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| 1 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis显示文摘 | Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang | 2015 | Cell Research2015，25，8： | 323 |
| 2 | Synthesis of ordered mesoporous carbonaceous materials and their highly efficient capture of uranium from solutions显示文摘An extremely effortless method was applied for successful synthesis of mesoporous carbonaceous materials(MCMs) using well-ordered mesoporous silica as template. Various characterizations(scanning electron microscopy(SEM), transmission electron microscopy(TEM), X-ray diffraction(XRD), Fourier transform infrared spectroscopy(FT-IR), Raman, X-ray photoelectron spectroscopy(XPS), Brunner-Emmet-Teller(BET) and Zeta potential) confirmed that MCMs had large surface area, uniform pore size distribution, and abundant oxygen-containing functional groups. The batch techniques were employed to study U(VI) adsorption on MCMs under a wide range of experiment conditions. The adsorption kinetics of U(VI) onto MCMs were well-fitted by pseudo-second-order kinetic model, indicating a chemisorption process. The excellent adsorption capacity of MCMs calculated from the Langmuir model was 293.95 mg g^(-1) at pH 4.0. The FT-IR and XPS analyses further evidenced that the binding of U(VI) onto MCMs was ascribed to the plentiful adsorption sites(–OH and –COOH groups) in the internal mesoporous structure, which could efficiently trap guest U(VI) ions. The results presented herein revealed that MCMs were ideal adsorbents in the efficient elimination of uranium or other lanthanides/actinides from aqueous solutions, which would play an important role in environmental pollution management application. | Chenlu Zhang Xing Li Zhongshan Chen Tao Wen Shuyi Huang Tasawar Hayat Ahmed Alsaedi Xiangke Wang | 2018 | Science China Chemistry2018，61，3： | 8 |
| 3 | Variations in carbon isotopic composition in the subcontinental lithospheric mantle beneath the Yangtze and North China Cratons:Evidence from in-situ analysis of diamonds using SIMS显示文摘The components and evolution of subcontinental lithospheric mantle beneath the North China Craton and the Yangtze Craton is a current topic in the geological study of China and the carbon isotopic composition of diamond is one of the most direct probes into cratonic lithospheric mantle processes.In this paper,in-situ SIMS(Secondary Ion Mass Spectrometry) techniques were used to analyze the carbon isotope compositions at different internal growth zones of diamonds from Shandong and Liaoning in the North China Craton and Hunan in the Yangtze Craton.It was found that the carbon isotopic range of diamonds from the North China Craton are rather distinct from those of the Yangtze Craton;the former has a range of 6.0‰ to 2.0‰(relative to VPDB) with an average value of 3.0‰ in their core areas,which is consistent with global peridotitic diamonds;the diamonds from the Yangtze Craton,however,have a carbon isotopic range from 8.6‰ to 3.0‰ with an average value of 7.4‰ in their core areas,being more consistent with global eclogitic diamonds.The variations of carbon isotope ratios between different internal growth zones in individual diamonds were different in the three diamond localities studied.There was a clear correlation between changes in carbon isotopic composition and phases of diamond dissolution and new growth,while no correlation was observed between δ13C and internal inclusions.The variations suggest that the carbon isotopic compositions of mantle fluids were changing during the process of diamond crystallization,and that the heterogeneity of the carbon isotopic composition in mantle carbon reservoirs was a more important factor than carbon isotope fractionation in controlling the carbon isotopic compositions and their variation in diamonds.In addition,the preliminary results of in-situ nitrogen analyses demonstrated that the variation of carbon isotopic compositions between the core and outer growth zones does not correlate with nitrogen abundances,implying either that diamonds crystallized in an open environment or that the carbon isotopic composition and nitrogen contents in mantle fluids were controlled by other,not yet understood factors.The experimental results provide hints that the isotopic composition of carbon and its original sources were different in metasomatic fluids controlling diamond formation in the mantle beneath the North China Craton and the Yangtze Craton. | CHEN Hua QIU ZhiLi LU TaiJin STERN Richard STACHEL Thomas SUN Yuan ZHANG Jian KE Jie PENG ShuYi QIN SheCai | 2013 | Chinese Science Bulletin2013，58，1： | 7 |
| 4 | Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells显示文摘各种各样的干细胞类型在对待光敏电阻器为他们的潜在的申请被测试了退化疾病,例如视网膜炎 pigmentosa (RP ) 和年龄相关的有斑点的退化(AMD ) 。仅仅胚胎的干细胞(转换字符) 到目前为止被显示了产生恢复光敏电阻器缺乏的老鼠的轻反应的功能的光敏电阻器房间,但是仍然有肿瘤形成的一些担心。在这研究,我们有成功地有教养的 Nestin + Sox2 + Pax6 + multipotent 从成年老鼠视网膜的网膜的干细胞(RSC ) ,它能够生产恢复跟随移植的光敏电阻器缺乏的 rd1 异种老鼠的轻反应的功能的光敏电阻器房间。在他们面对 FGF 和 EGF 为超过 35 个段落被扩展了以后,有教养的 RSC 仍然维持稳定的增长和区别潜力。在合适的区别条件下面,他们能区分进在成年视网膜发现的所有主要网膜的房间类型。更重要地,他们能高效地在优化区别条件下面区分进光敏电阻器房间。直到慢慢地堕落的 rd7 异种的 subretinal 空间的后面的移植看,导出 RSC 的光敏电阻器房间与居民一起集成到视网膜,词法上类似于的内长的光敏电阻器和形成的 synapases 网膜的神经原。当移植了进光敏电阻器缺乏的 rd1 异种老鼠的眼睛时,一个 RP 模型,导出 RSC 的光敏电阻器能部分恢复轻反应,显示那些导出 RSC 的光敏电阻器是功能的。最后,为在移植光敏电阻器的眼睛的肿瘤形成没有证据。因此,这研究证明了从成年视网膜孤立的 RSC 有生产能潜在地恢复光敏电阻器房间的损失在 RP 和 AMD 引起的失去的视觉的功能的光敏电阻器房间的潜力。 | Tianqing Li Michelle Lewallen Shuyi Chen Wei Yu Nian Zhang Ting Xie | 2013 | Cell Research2013，23，6： | 7 |
| 5 | Correlation between echolocation calls and morphological features among three kinds of bats显示文摘The correlation between echolocation sound and morphological features of 18 species of bats, which are subordinated to 3 families including rhinolophidae, hipposideridae and vespertilionidae is studied. Pearson's correlation and regression analysis are adopted to analyze the correlations between noseleaf width (NW) and forearm length (FAL), NW and dominant frequency (DF), FAL and DF. The results show a positive correlation between NW and FAL and a negative correlation between NW and DF in Rhinolophidae. In each family, there is a negative correlation between FAL and DF. Some species have a higher or lower frequency than predicted one according to their body size. There are significant differences of the regression equation of FAL and DF among the three families. For the bats with the same body size, the order in frequency is: hipposiderid bats> rhinolophid bats> vespertilionid bats. The mechanism of interrelationship between FAL and DF of bats, the reason why these deviations occur in correlativity of the three families and the mechanism of the interaction between morphological, physiological and ecological characteristics are discussed. | FENG Jiang , CHEN Min, LI Zhenxin, ZHANG Shuyi, ZHAO Huihua and ZHOU Jiang(1. Environmental Science Department, Northeast Normal University, Changchun 130024, China 2. Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China 3. Biology Department, Guizhou Normal University, Guiyang 550000, China) | 2002 | Progress in Natural Science:Materials International2002，12，9： | 4 |
| 6 | Sliding-mode-disturbance-observer-based adaptive neural control of uncertain discrete-time systems显示文摘Dear editor,For real-world control systems,there are often system uncertainties caused by modeling errors,disturbances caused by external unknown environments,and saturation caused by physical limitations of the actuator.The above-mentioned problems can not only degrade the performance of the controlled object,but also result in system instability.However,the issues of system uncertainties,input saturation,and external disturbances have seldom been considered in combination in the existing research on the control of continuous-time and discrete-time systems[1–5].In recent years,the utilization of digital computers and samplers in actual control plants has made the controller design based on discrete-time system representation more reasonable than that based on continuoustime representation.Thus,this study presents the design method of a discrete-time adaptive neural(DTAN)tracking control scheme for uncertain discrete-time multi-input and multi-output(MIMO)nonlinear systems with external disturbances and input saturation based on a discretetime sliding mode disturbance observer(SMDO). | Shuyi SHAO Mou CHEN | 2020 | Science China(Information Sciences)2020，63，4： | 4 |
| 7 | Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy显示文摘Given the opposing effects of Akt and AMP-activated protein kinase(AMPK)on metabolic homeostasis,this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic steatosis.Akt2–Ampkα2 double knockout(DKO)mice were placed on high fat diet for 5 months.Glucose metabolism,energy homeostasis,cardiac function,lipid accumulation,and hepatic steatosis were examined.DKO mice were lean without anthropometric defects.High fat intake led to adiposity and decreased respiratory exchange ratio(RER)in wild-type(WT)mice,which were ablated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.High fat intake increased blood and hepatic triglycerides and cholesterol,promoted hepatic steatosis and injury in WT mice.These effects were eliminated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet promoted fat accumulation,and enlarged adipocyte size,the effect was negated in DKO mice.Fat intake elevated fatty acid synthase(FAS),carbohydrate-responsive element-binding protein(CHREBP),sterol regulatory element-binding protein 1(SREBP1),peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),peroxisome proliferator-activated receptor-α(PPARα),PPARγ,stearoyl-CoA desaturase 1(SCD-1),phosphoenolpyruvate carboxykinase(PEPCK),glucose 6-phosphatase(G6Pase),and diglyceride O-acyltransferase 1(DGAT1),the effect was absent in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet dampened mitophagy,promoted inflammation and phosphorylation of forkhead box protein O1(FoxO1)and AMPKα1(Ser^(485)),the effects were eradicated by DKO.Deletion of Parkin effectively nullified DKO-induced metabolic benefits against high fat intake.Liver samples from obese humans displayed lowered microtubule-associated proteins 1A/1B light chain 3B(LC3B),Pink1,Parkin,as well as enhanced phosphorylation of Akt,AMPK(Ser^(485)),and FoxO1,which were consolidated by RNA sequencing(RNAseq)and mass spectrometry analyses from rodent and human livers.These data suggest that concurrent deletion of Akt2 and AMPKα2 offers resilience to fat diet-induced obesity and hepatic steatosis,possibly through preservation of Parkin-mediated mitophagy and lipid metabolism. | Shuyi Wang Jun Tao Huaguo Chen Machender R.Kandadi Mingming Sun Haixia Xu Gary D.Lopaschuk Yan Lu Junmeng Zheng Hu Peng Jun Ren | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 8 | 雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应显示文摘文章简介线粒体在细胞死亡、自噬、免疫和炎症中起着不可或缺的作用。前期研究发现,孤儿核受体Nur77通过靶向线粒体诱导细胞凋亡。本文报道了Nur77作为具有抗炎作用的雷公藤红素的直接靶点,介导雷公藤红素通过自噬清除损伤线粒体,抑制炎症反应而达到治疗炎症疾病包括肥胖症的功能。 | Mengjie Hu Qiang Luo Gulimiran Alitongbieke Shuyi Chong Chenting Xu Lei Xie Xiaohui Chen Duo Zhang Yuqi Zhou Zhaokai Wang Xiaohong Ye Lijun Cai Fang Zhang Huibin Chen Fuquan Jiang Hui Fang Shanjun Yang Jie Liu Maria T.Diaz-Meco Ying Su Hu Zhou Jorge Moscat Xiangzhi Lin 张晓坤 | 2018 | 科学新闻2018，0，4： | 3 |
| 9 | Compact and broadband multimode waveguide bend by shape-optimizing with transformation optics显示文摘Multimode waveguide bend is one of the key components for realizing high-density mode-division multiplexing systems on chip.However,the reported multimode waveguide bends are either large,bandwidth-limited or fabrication-complicated,which hinders their applications in future high-density multimode photonic circuits.Here we propose a compact multimode waveguide bend supporting four TE modes simply by shape-optimizing with transformation optics.The shape of the waveguide is optimized in the virtual space with gradient distribution of the refractive index,so that the scattering loss and intermode cross talk are well suppressed.After conformal mapping back into the physical space,a compact(effective radius of 17μm)multimode bending waveguide is obtained.Simulations show that the proposed multimode waveguide bend has little loss(<0.1 dB)and low cross talk(<−20 dB)throughout an ultrabroad wavelength range of 1.16–1.66μm.We also fabricated the shape-optimized multimode bending waveguide on a silicon-on-insulator wafer.At 1550 nm wavelength,the measured excess losses for the four lowest-order TE modes are less than 0.6 dB,and the intermode cross talks are all below−17 dB.Our study paves the way for realizing high-density and large-scale multimode integrated optical circuits for optical interconnect. | SHUYI LI LIFENG CAI DINGSHAN GAO JIANJI DONG JIN HOU CHUNYONG YANG SHAOPING CHEN XINLIANG ZHANG | 2020 | Photonics Research2020，8，12： | 3 |
| 10 | CPTA treatment reveals potential transcription factors associated with carotenoid metabolism in flowers of Osmanthus fragrans显示文摘Osmanthus fragrans is one of the top ten traditional flowers in China.It is divided into three different groups according to its color.α-Carotene and β-carotene are the main determinants to distinguish the color differences between three groups.However,the dominant genes and transcription factors involved in carotenoid metabolism remain unclear.CPTA treatment(0.7mmol·L−1)remarkably promoted lycopene,α-carotene and β-carotene contents in flowers.Transcriptome sequencing analysis revealed that CPTA treatment could trigger chain reactions in carotenoid metabolism pathway genes.Four up-regulated and 10 down-regulated transcription factors which have close association with carotenoid variation were significantly induced by CPTA treatment.The up-regulated TFs such as MYB43,MYB123,HSF,were further subjected to transcript expression determination in different cultivars with drastic colors.Among them,transcript expression of four up-regulated TFs coincided with the carotenoid accumulation in different cultivars.We selected up-regulated OfMYB43 to verify its function,which is related to stress tolerance and transcriptional regulation.Transient overexpression of OfMYB43 in O.fragrans flowers showed that it could remarkably promote the expression of PDS,ZISO,LCYE and CCD4,leading to increased accumulation of β-branch carotenoids.OfMYB43 was a potential positive regulator of carotenoid biosynthesis in O.fragrans flowers.This study provides insight into the molecular mechanism of carotenoid metabolism in O.fragrans. | Wan Xi Yanhong He Linlin Zhu Shiyang Hu Shuyi Xiong Yi Zhang Jingjing Zou Hongguo Chen Caiyun Wang Riru Zheng | 2021 | Horticultural Plant Journal2021，7，5： | 3 |
| 11 | Effects of Ginsenoside Rg1 on nuclear factor-kappa B activity in beta amyloid protein-treated neural cells显示文摘BACKGROUND:Modern pharmacological studies have shown that Ginsenoside Rg1 is one of the active components of ginseng that promote intelligence in the nervous system.Ginsenoside Rg1 can improve memory and learning in mouse models ofβ-amyloid protein(Aβ)-induced dementia. OBJECTIVE:To investigate whether effects of Ginsenoside Rg1 against Aβare associated with activity of nuclear factor-kappa B(NF-κB). DESIGN,TIME AND SETTING:The randomized,controlled,cell biological experiment was performed at the DME Center,Institute of Clinical Pharmacology,Guangzhou University of Chinese Medicine,China from July 2005 to May 2006. MATERIALS:Beta-amyloid fragment 25-35(Aβ_(25-35)) was supplied by the Neural Biochemical Laboratory,Xuanwu Hospital,Capital Medical University,China.Ginsenoside Rg1 was obtained from National Institute for the Control of Pharmaceutical and Biological Products,China.Rabbit anti-rat NF-κB p65 antibody was purchased from Santa Cruz Biotechnology,USA. METHODS:Hippocampal neurons and cortical astrocytes of neonatal Sprague Dawley rats were harvested and treated with various concentrations(0,5,10,20,and 40μmol/L) of Aβfor 6,12,and 24 hours to establish cellular models of Alzheimer's disease.Cellular models were pretreated with various concentrations of Ginsenoside Rg1(1,2,4,8,and 16μmol/L).According to cell morphology and activity,the following conditions were selected:40μmol/L Aβfor 24 hours,as well as 2,4,and 8μmol/L Ginsenoside Rg1.NF-κB activity was observed using immunofluorescence and cytochemical staining. MAIN OUTCOME MEASURES:Morphology and viability of hippocampal neurons and cortical astrocytes,and activities of NF-κB were measured. RESULTS:Hippocampal neuron activity was significantly greater in the normal and 2 and 4μmol/L Ginsenoside Rg1 groups compared with the model group(P<0.05).Astrocyte activity was significantly greater in the normal,1,2,4,8,and 16μmol/L Ginsenoside Rg1 groups compared with the model group(P<0.05).NF-κB activity of hippocampal neurons was significantly greater in the normal,2,4,and 8μmol/L Ginsenoside Rg1 groups compared with the model group(P<0.01). NF-κB activity of astrocytes was significantly less in the normal,2,4,and 8μmol/L Ginsenoside Rg1 groups compared with the model group(P<0.01 or P<0.05).No significant difference in NF-κB activity was determined between the 2μmol/L Ginsenoside Rg1 and normal groups(P>0.05). CONCLUSION:Ginsenoside Rg1 protected neural cells by upregulating NF-κB activity in neurons and downregulating NF-κB activity in astrocytes.Ginsenoside Rg1(2μmol/L) maintained cell activity and NF-κB activity at normal levels. | Yunbo Chen Dapeng Zhang Mei Feng Qi Wang Shuyi Cheng Weixiong Liang Zehuai Wen | 2009 | Neural Regeneration Research2009，4，8： | 2 |
| 12 | Modeling Trusted Computing显示文摘In this paper, a formal approach based on predicate logic is proposed for representing and reasoning of trusted computing models. Predicates are defined to represent the characteristics of the objects and the relationship among these objects in a trusted system according to trusted computing specifications. Inference rules of trusted relation are given too. With the semantics proposed, some trusted computing models are formalized and verified, which shows that Predicate calculus logic provides a general and effective method for modeling and reasoning trusted computing systems. | CHEN Shuyi WEN Yingyou ZHAO Hong | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 2 |
| 13 | Flotation performance of a novel Gemini collector for kaolinite at low temperature显示文摘How to sustainably produce bauxite by effective reverse froth flotation of kaolinite at low temperature is an urgent problem to be solved in the field of mineral processing.In this work,a novel amino-based Gemini surfactant butadiyl-1,4-bis(dimethyl dodecylammonium bromide)(BBDB) was prepared and first utilized as a novel collector for kaolinite flotation.Its flotation performance for kaolinite was compared with that of the common monomolecular surfactant 1-dodecylamine(DDA) by micro-flotation tests.The tests results indicated that 95% kaolinite recovery was obtained using 2.0×10^(-4) mol/L BBDB at 25℃ which was half of the dosage when DDA obtained the maximum kaolinite recovery of81%.At extremely low temperature(0℃),3.0×10^(-4) mol/L BBDB could still collect 91% kaolinite,while DDA showed a frustrating ability.The contact angle tests indicated that BBDB could still significantly improve the hydrophobicity of the kaolinite surface(contact angle 71.7°) than DDA(contact angle only25.8°) at 0℃.The Krafft point comparison tests indicated that BBDB had a much lower Krafft point(below0℃) than DDA.Fourier transform infrared spectroscopy(FTIR)-spectrum analysis and zeta potential measurements showed that BBDB was physically adsorbed on the surface of kaolinite through electrostatic interaction. | Shiyong Zhang Zhiqiang Huang Hongling Wang Rukuan Liu Chen Cheng Shuyi Shuai Yajing Hu Zhiqun Guo Xinyang Yu Guichun He Weng Fu | 2021 | International Journal of Mining Science and Technology2021，31，6： | 2 |
| 14 | Recombinant Clostridium difficile toxin B induces endoplasmic reticulum stress in mouse colonal carcinoma cells显示文摘Clostridium 顽固在人和动物是联系抗菌素的腹泻和 pseudomembranous 大肠炎的主要原因。它的致病力首先被连接到二外毒素(TcdA 和 TcdB ) 的分泌物。尽管在 TcdA 和 TcdB 的有毒的机制的大进步被获得了,关于 apoptotic 机制有许多冲突报告。更重要地, apoptotic endoplasmic 蜂窝胃(嗯) 应力在与能引起腹泻和大肠炎的细胞毒素客气的 Shiga toxinsanother 对待的房间被报导了。此处,我们检查了 TcdB 是否能导致嗯应力。结果证明 recombinant TcdB (rTcdB ) 激活展开的蛋白质反应的分子的标记,建议导致的那 rTcdB 嗯在 CT26 房间的应力。然而, rTcdB 没导致 C/EBP 相应蛋白质(砍) 的起来规定, apoptotic 的一个经典调停人嗯应力,而是它激活半胱氨酸丁氨二酸的先锋酸特定的朊酶 12 (caspase-12 ) , apoptotic 的一个争论调停人嗯应力。而且,活动缺乏的变异的 recombinant TcdB 导致了的 glucosyltransferase 嗯应力,不过,它有不细胞毒素或 CT26 房间上的 cytopathic 效果。总的来说,这些数据表明了那嗯 rTcdB 导致的应力是 glucosyltransferase 独立的,显示那嗯 rTcdB 导致的应力是 non-apoptotic。这个工作也为我们提供新卓见进砍蛋白质表示规定和砍表示的角色的分子的机制在嗯应力。 | Chunli Sun Haiying Wang Shuyi Chen Zhendong Li Shan Li Jufang Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 2 |
| 15 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 16 | Salubrinal protects against Clostridium difficile toxin B-induced CT26 cell death显示文摘Clostridium 顽固(C。顽固) 被认为在动物和人是联系抗菌素的腹泻和 pseudomembranous 大肠炎的主要原因。C 的流行。自从 2000,顽固感染(CDI ) 一直在增加。C 的二外毒素。顽固,毒素 A (TcdA ) 和毒素 B (TcdB ) , CDI 的主要毒力因素,能在宿主 cytosol 导致 Rho GTPases 的 glucosylation,正在导致细胞词法变化,细胞 apoptosis,和细胞死亡。导致 TcdB 的房间死亡的机制被调查十年了,但是它仍然不完全被理解。TcdB 经由在 CT26 房间线(BALB/C 老鼠冒号肿瘤房间) 表明小径的 PERK-eIF2 导致 endoplasmic 蜂窝胃应力,这被报导了。在这研究,我们发现了那 salubrinal, eIF2 dephosphorylation 的一个选择禁止者,高效地保护 CT26 房间线免于导致 TcdB 的房间死亡并且试着探索在这保护的效果位于下面的机制。我们的结果证明那 salubrinal 保护 CT26 房间免受的伤害调停 TcdB 细胞毒素并且 cytopathic 效果,经由 caspase-9-dependent 小径, eIF2 发信号小径,和 autophagy 禁止暴露毒素的房间的 apoptosis 和死亡。这些调查结果将对 CDI 治疗的发展有用。 | Shuyi Chen Chunli Sun Huawei Gu Haiying Wang Shan Li Yi Ma Jufang Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 2 |
| 17 | circStrn3 is involved in bone cancer pain regulation in a rat model显示文摘Bone cancer pain(BCP)is a common chronic pain that is caused by a primary or metastatic bone tumor,More detailed molecular mechanisms of BCP are warranted.In this study,we established a BCP rat model.The von Frey hair test,body weight,and hematoxylin and eosin staining were employed.We screened differentilly expressed circRNAs(DECs)between the BCP group and sham group.The results revealed that 850 DECs were significantly up-regulated and 644 DECs were significantly down-regulated in the BCP group.Furthermore,we identified 1177 diffrentially expressed genes(DEGs)significantly up-regulated and 565 DEGs significantly down-regulated in the BCP group.Gene Ontology annotation of all 1742 DEGs revealed that biological regulation of metabolic processes,cellular processes,and binding were the top enriched terrms.For Kyoto Ency-clopedia of Genes and Genomes analysis,phagosome,HTLV-I infection,proteoglycans in cancer,and herpes simplex infection were significantly enriched in this study.In addition,we identified four selected circRNAs,chr6:72418120|72430205.chr20:756105717573740,chr18:69943105|69944476,and chr5:167516581|167558250,by quantitative real time PCR.chr6:72418120|72430205(circStrn3)was selected for further study based on expression level and the circRNA--miRNA--mRNA network table.Western blot analysis suggested that knockdown of circStrn3 could effectively induce Walker 256 cell apoptosis.In summary,our study provided a more in-depth understanding of the molecular mechanisms of BCP. | Yiwen Zhang Xiaoxia Zhang Zumin Xing Shuyi Tang Hanwen Chen Zhongqi Zhang Jiyuan Li Yalan Li | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 18 | Diurnal variation and life-cycle of deep convective systems over the tropical Pacific warm pool显示文摘 | Shuyi S Chen Houze R A | 1997 | Quarterly Jounal of Royal Meteorological Society1997，123，： | 1 |
| 19 | The effect of postannealing on the electrical properties of well - aligned n- ZnO nanorods/p- Si heterojunction 显示文摘 | Liu Shuyi Chen Tao Jiang Yulong | 2009 | Journal of Applied Physics2009，105，11： | 1 |
| 20 | New technology of pulsating high gradient magnetic separation显示文摘 | Xiong Dahe Liu Shuyi Chen Jin | 1998 | International Journal of Mineral Processing1998，54，2： | 1 |
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