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| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 3 | Enhanced hydrogen evolution reaction over molybdenum carbide nanoparticles confined inside single-walled carbon nanotubes显示文摘Carbon nanotubes(CNTs) have shown as unique nanoreactors to tune the catalytic activity of confined nano-catalysts. Here we report that the catalytic performance of molybdenum carbide nanoparticles(MoC_x NPs) for the hydrogen evolution reaction(HER) process can be enhanced by encapsulation within single-walled carbon nanotubes(SWNTs) with a diameter of 1–2 nm. The catalyst with MoC_x NPs located on the interior surface of SWNTs(MoCx@SWNTs) exhibits a lower onset over-potential and a smaller Tafel slope than the one with MoC_x NPs attached on the exterior surface(MoCx/SWNTs). This is likely attributed to the much smaller particle size and the more reduced states of the confined MoC_x NPs, as well as the larger specific surface area of MoCx@SWNTs compared with Mo Cx/SWNTs. In addition, the electronic structure of the confined MoC_x NPs might be modified by the confinement effects of SWNTs, and hence the adsorption free energy of H atoms on the confined MoC_x NPs, which could also contribute to their higher performance. These results suggest that the SWNTs can be further explored for constructing novel catalysts with beneficial catalytic performance. | Tingting Cui Jinhu Dong Xiulian Pan Tie Yu Qiang Fu Xinhe Bao | 2019 | Journal of Energy Chemistry2019，28，1： | 7 |
| 4 | Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation显示文摘The intracellular pathogen Mycobacterium tuberculosis(Mtb)can survive in the host and cause disease by interfering with a variety of cellular functions.The mammalian cell entry 2(mce2)operon of Mtb has been shown to contribute to tuberculosis pathogenicity.However,little is known about the regulatory roles of Mtb Mce2 family proteins towards host cellular functions.Here we show that the Mce2 family protein Mce2E suppressed the macrophage innate immune response and promoted epithelial cell proliferation.Mce2E inhibited activation of the extracellular signal-regulated kinase(ERK)and Jun N-terminal kinase(JNK)mitogen-activated protein kinase(MAPK)signaling pathways in a non-canonical D motif(a MAPK-docking motif)-dependent manner,leading to reduced expression of TNF and IL-6 in macrophages.Furthermore,Mce2E promoted proliferation of human lung epithelium-derived lung adenoma A549 cells by inhibiting K48-linked polyubiquitination of eEF1A1 in aβstrand region-dependent manner.In summary,Mce2E is a novel multifunctional Mtb virulence factor that regulates host cellular functions in a niche-dependent manner.Our data suggest a potential novel target for TB therapy. | Lihua Qiang Jing Wang Yong Zhang Pupu Ge Qiyao Chai Bingxi Li Yi Shi Lingqiang Zhang George Fu Gao Cui Hua Liu | 2019 | Cellular & Molecular Immunology2019，16，4： | 7 |
| 5 | Fabrication of metal nanoclusters on graphene grown on Ru(0001)显示文摘Monolayer graphene was epitaxially grown on Ru(0001) through exposure of the Ru(0001) to ethylene at room temperature followed by annealing in ultrahigh vacuum at elevated temperatures. The resulting graphene structures were studied by scanning tunneling microscopy (STM), X-ray photoelectron spectroscopy (XPS), and ultraviolet photoelectron spectroscopy (UPS). The graphene/Ru(0001) surface was used as a periodic template for growth of metal nanoclusters. Highly dispersed Pt clusters with well controlled size and spatial distribution were fabricated on the surface. | ZHANG Hui FU Qiang CUI Yi TAN DaLi BAO XinHe | 2009 | Chinese Science Bulletin2009，54，14： | 4 |
| 6 | Hepatitis B Immunoprophylactic Failure and Characteristics of the Hepatitis B Virus Gene in Mother-Infant Pairs in Parts of China显示文摘Objective To determine the hepatitis B immunoprophylactic failure rate in infants born to hepatitis B virus(HBV) infected mothers and to characterize HBV genes. Methods HBV-serological testing was conducted for pregnant women and infants. The complete genomes of 30 HBV isolates were sequenced, and genetic characteristics were analyzed using MEGA 5 software. Results The immunoprophylactic failure rate for infants who had completed the scheduled hepatitis B vaccination program was 5.76%(32/556). High sequence homology(99.8%-100%) was observed in 8 of the 10 mother-infant pairs. We identified 19 subgenotype C2 strains, 9 subgenotype B2 strains, and 2 subgenotype C1 strains. Three serotypes were detected: adr(19/30), adw(9/30), and ayw(2/30). The frequency of amino acid mutation of the ‘a' determinant region was 16.67%(5/30), including that of Q129 H, F134 Y, S136 Y, and G145 E. We detected 67 amino acid mutations in the basal core promoter, precore, and core regions of the genome. Conclusion The immunoprophylactic failure rate in infants born to HBV-infected mothers is low in the regions of China examined during this study. Moreover, HBV mutation in the ‘a' determinant region could not account for immunoprophylactic failure for all infants. | YIN Wen Jiao SHEN Li Ping WANG Fu Zhen ZHANG Guo Min ZHENG Hui WANG Feng LIU Tie Zhu MENG Qing Ling YI Yao CUI Fu Qiang BI Sheng Li | 2016 | Biomedical and Environmental Sciences2016，29，11： | 3 |
| 7 | The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling显示文摘The E3 ubiquitin ligase(E3)-mediated ubiquitination and deubiquitinase(DUB)-mediated deubiquitination processes are closely associated with the occurrence and development of colonic inflammation.Ovarian tumor deubiquitinase 1(OTUD1)is involved in immunoregulatory functions linked to infectious diseases.However,the effect of OTUD1 on intestinal immune responses during colonic inflammatory disorders such as inflammatory bowel disease(IBD)remains unclear.Here,we show that loss of OTUD1 in mice contributes to the pathogenesis of dextran sulfate sodium(DSS)-induced colitis via excessive release of proinflammatory cytokines.In addition,bone marrow transplantation experiments revealed that OTUD1 in hematopoietic cells plays a dominant role in protection against colitis.Mechanistically,OTUD1 physically interacts with receptor-interacting serine/threonine-protein kinase 1(RIPK1)and selectively cleaves K63-linked polyubiquitin chains from RIPK1 to inhibit the recruitment of NF-κB essential modulator(NEMO).Moreover,the expression of OTUD1 in mucosa samples from ulcerative colitis(UC)patients was lower than that in mucosa samples from healthy controls.Furthermore,we demonstrate that the UC-associated OTUD1 G430V mutation abolishes the ability of OTUD1 to inhibit RIPK1-mediated NF-κB activation and intestinal inflammation.Taken together,our study unveils a previously unexplored role of OTUD1 in moderating intestinal inflammation by inhibiting RIPK1-mediated NF-κB activation,suggesting that the OTUD1-RIPK1 axis could be a potential target for the treatment of IBD. | Bo Wu Lihua Qiang Yong Zhang Yesheng Fu Mengyuan Zhao Zehui Lei Zhe Lu Yan-Ge Wei Hongmiao Dai Yingwei Ge Mingqiu Liu Xuemei Zhou Zhiqiang Peng Hongchang Li Chun-Ping Cui Jing Wang Hui Zheng Cui Hua Liu Lingqiang Zhang | 2022 | Cellular & Molecular Immunology2022，19，2： | 3 |
| 8 | Dynamic nanoscale imaging of enriched CO adlayer on Pt(111)confined under h-BN monolayer in ambient pressure atmospheres显示文摘Fun dame ntal un derstandi ng of chemistry confined to nano space remains a challe nge since molecules en capsulated in confined microe nviron merits are difficult to be characterized.Here,we show that CO adsorptio n on Pt(111)8nfined un der mono layer hexago nal boron nitride(h-BN)can be dynamically imaged using near ambient pressure seanning tunneling microscope(NAP-STM)and thanks to tunneling transparency of the top h-BN layer.The observed CO superstructures on Pt(111)in different CO atmospheres allow to derive surface coverages of CO adlayers,which are higher in the 8nfined nano space between h-BN and Pt(111)than those on the ope n Pt surface un der the same conditions.Dynamic NAP-STM imaging data together with theoretical calculations confirm confinement-induced molecule enrichment effect within the 2D nano space,which reveals new chemistry aroused by the confined nano reactor. | Hao Wu Pengju Ren Peng Zhao Zhongmiao Gong Xiaodong Wen Yi Cui Qiang Fu Xinhe Bao | 2019 | Nano Research2019，12，1： | 2 |
| 9 | Utilization threshold of surface water and groundwater based on the system optimization of crop planting structure显示文摘Based on the diversity of the agricultural system, this research calculates the planting structures of rice, maize and soybean considering the optimal economic-social-ecological aspects. Then, based on the uncertainty and randomness of the water resources system,the interval two-stage stochastic programming method,which introduces the uncertainty of the interval number, is used to calculate the groundwater exploitation and the use efficiency of surface water. The method considers the minimum cost of water as the objective of the uncertainty model for surface water and groundwater joint scheduling optimization for different planting structures. Finally, by calculating harmonious entropy, the optimal exploitation utilization interval of surface water and groundwater is determined for optimal cultivation in the Sanjiang Plain.The optimal matching of the planting structure under the economic system is suitable when the mining ratio of the surface is in 44.13%–45.45% and the exploitation utilization of groundwater is in 54.82%–66.86%, the optimal planting structure under the social system is suitable when surface water mining ratio is in 47.84%–48.04% and the groundwater exploitation threshold is in 67.07%–72.00%. This article optimizes the economicsocial-ecological-water system, which is important for the development of a water- and food-conserving society and providing a more accurate management environment. | Qiang FU Jiahong LI Tianxiao LI Dong LIU Song CUI | 2016 | Frontiers of Agricultural Science and Engineering2016，3，3： | 2 |
| 10 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 11 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
| 12 | Occurrence, variations, and risk assessment of neonicotinoid insecticides in Harbin section of the Songhua River, northeast China显示文摘Neonicotinoid insecticides(NNIs)have been intensively used and exploited,resulting in their presence and accumulation in multiple environmental media.We herein investigated the current levels of eight major NNIs in the Harbin section of the Songhua River in northeast China,providing the first systematic report on NNIs in this region.At least four NNIs in water and three in sediment were detected,with total concentrations ranging from 30.8 to 135 ng L^(-1) and from 0.61 to 14.7 ng g^(-1) dw,respectively.Larger spatial variations in surface water NNIs concentrations were observed in tributary than mainstream(p<0.05)due to the intensive human activities(e.g.,horticulture,urban landscaping,and household pet flea control)and the discharge of wastewater from many treatment plants.There was a significant positive correlation(p<0.05)between the concentrations of residual imidacloprid(IMI),clothianidin(CLO),and S4NNIs in the sediment and total organic carbon(TOC).Due to its high solubility and low octanol-water partition coefficient(Kow),the sediment-water exchange behavior shows that NNIs in sediments can re-enter into the water body.Human exposure risk was assessed using the relative potency factor(RPF),which showed that infants have the highest exposure risk(estimated daily intake(SIMIeq EDI):31.9 ng kg^(-1) bw$d^(-1)).The concentration thresholds of NNIs for aquatic organisms in the Harbin section of the Songhua River were determined using the species sensitivity distribution(SSD)approach,resulting in a value of 355 ng L^(-1) for acute hazardous concentration for 5%of species(HC5)and 165 ng L^(-1) for chronic HC5.Aquatic organisms at low trophic levels were more vulnerable to potential harm from NNIs. | Zhikun Liu Song Cui Leiming Zhang Zulin Zhang Rupert Hough Qiang Fu Yi-Fan Li Lihui An Mingzhi Huang Kunyang Li Yuxin Ke Fuxiang Zhang | 2021 | Environmental Science and Ecotechnology2021，，4： | 2 |
| 13 | Respiratory syncytial virus infection in immunocompetent and immunocompromised murine显示文摘The purpose of this study is to distinguish respiratory syncytial virus ( RSV) infection and immunology between immunocompetent and immunocompromised murine and to explore immune mechanism of RSV infection. At various time points after RSV infection of BALB/c mice and nude mice, pulmonary viral titers were assayed, RSV antigen was tested by direct immune-fluorescent assay and immu nohistochemistry. Pulmonary mRNA expressions of Toll like receptor (TLR)2 and TLR4 were assayed by RT-PCR. CD4+ cells and CD8+ cells in peripheral blood were examined by flow cytometry and plasma total IgE was assayed by ELISA. Leukocytes in bronchoalveolar lavage fluid (BALF) and pulmonary histology were identified to reflect airway inflammation. It was found that RSV titers of both mice peaked on the 3rd day post infection with a much higher level of viral titer in nude mice than in BALB/c mice and a longer viral duration in nude mice (over 9 days post infection) than in BALB/c mice (6 days post infection). RSV infection induced higher viral antigen expression in nude mice (0.267±0.045) than in BALB/c mice (0.168±0.031). RSV infection enhanced pulmonary TLR4 expression of BALB/c mice (51.96%±11.34%) and nude mice (48.96%±12.35%) compared with each control (34.04%±10.06% and 32.37%±9.87% respectively). CD4+ peripheral blood cells increased in RSV infected BALB/c mice (66.51%±2.09%) compared with the control BALB/c mice (51.63%±5.90%), and CD4+ cells and CD8+ cells were deficient in nude mice. RSV infection increased plasma total IgE in both mice, and BALB/c mice had a larger amount of IgE on the 7th day post infection (9.02 ng/ml±2.90 ng/ml) and on the 14th day post infection (12.76 ng/ml±4.15 ng/ml) than corresponding nude mice (3.72 ng/ml±1.06 ng/ml and 7.62 ng/ml±3.08 ng/ml respectively on the 7th and 14th day post infection). RSV infected nude mice had more severe airway inflammation than infected BALB/c mice. It is concluded that BALB/c mice and nude mice presented similar RSV infectious characteristics. However, infection of nude mice showed higher viral titer with longer duration and more severe airway inflammation, lower level of plasm total IgE and CD4+ peripheral blood cells, but the similar pulmonary TLR4 expression with BALB/c mice. | JUAN ZHOU Yu XIA CUI XI QIANG YANG ZHOU FU LI PING JIANG LI JIA WANG | 2006 | Journal of Microbiology and Immunology2006，4，1： | 2 |
| 14 | Dynamic observation of in-plane h-BN/graphene heterostructures growth on Ni(lll)显示文摘The lateraI incorporation of graphene and hexagonal boron nitride(h-BN)onto a substrate surface creates irvplane h-BN/graphene heterostructures,which have promising applications in novel two-dimensional electronic and photoelectronic devices.The quality of h-BN/graphene domain boundaries depends on their orientation,which is crucial for device performances.Here,the heteroepitaxial growth of graphene along the edges of h-BN domains on Ni(111)surfaces as well as the growth dynamics of h-BN using chemical vapor deposit!on(CVD)are in situ investigated by surface imaging measurements.The nucieating seed effect of h-BN has been revealed,which con tributes to the single orie ntation of heterostructures with epitaxial stitch i ng.Further,the growth of h-BN prior to that of graphene is essential to obtain high-quality in-plane h-BN/graphene heterostructures on Ni(111).The“compact to fractal”shape transition of h-BN domains appears with the increasing surface concentration of the growth blocks,suggesting that the dynamic growth mechanism follows diffusion-limited aggregation(DLA)but not reaction・limited aggregation(RLA).Our results provide in sights into the syn thesis of well-defi ned h-BN/graphene heterostructures and deep un derstanding of the growth dynamics of h-BN on metal surfaces. | Wei Wei Jiaqi Pan Chanan Euaruksakul Yang Yang Yi Cui Qiang Fu Xinhe Bao | 2020 | Nano Research2020，13，7： | 2 |
| 15 | RHOBTB3 promotes proteasomal degradation of HIFa through facilitating hydroxylation and suppresses the Warburg effect显示文摘 | Chen-Song Zhang Qi Liu Mengqi Li Shu-Yong Lin Yongying Peng Di Wu Terytty Yang Li Qiang Fu Weiping Jia Xinjun Wang Teng Ma Yue Zong Jiwen Cui Chengfei Pu Guili Lian Huiling Guo Zhiyun Ye Sheng-Cai Lin | 2015 | Cell Research2015，25，9： | 2 |
| 16 | Controlled growth of uniform two-dimensional ZnO overlayers on Au(111)and surface hydroxylation显示文摘Ultrathin ZnO nano structures prese nt in teresti ng two-dimensi on al(2D)graphene-like structure in contrast to wurtzite structure in bulk ZnO.Growth on Au(111)has been regarded as a well-established route to the 2D ZnO layers while controlled growth of uniform ZnO nano structures remains as a challe nge.Here,reactive deposition of Zn in O3 and NO2 was employed,which is investigated by sea nning tunneling microscopy and X-ray photoelectr on spectroscopy(XPS).We dem on strate that uniform ZnO mono layer nanoislands and films can be obtained on Au(111)using O3 and uniform ZnO bilayer nanoislands and films form on Au(111)using NO2,respectively.Formation of atomic oxyge n overlayers on Au(111)via exposure to O3 is critical to the formatio n of uniform ZnO mono layer nano structures atop.Near ambient pressure XPS studies revealed that n early full hydroxy lati on occurs on mono layer ZnO structures upon exposure to near ambient pressure water vapor or atomic hydrogen species,while partial surface hydroxylation happens on bilayer ZnO under the same gaseous exposure conditions. | Hao Wu Qiang Fu Yifan Li Yi Cui Rui Wang Nan Su Le Lin Aiyi Dong Yanxiao Ning Fan Yang Xinhe Bao | 2019 | Nano Research2019，12，9： | 1 |
| 17 | Modeling and flapping vibration suppression of a novel tailless flapping wing micro air vehicle显示文摘This paper establishes and analyzes a high-fidelity nonlinear time-periodic dynamic model and the corresponding state observer for flapping vibration suppression of a novel tailless Flapping Wing Micro Air Vehicle(FWMAV),named NPU-Tinybird.Firstly,a complete modeling of NPU-Tinybird is determined,including the aerodynamic model based on the quasi-steady method,the kinematic and dynamic model about the mechanism of flapping and attitude control,combined with the single rigid body dynamic model.Based on this,a linearized longitudinal pitch dynamic cycle-averaged model is obtained and analyzed through the methods of neural network fitting and system identification,preparing for the design of flapping vibration suppression observer.Flapping vibration is an inherent property of the tailless FWMAV,which arises from the influence of time-periodic aerodynamic forces and moments.It can be captured by attitude and position sensors on the plane,which impairs the flight performance and efficiency of flight controller and actuators.To deal with this problem,a novel state observer for flapping vibration suppression is designed.A robust optimal controller based on the linear quadratic theory is also designed to stabilize the closed-loop system.Simulation results are given to verify the performance of the observer,including the closed loop responses combined with robust optimal controller,the comparison of different parameters of observer and the comparison with several classic methods,such as Kalman filter,H-infinity filter and low-pass filter,which prove that the novel observer owns a fairly good suppression effect on flapping vibration and benefits for the improvement of flight performance and control efficiency. | Siqi WANG Bifeng SONG Ang CHEN Qiang FU Jin CUI | 2022 | Chinese Journal of Aeronautics2022，35，3： | 1 |
| 18 | Immunizaiton Coverage and Its Determi- nants in Children Aged 12-23 Months in Gansu, China显示文摘 | Fu - Qiang Cui Rosa Gofin | 2007 | Vaccine2007，25，4： | 1 |
| 19 | Temporal-spatial Analysis on Urban and Rural Drinking Water Health Monitoring of Tianjin in 2013显示文摘[Objective] Grasp quality and health status of drinking water,and provide scientific basis for decision making of health administrative department. [Method]According to the Standards for Drinking Water Quality( GB 5749- 2006),monitoring results of Tianjin urban and rural drinking water health in 2013 were evaluated,and software SPSS 20. 0 and GeoD a was used for temporal-spatial analysis on water quality. [Result]There were 2 882 copies of monitoring samples in total,in which both finished water and tap water of urban district were qualified,while qualified rates of tap water and secondary water supply from the county were respectively 86. 36% and 93. 91%,and major exceeding indexes were pH and total number of colonies. Qualified rates of tap water and secondary water supply from the county had difference( χ2= 1 576. 875,P < 0. 01). Quality of tap water( χ2= 5. 425,P > 0. 05) and secondary water supply( χ2= 16. 009,P > 0. 05) was stable at temporal distribution( January-December),but spatial distribution of tap water had certain regional difference( χ2= 1 255. 802,P < 0. 01). [Conclusion] General quality situation of Tianjin urban and rural drinking water was better,but qualified rate of water quality in some counties was lower,which had safety risk and threatened the health of residents in the corresponding county. The related departments should enhance the supervision and management of drinking water supply,improve supply water quality,strengthen water quality monitoring,and guarantee drinking water safety. Geographic information system can better realize visualization of drinking water quality monitoring information. | Fu Gang Zeng Qiang Zhao Liang Feng Baojia Wang Rui Zhang Lei Wang Yang Cui Yushan Zhang Yue Liu Hongliang | 2016 | Meteorological and Environmental Research2016，7，3： | 1 |
| 20 | The effect of poly(vinyl alcohol) hydrolysis on the properties of its blends with nylon 6显示文摘 | Cui Li Fu Qiang Chang Changjung etal | 2009 | Polym Eng Sci2009，49，8： | 1 |
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