|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Acute and persisting Th2-like immune response after fractionated colorectal γ-irradiation显示文摘AIM:To investigate if an immune imbalance may account for the development and progression of chronic radiation enteritis.We analyzed the Th1/Th2 immune response profile early and 6 mo after fractionated colorectal irradiation. METHODS:A rat model of fractionated colorectal γ-irradiation(4-Gy fractions,3 fractions per week)was designed to investigate the effects of cumulative dose on inflammatory mediators(cytokines and chemo- kines)and immune response(Th1/Th2 profile and im- munosuppressive mediator IL-10)during acute(early) response and 6 mo after the end of fractionated irradia- tion(chronic response).Analyses were performed 1 d after the cumulative doses of 16 Gy and 36 Gy and 1 d, 3 d,and 26 wk after the cumulative dose of 52 Gy. RESULTS:Without causing histological damage,fractionated radiation induced elevated expression of IL-1β, TNFα,MCP-1,and iNOS in distal colonic mucosa during the early post-irradiation phase.At that time,a Th2 profile was confirmed by expression of both the Th2-specific transcription factor GATA-3 and the chemokine receptor CCR4 and by suppression of the Th1 cytokine IFNγ/IP-10 throughout the irradiation protocol.After 6 mo,despite the 2-fold reduction of iNOS and MCP-1 levels,the Th2 profile persisted,as shown by a 50% reduction in the expression of the Th1 transcription factor T-bet,the chemokine receptor CCXCR3,and the IFNγ/ STAT1 pathway.At the same time-point,the immuno-suppressive IL-10/STAT3 pathway,known to regulate the Th1/Th2 balance,was expressed,in irradiated rats, at approximately half its level as compared to controls.This suppression was associated with an overexpression of SOCS3,which inhibits the feedback of the Th1 polarization and regulates IL-10 production. CONCLUSION:Colorectal irradiation induces Th2 polarization,defective IL-10/STAT3 pathway activation and SOCS3 overexpression.These changes,in turn,maintain a immunological imbalance that persists in the long term. | Olivier Grémy Marc Benderitter Christine Linard | 2008 | World Journal of Gastroenterology2008，14，46： | 15 |
| 2 | Structural and functional reorganization of propriospinal connections promotes functional recovery after spinal cord injury显示文摘Axonal regeneration and fiber regrowth is limited in the adult central nervous system, but research over the last decades has revealed a high intrinsic capacity of brain and spinal cord circuits to adapt and reorganize after smaller injuries or denervation. Short-distance fiber growth and synaptic rewiring was found in cortex, brain stem and spinal cord and could be associated with restoration of sensorimotor functions that were impaired by the injury. Such processes of structural plasticity were initially observed in the corticospinal system following spinal cord injury or stroke, but recent studies showed an equally high potential for structural and functional reorganization in reticulospinal, rubrospinal or propriospinal projections. Here we review the lesion-induced plastic changes in the propriospinal pathways, and we argue that they represent a key mechanism triggering sensorimotor recovery upon incomplete spinal cord injury. The formation or strengthening of spinal detour pathways bypassing supraspinal commands around the lesion site to the denervated spinal cord were identified as prominent neural substrate inducing substantial motor recovery in different species from mice to primates. Indications for the existence of propriospinal bypasses were also found in humans after cortical stroke. It is mandatory for current research to dissect the biological mechanisms underlying spinal circuit remodeling and to investigate how these processes can be stimulated in an optimal way by therapeutic interventions(e.g., fiber-growth enhancing interventions, rehabilitation). This knowledge will clear the way for the development of novel strategies targeting the remarkable plastic potential of propriospinal circuits to maximize functional recovery after spinal cord injury. | Linard Filli Martin E.Schwab | 2015 | Neural Regeneration Research2015，10，4： | 9 |
| 3 | Caffeic acid phenethyl ester modifies the Thl/Th2 balance in ileal mucosa afterγ-irradiation in the rat by modulating the cytokine pattern显示文摘AIM: To pharmacologically modulate Th polarization in the ileum exposed to ionizing radiation by using the immuno-modulatory/apoptotic properties of Caffeic Acid Phenethyl Ester (CAPE). METHODS: Rats received CAPE (30 mg/kg) treatment ip 15 min prior to intestinal 10 Gyγ-irradiation and once a day for a 6 d period after irradiation. Expression of genes implicated in Th differentiation in ileal mucosa (IL-23/IL-12Rβ2), Th cytokine responses (IFN-γ, IL-2, IL-4, IL-13), Th migratory behaviour (CXCR3, CCR5, CCR4), Th signalling suppressors (SOCS1, SOCS3), transcription factor (T-Bet, GATA-3) and apoptosis (FasL/Fas, TNF/TNFR, XIAP, Bax, caspase-3) was analyzed by RT-PCR 6 h and 7 d post-irradiation. CD4+ and TUNEL positive cells were visualized by immunostaining. RESULTS: The expression of Th1-related cytokine/ chemokine receptors (IFN-γ, IL-2, CXCR3, CCR5) was repressed at 7 d post-irradiation while Th2 cell cytokine/ chemokines (IL-4, IL-13, CCR4) were not repressed or even upregulated. The irradiation-induced Th2 profile was confirmed by the upregulation of both Th2-specific transcription factor GATA-3 and SOCS3. Although an apoptosis event occurred 6 h after 10 Gy of intestinalγ-irradiation, apoptotic mediator analysis showed a tendency to apoptotic resistance 7 d post-irradiation. CAPE amplified apoptotic events at 6h and normalized Bax/ FasL expressions at 7 d. CONCLUSION: CAPE prevented the ileal Th2 immune response by modulating the irradiation-influenced cytokine environment and apoptosis. | Olivier Grémy Marc Benderitter Christine Linard | 2006 | World Journal of Gastroenterology2006，12，31： | 4 |
| 4 | Assessment of somatic K-ras mutations as a mechanism associated with resist- ance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic eolorectal cancer显示文摘 | Linardou H Dahabreh IJ Kanaloupiti D | 2008 | Lancet Oncol2008，9，10： | 1 |
| 5 | Changes in gut neurotensin and modified colonic motility following whole-body irradiation in rat显示文摘 | LINARD C GRIFFTS N M ESPPOTO V | 1997 | International Journal of Radiation Biology1997，71，5： | 1 |
| 6 | Trastuzumab in the adjuvant treatment of earlvstage breast cancels, a svstematic review recta - analysis of randomized controlled trials 显示文摘 | Dahabreh IJ Linardou H Siannis F | 2008 | Oneologist2008，13，： | 1 |
| 7 | Beneficial use of pulp and paper residues for soil amendment in the province of Quebec显示文摘 | Leclerc J Linard A Villeneuve F | 1999 | Pulp & Paper Canada1999，100，7： | 1 |
| 8 | Acute induction of inflammatory cytokine expression after gamma-irradiation in the rat:Effect of an NF-kappaB inhibitor显示文摘 | LINARD C MARQUETTE C MATHIEU J | 2004 | International Journal of Radiation Oncology Biology Physics2004，58，2： | 1 |
| 9 | Pathogenic landscapes: interactions between land, people, disease vectors, and their animal hosts 显示文摘 | Eric F Lambin Annelise Tran Sophie O Vanwambeke Catherine Linard Valerie Soti | 2010 | International journal of health geographics2010，，9： | 1 |
| 10 | Effect of Maillard reaction conditions on browning and antiradical activity of sugar-tuna stomach hydrolysate model system 显示文摘 | SUMAYA-MARTINEZ M T THOMAS S LINARD B | 2005 | Food Research International2005，38，： | 1 |
| 11 | Abdominal irradiation increases inflammatory cytokine expression and activates NF- B in rat ileal muscularis layer显示文摘 | Linard C Ropenga A Vozenin-Brotons MC | 2003 | Am J Physiol Gastrointest Liver Physio12003，285，3： | 1 |
| 12 | Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC 显示文摘 | Linardou H Dahabreh U Bafaloukos D | 2009 | Nat Rev Clin Oncol2009，6，6： | 1 |
| 13 | Estrogen receptors in the brain-pituitary complex and the neuroendocrine regulation of gonadotropin release in rainbow trout显示文摘 | Kah O I Anglade B Linard F | 1997 | Fish Physiol Biochem1997，，： | 1 |
| 14 | Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC 显示文摘 | Linardou H Dahabreh IJ Bafaloukos D | 2009 | NatRev Clin Oncol2009，6，6： | 1 |
| 15 | Reduction of peroxisome proli - feration - activated receptor gamma expression by gamma - irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5 - aminosalicylic acid agonist 显示文摘 | Linard C Gremy O Benderitter M | 2008 | J Pharmacol Exp Ther2008，324，： | 1 |
| 16 | Disaggregat- ing census data for population mapping using random for- ests with remotely-sensed and ancillary data显示文摘 | Stevens F R Gaughan A E Linard C | 2015 | PLoS ONE2015，10，10： | 1 |
| 17 | A network of genetic events sufficient to convert nomaal human cells to a tumorigenic state 显示文摘 | Kendall SD Linardic CM Adam SJ | 2005 | Cancer Res2005，65，21： | 1 |
| 18 | EGFR gene copy number as a predictive biomarker for patients receiving tyrosine kinase inhibitor treatment:a systematic review and meta analysis in non-small-cell lung cancer显示文摘 | Dahabreh I J Linardou H Kosmidis P | 2011 | Ann Oncol2011，22，3： | 1 |
| 19 | Abdominal irradiation increases inflammatory cytokine expression and activates NF-kB in rat ileal muscularis layer显示文摘 | Linard C Ropenga A Vozenin-Brotons MC | 2003 | Am J Physiol Gastrointest Liver Physiol2003，285，3： | 1 |
| 20 | Effect of Maillard reaction conditions on browning and antiradical activity of sugar-tuna stomach hydrolysate model system显示文摘 | Sumaya-Martinez M T Thomas S Linard B | 2005 | Food Resea- rch International2005，38，89： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员