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| 1 | 应用于区域交通战略规划中的情景规划显示文摘本文简要回顾了情景规划从商业战略规划活动中产生后的历史,对其目标与局限性进行了综述。然后文章回顾了情景规划在区域交通规划中的应用背景和先例,介绍了情景规划在休新敦大都市区交通中应用和深化的工作框架,讨论了这一应用的主要成果和教训,并时进一步的发展潜力和改进措施提出了作者的观察和结论。 | Christopher Zegras Joseph Sussman Christopher Conklin 高璟 | 2006 | 国外城市规划2006，21，6： | 5 |
| 2 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 3 | Delayed pancreaticoduodenectomy for cancer patients with prior ERCP-placed, nonforeshortening, self-expanding metal stents: a positive outcome显示文摘 | Christopher Lawrence Douglas A. Howell Donald E. Conklin Andreas M. Stefan Ronald F. Martin | 2006 | Gastrointestinal Endoscopy2006，，： | 1 |
| 4 | Lipid biology of breast cancer显示文摘 | Jan Baumann Christopher Sevinsky Douglas S. Conklin | 2013 | BBA - Molecular and Cell Biology of Lipids2013，，： | 1 |
| 5 | The impact of climate change on California’s ecosystem services显示文摘 | M. Rebecca Shaw Linwood Pendleton D. Richard Cameron Belinda Morris Dominique Bachelet Kirk Klausmeyer Jason MacKenzie David R. Conklin Gregrory N. Bratman James Lenihan Erik Haunreiter Christopher Daly Patrick R. Roehrdanz | 2012 | Climatic Change2012，，1： | 1 |
| 6 | High-Content Screening and Analysis of Stem Cell-Derived Neural Interfaces Using a Combinatorial Nanotechnology and Machine Learning Approach显示文摘A systematic investigation of stem cell-derived neural interfaces can facilitate the discovery of the molecular mechanisms behind cell behavior in neurological disorders and accelerate the development of stem cell-based therapies.Nevertheless,high-throughput investigation of the cell-type-specific biophysical cues associated with stem cell-derived neural interfaces continues to be a significant obstacle to overcome.To this end,we developed a combinatorial nanoarray-based method for high-throughput investigation of neural interface micro-/nanostructures(physical cues comprising geometrical,topographical,and mechanical aspects)and the effects of these complex physical cues on stem cell fate decisions.Furthermore,by applying a machine learning(ML)-based analytical approach to a large number of stem cell-derived neural interfaces,we comprehensively mapped stem cell adhesion,differentiation,and proliferation,which allowed for the cell-type-specific design of biomaterials for neural interfacing,including both adult and human-induced pluripotent stem cells(hiPSCs)with varying genetic backgrounds.In short,we successfully demonstrated how an innovative combinatorial nanoarray and ML-based platform technology can aid with the rational design of stem cell-derived neural interfaces,potentially facilitating precision,and personalized tissue engineering applications. | Letao Yang Brian M.Conley Jinho Yoon Christopher Rathnam Thanapat Pongkulapa Brandon Conklin Yannan Hou Ki-Bum Lee | 2023 | Research2023，，1： | 0 |
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