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| 1 | Osteogenic effects of D(+)β-3,4-dihydroxyphenyl lactic acid (salvianic acid A, SAA) on osteoblasts and bone marrow stromal cells of intact and prednisone-treated rats显示文摘 | Liao CUI Yu-yu LIU Tie WU Chun-mei AI Huai-qing CHEN | 2009 | Acta Pharmacologica Sinica2009，30，3： | 29 |
| 2 | Incidence of Pleural Effusion in Patients with Pulmonary Embolism显示文摘 | Min Liu Ai Cui Zhen-Guo Zhai Xiao-Juan Guo Man Li Lei-Lei Teng Li-Li Xu Xiao-Juan Wang Zhen Wang Huan-Zhong Shi | 2015 | Chinese Medical Journal2015，，8： | 25 |
| 3 | Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination显示文摘 | Yiqiang Cui Yuyu Niu Jiankui Zhou Yongchang Chen Yiwei Cheng Shangang Li Zongyong Ai Chu Chu Hong Wang Bo Zheng Xuejin Chen Jiahao Sha Xuejiang Guo Xingxu Huang Weizhi Ji | 2018 | Cell Research2018，28，3： | 13 |
| 4 | Characteristics of pulmonary inflammation in combined pulmonary fibrosis and emphysema显示文摘 | ZHAO Ying CUI Ai WANG Feng WANG Xiao-juan CHEN Xing JIN Mu-lan HUANG Ke-wu | 2012 | Chinese Medical Journal2012，，17： | 8 |
| 5 | CIVB flashback analysis of hydrogen flame based on azimuthal vorticity at mixing zone exit显示文摘Swirl-premixed combustion systems exhibit potential to meet future regulations on pollution emissions. However, combustion induced vortex breakdown(CIVB) flashback is frequently observed in these systems, especially for high hydrogen content fuel. In this study, a swirl-premixed burner with diverging centerbody was used to investigate CIVB flashback based on azimuthal vorticity at mixing zone exit. Through 2D axisymmetric model, it was found that there was a maximal azimuthal vorticity at mixing zone exit for each equivalence ratio. The physical meaning of these maximal azimuthal vorticity values was the minimally required azimuthal vorticity to trigger CIVB flashback. At the same time, the required azimuthal vorticity declined with the increase of equivalence ratio since turbulent burning velocity started to control flashback. Nevertheless, azimuthal vorticity offered by heat release increased with the increase of equivalence ratio, which promoted flame propagating upstream continually. | TIAN Xiao Jing XING Shuang Xi CUI Yu Feng FANG Ai Bing NIE Chao Qun | 2014 | Science China(Technological Sciences)2014，57，12： | 7 |
| 6 | Effects of nuclei ambiguus and dorsal motor nuclei of vagus on gastric H^+ and HCO_3^- secretion in rats显示文摘AIM: To determine the effects of electrical stimulation of nucleus ambiguus (NA) and dorsal motor nuclei of vagus (DMV) on gastric acid and bicarbonate secretion in rats. METHODS: NA and DMV in rats were electrically stimulated. Pylorus ligation or esophagus perfusion was used to collect the gastric secretion. The titratable H+ quantum, H+ concentration, HCO3- secretion quantum were measured. RESULTS: Electrical stimulation of NA had no effects on the volume of gastric juice, titratable acidity and acid concentration, but elicited a pronounced increase in the total bicarbonate. However, electrical stimulation of DMV significantly increased the titratable acidity, the volume of gastric juice and the acid concentration. Similarly, electrical stimulation of either NA or DMV decreased the respiratory frequency and sinus bradycardia. CONCLUSION: NA in rats can not control the secretion of gastric acid but the secretion of bicarbonate in gastric juice, while DMV controls the secretion of gastric acid. | Xue-Ying Zhang Hong-Bin Ai Xi-Yun Cui | 2006 | World Journal of Gastroenterology2006，12，20： | 5 |
| 7 | Effects and mechanisms of L-glutamate microinjected into nucleus ambiguus on gastric motility in rats显示文摘背景 L-glutamate (L-GLU ) 是在原子核 ambiguus (NA ) 的主要 neurotransmitter,它能调制呼吸,动脉的压力,心率,等等。这研究在一个乳胶汽球与一个压力变换器连接了的 rats.Methods 在胃的活动性上调查了 L-GLU microinjected 的效果和机制进 NA 为胃的活动性的连续记录通过 forestomach 被插入到幽门。在 5 以内的胃的收缩波浪的全部的振幅,全部的持续时间,和活动性索引在 microinjection 前并且在 microinjection 以后纪录是 measured.Results L-GLU (在 50 nl 正常的 5 nmol , 10 nmol 和 20 nmol 盐( PS )分别地)进正确 NA 的 microinjected 显著地禁止了胃的活动性,当时 microinjection 生理在一样的位置和一样的体积盐没改变胃的活动性。禁止的效果被 D-2-amino-5-phophonovalerate 堵住( D-AP5 , 5 nmol ,在 50 nl PS ),特定的 N-methyl-D-aspartic 酸( NMDA )受体对手,但是没被6-cyaon-7-nitroquinoxaline-2,3-( 1H,4H )影响 -dione ( CNQX )( 5 nmol ,在 50 nl PS ), non-NMDA ionotropic 受体对手。双边的 subdiaphragmatic vagotomy 由 L-GLU 的 microinjection 废除了禁止的效果进 NA。进 NA 的 L-GLU 的结论 Microinjection 通过特定的 NMDA 受体活动,不是 non-NMDA 受体活动禁止胃的活动性,并且传出小径是 vagal 神经。 | SUN Hong-zhao ZHAO Shu-zhen CUI Xi-yun AI Hong-bin | 2010 | Chinese Medical Journal2010，，8： | 4 |
| 8 | ALM1, encoding a Fe-superoxide dismutase, is critical for rice chloroplast biogenesis and drought stress response显示文摘Chloroplasts are the center of plant life activities including photosynthesis,growth and development,and abiotic stress response.Chloroplast development and biogenesis in rice have been studied in detail,but how does abiotic stress affect chloroplasts is less studied.We obtained an albino mutant,alm1,whose chlorophyll content was greatly decreased.Transmission electron microscopy showed that chloroplast development in alm1 was blocked,especially in thylakoid-like structures,which could not form normally.The ALM1 gene encodes a chloroplast-localized superoxide dismutase.Full-length ALM1 successfully restored the non-albino phenotype,and in knockout lines,the albino phenotype reappeared.The ALM1gene is expressed mainly in young leaves.alm1 plants died as a consequence of excessive reactive oxygen accumulation after the third-leaf stage.A series of biochemical assays verified that ALM1 interacted with the OsTrxz protein,which is one of the components of plastid-encoded RNA polymerase (PEP) complexes.A western blot experiment indicated that ALM1 played an important role in stabilizing OsTrxz in rice.An overexpression test of ALM1 revealed that ALM1 can increase drought resistance by removing excess reactive oxygen in rice seedlings.This study suggests that ALM1 not only participates in rice chloroplast biogenesis,but also increases rice stress resistance by scavenging excess reactive oxygen. | Yanwei Wang Chen Deng Pengfei Ai Xue’an Cui Zhiguo Zhang | 2021 | The Crop Journal2021，9，5： | 4 |
| 9 | Prognostic value of MET, cyclin D1 and MET gene copy number in non-small cell lung cancer显示文摘The aim of this study was to analyze the correlation of the expression of MET and cyclin D1 and MET gene copy number in non-small cell lung cancer (NSCLC) tissues and patient clinicopathologic characteristics and survival. Sixty-one NSCLC tissue specimens were included in the study. The expression of MET and cyclin D1 was evaluated by immunohistochemistry and MET gene copy number was assessed by quantitative real-time polymerase chain reaction (Q-PCR). Positive expression of MET and cyclin D1 protein and increased MET gene copy number occurred in 59.0%, 59.0% and 18.0% of 61 NSCLC tissues, respectively. MET-positivity correlated with poor differentiation (P=0.009). Increased MET gene copy number was significantly associated with lymph node metastasis (P=0.004) and advanced tumor stage (P=0.048), while the expression of cyclin D1 was not associated with any clinicopathologic parameters. There was a significant correlation between the expression of MET and MET gene copy number (P=0.002). Additionally, the expression of cyclin D1 had a significant association with the expression of MET as well as MET gene copy number (P=0.002 and P=0.017, respectively). MET-positivity and increased MET gene copy number were significantly associated with poor overall survival (P=0.003 and P<0.001, respectively) in univariate analysis. Multivariate Cox proportional hazard analysis confirmed that the expression of MET and MET gene copy number were prognostic indicators of NSCLC (P=0.003 and P=0.001, respectively). The overexpression of MET and the increased MET gene copy number might be adverse prognostic factors for NSCLC patients. The activation of the MET/cyclin D1 signaling pathway may contribute to carcino- genesis and the development of NSCLC, and may represent a target for therapy. | Wenze Sun Liping Song Ting Ai Yingbing Zhang Ying Gao Jie Cui | 2013 | The Journal of Biomedical Research2013，27，3： | 3 |
| 10 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 11 | Mouse knockout models reveal largely dispensable but context-dependent functions of IncRNAs during development显示文摘 | Xue Han Sai Luo Guangdun Peng Yuyang Lu Guizhong Cui Lichao Liu Pixi Yan Yafei Yin Wei Liu Ran Wang Jiejie Zhang Shanshan Ai Zai Chang Jie Na Aibin He Naihe Jing Xiaohua Shen | 2018 | Journal of Molecular Cell Biology2018，10，2： | 3 |
| 12 | Infection with severe fever with thrombocytopenia virus in healthy population:a cohort study in a high endemic region,China显示文摘Background: Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic region.Methods: A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive rates.Results: Totally 886 individuals were recruited. The baseline seroprevalence that was tested before the epidemic season was 11.9% (70/587) for IgG and 6.8% (40/587) for NAb, which was increased to 13.4% (47/350) and 7.7% (27/350) during the epidemic season, and further to 15.8% (80/508) and 9.8% (50/508) post epidemic. The IgG antibody-based seropositivity was significantly related to the patients aged ≥ 70 years old [adjusted odds ratio (OR) = 2.440, 95% confidence interval (CI): 1.334-4.461 compared to the group of < 50 years old,P = 0.004], recent contact with cats (adjustedOR = 2.195, 95%CI: 1.261-3.818,P = 0.005), and working in tea garden (adjustedOR = 1.698, 95%CI: 1.002-2.880,P = 0.049) by applying multivariate logistic regression model. The NAb based seropositivity was similarly related to the patients aged ≥ 70 years old (adjustedOR = 2.691, 95%CI: 1.271-5.695 compared to the group of < 50 years old,P = 0.010), and recent contact with cats (OR = 2.648, 95%CI: 1.419-4.941,P = 0.002). For a cohort of individuals continually sampled with 1-year apart, the anti-SFTSV IgG were maintained at a stable level, while the NAb level reduced.Conclusions: Subclinical infection might not provide adequate immunity to protect reinfection of SFTSV, thus highlighting the ongoing threats of SFTS in endemic regions, which called for an imperative need for vaccine development. Identification of risk factors might help to target high-risk population for public health education and vaccination in the future. | Xiao‑Lei Ye Ke Dai Qing‑Bin Lu Yan‑Qin Huang Shou‑Ming Lv Pan‑He Zhang Jia‑Chen Li Hai‑Yang Zhang Zhen‑Dong Yang Ning Cui Chun Yuan Kun Liu Xiao‑Ai Zhang Jiu‑Song Zhang Hao Li Yang Yang Li‑Qun Fang Wei Liu | 2021 | Infectious Diseases of Poverty2021，10，6： | 3 |
| 13 | Establishment and characterization of an astroglial cell line derived from the brain of half-smooth tongue sole(Cynoglossus semilaevis)显示文摘An astroglial cell line was established from the brain of half smooth tongue sole(Cynoglossus semilaevis)and was designated as CSAC.CSAC shows the morphological homogeneity of epithelial cells.The cell identity was tested by the presence of glial fibrillary acidic protein(GFAP),which was revealed by RT-PCR and immunofluorescence.The cell line was optimally maintained at 24 °C in minimum essential medium supplemented with HEPES,antibiotics,20%fetal bovine serum,2-Mercaptoethanol(2-Me) and basic fibroblast growth factor.Chromosome analysis revealed that the CSAC cells maintained a normal diploid chromosome number(2n=42).The fluorescent signals were observed in CSAC after the cells were transfected with green fluorescent protein(GFP) reporter plasmids.The CSAC cell line may serve as a valuable tool for studies on the potential functions of fish astroglial cells. | Tian-Zi WANG Ai SUN Na WANG Zhong-Kai CUI Song-Lin CHEN Zhen-Xia SHA | 2015 | Zoological Research2015，36，5： | 2 |
| 14 | Electrochemical determination of bisphenol A at Mg - A1 - CO3 layered double hydroxide modified glassy carbon electrode 显示文摘 | Yin H S Cui L Ai S Y | 2010 | Electrochimica Acta2010，55，： | 1 |
| 15 | Experimental realization of nonadiabatic holonomic single‐qubit quantum gates with two dark paths in a trapped ion显示文摘For circuit-based quantum computation,experimental implementation of a universal set of quantum logic gates with high-fidelity and strong robustness is essential and central.Quantum gates induced by geometric phases,which depend only on global properties of the evolution paths,have built-in noise-resilience features.Here,we propose and experimentally demonstrate nonadiabatic holonomic single-qubit quantum gates on two dark paths in a trapped ^(171)γδ^(+)ion based on four-level systems with resonant drives.We confirm the implementation with measured gate fidelity through both quantum process tomography and randomized benchmarking methods.Meanwhile,we find that nontrivial holonomic two-qubit quantum gates can also be realized within current experimental technologies.Compared with previous implementations,our experiments share both the advantages of fast nonadiabatic evolution and robustness against systematic errors.Therefore,our experiments confirm a promising method for fast and robust holonomic quantum computation. | Ming-Zhong Ai Sai Li Ran He Zheng-Yuan Xue Jin-Ming Cui Yun-Feng Huang Chuan-Feng Li Guang-Can Guo | 2022 | Fundamental Research2022，2，5： | 1 |
| 16 | Multi-targeted histone deacetylase inhibitors in cancer therapy显示文摘 | Ai T Cui H Chen L | 2012 | Curr Med Chem2012，19，4： | 1 |
| 17 | Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation 显示文摘 | Pogue AI Cui JG Li YY | 2010 | Neuroscience letters2010，476，1： | 1 |
| 18 | Extraction, partial characterization and bioactivity of polysaccharides from boat-fruited sterculia seeds显示文摘 | Lianzhong Ai Jinhong Wu Na Che Yan Wu Steve W. Cui | 2012 | International Journal of Biological Macromolecules2012，，5： | 1 |
| 19 | Effects of single-prolonged stress on neurons and their afferent inputs in the amygdala显示文摘 | Cui H Sakamoto H Higashi S et ai | 2008 | Neuroscience2008，152，3： | 1 |
| 20 | Clinical importance of SF3 B 1 mutations in Chinese with myelodysplastic syndromes with ring sideroblasts 显示文摘 | Cui R Gale RP Xu Z et aI | 2012 | Leuk Res2012，36，11： | 1 |
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