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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | CD8:Adhesion Molecule,Co-Receptor and Immuno-Modulator显示文摘CD8 is a cell surface glycoprotein found in cytotoxic T lymphocytes, which are important components in cellular immunity, esp. In the immune response to cancer and chronic infections. There are two forms of CD8,either as an αα homodimer or αβ heterodimer. It acts as an 'assistant' or co-receptor in the function of cytotoxic T cells where specific immunity is mediated by interaction of specific T cell receptor (αβTCR) and its ligand peptide major histocompatibility complex (pMHC). CD8 also binds to pMHC but away from the interface of pMHC and TCR contact, thereof no influence on the specificity of this interaction. If the TCR and CD8 bind to the same pMHC at the same time, CD8 is defined as a co-receptor, functioning through its signalling via its cytoplasmic tyrosine phosphorylation pathway; if CD8 binds to pMHC independently of the TCR, it is defined as an adhesion molecule. At present, the co-receptor function theory is dominated in the field.Recent study has also shown that murine CD8αα binds to TL antigen, an MHC homologue, therefore acts as an immuno-modulator. In this review, we discuss these current understandings of the three aspects of the CD8 functions and their structural basis. | David K Cole George F Gao | 2004 | Cellular & Molecular Immunology2004，1，2： | 4 |
| 3 | Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23–01): a phase 3 randomised controlled trial显示文摘 | Viviana Galimberti Bernard F Cole Stefano Zurrida Giuseppe Viale Alberto Luini Paolo Veronesi Paola Baratella Camelia Chifu Manuela Sargenti Mattia Intra Oreste Gentilini Mauro G Mastropasqua Giovanni Mazzarol Samuele Massarut Jean-Rémi Garbay Janez Zgajn | 2013 | Lancet Oncology2013，，4： | 2 |
| 4 | A Refinement of the Crystal Structure of Gypsum CaSO4 · 2H2O 显示文摘 | Cole W F Lancucki C J | 1974 | Acta Crystallogphy1974，30，： | 1 |
| 5 | Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies 显示文摘 | Calon F Cole G | 2007 | Prostaglandins leukotrienes and essential fatty acids2007，77，： | 1 |
| 6 | Damper models for heav5 vehicle-ride dynamics显示文摘 | Besinger F H Cebon D Cole D J | 1995 | Vehicle System Dynamics1995，24，1： | 1 |
| 7 | Psychosocial risk factors in post-stroke despression: a systemtic review显示文摘 | Ouimet MA Primeau F Cole MG | 2001 | Can J Pscy- hialry2001，46，9： | 1 |
| 8 | Estimation of available phosphorus in soils by extraction with sodium bicarbonate 显示文摘 | Olsen S R Cole C V Watanabe F S | 1954 | USDA Circ1954，939，： | 1 |
| 9 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 10 | Carbon dioxidesupersaturation in the surface waters of lakes 显示文摘 | Cole J J Caraco F N Kling W G | 1994 | Science1994，265，5178： | 1 |
| 11 | Breeding and genetics symposium: really big data: processing and analysis of very large data sets 显示文摘 | Cole J B Newman S Foertter F | 2012 | Journal of Animal Sciences2012，90，3： | 1 |
| 12 | Transesophageal echocardiography in quantification of emboli during femoral nailing: reamed versus undreamed techniques显示文摘 | Coles R E Clements F M Lardenoye J W | 2010 | J South Orthop Assoc2010，9，3： | 1 |
| 13 | Carbon dioxide concentration and atmospheric flux in the Hudson River 显示文摘 | Raymond P A Caraco N F Cole J J | 1997 | Estuaries1997，20，2： | 1 |
| 14 | The role membrane damage plays in cold shock and freezing injury 显示文摘 | De Leeuw F E Cole brander B Verkleij A J | 1990 | Reprod Domest Anita Supplement1990，1，： | 1 |
| 15 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lüddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 16 | The development and potential application of Pb-Al alloy显示文摘 | Cole Jerome F Coodwin Frank E | 1990 | JOM1990，，6： | 1 |
| 17 | Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells显示文摘 | Marson A Levine S S Cole M F Frampton G M Brambrink T Johnstone S | 2008 | Cell2008，134，： | 1 |
| 18 | Absolute limit for the capillary rise of a fluid显示文摘 | Caupin F Cole M W Balibar S | 2008 | Europhysics Letters2008，，28： | 1 |
| 19 | Carbon-dioxide su- persaturation in the surface waters of lakes 显示文摘 | Cole J J Caraco N F Kling G W | 1994 | Science1994，265，： | 1 |
| 20 | In Search of Environmental Spillovers显示文摘 | Albornoz F Cole M A Elliott R J | | 0，，01： | 1 |
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