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| 1 | New serological biomarkers of inflammatory bowel disease显示文摘Serological biomarkers in inflammatory bowel disease (IBD) are a rapidly expanding list of non-invasive tests for objective assessments of disease activity, early diagnosis, prognosis evaluation and surveillance. This review summarizes both old and new biomarkers in IBD, but focuses on the development and character-ization of new serological biomarkers (identifi ed since 2007). These include fi ve new anti-glycan antibodies, anti-chitobioside IgA (ACCA), anti-laminaribioside IgG (ALCA), anti-manobioside IgG (AMCA), and antibod-ies against chemically synthesized (∑) two major oligomannose epitopes, Man α-1,3 Man α-1,2 Man (∑Man3) and Man α-1,3 Man α-1,2 Man α-1,2 Man (∑Man4). These new biomarkers serve as valuable complementary tools to existing biomarkers not only in differentiating Crohn's disease (CD), ulcerative colitis (UC), normal and other non-IBD gut diseases, but also in predicting disease involvement (ileum vs colon), IBD risk (as subclinical biomarkers), and disease course (risk of complication and surgery). Interestingly, the prevalence of the antiglycan antibodies, including anti-Saccharomyces cerevisiae antibodies (ASCA), ALCA and AMCA, was found to be associated with single nucleotide polymorphisms (SNPs) of IBD susceptible genes such as NOD2/CARD15, NOD1/CARD4, toll-likereceptors (TLR) 2 and 4, and β-defensin-1. Further-more, a gene dosage effect was observed: anti-glycan positivity became more frequent as the number of NOD2/CARD15 SNPS increased. Other new serum/ plasma IBD biomarkers reviewed include ubiquitination factor E4A (UBE4A), CXCL16 (a chemokine), resistin, and apolipoprotein A-IV. This review also discusses the most recent studies in IBD biomarker discovery by the application of new technologies such as proteomics, fourier transform near-infrared spectroscopy, and mul-tiplex enzyme-linked immunosorbent assay (ELISA)'s (with an emphasis on cytokine/chemokine profiling). Finally, the prospects of developing more clinically use-ful novel diagnostic algorithms by incorporating new technologies in serological biomarker profiling and integrating multiple biomarkers with bioinformatics analysis/modeling are also discussed. | Xuhang Li Laurie Conklin Philip Alex | 2008 | World Journal of Gastroenterology2008，14，33： | 6 |
| 2 | 应用于区域交通战略规划中的情景规划显示文摘本文简要回顾了情景规划从商业战略规划活动中产生后的历史,对其目标与局限性进行了综述。然后文章回顾了情景规划在区域交通规划中的应用背景和先例,介绍了情景规划在休新敦大都市区交通中应用和深化的工作框架,讨论了这一应用的主要成果和教训,并时进一步的发展潜力和改进措施提出了作者的观察和结论。 | Christopher Zegras Joseph Sussman Christopher Conklin 高璟 | 2006 | 国外城市规划2006，21，6： | 5 |
| 3 | Formulaic Sequences: Are They Processed More Quickly than Nonformulaic Language by Native and Nonnative Speakers?显示文摘 | Kathy Conklin Norbert Schmitt | 2008 | Applied Linguistics2008，，1： | 4 |
| 4 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 5 | Intravitreal delivery of ciprofloxacin 显示文摘 | Hainsworth DP Conklin JD Bierly JR | 1996 | J Ocul Pharmacol Ther1996，12，2： | 1 |
| 6 | Affect regulation in Borderline Personality Disorder显示文摘 | Conklin C Z Bradley R Westen D | 2006 | The Journal of Nervous and Mental Dis- ease2006，194，2： | 1 |
| 7 | Longitudinal investigation of adaptive functioning following conformal irradiation for pediatric craniopharyngioma and low-grade glioma显示文摘 | Netson KL Conklin HM Wu S | 2013 | Int J Radiat Oncol Biol Phys2013，85，5： | 1 |
| 8 | High perceived stress in relation to life events is associated with blunted cardiac reactivity 显示文摘 | Ginty A T Conklin S M | 2001 | Biol Psychol2001，86，2： | 1 |
| 9 | The Balancing Act: The Role of Transnational Habitus and Social Networks in Balancing Transnational Entrepreneurial Activities 显示文摘 | PATEL P CONKLIN B | 2009 | Entrepreneurship Theory & Practice2009，33，5： | 1 |
| 10 | Genistein and quercetin increase connexin43 and suppress growth of breast cancer cells 显示文摘 | Conklin CM Bechberger JF MacFabe D | 2007 | Carcinogenesis2007，28，1： | 1 |
| 11 | Genetic evidence for the role of GDP-mannose in plant ascorbic acid biosynthesis显示文摘 | CONKLIN NORRIS S R WHEELER G L | 1999 | PNAS1999，96，： | 1 |
| 12 | Differential accumulation of antioxidant mRNAs in Arabidopsis thaliana exposed to ozone显示文摘 | Conklin P L Last R L | 1995 | Plant Physiol1995，109，： | 1 |
| 13 | Reduction in density of transverse tubules and L-type Ca(2+) channels in canine tachycardia-induced heart failure显示文摘 | He J Conklin MW Foell JD | 2001 | Cardiovasc Res2001，49，： | 1 |
| 14 | Genistdn and quercetin increase connexin43 and suppress growth of breast cancer cells显示文摘 | Conklin CM Bechberger JF MacFabe D | 2007 | Carcinogenesis2007，28，1： | 1 |
| 15 | 14-3-3 proteins associate with cdc25 phosphatases显示文摘 | Conklin DS Galaktionov K Beach D | 1995 | Proc Natl Acad Sci USA1995，92，17： | 1 |
| 16 | Germ cell neoplasms of sacrococcygeal region显示文摘 | Conklin J Abell MR | 1967 | Cancer1967，20，： | 1 |
| 17 | Identification of ascorbic acid-deficient Arabidopsis thaliana mutuant显示文摘 | CONKLIN SARACCO S A NORRIS S R | 2000 | Genetics2000，154，： | 1 |
| 18 | Germline transmission of RNAi in mice显示文摘 | Carmell MA Zhang L Conklin DS | 2003 | Nat Struct Biol2003，10，： | 1 |
| 19 | Arabidopsis thaliana VTC4encodes L-galactose-1-P phosphatase,aplant ascorbic acid biosynthetic enzyme显示文摘 | Conklin P L Gatzek S Wheeler G L | 2006 | Journal of Biology Chemistry2006，281，15： | 1 |
| 20 | Biosynthesis of ascorbic acid in plants:a renaissance显示文摘 | Smirnoff N Conklin P L Loewus F A | | 0，，： | 1 |
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