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| 1 | Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases显示文摘AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific probes.RESULTS:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy population.In NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver disease.However,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory alterations.The linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of NAFLD.CONCLUSION:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis. | Johannes W Rey Andrea Noetel Aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans Peter Dienes Uta Drebber Margarete Odenthal | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 2 | Intraperitoneal chemotherapy and its evolving role in management of gastric cancer with peritoneal metastases显示文摘Advanced gastric cancer(GC) has been recognized as lethal disease when peritoneal metastases(PM) occurred.There is no standard treatment for advanced GC with PM.Until 1980s,the therapeutic arena for these patients had remained stagnant,with no therapeutic approach having shown a survival gain in GC with PM.However,cytoreductive surgery(CRS) with peritonectomy procedures and intraperitoneal chemotherapy(IPC) promising new combined therapeutic approach to achieve disease control for GC with PM.The recent publications changed the GC with PM treatment landscape by providing an evidence that CRS and IPC led to prolongation in overall survival(OS).This review will provide an overview of the evolving role of CRS and IPC in the management of advanced GC with PM in the current era. | Emel Canbay Yutaka Yonemura Bjorn Brucher Seung Hyuk Baik Paul H.Sugarbaker | 2014 | Chinese Journal of Cancer Research2014，26，1： | 10 |
| 3 | Potential triggering factors of acute liver failure as a first manifestation of autoimmune hepatitis-a single center experience of 52 adult patients显示文摘AIM To investigate potential triggering factors leading to acute liver failure(ALF) as the initial presentation of autoimmune hepatitis(AIH).METHODS A total of 565 patients treated at our Department between 2005 and 2017 for histologically-proven AIH were retrospectively analyzed. However, 52 patients(9.2%) fulfilled the criteria for ALF defined by the 'American Association for the Study of the Liver(AASLD)'. According to this definition, patients with 'acute-on-chronic' or 'acute-on-cirrhosis' liver failure were excluded. Following parameters with focus on potential triggering factors were evaluated: Patients' demographics, causation of liver failure, laboratory data(liver enzymes, MELD-score, autoimmune markers, virus serology), liver histology, immunosuppressive regime, and finally, outcome of our patients.RESULTS The majority of patients with ALF were female(84.6%) and mean age was 43.6 ± 14.9 years. Interestingly, none of the patients with ALF was positive for antiliver kidney microsomal antibody(LKM). We could identify potential triggering factors in 26/52(50.0%) of previously healthy patients presenting ALF as their first manifestation of AIH. These were drug-induced ALF(57.7%), virus-induced ALF(30.8%), and preceding surgery in general anesthesia(11.5%), respectively. Unfortunately, 6 out of 52 patients(11.5%) did not survive ALF and 3 patients(5.7%) underwent liver transplantation(LT). Comparing data of survivors and patients with non-recovery following treatment, MELDscore(P < 0.001), age(P < 0.05), creatinine(P < 0.01), and finally, ALT-values(P < 0.05) reached statistical significance. CONCLUSION Drugs, viral infections, and previous surgery may trigger ALF as the initial presentation of AIH. Advanced age and high MELD-score were associated with lethal outcome. | Matthias Buechter Paul Manka Falko Markus Heinemann Monika Lindemann Hideo Andreas Baba Martin Schlattjan Ali Canbay Guido Gerken Alisan Kahraman | 2018 | World Journal of Gastroenterology2018，24，13： | 8 |
| 4 | Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells显示文摘AIM To examine the influence on apoptotic mechanisms following inhibition of polo-like kinases as therapeuticallyapproach for cholangiocellular cancer treatment. METHODS As most cholangiocarcinomas are chemotherapyresistant due to mechanisms preventing tumor cell death, we investigated the effect of Cisplatin on cholangiocellular carcinoma(CCA) cell lines KMCH-1 and Mz-Ch-1. Polo-like kinases(PLK) are important regulators of the cell cycle and their inhibition is discussed as a potential therapy while PLK inhibition can regulate apoptotic mediators. Here, cells were treated with PLK inhibitor BI6727(Volasertib), Cisplatin, and in combination of both compounds. Cell viability was assessed by MTT; apoptosis was measured by DAPI staining and caspase-3/-7 assay. Western blot and q RT-PCR were used to measure expression levels of apoptosis-related molecules Bax and Bcl-2. RESULTS The cell viability in the CCA cell lines KMCH-1 and Mz-Ch-1 was reduced in all treatment conditions compared to vehicle-treated cells. Co-treatment with BI6727 and cisplatin could even enhance the cytotoxic effect of cisplatin single treatment. Thus, co-treatment of cisplatin with BI6727 could slightly enhance the cytotoxic effect of the cisplatin in both cell lines whereas there was evidence of increased apoptosis induction solely in Mz-Ch-1 as compared to KMCH-1. Moreover, PLK inhibition decreases protein levels of Bcl-2; an effect that can be reversed by the proteasomal degradation inhibitor MG-132. In contrast, protein levels of Bax were not found to be altered by PLK inhibition. These findings indicate that cytotoxic effects of Cisplatin in Mz-Ch-1 cells can be enhanced by co-treatment with BI6727.CONCLUSION In conclusion, BI6727 treatment can sensitize CCA cells to cisplatin-induced apoptosis with proteasomal Bcl-2 degradation as an additional pro-apoptotic effect. | Svenja Sydor Sami Jafoui Lena Wingerter Sandra Swoboda Joachim C Mertens Guido Gerken Ali Canbay Andreas Paul Christian D Fingas | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 5 | Extrahepatic complications of nonalcoholic fatty liver disease显示文摘 | Matthew J. Armstrong Leon A. Adams Ali Canbay Wing‐Kin Syn | 2014 | Hepatology2014，，： | 2 |
| 6 | Endoscopic treatment of pediatric post‐transplant biliary complications is safe and effective显示文摘 | Alexander Dechêne Cathrin Kodde Simone Kathemann Jürgen Treckmann Elke Lainka Andreas Paul Guido Gerken Ariel E. Feldstein Peter F. Hoyer Ali Canbay | 2015 | Digestive Endoscopy2015，，4： | 2 |
| 7 | Gastric Necrosis and Perforation Caused by Acute Gastric Dilatation: Report of a Case显示文摘 | Mustafa Turan Metin ?en Emel Canbay Kursat Karadayi Esin Yildiz | 2003 | Surgery Today2003，，4： | 2 |
| 8 | Preoperative Carcinoembryonic Antigen Level Predicts Prognosis in Patients with Pseudomyxoma Peritonei Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy显示文摘 | Emel Canbay Haruaki Ishibashi Shouzou Sako Akiyoshi Mizumoto Masamitsu Hirano Masumi Ichinose Nobuyuki Takao Yutaka Yonemura | 2013 | World Journal of Surgery2013，，6： | 2 |
| 9 | Differentiating a large abdominal cystic lymphangioma from multicystic mesothelioma: report of a case显示文摘 | Hiroshi Nagata Yutaka Yonemura Emel Canbay Haruaki Ishibashi Makoto Narita Makio Mike Nobuyasu Kano | 2014 | Surgery Today2014，，7： | 2 |
| 10 | Ketarnine , but not priming, improves intubating conditions during a propofol-rocuronium induction显示文摘 | TOPCUOGLU P T UZUN S CANBAY 0 et a1 | 2010 | Can J Anest h2010，57，2： | 1 |
| 11 | Free fatty acids promotes hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway显示文摘 | FELDSTEIN A E WERNEBURG N W CANBAY A | 2004 | Hepatology2004，40，18： | 1 |
| 12 | the nexus ofliver injury and fibrosis显示文摘 | Canbay A Friedman S Gores GJ | | Hepatology0，39，： | 1 |
| 13 | Free fatty acids promote hepatic iipotoxicity by stimulating TNF alpha expression via a lysosomal pathway显示文摘 | Feldstein AE Werneburg NW Canbay A | 2004 | Hep- atology2004，40，1： | 1 |
| 14 | Persistently altered visceral perception after resection of an esophageal granular cell myoblastoma:a therapeutic concept revisited显示文摘 | Canbay A Gieseler RK Hoffmann P | 2003 | Z Gastroenterol2003，41，9： | 1 |
| 15 | Magnetic susceptibility and heavy-metal contamination in topsoils along the Izmit Gulf coastal area and Izaytas (Turkey) 显示文摘 | CANBAY M AYDIN A KURTULUS C | 2010 | Journal Applied Geophys- ical2010，70，6： | 1 |
| 16 | Apoptosis:the nexus of liver injury and fibrosis显示文摘 | Friedman S Gores GJ | 2004 | Hepatology2004，39，： | 1 |
| 17 | Hepalecyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis显示文摘 | Feldstein AE Canbay A Angulo P | 2003 | Gastroenterology2003，125，： | 1 |
| 18 | Free fatty acids promote hepatic iipotoxicity by stimulating TNF alpha expression via a lysosomal pathway显示文摘 | Feldstein AE Werneburg NW Canbay A | 2004 | Hepatology2004，40，1： | 1 |
| 19 | Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis显示文摘 | Feldstein AE Canbay A Angulo P | 2003 | Gastroenterology2003，125，2： | 1 |
| 20 | Apoptosis:the nexus of liver injury and fibrosis显示文摘 | Friedmans Gores GJ | 2004 | Hepatology2004，38，2： | 1 |
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