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| 1 | Colorectal liver metastases: Current management and future perspectives显示文摘The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology(cross sectional,nuclear medicine and interventional),Oncology,Liver surgery,Colorectal surgery,and Histopathology.Patient management is based on assessment of sophisticated clinical,radiological and biomarker information.Despite incomplete evidence in this very heterogeneous patient group,maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure.To this end,liver resection is maximised by the use of downsizing chemotherapy,optimisation of liver remnant by portal vein embolization,associating liver partition and portal vein ligation for staged hepatectomy,and combining resection with ablation,in the context of improvements in the functional assessment of the future remnant liver.Liver resection may safely be carried out laparoscopically or open,and synchronously with,or before,colorectal surgery in selected patients.For unresectable patients,treatment options including systemic chemotherapy,targeted biological agents,intraarterial infusion or bead delivered chemotherapy,tumour ablation,stereotactic radiotherapy,and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability.Currently evolving areas include biomarker characterisation of tumours,the development of novel systemic agents targeting specific oncogenic pathways,and the potential reemergence of radical surgical options such as liver transplantation. | Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet | 2020 | World Journal of Clinical Oncology2020，11，10： | 5 |
| 2 | Lipid-polymer hybrid nanoparticles with rhamnolipid-triggered release capabilities as anti-biofilm drug delivery vehicles显示文摘In lung biofilm infection therapies, the use of lipid-polymer hybrid nanoparticles to encapsulate drugs has emerged as a promising alternative to using liposomes because they have superior physicochemical stability and still possess the biofilm affinity and sputum-penetrating ability of liposomes. To be deemed equally efficacious as liposomes against bacterial biofilms, however, the capability of hybrid nanoparticles to target-release encapsulated drugs at biofilm colonies must be demonstrated. This communication details our investigations into the trigger-release characteristics of hybrid nanoparticles in response to encountering rhamnolipids, which are ubiquitously present in biofilm colonies of Pseudomonas aeruginosa, a major respiratory pathogen. Poly(lactic-co-glycolic acid) and phosphatidylcholine were used as the polymer nanoparticle core and lipid coat, respectively. These investigations were performed using compounds from various biopharmaceutical classification systems (BCS) that differ in their lipid-membrane perme- abilities. The release of BCS Class III compounds, which have poor lipid-membrane permeabilities, was successfully triggered by rhamnolipids at a concentration approximately equal to their clinically observed value, and this release was attributed to the disruption of lipid coats by rhamnolipid micelles. Not unexpectedly, BCS Class I compounds, which have high lipid-membrane permeabilities, were released freely whether or not rhamnolipids were present. The rate of the triggered release can be controlled by incor-porating an additional lipid layer on the hybrid nanoparticles via the electrostatically driven adsorption of lipid vesicles. | Wean Sin Cheow Kunn Hadinoto | 2012 | Particuology2012，10，3： | 5 |
| 3 | A Review of Mucinous Cystic Neoplasms of the Pancreas Defined by Ovarian-type Stroma: Clinicopathological Features of 344 Patients显示文摘 | Brian K. P. Goh MBBS MMed (Surgery) MRCS Yu-Meng Tan BSc (Hons) MBBS FRCS Yaw-Fui A. Chung MBBS FRCS Pierce K. H. Chow MBBS FRCS PhD Peng-Chung Cheow MBBS FRCS Wai-Keong Wong MBBS FRCS London L. P. J. Ooi MBBS FRCS MD | 2006 | World Journal of Surgery2006，，12： | 2 |
| 4 | Pancreatic Serous Oligocystic Adenomas: Clinicopathologic Features and a Comparison with Serous Microcystic Adenomas and Mucinous Cystic Neoplasms显示文摘 | Brian K.P. Goh MBBS MMed Yu-Meng Tan BSc MBBS Wai-Ming Yap MBBS Peng-Chung Cheow MBBS Pierce K.H. Chow MBBS PhD Yaw-Fui Alexander Chung MBBS Wai-Keong Wong MBBS London L.P.J. Ooi MBBS MD | 2006 | World Journal of Surgery2006，，8： | 2 |
| 5 | 16-MDCT in the detection of occult wrist fractures:a comparison with skeletal scintigraphy显示文摘 | Groves AM Cheow H Balall K | 2005 | AJR2005，184，5： | 1 |
| 6 | 16-MDCT in the detection of occult wrist fractures:a comparison with skeletal scintigraphy显示文摘 | Groves AM Cheow H Balan K | | 0，，： | 1 |
| 7 | Imaging of malignant infantile osteopetrosis before and after bone marrow transplantation显示文摘 | Cheow HK Steward CG Grier DJ | 2001 | Pediatr Radiol2001，31，12： | 1 |
| 8 | An Appraisal of Surgical and Percutaneous Drainage for Pyogenic Liver Abscesses Larger Than 5 cm显示文摘 | Yu-Meng Tan Alexander Yaw-Fui Chung Pierce Kah-Hoe Chow Peng-Chung Cheow Wai-Keong Wong London Lucien Ooi Khee-Chee Soo | 2005 | Annals of Surgery2005，，3： | 1 |
| 9 | Accurate preoperative localization of insulinomas avoids the need for blind re- section and reoperation: analysis of a single institution experience with 17 surgically treated tumors over 19 years显示文摘 | Goh BK Ooi LL Cheow PC | 2009 | J Gastrointest Surg2009，13，6： | 1 |
| 10 | Multiplexed locussp-ecific analysis of DNA methylation in single cells显示文摘 | Cheow LF Quake SR Burkholder WF | 2015 | Nat Protoc2015，10，4： | 1 |
| 11 | Spray-freeze-drying production of thermally sensitive polymeric nanoparticle aggregates for inhaled drug delivery:Effect of freeze-drying adjuvants显示文摘 | Cheow WS Mabell LN Kho K | 2011 | International Journal of Clinical Pharmacy2011，404，： | 1 |
| 12 | Cystic neoplasms of the pancreas with mucin-produetion 显示文摘 | Goh BK Tan YM Cheow PC | 2005 | EJSO2005，31，3： | 1 |
| 13 | Pancreaticoduodenectomy for locally advanced stomach cancer:preliminary results显示文摘 | Chan WH Cheow PC Chung AY | | 0，，09： | 1 |
| 14 | Effect of fish,starchand salt contents on the microstructure and expansion of fishcrackers ( ' keropok')显示文摘 | Cheow C S Yu S Y Howell N K | 1999 | Journal of the Science of Food andAgriculture1999，79，6： | 1 |
| 15 | Dry powder inhaler formulation of lipid-polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particles 显示文摘 | Yang Y Cheow WS Hadinoto K | 2012 | Int J Pharm2012，434，12： | 1 |
| 16 | Effects of chemical interesterification on physicochemical propertiesof palm stearin and palm kernel olein blends 显示文摘 | NORIZZAH A R CHONG C L CHEOW C S | 2004 | Food Chem2004，86，2： | 1 |
| 17 | Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery plat- form: A review 显示文摘 | HADINOTO K SUNDARESAN A CHEOW WS | 2013 | Eur J Pharm Biopharm2013，85，3： | 1 |
| 18 | 16-MDCT in the detection of occult wrist fractures: a comparison with skeletal scintigraphy显示文摘 | Groves AM Cheow H Balan K | 2005 | AJR2005，184，5： | 1 |
| 19 | Determination of organochlorine and pyrethroid pesticides in fruit and vegetables using solid phase extraction clean-up cartridges显示文摘 | Zawiyah Sharif Yaakob Bin Che Man Nazimah Sheikh Abdul Hamid Chin Cheow Keat | 2006 | Journal of Chromatography A2006，，1： | 1 |
| 20 | Cystic neoplasms of the pancreas with mucin-production显示文摘 | Tan YM Cheow PC | 2005 | Eur J Surg Oncol2005，31，3： | 1 |
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