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| 1 | Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide显示文摘Long-acting glucagon-like peptide-1(GLP-1) analogues marketed for type 2 diabetes(T2D) treatment have been showing positive and protective effects in several different tissues, including pancreas, heart or even brain. This gut secreted hormone plays a potent insulinotropic activity and an important role in maintaining glucose homeostasis. Furthermore, growing evidences suggest the occurrence of several commonalities between T2 D and neurodegenerative diseases, insulin resistance being pointed as a main cause for cognitive decline and increased risk to develop dementia. In this regard, it has also been suggested that stimulation of brain insulin signaling may have a protective role against cognitive deficits. As GLP-1 receptors(GLP-1R) are expressed throughout the central nervous system and GLP-1 may cross the blood-brain-barrier, an emerging hypothesis suggests that they may be promising therapeutic targets against brain dysfunctional insulin signaling-related pathologies. Importantly, GLP-1 actions depend not only on the direct effect mediated by its receptor activation, but also on the gut-brain axis involving an exchange of signals between both tissues via the vagal nerve, thereby regulating numerous physiological functions(e.g., energy homeostasis, glucose-dependent insulin secretion, as well as appetite and weight control). Amongst the incretin/GLP-1 mimetics class of anti-T2 D drugs with an increasingly described neuroprotective potential, the already marketed liraglutide emerged as a GLP-1R agonist highly resistant to dipeptidyl peptidase-4 degradation(thereby having an increased half-life) and whose systemic GLP-1R activity is comparable to that of native GLP-1. Importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against T2 D, stroke and Alzheimer disease(AD), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in AD biomarkers. Herein, we discuss the GLP-1 action through the gut-brain axis, the hormone's regulation of some autonomic functions and liraglutide's neuroprotective potential. | Emanuel Monteiro Candeias Inês Carolina Sebastio Susana Maria Cardoso Sónia Catarina Correia Cristina Isabel Carvalho Ana Isabel Plácido Maria Sancha Santos Catarina Resende Oliveira Paula Isabel Moreira Ana Isabel Duarte | 2015 | World Journal of Diabetes2015，6，6： | 9 |
| 2 | Clinical implication of 14-3-3 epsilon expression in gastric cancer显示文摘AIM:To evaluate for the first time the protein and mRNA expression of 14-3-3εin gastric carcinogenesis.METHODS:14-3-3εprotein expression was determined by western blotting,and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples.RESULTS:Authors observed a significant reduction of 14-3-3εprotein expression in gastric cancer(GC)samples compared to their matched non-neoplastic tissue.Reduced levels of 14-3-3εwere also associated with diffuse-type GC and early-onset of this pathology.Our data suggest that reduced 14-3-3εmay have a role in gastric carcinogenesis process.CONCLUSION:Our results reveal that the reduced 14-3-3εexpression in GC and investigation of 14-3-3ε interaction partners may help to elucidate the carcino-genesis process. | Mariana Ferreira Leal Danielle Queiroz Calcagno Smia Demachki Paulo Pimentel Assumpo Roger Chammas Rommel Rodríguez Burbano Marília de Arruda Cardoso Smith | 2012 | World Journal of Gastroenterology2012，18，13： | 6 |
| 3 | Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy显示文摘Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric alterations.It occurs in acute and chronic hepatic disease and also in patients with portosystemic shunts.The presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver depuration.Therefore,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a contraindication.In this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic shunt.Case report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant factors.She had a wide portosystemic shunt and also portal vein thrombosis.The abdominal angiography confirmed the splenorenal shunt and showed other shunts.The larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt HE.There was a little increase of esophageal and gastric varices,but no endoscopic treatment was needed.Since portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt embolization.However,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE recovery.In conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis.As the patient had other shunts,she was successfully treated by embolization of the larger shunt. | Letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 4 | Tracheobronchial Polyflex stents for the management of benign refractory hypopharyngeal strictures显示文摘AIM:To describe a modified technique for placement of a tracheobronchial self-expanding plastic stent(SEPS) in patients with benign refractory hypopharyngeal strictures in order to improve dysphagia and allow stricture remodeling.METHODS:A case series of four consecutive patients with complex hypopharyngeal strictures after combinedtherapy for laryngeal cancer,previously submitted to multiple sessions of dilation without lasting improvement,is presented.All patients underwent placement of a small diameter and unflared tracheobronchial SEPS.Main outcome measurements were improvement of dysphagia and avoiding of repeated dilation.RESULTS:The modified introducer system allowed an easy and technically successful deployment of the tracheobronchial Polyflex stent through the stricture.All four patients developed complications related to stent placement.Two patients had stent migration(one proximal and one distal),two patients developed phanryngocutaneous fistulas and all patients with stents in situ for more than 8 wk had hyperplastic tissue growth at the upper end of the stent.Stricture recurrence was observed at 4 wk follow-up after stent removal in all patients CONCLUSION:Although technically feasible,placement of a tracheobronchial SEPS is associated with a high risk of complications.Small diameter stents must be kept in place for longer than 3 mo to allow adequate time for stricture remodeling. | Rui Almeida Silva Nuno Mesquita Pedro Pimentel Nunes Elisabete Cardoso Ricardo Marcos Pinto Luís Moreira Dias | 2012 | World Journal of Gastroenterology2012，18，6： | 2 |
| 5 | Blind Source Separadon--Semiparametric Statistical Approach显示文摘 | Amari S I Cardoso J F | 1997 | IEEE Tram on Signal Processing1997，45，11： | 1 |
| 6 | Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor显示文摘 | Wu Y Sun H Basta-Pljakic J Cardoso L Kennedy OD Jasper H Domene H Karabatas L Guida C Schaffler MB Rosen CJ Yakar S | | 0，，： | 1 |
| 7 | The electronic properties of sputtered chromium and iron oxide films显示文摘 | G Goodlet S Faty S Cardoso P.P Freitas A.M.P Sim?es M.G.S Ferreira M Da Cunha Belo | 2003 | Corrosion Science2003，，6： | 1 |
| 8 | Biocontrol of sheath blight by Trichoderma asperellum in tropical lowland rice 显示文摘 | de Fran~a S K S Cardoso A F Lustosa D C | 2015 | Agronomy for Sustainable Development2015，35，1： | 1 |
| 9 | Ecological quality assessment of small estuaries from the Portuguese coast based on fish assemblages indices显示文摘 | Inês Cardoso Miguel Pessanha Pais Sofia Henriques Luís Cancela da Fonseca Henrique N. Cabral | 2011 | Marine Pollution Bulletin2011，，5： | 1 |
| 10 | Electric power transmission at voltages of 1 000kV AC or ±600kV DC and above 显示文摘 | Manzoni G Annestrand S A Cardoso R etal | 1989 | Electra1989，，122： | 1 |
| 11 | Posttraumatic hydrocephalus:a respective review显示文摘 | Cardoso E R Galbraith S | 1985 | Surg Neurol1985，23，： | 1 |
| 12 | Distributions of indoor and outdoor air pollutants in Rio de Janeiro,Brazil:implications to indoor air quality in bayside offices显示文摘 | Brickus L S R Cardoso J N Neto F R D A | 1998 | Environ Sci Technol1998，32，： | 1 |
| 13 | The European Society of Breast Cancer Specialists recommendations for the management of young women with breast cancer显示文摘 | Cardoso F Loibl S Pagani O | 2012 | Eur J Cancer2012，48，18： | 1 |
| 14 | Validation of the determination of oxymetholone in human plasma analysis using gas chromatography-mass spectrometry Application to pharmacokinetic studies显示文摘 | Cardoso G R Marlice A Marques S | 2002 | Journal of Chromatography B2002，775，1： | 1 |
| 15 | A rapid and sensitive method for dimethylsulphide analysis in Brazilian sugar cane sugar spirits and other distilled beverages显示文摘 | CARDOSO D R ANDRADE-SOBRINHO L G A LIMA-NETO B S | 2004 | Journal of the Brazilian Chemical Society2004，15，2： | 1 |
| 16 | Biochemical and genetic characterization of the pathways for trehalose metabolism in Propionibacterium freudenreichii, and their role in stress response显示文摘 | Cardoso F S Castro R Borges N | 2007 | Microbiology2007，153，1： | 1 |
| 17 | Extraction and re- extraction of phenylalanine by cationic reversed micelles in hollow fibre contactors显示文摘 | CARDOSO M M VIEGAS R M C CRESPO J P S G | 1999 | Journal of Membrane Scince1999，156，2： | 1 |
| 18 | Preliminary in-hospital experience with a fully automatic external cardiover terdefibril lator显示文摘 | Bento AM Cardoso LF Timerman S | 2004 | Resuscitation2004，63，1： | 1 |
| 19 | Scalar, electromagnetic, and Weyl perturbations of BTZ black holes: Quasinormal modes显示文摘 | CARDOSO V LEMOS J P S | 2001 | Phys Rev D2001，63，12： | 1 |
| 20 | Posttraumatic hydrocephalus:a respective review显示文摘 | Cardoso ER Galbraith S | 1985 | Surg Neurol1985，23，： | 1 |
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