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| 1 | Exogenous NADPH ameliorates myocardial ischemia–reperfusion injury in rats through activating AMPK/mTOR pathway显示文摘Our previous study shows that nicotinamide adenine dinucleotide phosphate(NADPH)plays an important role in protecting against cerebral ischemia injury.In this study we investigated whether NADPH exerted cardioprotection against myocardial ischemia/reperfusion(I/R)injury.To induce myocardial I/R injury,rats were subjected to ligation of the left anterior descending branch of coronary artery for 30 min followed by reperfusion for 2 h.At the onset of reperfusion,NADPH(4,8,16 mg·kg?1·d?1,iv)was administered to the rats.We found that NADPH concentrations in plasma and heart were signi?cantly increased at 4 h after intravenous administration.Exogenous NADPH(8?16 mg/kg)signi?cantly decreased myocardial infarct size and reduced serum levels of lactate dehydrogenase(LDH)and cardiac troponin I(cTn-I).Exogenous NADPH signi?cantly decreased the apoptotic rate of cardiomyocytes,and reduced the cleavage of PARP and caspase-3.In addition,exogenous NADPH reduced mitochondrial vacuolation and increased mitochondrial membrane protein COXIV and TOM20,decreased BNIP3L and increased Bcl-2 to protect mitochondrial function.We conducted in vitro experiments in neonatal rat cardiomyocytes(NRCM)subjected to oxygen–glucose deprivation/restoration(OGD/R).Pretreatment with NADPH(60,500 nM)signi?cantly rescued the cell viability and inhibited OGD/R-induced apoptosis.Pretreatment with NADPH signi?cantly increased the phosphorylation of AMPK and downregulated the phosphorylation of mTOR in OGD/R-treated NRCM.Compound C,an AMPK inhibitor,abolished NADPH-induced AMPK phosphorylation and cardioprotection in OGD/R-treated NRCM.In conclusion,exogenous NADPH exerts cardioprotection against myocardial I/R injury through the activation of AMPK/mTOR pathway and inhibiting mitochondrial damage and cardiomyocyte apoptosis.NADPH may be a potential candidate for the prevention and treatment of myocardial ischemic diseases. | Jiang Zhu Yi-fei Wang Xiao-ming Chai Ke Qian Ling-wei Zhang Peng Peng Pei-min Chen Jian-fang Cao Zheng-hong Qin Rui Sheng Hong Xie | 2020 | Acta Pharmacologica Sinica2020，41，4： | 19 |
| 2 | Characteristics of and strategies for patients with severe burn-blast combined injury显示文摘背景严重灼伤强风联合了损害是对为它的高死亡的医疗队的大挑战。这研究的目的是阐明损害并且到现在的临床的特征我们有严重灼伤强风的五个病人联合了的如此的 cases.Methods 的治疗上的临床的经验损害进入我们在 2005 年 6 月 7 日 77 个小时损害以后的医院。灼伤程度从 80% ~ 97%(89.6% 鞪? 亘吗?? | CHAI Jia-ke SHENG Zhi-yong LU Jiang-yang WEN Zhong-guang YANG Hong-ming JIA Xiao-ming LI Li-gen CAO Wei-hong HAO Dai-feng SHEN Chuan-an TUO Xiao-ye LIANG Li-ming WANG Shu-jun | 2007 | Chinese Medical Journal2007，，20： | 17 |
| 3 | Comparison of microstructures and mechanical properties of composite extruded AZ31 sheets显示文摘The microstructures and mechanical properties of the composite extruded AZ31/AZ31 and AZ31/4047 Al sheets were investigated and made a comparison to the conventional extruded AZ31 sheet.Owing to the introduced intense shear deformation at the interface during the composite extrusion,grain refinement and tilted texture were detected in AZ31 layers of the AZ31/AZ31 and AZ31/4047 Al sheets,while the conventional extruded AZ31 sheet exhibited a relative coarse,inhomogeneous microstructure and strong basal texture.The compressiontension yield ratio was increased gradually from the AZ31 to the AZ31/AZ31 and AZ31/4047 Al sheets.Besides,the AZ31/4047 Al sheet could successfully accomplish the whole bending forming process at room temperature,while the AZ31 and AZ31/AZ31 sheets were both bend-formed to failure with significant cracks in the outer tensile region under the identical bending parameters.Moreover,under the same bending strain,both the outward offset degree of strain neutral layer and the sheet thickening were more serious in the AZ31/4047 Al composite sheet than those of the AZ31 and AZ31/AZ31 sheets.The foremost reason was the quite wide gap of material properties between Mg alloy AZ31 layer(tensile loading in the outer region)and Al 4047 layer(compressive loading in the inner region). | Yanfu Chai Yan Song Bin Jiang Jie Fu Zhongtao Jiang Qingshan Yang Haoran Sheng Guangsheng Huang Dingfei Zhang Fusheng Pan | 2019 | Journal of Magnesium and Alloys2019，7，4： | 11 |
| 4 | Treatment strategies for mass burn casualties显示文摘因为很多严重受伤的病人在一短时间以内被送,背景集体灼伤伤亡总是是对一个医疗队的大挑战。通常,高死亡正在逼近。从牺牲品的成功的治疗获得的经验可能在在武装 conflict.Methods 指导集体伤亡的照顾是有用的在单个批的 35 个灼伤牺牲品,坐飞机不停地被转移并且从一个远省的高速公路,被承认 48 个小时损害以后。所有病人与吝啬的年龄是男性的(22.4 ? 蟠 ?( | CHAI Jia-ke SHENG Zhi-yong YANG Hong-ming HAO Dai-feng SHEN Chuan-an JIA Xiao-ming LI Feng JING Sa LI Li-gen SONG Hui-feng JIA Chi-yu TUO Xiao-ye SUN Tian-jun HU Quan | 2009 | Chinese Medical Journal2009，，5： | 10 |
| 5 | Association between polymorphism rs6983267 and gastric cancer risk in Chinese population显示文摘AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk. METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer. RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively). CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed. | Yi Guo Jing Fang Yan Liu Hai-Hui Sheng Xiao-Yan Zhang Hai-Na Chai Wei jin Ke-Hao Zhang Chang-Qing Yang Heng-jun Gao | 2011 | World Journal of Gastroenterology2011，17，13： | 5 |
| 6 | Consensus on the digestive endoscopic tunnel technique显示文摘With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) tract.At present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative treatment.The International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations). | Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai | 2019 | World Journal of Gastroenterology2019，25，7： | 5 |
| 7 | Autonomous Domain Correlation-Based Cross-domain Network View Caching Method for SDN Distributed Controller显示文摘Software-defined networks(SDN) maintain a global view of the network, thus improving the intelligence of forwarding decisions. With the expansion of the network scale, distributed controllers are used in a variety of large-scale networks in which subnetworks managed by controller instance are called autonomous domains. We analyze statistic frequency of communication across the autonomous domain. We calculate the autonomous domain correlations for controller instances using acquired statistical information. We cache network views to highly correlated controller instances. Distributed controllers are capable of considering both the average response time and overall storage. An experiment shows that our method can fully take advantage of these two performance indicators. | FU Tao HU Liang CHAI Sheng CHE Xilong | 2016 | Chinese Journal of Electronics2016，25，6： | 3 |
| 8 | SPHLU:An Efficient Algorithm for Processing PRkNN Queries on Uncertain Data显示文摘Query on uncertain data has received much attention in recent years, especially with the development of Location-based services(LBS). Little research is focused on reverse k nearest neighbor queries on uncertain data. We study the Probabilistic reverse k nearest neighbor(PRkN N) queries on uncertain data. It is succinctly shown that, PRkN N query retrieves all the points that have higher probabilities than a given threshold value to be the Reverse k-nearest neighbor(RkN N) of query data Q.The previous works on this topic mostly process with k > 1.Some algorithms allow the cases for k > 1, but the efficiency is inefficient especially for large k. We propose an efficient pruning algorithm — Spatial pruning heuristic with louer and upper bound(SPHLU) for solving the PRkN N queries for k > 1. The experimental results demonstrate that our algorithm is even more efficient than the existent algorithms especial for a large value of k. | WANG Shengsheng LI Yang CHAI Sheng BOLOU Bolou Dickson | 2016 | Chinese Journal of Electronics2016，25，3： | 3 |
| 9 | Discovery of novel PTP1B inhibitors with antihyperglycemic activity显示文摘 | Zhang LIU Qian CHAI Yuan-yuan LI Qiang SHEN Lan-ping MA Li-na ZHANG Xin WANG Li SHENG Jing-ya LI Jia LI Jing-kang SHEN | 2010 | Acta Pharmacologica Sinica2010，31，8： | 3 |
| 10 | Effect of burn injury on apoptosis and expression of apoptosis-related genes/proteins in skeletal muscles of rats显示文摘 | Hongjie Duan Jiake Chai Zhiyong Sheng Yongming Yao Huinan Yin Liming Liang Chuanan Shen Jing Lin | 2009 | Apoptosis2009，，1： | 2 |
| 11 | The relationship between skeletal muscle proteolysis and ubiquitin–proteasome proteolytic pathway in burned rats显示文摘 | Jiake Chai Yanqiu Wu Zhiyong Sheng | 2002 | Burns2002，，6： | 2 |
| 12 | Role of ubiquitin-proteasome pathway in skeletal muscle wasting in rats with endotoxemia显示文摘 | Jiake Chai Yanqiu Wu Zhiyong Sheng (Zy Sheng) | 2003 | Critical Care Medicine2003，，6： | 2 |
| 13 | A Pruning Based Continuous RkNN Query Algorithm for Large k显示文摘 | WANG Shengsheng CHAI Sheng LV Qiannan | 2012 | Chinese Journal of Electronics2012，21，3： | 2 |
| 14 | PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors显示文摘 | Kevin C. Soares Agnieszka A. Rucki Annie A. Wu Kelly Olino Qian Xiao Yi Chai Anthony Wamwea Elaine Bigelow Eric Lutz Linda Liu Sheng Yao Robert A. Anders Daniel Laheru Christopher L. Wolfgang Barish H. Edil Richard D. Schulick Elizabeth M. Jaffee Lei Zhen | 2015 | Journal of Immunotherapy2015，，1： | 2 |
| 15 | 5-coordinated aluminum complexes having two 2, 4-dimethyl-8-hydroxylquinoline ligands and a phenolic ligand as possible materials for white emission organic light-emitting deviees显示文摘 | Sheng Yong Chai Rui Zhou | 2005 | Thin Solid Films2005，479，12： | 1 |
| 16 | Strategies for mass burn casualties transferred from a distance-clinical experience显示文摘 | Jiake Chai Zhiyong Sheng Hongming Yang | 2005 | Wehrmedizn and Wehrpharmazie2005，，2： | 1 |
| 17 | Successful treatment of invasive burn wound infection with sepsis in patients with major burns显示文摘 | Jiake Chai Zhiyong Sheng Hongming Yang | 2000 | Chin Med J2000，113，12： | 1 |
| 18 | Repair and reconstruction of massively damaged burn wounds显示文摘 | Chai J Song H Sheng Z et a | 2003 | Burns2003，29，7： | 1 |
| 19 | The relationship between skeletal muscle proteolysis and ubiquifin-proteasome proteolytic pathway in burned rats显示文摘 | Chai J Wu Y Sheng Z | 2002 | Bums2002，28，6： | 1 |
| 20 | A comparative study on the predictive value of digital subtraction angiography and B-mode ultrasonography in evaluating arterial injury in high-voltage electrical burn of the forearm显示文摘 | Li L Chai J K Sheng Z C | 2006 | J Burn Care Res2006，27，4： | 1 |
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