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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Synthesis of polysty- rene/silica composite particles by soap- free emulsion polymerization using positively charged colloidal silica 显示文摘 | Lee J W Hong C K Choe S J | 2007 | Journal of Colloid and Inteace Science2007，310，： | 1 |
| 3 | Managed care per- spective on three new agents for type 2 diabetes显示文摘 | VanDeKoppel S Choe H M Sweet B V | 2008 | J Manag Care Pharm2008，14，4： | 1 |
| 4 | Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection显示文摘 | Liu R Paxton WA Choe S | | 0，，： | 1 |
| 5 | T-DNA tagged knockout mutation of rice OsGSK1, an orthologue of Arabidopsis BIN2, with enhanced tolerance to various abiotic stresses 显示文摘 | Koh S Lee S C Kim M K Koh J H Lee S An G Choe S Kim S R | 2007 | Plant Molecular Biology2007，65，4： | 1 |
| 6 | Surface analysis of clinically failed dental implant fixture显示文摘 | CHOE H C HONG K S KO Y M KIM B O | 2006 | J Kor Inst Met & Mater2006，44，： | 1 |
| 7 | Cathodoluminescence Study of Novel Sol-gel Derived Y3-xAl5O12:Tbx Phosphors显示文摘 | Choe J Y Ravichandran D Blomquist S M | 2001 | Journal of Luminescence2001，93，： | 1 |
| 8 | Nitrate reduction by zero-valent iron under di{ferent pH regimes显示文摘 | CHOE S LILJESTRAND H M KHIM J | 2004 | Applied Geo- chemistry2004，19，3： | 1 |
| 9 | Stability characteristics of Pt1Ni1/C as cathode catalysts in membrane electrode assembly of polymer electrolyte membrane fuel cell显示文摘 | CHO Y H JEON T Y YOO S J LEE K S AHN M KIM O H CHO Y H LIM J W JUNG N YOON W S CHOE H SUNG Y E | 2012 | Electrochim Acta2012，59，： | 1 |
| 10 | CIY24, a novel cancer biomarker, predicting disease -free survival ofnon - small cell lung carcinomas : a retrospective study of prognos- tic factor analysis from the viewpoint of forthcoming(seventh) new TNM classification显示文摘 | Lee HJ Choe G Jheon S | 2010 | J Thorac Onco12010，5，5： | 1 |
| 11 | The crystal structure of diphtheria toxin 显示文摘 | Choe S Bennett MJ Fujii G | 1992 | Nature1992，357，6375： | 1 |
| 12 | Workflow for quantita- tive proteomic analysis of Clostridium acetobutylicum ATCC 824 using iTRAQ tags显示文摘 | HOU S JONES S W CHOE L H | 2013 | Methods2013，61，3： | 1 |
| 13 | Sonochemical synthesis of amorphous iron显示文摘 | SUSLICK K S CHOE S B CICHOWLAS A A | 1991 | Nature1991，353，： | 1 |
| 14 | Activation of protein kinase A induces neuronal differentiation of HiB5 hippocampal progenitor cells 显示文摘 | Kim G Choe Y Park J Cho S Kim K | 2002 | Mol Brain Res2002，109，12： | 1 |
| 15 | 显示文摘 | Choe S B Cichowlas | 1991 | Nature1991，353，： | 1 |
| 16 | A High Dynamic PEM Fuel Cell Model with Temperature Effects显示文摘 | Shah Y Y Choe S Y | 2005 | Journal of Power Sources2005，145，1： | 1 |
| 17 | Brassinosteroid biosynthesis and dwarf mutants显示文摘 | Kwon M Choe S | 2005 | Journal of Plant Biology2005，48，1： | 1 |
| 18 | A new simulation model of PMSM motor with real back EMF waveform显示文摘 | | 2000 | Proceeding from Computers in Power Electronics2000，，1618： | 1 |
| 19 | The crystal structure of diphtheria toxin显示文摘 | Choe S Bennett M Fujii G | 1992 | Nature1992，357，： | 1 |
| 20 | Tumor Cavitation in Stage I Non Small Cell Lung Cancer: Epidermal Growth Factor Receptor Expression and Prediction of Poor Outcome显示文摘 | Amir Onn Du I1wan Choe Roy S Herbst | 2005 | Radiology2005，237，： | 1 |
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