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| 1 | High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis显示文摘AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity. | Aldo Spadaro Vincenza Tortorella Carmela Morace Agostino Fortiguerra Paola Composto Caterina Bonfiglio Angela Alibrandi Carmelo Luigiano Giuseppe De Caro Antonino Ajello Oscar Ferraù Maria Antonietta Freni | 2008 | World Journal of Gastroenterology2008，14，10： | 19 |
| 2 | Treatment of colorectal cancer in the elderly显示文摘Colorectal cancer has a high incidence, and approxi-mately 60% of colorectal cancer patients are older than 70, with this incidence likely increasing in the near future. Elderly patients(> 70-75 years of age) are a very heterogeneous group, ranging from the very fit to the very frail. Traditionally, these patients have often been under-treated and recruited less frequently to clinical trials than younger patients, and thus are underrepresented in publications about cancer treatment. Recent studies suggest that fit elderly patients can be treated in the same way as their younger counterparts, but the treatment of frail patients with comorbidities is still a matter of controversy. Many factors should be taken into account, including fitness for treatment, the wishes of the patient and family, and quality of life. This review will focus on the existing evidence for surgical, oncologic, and palliative treatment in patients over 70 years old with colorectal cancer. Careful patient assessment is necessary in order to individualize treatment approach, and this should rely on a multidisciplinary process. More well-designed controlled trials are needed in this patient population. | Monica Millan Sandra Merino Aleidis Caro Francesc Feliu Jordi Escuder Tani Francesch | 2015 | World Journal of Gastrointestinal Oncology2015，7，10： | 9 |
| 3 | Levofloxacin/amoxicillin-based schemes vs quadruple therapy for Helicobacter pylori eradication in second-line显示文摘Worldwide prevalence of Helicobacter pylori(H.pylori) infection is approximately 50%,with the highest being in developing countries.We compared cure rates and tolerability(SE) of second-line anti-H.pylori levofloxacin/amoxicillin(LA)-based triple regimens vs standard quadruple therapy(QT).An English language literature search was performed up to October 2010.A meta-analysis was performed including randomized clinical trials comparing 7-or 10-d LA with 7-d QT.In total,10 articles and four abstracts were identified.Overall eradication rate in LA was 76.5%(95% CI:64.4%-97.6%).When only 7-d regimens were included,cure rate was 70.6%(95% CI:40.2%-99.1%),whereas for 10-d combinations,cure rate was significantly higher(88.7%;95% CI:56.1%-109.9%;P < 0.05).Main eradication rate for QT was 67.4%(95% CI:49.7%-67.9%).The 7-d LA and QT showed comparable efficacy [odds ratio(OR):1.09;95% CI:0.63-1.87],whereas the 10-d LA regimen was significantly more effective than QT(OR:5.05;95% CI:2.74-9.31;P < 0.001;I 2 = 75%).No differences were reported in QT eradication rates among Asian and European studies,whereas LA regimens were more effective in European populations(78.3% vs 67.7%;P = 0.05).Incidence of SE was lower in LA therapy than QT(OR:0.39;95% CI:0.18-0.85;P = 0.02).A higher rate of side effects was reported in Asian patients who received QT.Our findings support the use of 10-d LA as a simple second-line treatment for H.pylori eradication with an excellent eradication rate and tolerability.The optimal second-line alternative scheme might differ among countries depending on quinolone resistance. | Simona Di Caro Lucia Fini Yayha Daoud Fabio Grizzi Antonio Gasbarrini Antonino De Lorenzo Laura Di Renzo Sara McCartney Stuart Bloom | 2012 | World Journal of Gastroenterology2012，18，40： | 9 |
| 4 | Natural hydroxyanthraquinoid pigments as potent food grade colorants:an overview显示文摘Natural pigments and colorants are widely used in the world in many industries such as textile dying,food processing or cosmetic manufacturing.Among the natural products of interest are various compounds belonging to carotenoids,anthocyanins,chlorophylls,melanins,betalains...The review emphasizes pigments with anthraquinoid skeleton and gives an overview on hydroxyanthraquinoids described in Nature,the first one ever published.Trends in consumption,production and regulation of natural food grade colorants are given,in the current global market.The second part focuses on the description of the chemical structures of the main anthraquinoid colouring compounds,their properties and their biosynthetic pathways.Main natural sources of such pigments are summarized,followed by discussion about toxicity and carcinogenicity observed in some cases.As a conclusion,current industrial applications of natural hydroxyanthraquinoids are described with two examples,carminic acid from an insect and Arpink red^(™)from a filamentous fungus. | Yanis CARO Linda ANAMALE Mireille FOUILLAUD Philippe LAURENT Thomas PETIT Laurent DUFOSSE | 2012 | Natural Products and Bioprospecting2012，2，5： | 8 |
| 5 | 基于微观力学模型的沥青混合料水损坏研究显示文摘水-荷载的耦合作用是沥青路面早期破坏的主要原因。该文提出了沥青混合料水损坏的微观力学模型,该模型可以用来量化分析在水-荷载的耦合作用下沥青混合料的损伤过程。同时,考虑到材料的力学性能是含水量的函数,利用内聚力模型对集料-沥青结合料间界面的粘结破坏进行了模拟,并通过沥青混合料内部应力、应变的变化研究了集料-沥青界面间裂缝发生的位置、时间和裂缝扩展过程。结果证明:微观力学模型可以用来揭示沥青混合料水损坏机理,并对连续损伤模型的建立具有一定指导意义。 | 张静 马士宾 魏连雨 孙敬福 Silvia Caro Eyad Masad Amit Bhasin Dallas Little | 2015 | 中外公路2015，35，6： | 8 |
| 6 | Appendicitis in double cecal appendix: Case report显示文摘Double cecal appendix is a rare anatomical variation. Approximately 100 cases have been reported worldwide. It is usually diagnosed incidentally during emergency appendectomies due to inflammatory processes in the cecal appendix. Case presentation: male, white, 36 years old, obese, presenting with pain in the lower abdomen for 24 h followed by nausea, vomiting and mild fever. He was subjected to additional tests, with the leukogram showing leukocytosis and abdominal ultrasonography depicting cecal appendix with thickened wall, locally associated with small quantities of liquid and intestinal loop obstruction. He underwent laparotomy, revealing acute appendicitis. Another intestinal loop obstruction was identified next to the ileum, leading to recognizing another cecal appendix after local dissection. Double appendectomy and segmental iliectomy were performed although not needed. Results of the anatomopathological examination of the surgical samples showed acute inflammation in the two cecal appendices. So, performing a routine retroperitoneal release and a complete cecum evaluation during such surgical procedures is recommended and suggested due to the possibility of not identifying a second cecal appendix. | José Roberto Alves Ícaro Godeiro de Oliveira Maranhão Patrick Vanttinny Vieira de Oliveira | 2014 | World Journal of Clinical Cases2014，2，8： | 4 |
| 7 | Short- and long-term efficacy of endoscopic balloon dilation in Crohn's disease strictures显示文摘AIM:To evaluate short- and long-term efficacy of endoscopic balloon dilation in a cohort of consecutive patients with symptomatic Crohn's disease (CD)-related strictures. METHODS:Twenty-six CD patients (11 men; median age 36.8 year, range 11-65 years) with 27 symptomatic strictures underwent endoscopic balloon dilation (EBD).Both naive and post-operative strictures, of any length and diameter, with or without associated fistula were included. After a clinical and radiological assessment, EBD was performed with a Microvasive Rigiflex through the scope balloon system. The procedure was considered successful if no symptom reoccurred in the following 6 mo. The long-term clinical outcome was to avoid surgery. RESULTS:The mean follow-up time was 40.7 ± 5.7 mo (range 10-94 mo). In this period, forty-six EBD were performed with a technical success of 100%. No procedure-related complication was reported. Surgery was avoided in 92.6% of the patients during the entire follow-up. Two patients, both presenting ileocecal strictures associated with fistula, failed to respond to the treatment and underwent surgical strictures resection. Of the 24 patients who did not undergo surgery, 11 patients received 1 EBD, and 13 required further dilations over time for the treatment of relapsing strictures (7 patients underwent 2 dilations, 5 patients 3 dilations, and 1 patient 4 dilations). Overall, the EBD success rate after the first dilation was 81.5%. No difference was observed between the EBD success rate for naive (n = 12) and post-operative (n = 15) CD related strictures (P > 0.05). CONCLUSION:EBD appears to be a safe and effective procedure in the therapeutic management of CD-related strictures of any origin and dimension in order to prevent surgery. | Nicola de'Angelis Maria Clotilde Carra Osvaldo Borrelli Barbara Bizzarri Francesca Vincenzi Fabiola Fornaroli Giuseppina De Caro Gian Luigi de'Angelis | 2013 | World Journal of Gastroenterology2013，19，17： | 4 |
| 8 | Antipredator deception in terrestrial vertebrates显示文摘 | Tim CARO | 2014 | Current Zoology2014，60，1： | 3 |
| 9 | Yield Response to Deficit Irrigation and Partial Root-Zone Drying in Processing Tomato (Lycopersicon esculentum Mill,)显示文摘 | Eugenio Nardella Marcella Michela Giuliani Giuseppe Gatta Antonio De Caro | 2012 | Journal of Agricultural Science and Technology(A)2012，2，2： | 3 |
| 10 | Symposia Report Immunoglobulin G for the Treatment of Chronic Pain:Report of an Expert Workshop显示文摘背景:慢性疼痛的治疗效果仍不理想。尽管现在治疗慢性疼痛的药物种类较多,但许多患者对疗效仍不满意或诉药物的副作用太大。越来越多的证据表明,免疫系统参与了伤害性和神经病理性慢性疼痛的病理过程。设计:在英国利物浦的专题会议上,专家们出示了免疫系统参与慢性疼痛的证据。近来的研究表明,静脉(IVIg)或皮下(SCIg)注射免疫调节药物——多价免疫球蛋白(Ig G)可缓解外周神经病理性疼痛和其他疼痛性疾病。专题会议讨论了IVIg和SCIg治疗的适应证、效价比及其副作用。结果:Ig G可缓解某些伤害性和神经病理性慢性疼痛,如糖尿病、干燥综合征、纤维肌痛症、复杂性区域疼痛综合征、小儿麻痹后遗症和继发于病理性自身抗体的疼痛。结论:Ig G对某些慢性疼痛具有一定的治疗前景。Ig G是一种相对安全的治疗方法,副作用少而轻,但价格较贵。今后有必要对Ig G治疗顽固性疼痛进行随机对照研究和预测性临床试验。 | Stefano Tamburin Kristian Borg Xavier J. Caro Stefano Jann Alexander J. Clark Francesca Magrinelli Gen Sobue Lars Werhagen Giampietro Zanette Haruki Koike Peter J. Spath Angela Vincent Andreas Goebel | 2014 | 中国疼痛医学杂志2014，20，11： | 3 |
| 11 | 国际文物保护与修复研究中心贺《遗产与保护研究》创刊显示文摘欢迎遗产领域一个新期刊的诞生,对国际文物保护与修复研究中心(ICCROM)而言是件非常高兴的事。特别是当她发生在中华人民共和国这样一个有着如此深厚文化底蕴的国度,而且贵刊又特别致力于包括自然遗产、文化遗产,物质文化遗产与非物质文化遗产等所有类型遗产的保护,感觉更是非同一般。作为联合国教科文组织于1956年创立的政府间组织,世界各地的遗产保护是ICCROM的主要关注之所在, | Stefano De Caro | 2016 | 遗产与保护研究2016，1，1： | 2 |
| 12 | Ant Algorithms for Discrete Optimization显示文摘 | Dorigo M Caro G D Gambardella L M | 1999 | Artificial Life1999，5，3： | 2 |
| 13 | B1a lymphocytes in the rectal mucosa of ulcerative colitis patients显示文摘AIM:To assess B1a cell expression in the rectal mucosa of ulcerative colitis (UC) patients in comparison with healthy controls.METHODS:Rectal mucosa biopsies were collected from 15 UC patients and 17 healthy controls.CD5 + B cells were analysed by three colour flow cytometry from rectal mucosal samples after mechanical disaggregation by Medimachine.Immunohistochemical analysis of B and T lymphocytes was also performed.Correlations between,on the one hand,rectal B1a cell concentrations and,on the other,erythrocyte sedimentation rate and C-reactive protein levels and clinical,endoscopic and histological disease activity indices were evaluated.RESULTS:Rectal B-lymphocyte (CD19 + /CD45 +) rate and concentration were higher in UC patients compared with those in healthy controls (47.85% ± 3.12% vs 26.10% ± 3.40%,P=0.001 and 501 ± 91 cells/mm 2 vs 117 ± 18 cells/mm 2,P < 0.001);Rectal B1a cell density (CD5 + CD19 +) was higher in UC patients than in healthy controls (85 ± 15 cells/mm 2 vs 31 ± 6.7 cells/mm 2,P=0.009).Rectal B1a cell (CD5/CD19 +) rate correlated inversely with endoscopic classification (Rs=-0.637,P < 0.05).CONCLUSION:B1a lymphocytes seem to be involved in the pathogenesis of UC,however,the role they play in its early phases and in disease activity,have yet to be defined. | Lino Polese Riccardo Boetto Giuseppe De Franchis Imerio Angriman Andrea Porzionato Lorenzo Norberto Giacomo Carlo Sturniolo Veronica Macchi Raffaele De Caro Stefano Merigliano | 2012 | World Journal of Gastroenterology2012，18，2： | 2 |
| 14 | Interest of combining an additive with dieselethanol blends for use in diesel engines 显示文摘 | DE CARO PS MOULOUNGUI Z VAITILINGOM G | 2001 | Fuel2001，80，4： | 2 |
| 15 | Effect of different probiotic preparations on anti- Helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study显示文摘 | Filippo Cremonini Simona Di Caro Marcello Covino Alessandro Armuzzi Maurizio Gabrielli Luca Santarelli Enrico C Nista Giovanni Cammarota Giovanni Gasbarrini Antonio Gasbarrini | 2002 | The American Journal of Gastroenterology2002，，11： | 2 |
| 16 | Ant algorithms for discrete optimization显示文摘 | Macro Dorigo Gianni Di Caro Luca M Gambardella | 1999 | Artificial Life1999，5，3： | 2 |
| 17 | The European experience with double-balloon enteroscopy: indications, methodology, safety, and clinical impact显示文摘 | Simona Di Caro Andrea May Dimitri G.N. Heine Lucia Fini Bruno Landi Lucio Petruzziello Christophe Cellier Chris J. Mulder Guido Costamagna Christian Ell Antonio Gasbarrini | 2005 | Gastrointestinal Endoscopy2005，，4： | 2 |
| 18 | Ant algorithms for discrete optimization显示文摘 | Dorigo M Di Caro G Gambardella L M | 1999 | Artificial Life1999，5，： | 2 |
| 19 | Middle cerebral artery thrombosis following blunt head trauma 显示文摘 | De Caro R Munari PF Parenti A | 1998 | Clin Neuropathol1998，17，： | 1 |
| 20 | Ant Algoithms for Descrite Optimization 显示文摘 | MARCO DORIGO GIANNI DI CARO | 1999 | Artificial Life1999，5，3： | 1 |
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