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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 3 | Phenotypic and genotypic differentiation of porcine Salmonella enterica sub spenterica serovar derby isolates显示文摘 | Michael G B Cardoso M Rabsch W | 2006 | Vet Microbiol2006，118，34： | 1 |
| 4 | Safety of blood products derived from plasma pool: The positive impact of anti-HCV screening on the quality of such products显示文摘 | Da Silva Cardoso M | 1996 | Vox Sang1996，71，3： | 1 |
| 5 | Evaluation of HSV-tk gene therapy in a rat model of chemically induced hepatocellular carcinoma by intratumoral and intrahepatic artery routes显示文摘 | Gerolami R Cardoso J Lewin M | | 0，，： | 1 |
| 6 | The electronic properties of sputtered chromium and iron oxide films显示文摘 | G Goodlet S Faty S Cardoso P.P Freitas A.M.P Sim?es M.G.S Ferreira M Da Cunha Belo | 2003 | Corrosion Science2003，，6： | 1 |
| 7 | Profile of microbial communities present in tibico(sugary kefir)grains from different Brazilian States显示文摘 | da CP MIGUEL M G CARDOSO P G MAGALHES K T | 2011 | World Journal of Microbiology and Biotechnology2011，27，8： | 1 |
| 8 | An imprinted antisense RNA overlaps UBE3A and a second maternally expressed transcript 显示文摘 | Rougeulle C Cardoso C Fontes M | 1998 | Nat Genet1998，19，1： | 1 |
| 9 | The mixing of liquids by a plume of low-Reynolds number bubbles显示文摘 | Cardoso SSS | 2000 | Chemical Engineering Science2000，55，14： | 1 |
| 10 | Identification of a low-risk subgroup of HER-2-positive breast cancer by the 70-gene prognosis signature显示文摘 | Knauer M Cardoso F Wesseling J | 2010 | Br J Cancer2010，103，12： | 1 |
| 11 | A blind source separation technique using second-order Statistics 显示文摘 | BELOOUCHRANI A KARIM A M CARDOSO J F | 1997 | IEEE Trans Signal Process1997，45，2： | 1 |
| 12 | Effect of transglutaminaseand carrageenan on restructured fish products containing dietaryfibres 显示文摘 | Cardoso C Mendes R Nunes M L | 2007 | International Journal of Food Science and Technology2007，42，： | 1 |
| 13 | Non-in- flammatory destructive periodontal disease : a clinical, mi- crobiological, immunological and genetic investigation 显示文摘 | Repeke C E Cardoso C R Claudino M | 2012 | Journal of Application Oral Science2012，20，1： | 1 |
| 14 | Plantain and ba- nana starches:granule structural characteristics explain the differences in their starch degradation patterns 显示文摘 | Soares C A Peroni-Okita F H G Cardoso M B | 2011 | J Agric Food Chem2011，59，12： | 1 |
| 15 | Topoisomerase-II alpha expression as a predictive marker in a populationof advanced breast cancer patients randomly treated eitherwith single-agent doxorubicin or single-agent docetaxel显示文摘 | Durbecq V Paesmans M Cardoso F | 2004 | Mol Cancer Ther2004，3，10： | 1 |
| 16 | Extraction and re- extraction of phenylalanine by cationic reversed micelles in hollow fibre contactors显示文摘 | CARDOSO M M VIEGAS R M C CRESPO J P S G | 1999 | Journal of Membrane Scince1999，156，2： | 1 |
| 17 | The use of the instantaneous-reactive-power signature analysis for rotorcage-fault diagnostics in three-phase induction motors显示文摘 | Mhamed D Cardoso A J M | | 0，，11： | 1 |
| 18 | Development of a healthylow-fat fishsausage containing dietary fibre 显示文摘 | Cardoso C Mendes R Nunes M L | 2008 | InternationalJournal of Food Science andTechnology2008，43，： | 1 |
| 19 | On-line fault detectionof aluminium electrolytic capacitors in step-down DC-DCconverters using input current and output voltage ripple显示文摘 | Amaral A M R Cardoso A J M | 2012 | IET Power Electronics2012，5，3： | 1 |
| 20 | Traumatized permanent teeth in Brazilian children assisted at the Federal University of Santa Catarina, Brazil 显示文摘 | Rocha MJ Cardoso M | 2001 | Dent Traumatol2001，17，6： | 1 |
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