acid and valeric acid of the × 4 dilution were 23.6,11.4,8.8 and 0.6 g/L respectively,and that of the ×16 dilution was 5.6,2.3,0.9 and 0.2 g/L respectively.Only acetic acid was detected in the ×64 dilution,and its level peaked on day 10.The results showed that the liquid pig manure was more suitable to enter the anaerobic methanogenic bioreactors after two weeks of acidification.During the acidification process,total P concentration increased during the first ten days,then dropped sharply,and rose again to a relatively high final concentration,while total N concentration rose initially and then declined.Based on the analysis of denaturing gradient gel electrophoresis (DGGE) and 16S rRNA gene clone library,we concluded that the acidification process reduced the number of pathogenic bacteria species in pig manure. | Dongdong Zhang Xufeng Yuan Peng Guo Yali Suo Xiaofen Wang Weidong Wang Zongjun Cui | 2011 | Journal of Environmental Sciences2011，23，3： | 4 |
| 10 | Innovative development path of ethnomedicines: an overview of ethnomedicines in China显示文摘疾病预防和治疗的长历史上,世界范围的祖先的人口在传统的药获得了知识和经验。例如,中国种族少数的 ethnomedicines 组成传统的药的重要部分。在我们的学习,我们第一澄清了 ethnomedicines 的概念和 ethnopharmacology 的涵义。ethnomedicine 研究的个性然后被总结,并且中国种族少数的 ethnomedicines 的发展侧面被调查当前的地位和存在问题讨论。在这个基础上,我们第一次提炼了 ethnomedicines 的创新发展路径,它为国际化被发现成就和努力的标准化发展研究工业化到 follows:resource 学习。我们发现站台建立并且队训练是完成创新开发的关键。因此,这研究为 ethnomedicine 开发提供了一个基础。 | Zhaoyun Zhu Ting Wang Dehuan Fu Yali Gui Jingkun Wang Tao Cui | 2016 | Frontiers of Medicine2016，10，2： | 4 |
| 11 | Microstructures and Tensile Properties of Hot-extruded Mg-6Zn-xCe(x=0,0.6,1.0,2.0) Alloys显示文摘Mg-6Zn-x Ce(x = 0, 0.6, 1.0, 2.0) alloy ingots with diameter of 50 mm were extruded into bars with diameter of 12 mm at 300 ℃. The microstructures were analyzed by X-ray diffraction, optical microscopy, scanning electron microscopy and transmission electron microscopy, and mechanical properties were tested at room temperature. The results showed that major intermetallic composition in as-cast Mg-6Zn and Mg-6Zn-0.6Ce alloys was Mg_4Zn_7 phase, during extrusion Mg_4Zn_7 phase was dissolved into matrix and then precipitated as MgZn_2. In as-cast and as-extruded Mg-6Zn-1Ce and Mg-6Zn-2Ce alloys the major intermetallic composition was T phase. The microstructure of as-extruded alloy was refined due to complete dynamic recrystallization, the average grain size decreased with increasing Ce content, which were 12.1, 11.7, 11.0 and 10.0 mm, respectively. High density MgZn_2 precipitated in Mg-6Zn and Mg-6Zn-0.6Ce alloys. The broken T phase particles were distributed linearly along extrusion direction. Mg-6Zn-0.6Ce alloy exhibited a high yield strength of 226.3 MPa that was about 24 MPa higher than Mg-6Zn alloy. However, with increasing Ce contents, the strengths were decreased slightly because the effects of precipitation strengthening of MgZn_2 and solid solute strengthening of Zn were weakened though the strengthening effect of T phase was enhanced. | 于合帅 杨文朋 CUI Hongbao GUO Xuefeng WANG Ying WU Yali | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，1： | 3 |
| 12 | Dark current mechanism of unpassivated mid wavelength type II InAs/GaSb superlattice infrared photodetector显示文摘We investigate the dark current mechanism for an unpassivated mid wavelength(MW) type II InAs/GaSb superlattice infrared photodetector by doing the variablearea diode tests. The bulk resistance-area product and the resistivity due to the surface current are determined to be17.72 X cm2 and 704.23 X cm at 77 K, respectively. It is found that for all the mesa sizes used, the dark current is dominated or predominated by the surface component, and with scaling back the mesa size, the surface current increases while the bulk component decreases. The activation energy is determined to be 145 meV for the temperature range around 140–280 K, while it is 6 meV when temperature is below 100 K. It is also found that the dark current is dominated by the generation-recombination current for the MW device when temperature is between140 and 280 K. | Qiong Li Wenquan Ma Yanhua Zhang Kai Cui Jianliang Huang Yang Wei Ke Liu Yulian Cao Weiying Wang Yali Liu Peng Jin | 2014 | Chinese Science Bulletin2014，59，28： | 3 |
| 13 | Development and Application of a Regional Land Subsidence Model for the Plain of Tianjin显示文摘In this paper, a coupled numerical groundwater and land subsidence model was developed for the Tianjin Plain. The model was employed to investigate the groundwater resources and their changes over the last decade, and to further predict the changing patterns of the groundwater level and associated land subsidence in future. First, according to the regional hydrogeology, the simulation area was defined with an area of 10.6×103 km2, which was divided into six aquifer units. A coupled groundwater and land subsidence numerical model was built by using Modflow2005 and the land subsidence simulation module SUB(subsidence and aquifer-system compaction), in which the groundwater flow was modeled as three-dimensional unsteady flow and the land subsidence simulation was based on one-dimensional consolidation theory. The model was then calibrated by using the groundwater level contour lines, hydrographs, and land subsidence hydrographs over the period of 1998–2008. In addition, groundwater balance analysis of the simulation period indicated that under multi-year groundwater withdrawal condition the cross-flow recharge, compression release, and lateral boundary inflow contributed 44.43%, 32.14%, and 21.88% to the deep aquifer recharge, respectively. Finally, the model was applied to predict the changing patterns of the groundwater levels and the associated variations in land subsidence under the control of groundwater exploitation after implementation of the south-to-north water diversion project. The simulation results demonstrated that the groundwater level may gradually increase year by year with an decrease in the groundwater withdrawal; and the land in dominated land subsidence regions including the urban area, Dagang, Hangu, Jinghai, Wuqing, and Jinnan, may rebound at an average rate of 2–3 mm/a, and the land subsidence rate in the other regions may decrease. | Yali Cui Chen Su Jingli Shao Yabin Wang Xiaoyuan Cao | 2014 | Journal of Earth Science2014，25，3： | 2 |
| 14 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 15 | Enhancement of Fe3O4/Au Composite Nanoparticles Catalyst in Oxidative Degradation of Methyl Orange Based on Synergistic Effect显示文摘Fe 3 O 4/Au nanoparticles (Fe 3 O 4/Au NP ) 催化剂被采用 H 2 O 2 作为氧化剂。评估 Fe 3 O 4/Au nanoparticles,不同降级条件被调查例如催化剂的数量, H 2 O 2 集中和 pH 价值。基于我们的数据,甲基橘子在一短时间完全被降级。提高的催化活动和增加的氧化率常数可以被归功于到 synergistic H 2 O 2 到哦激进,它是强壮的氧化种类之一。而且, Fe 3 O 4/Au nanoparticles 展出了令人满意为潜在的工业申请再循环性能。 | Qin Gao Yan Xing Mingli Peng Yongshuai Liu Zhiyi Luo Yanyan Jin Haiming Fan Kebin Li Chao Chen Yali Cui | 2017 | Chinese Journal of Chemistry2017，35，9： | 2 |
| 16 | Unimodal productivity-biodiversity relationship along the gradient of multidimensional resources across Chinese grasslands显示文摘Resources can affect plant productivity and biodiversity simultaneously and thus are key drivers of their relationships in addition to plant-plant interactions.However,most previous studies only focused on a single resource while negle cting the nature of resource multidimensionality.Here we integrated four essential resources for plant growth into a single metric of resource diversity(RD)to investigate its effects on the productivity-biodiversity relationship(PBR)across Chinese grasslands.Results showed that habitats differing in RD have different PBRs—positive in low-resource habitats,but neutral in medium-and high-resource ones—while collectively,a weak positive PBR was observe d.However,when excluding direct effects of RD on productivity and biodiversity,the PBR in high-resource habitats became negative,which leads to a unimodal instead of a positive PBR along the RD gradient.By integrating resource effects and changing plant-plant interactions into a unified framework with the RD gradient,our work contributes to uncovering underlying me chanisms for inconsistent PBRs at large scales. | Yanfen Wang Jianqing Du Zhe Pang Yali Liu Kai Xue Yann Hautier Biao Zhang Li Tang Lili Jiang Baoming Ji Xingliang Xu Jing Zhang Ronghai Hu Shutong Zhou Fang Wang Rongxiao Che Di Wang Chaoting Zhou Xiaoyong Cui Nico Eisenhauer Yanbin Hao | 2022 | National Science Review2022，9，12： | 2 |
| 17 | Experimental Study on Determining the Optimum Cigarette Butt Content of Modified Bituminous Mixture of Cigarette Butts显示文摘 | Yi CUI Zhao-rong WU Yali LI Hang YANG | 2018 | Journal of Civil Engineering and Architecture2018，12，6： | 1 |
| 18 | The Synthesis of GoldMag Nano-Particles and their Application for Antibody Immobilization显示文摘 | Yali Cui Yani Wang Wenli Hui Zhifeng Zhang Xiaofang Xin Chao Chen | 2005 | Biomedical Microdevices2005，，2： | 1 |
| 19 | Preparation and characterization of Fe3O4composite particles显示文摘 | Yali Cui Wenli Hui Huirong Wang Lijun Wang Chao Chen | 2004 | Science in China Series B: Chemistry2004，，2： | 1 |
| 20 | Preparation and mechanism of Fe3O4/Au core/shell super-paramagnetic microspheres显示文摘 | Yali Cui Daodao Hu Yu Fang Jianbiao Ma | 2001 | Science in China Series B: Chemistry2001，，4： | 1 |
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