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| 1 | Normal aspects of colorectal motility and abnormalities in slow transit constipation显示文摘Human colonic motility is a relatively difficult topic to investigate. However, the refinement of manometric techniques in recent years enabled us to study both the proximal and distal segments of the viscus. The present paper reviews our knowledge about normal aspects of colorectal motility in man and the abnormalities found in slow transit constipation (STC), one of the most frequent and difficult to treat subtypes of constipation. An internetbased search strategy of the Medline and Science Citation Index was performed using the keywords colon, colonic,colorectal, constipation, slow transit, motility, recal, rectum in various combinations with the Boolean operators AND, OR and NOT. Only articles related to human studies were used, and manual cross-referencing was also performed.Most of colonic motor activity is represented by single nonpropagated contractions, rarely organized in bursts; this activity is maximal during the day, especially after waking and following meals. In addition, a specialized propagated activity with propulsive features is detectable, represented by high- and low-amplitude propagated contractions. In the severe form of constipation represented by the slow transit type, the above motor activity is completely deranged. In fact, both basal segmental activity (especially in response to meals) and propagated activity (especially that of high amplitude) are usually decreased, and this may represent a physiologic marker of this disorder. Human colonic motor activity is quite a complex issue, still only partly understood and investigated, due to anatomic and physiological difficulties. In recent years, however, some more data have been obtained, even in proximal segments. These data have helped in elucidating, althoughonly in part, some pathophysiological mechanisms of chronic constipation, and especially of the STC subtype. | Gabrio Bassotti Giuseppe de Roberto Danilo Castellani Luca Sediari Antonio Morelli | 2005 | World Journal of Gastroenterology2005，11，18： | 21 |
| 2 | Liver resection versus radiofrequency ablation in the treatment of cirrhotic patients with hepatocellular carcinoma显示文摘BACKGROUND: Hepatocellular carcinoma is the most common type of primary liver tumor and its incidence is increasing worldwide. The study aimed to compare patients subjected to liver resection or radiofrequency ablation. METHODS: One hundred and forty cirrhotic patients in stage A or B of Child-Pugh with single nodular or multinodular hepatocellular carcinoma were included in this retrospective study. Among them, 87 underwent surgical resection, and 53 underwent percutaneous radiofrequency ablation. Patient charac-teristics, survival, and recurrence-free survival were analyzed. RESULTS: Recurrence-free survival was longer in the resection group in comparison to the radiofrequency group with a median recurrence-free time of 36 versus 26 months, respectively (P=0.01, HR=1.52, 95% CI: 1.05-2.25). In the resection group, median survival was 46 months, with the 1-, 3- and 5-year survival rates of 89.7%, 72.4% and 40.2%. In the radiofrequency group, median survival was 32 months, with the 1-, 3- and 5-year survival rates of 83.0%, 43.4% and 22.6% (P<0.01). CONCLUSIONS: Surgical resection improves the overall survival and recurrence-free survival in comparison with radiofrequency ablation. New evidences are needed to define the real role of the percutaneous technique as an alternative to surgery. | Amilcare Parisi Jacopo Desiderio Stefano Trastulli Elisa Castellani Rosario Pasquale Roberto Cirocchi Carlo Boselli Giuseppe Noya | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 8 |
| 3 | Usefulness of staging systems and prognostic scores for hepatocellular carcinoma treatments显示文摘Therapeutic management of hepatocellular carcinoma(HCC) is quite complex owing to the underlying cirrhosis and portal vein hypertension. Different scores or classification systems based on liver function and tumoral stages have been published in the recent years. If none of them is currently 'universally' recognized, the Barcelona Clinic Liver Cancer(BCLC) staging system has become the reference classification system in Western countries. Based on a robust treatment algorithm associated with stage stratification, it relies on a high level of evidence. However, BCLC stage B and C HCC include a broad spectrum of tumors but are only matched with a single therapeutic option. Some experts have thus suggested to extend the indications for surgery or for transarterial chemoembolization. In clinical practice, many patients are already treated beyond the scope of recommendations. Additional alternative prognostic scores that could be applied to any therapeutic modality have been recently proposed. They could represent complementary tools to the BCLC staging system and improve the stratification of HCC patients enrolled in clinical trials, as illustrated by the NIACE score. Prospective studies are needed to compare these scores and refine their role in the decision making process. | Xavier Adhoute Guillaume Penaranda Jean Luc Raoul Patrice Le Treut Emilie Bollon Jean Hardwigsen Paul Castellani Hervé Perrier Marc Bourlière | 2016 | World Journal of Hepatology2016，8，17： | 7 |
| 4 | Linear endoscopic ultrasonography vs magnetic resonance imaging in ampullary tumors显示文摘AIM:To assess linear endoscopic ultrasound (L-EUS) and magnetic resonance imaging (MRI) in biliary tract dilation and suspect small ampullary tumor.METHODS:L-EUS and MRI data were compared in 24 patients with small ampullary tumors;all with subsequent histological confirmation.Data were collected prospectively and the accuracy of detection,histological characterization and N staging were assessed retrospectivelyusing the results of surgical or endoscopic treatment as a benchmark.RESULTS:A suspicion of ampullary tumor was present in 75% of MRI and all L-EUS examinations,with 80% agreement between EUS and histological findings at endoscopy.However,L-EUS and histological TN staging at surgery showed moderate agreement (κ=0.54).CONCLUSION:L-EUS could be a useful adjunct as a diagnostic tool in the evaluation of patients with sus-pected ampullary tumors. | Raffaele Manta Rita Conigliaro Danilo Castellani Alessandro Messerotti Helga Bertani Giuseppe Sabatino Elena Vetruccio Luisa Losi Vincenzo Villanacci Gabrio Bassotti | 2010 | World Journal of Gastroenterology2010，16，44： | 6 |
| 5 | Recommendations for the use of chemoembolization in patients with hepatocellular carcinoma: Usefulness of scoring system?显示文摘Several hepatocellular carcinoma(HCC) staging systems have been established, and a variety of countryspecific treatment strategies are also proposed. The barcelona- clinic liver cancer(BCLC) system is the most widely used in Europe. The Hong Kong liverCancer is a new prognostic staging system; it might become the reference system in Asia. Transarterial chemoembolization(TACE) is the most widely used treatment for HCC worldwide; but it showed a benefit only for intermediate stage HCC(BCLC B), and there is still no consensus concerning treatment methods and treatment strategies. In view of the highly diverse nature of HCC and practices, a scoring system designed to assist with decision making before the first TACE is performed or prior to repeating the procedure would be highly useful. | Xavier Adhoute Guillaume Penaranda Paul Castellani Herve Perrier Marc Bourliere | 2015 | World Journal of Hepatology2015，7，3： | 6 |
| 6 | Carbon Dioxide Capture Using Gas Hydrate Technology显示文摘 | Beatrice Castellani Mirko Filipponi Andrea Nicolini Franco Cotana Federico Rossi | 2013 | Journal of Energy and Power Engineering2013，7，5： | 2 |
| 7 | 不同橡胶含量的熔融丙烯腈——三元乙丙—苯乙烯(AES)的动态粘弹性能显示文摘1 前言分散相的存在能够引起聚合物流变学的重大改变。最具代表性的一个例子是橡胶改性的热塑性塑料。已经报道过橡胶韧化的聚合物,诸如丙烯腈-丁二烯-苯乙烯共聚物,高耐冲击聚苯乙烯(HIPS), | Leonardo Castellani 袁正才 | 1992 | 橡胶参考资料1992，，8： | 2 |
| 8 | Sustainable performance index for tourism policy development显示文摘 | V. Castellani S. Sala | 2009 | Tourism Management2009，，6： | 2 |
| 9 | Antibodies Anti‐Caga Cross‐React with Trophoblast Cells: A Risk Factor for Pre‐Eclampsia?显示文摘 | Francesco Franceschi Nicoletta Di Simone Silvia D’Ippolito Roberta Castellani Fiorella Di Nicuolo Giovanni Gasbarrini Yoshio Yamaoka Tullia Todros Giovanni Scambia Antonio Gasbarrini | 2012 | Helicobacter2012，，6： | 2 |
| 10 | Surgery in asymptomatic patients with colorectal cancer and unresectable liver metastases: the authors’ experience显示文摘 | Claudio Renzi Castellani Francesco Barberini Roberto Cirocchi Gemini Noya Boselli Parisi Corsi Desiderio Adriano Redler Trastulli Alberto Santoro | 2013 | 2013 (defa)2013，，： | 2 |
| 11 | Steel - concrete bond deterioration due to corrosion: finite- element analysis for different confinement levels显示文摘 | Berra M Castellani A Coronelli D etal | 2000 | Magazine of Concrete Research2000，55，3： | 1 |
| 12 | The proinflammatory inter- leukin-21 elicits anti-tumor response and mediates autoimmunity 显示文摘 | Castellani ML Salini V Frydas S | 2006 | Int J Immunopathol Pharmacol2006，19，2： | 1 |
| 13 | Heparin and low-dose aspirin restore placental human chorlonic gonadotrophin secretion abolished by antiphospholipid antibody-containing sere 显示文摘 | Di simone N Ferrazzai S Castellani R | 1997 | Hum Reprod1997，12，： | 1 |
| 14 | Long - term results and quality of life in patients treated with hemorrhoidectomy using two different techniques: Ligasure versus transanal hemorrhoidal dearterialization显示文摘 | Zampieri N Castellani R Andreoli R | 2012 | Am J Surg2012，204，5： | 1 |
| 15 | Iron:the Redox-active center of oxidative stress in Alzheimer disease显示文摘 | Castellani RJ Moreira PI Liu G | | 0，，10： | 1 |
| 16 | Differential activation of neuronal ERK,JNK/SAPK and p38 in Alzheimer disease:the ‘two hit' hypothesis显示文摘 | Zhu X Castellani RJ Takeda A | 2001 | Mech Ageing Dev2001，123，1： | 1 |
| 17 | Positional cloning of the combined hyperlipidemia gene Hyplipl显示文摘 | Bodnar JS Chatterjee A Castellani LW | 2002 | Nat Genet2002，30，1： | 1 |
| 18 | Neuroprotein s-100B a useful parameter in paediatric pa- tients with mild traumatic brain illjury? 显示文摘 | CASTELLANI C BIMBASHI P RUTTENSTOCK E | 2009 | Acta Paediatr2009，98，10： | 1 |
| 19 | Nonsmooth invex functions and sufficient optimality conditions显示文摘 | Castellani M | | 0，，02： | 1 |
| 20 | Intracellular localization and isoform expression of the voltage-dependent anion channel (VDAC) in normal and dystrophic skeletal muscle显示文摘 | Roberto Massa Lionel Njl Marlier Alessandro Martorana Simona Cicconi Daniela Pierucci Patrizia Giacomini Vito de Pinto Loriana Castellani | 2000 | Journal of Muscle Research and Cell Motility2000，，5： | 1 |
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