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| 1 | Strategies for combating bacterial biofilm infections显示文摘Formation of biofilm is a survival strategy for bacteria and fungi to adapt to their living environment, especially in the hostile environment. Under the protection of biofilm, microbial cells in biofilm become tolerant and resistant to antibiotics and the immune responses, which increases the difficulties for the clinical treatment of biofilm infections. Clinical and laboratory investigations demonstrated a perspicuous correlation between biofilm infection and medical foreign bodies or indwelling devices. Clinical observations and experimental studies indicated clearly that antibiotic treatment alone is in most cases insufficient to eradicate biofilm infections. Therefore, to effectively treat biofilm infections with currently available antibiotics and evaluate the outcomes become important and urgent for clinicians. The review summarizes the latest progress in treatment of clinical biofilm infections and scientific investigations, discusses the diagnosis and treatment of different biofilm infections and introduces the promising laboratory progress,which may contribute to prevention or cure of biofilm infections. We conclude that, an efficient treatment of biofilm infections needs a well-established multidisciplinary collaboration, which includes removal of the infected foreign bodies, selection of biofilm-active,sensitive and well-penetrating antibiotics, systemic or topical antibiotic administration in high dosage and combinations, and administration of anti-quorum sensing or biofilm dispersal agents. | Hong Wu Claus Moser Heng-Zhuang Wang Niels Hφiby Zhi-Jun Song | 2015 | International Journal of Oral Science2015，7，1： | 27 |
| 2 | 乙型肝炎病毒慢性感染者血清中不同类型病毒转录体的检测及其意义显示文摘目的:建立针对乙型肝炎病毒(HBV)全长型(fRNA)和顿挫型转录体(trRNA)的血清学检测方法,并探讨其临床应用价值.方法:自患者血清中提取病毒核酸,经PCR及PRT-PCR进行扩增,琼脂糖电泳显示产物,Southern印迹验证反应的特异性.取代表性产物克隆,测序.结果:在HBV慢性携带者的血清中检测到了在上述不同poly(A)位点成熟的病毒RNA.血清中fRNA的检出与e抗原阳性和较强的病毒DNA信号相对应,与转氨酶活性呈正相关,这一血清学指标反映了病毒复制;而trRNA的检出与e抗原阳性和转氨酶活性无关,不象fRNA那样依赖于血清中病毒DNA的量.二者检出率随年龄有不同变化,前者随年龄增加而进行性减低乃至转阴;而后者在10-20岁期间检出率升至80%,以后维持在较高水平.即使在某些表面抗原阴性血清中,也能检测到trRNA和不在上述两个位点成熟的病毒RNA.这些转录体在某些隐源性肝硬变和丙型肝炎患者血清中也存在.结论:病毒转录体的血清学检测有助于确定目前尚不认识的HBV感染期,可用来更准确地区分复制期和非复制期以及检出隐匿性HBV感染. | 苏勤 张伟 刘节 王淑芳 Kunio Takegoshi Claus H Schrder | 2003 | 世界华人消化杂志2003，11，2： | 16 |
| 3 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 4 | Boron nitride: a novel support for ruthenium-based ammonia synthesis catalysts显示文摘 | Claus J H | 2001 | J Catal2001，200，： | 2 |
| 5 | Trypsinogen activation and glutathione content are linked to pancreatic injury in models of biliary acute pancreatitis显示文摘 | Reinhard Lüthen James H. Grendell Claus Niederau Dieter H?ussinger | 1998 | International Journal of Pancreatology1998，，3： | 2 |
| 6 | Pelvic inflammatory disease and risk of invasive ovarian cancer and ovarian borderline tumors显示文摘 | Christina B. Rasmussen Mette T. Faber Allan Jensen Estrid H?gdall Claus H?gdall Jan Blaak?r Susanne K. Kjaer | 2013 | Cancer Causes & Control2013，，7： | 2 |
| 7 | Experimental Validation of a New Ultrasound Method for the Simultaneous Assessment of Radial and Longitudinal Myocardial Deformation Independent of Insonation Angle显示文摘 | Stian Langeland Jan D’hooge Patrick F. Wouters H Alex Leather Piet Claus Bart Bijnens George R. Sutherland | 2005 | Circulation2005，，14： | 2 |
| 8 | SPQD14120800011178显示文摘 | Kordes Claus Sawitza Iris G?tze Silke Herebian Diran H?ussinger Dieter | 2014 | Journal of Clinical Investigation2014，，12： | 2 |
| 9 | Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice显示文摘AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or not.METHODS:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α2a.All questionnaires included reasons against treatment mentioned by the physician.RESULTS:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment rate.Treatment and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language problems.Treatment rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were low.CONCLUSION:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients. | Claus Niederau Dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 10 | Nanosized zeolite crystals-conven- ient control of crystal size distribution by confined space synthesis 显示文摘 | Madsen C Claus J H | 1999 | Chem Commun1999，，： | 1 |
| 11 | Pretreatment evalu- ation of prostate cancer:role of MR imaging and IH MR spectros- copy显示文摘 | Claus FG Hricak H Hattery RR | 2004 | Radiographics2004，24，1： | 1 |
| 12 | Zeolites by confined space synthesis-characterization of the acid sites in nanosized ZSM-5 by ammonia desorption and27 AL/29 Si-MAS NMR spectroscopy 显示文摘 | Claus J H Jacobsen Madsen C Ton V W Janssen | 2000 | Microporous and Mesoporous Mater2000，39，： | 1 |
| 13 | Selective hydrogenolysis of glycerol over copper catalysts both in liquid and vapour phase: Correlation between the copper surface area and the catalyst's activity 显示文摘 | BIENHOLZ A HOFMANN H CLAUS P | 2011 | Applied Catalysis A: General2011，391，12： | 1 |
| 14 | Interpleural analgesia doesnot influence postthoracotomy pain 显示文摘 | Silomon M Claus T Huwer H | 2000 | Anesth Analg2000，91，1： | 1 |
| 15 | The relationship of natural androgens to coronary disease in males:a review显示文摘 | Peter A Jens H Claus C | 1996 | Atherosclerosis1996，125，1： | 1 |
| 16 | Modelling the developmentof cortical systems networks显示文摘 | Marcus K Claus C H | 2004 | Neurocomputing2004，58，58： | 1 |
| 17 | Development of a questionnaire for assessment of the psychosocial impact of dental aesthetics in young adults显示文摘 | Klages U Claus N Wehrbein H | | 0，，2： | 1 |
| 18 | The relationship of natural androgens to coronary heart disease in males : a review 显示文摘 | Peter A Jens H Claus C | 1996 | Atherosclerosis1996，125，1： | 1 |
| 19 | Real-time impedance analysis of host cell response to meningococcal infection 显示文摘 | SIANINA H KONIG A CLAUS H | 2011 | Journal of Microbiological Methods2011，84，1： | 1 |
| 20 | Long-Term Outcome of Mitomycin C- and 5-FU-Based Primary Radiochemotherapy for Esophageal Cancer显示文摘 | Maria Wolf Franz Zehentmayr Maximilian Niyazi Ute Ganswindt Wolfgang Haimerl Michael Schmidt Dieter H?lzel Claus Belka | 2010 | Strahlentherapie und Onkologie2010，，7： | 1 |
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