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| 1 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 2 | Seeing is believing:anti-PD-1/PD-L1 monoclonal antibodies in action for checkpoint blockade tumor immunotherapy显示文摘Structural immunology,focusing on structures of host immune related molecules,enables the immunologists to see what the molecules look like,and more importantly,how they work together.Antibody-based PD-1/PD-L1 blockade therapy has achieved brilliant successes in clinical applications.The recent breakthrough of the complex structures of checkpoint blockade antibodies with their counterparts,pembrolizumab with PD-1 and avelumab with PD-L1,have made it clear how these monoclonal antibodies compete the binding of PD-1/PD-L1 and function to blockade the receptor-ligand interaction.Herein,we summarize the structural findings of these two reports and look into the future for how this information would facilitate the development of more efficient PD-1/PD-L1 targeting antibodies,small molecule drugs,and other protein or non-protein inhibitors. | Shuguang Tan Catherine W-H Zhang George F Gao | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 8 |
| 3 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 4 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 5 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 6 | Heavy metal removal from sediments by biosurfactants显示文摘 | Catherine N Mulligan Raymond N Yong Bernard F Gibbs | 2001 | Journal of Hazardous Materials2001，，1： | 2 |
| 7 | Characterization of adsorbed species on TiO2 after photocatalytic oxidation of toluene显示文摘 | Catherine M B John L F 2001 | 2001 | J Catal2001，200，1： | 1 |
| 8 | Focal cerebral ischemia induces active proteases that degrade microvascular matrix显示文摘 | Shunichi F Catherine A | 2004 | Stroke2004，35，： | 1 |
| 9 | Antibiosis revisited: bacterio- cins produced by dairy starter cultures显示文摘 | Susan F B Catherine G N | 1993 | Journal of Dairy Science1993，76，8： | 1 |
| 10 | Statistical analysis of hyper spectral data from two Swedish lakes显示文摘 | PETER F TOMMY L CATHERINE O | 2001 | The Sci- ence of the Total Environment2001，，268： | 1 |
| 11 | The Walk the Talk Team: the Secrets of Highly Active Older Adults显示文摘 | THEA F CATHERINE T MAUREEN C | 2013 | Journal of Aging Studies2013，27，3： | 1 |
| 12 | Automation and optimization of glycine Synthesis显示文摘 | Mehrdad N Catherine P | 1996 | Process Control Qual1996，8，1： | 1 |
| 13 | Pathogenic landscapes: interactions between land, people, disease vectors, and their animal hosts 显示文摘 | Eric F Lambin Annelise Tran Sophie O Vanwambeke Catherine Linard Valerie Soti | 2010 | International journal of health geographics2010，，9： | 1 |
| 14 | Single risk fact or interventions to promote physical activity among patients with chronic disease显示文摘 | Catherine H Martin F Hassan S | 2008 | Cana Fami Physiei2008，54，8： | 1 |
| 15 | Universal integrated extraction and clean-up system for the measurement of trace levels of halogenated pollutants in biological fluids and solids 显示文摘 | J F Focant Catherine Pirard | 2003 | Organohalogen compounds2003，60，： | 1 |
| 16 | X-12-ARIMA and its application to some Italian indicator series显示文摘 | David F Findley Catherine C Hood | 1999 | Journal of the American Statistical Association1999，，： | 1 |
| 17 | Acquired autoimmune thrombocytopenia after allogeneic bone marrow transplantation 显示文摘 | Philippe B Catherine C Patricia F | 1985 | British Journal of Haematology1985，59，： | 1 |
| 18 | Statistical analysis of hyper spectral data from two Swedish lakes显示文摘 | Peter F Tommy L Catherine O | 2001 | The Science of the Total Environment2001，，268： | 1 |
| 19 | Pancreatitis-associated acute lung iniury: new insights 显示文摘 | Catherine M Michael A Jean-Louis F | 2003 | Chest2003，124，6： | 1 |
| 20 | New frontiers in CT imaging of airway disease显示文摘 | Philippe AG Catherine BA Catalin F | 2002 | Ear J Radio12002，12，2： | 1 |
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