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| 1 | Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model显示文摘Objective: To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis(CBP) rat model.Methods: The SpragueDawley rats were divided into 4 groups,including control,ciprofloxacin,anthocyanins and anthocyanins with ciprofloxacin groups(n=8 in each group).Then,drip infusion of bacterial suspension(Escherichia coli Z17O_2:K_1:H^-) into Sprague-Dawley rats was conducted to induce CBP.In 4 weeks,results of prostate tissue,urine culture,and histological analysis on the prostate were analyzed for each group.Results: The use of ciprofloxacin,anthocyanins,and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group(P<0.05).The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group(P<0.05).Conclusions: These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects,as well as a synergistic effect with ciprofloxacin.Therefore,we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success. | Byung Il Yoon Woong Jin Bae Yong Sun Choi Su Jin Kim U Syn Ha Sung-Hoo Hong Dong Wan Sohn Sae Woong Kim | 2018 | Chinese Journal of Integrative Medicine2018，24，8： | 11 |
| 2 | Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans显示文摘 | Omenetti Alessia Porrello Alessandro Jung Youngmi Yang Liu Popov Yury Choi Steve S Witek Rafal P Alpini Gianfranco Venter Juliet Vandongen Hendrika M Syn Wing-Kin Baroni Gianluca Svegliati Benedetti Antonio Schuppan Detlef Diehl Anna Mae | 2008 | Journal of Clinical Investigation2008，，10： | 3 |
| 3 | Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria:a meta-analysis of 18,421 patients显示文摘Background:Outcomes after liver resection(LR)and liver transplantation(LT)for hepatocellular carcinoma(HCC)are heterogenous and may vary by region,over time periods and disease burden.We aimed to compare overall survival(OS)and disease-free survival(DFS)between LT versus LR for HCC within the Milan criteria.Methods:Two authors independently searched Medline and Embase databases for studies comparing survival after LT and LR for patients with HCC meeting the Milan criteria.Meta-analyses and meta-regression were conducted using random-effects models.Results:We screened 2,278 studies and included 35 studies with 18,421 patients.LR was associated with poorer OS[hazard ratio(HR)=1.44;95%confidence interval(CI):1.14-1.81;P<0.01]and DFS(HR=2.71;95%CI:2.23-3.28;P<0.01)compared to LT,with similar findings among intention-to-treat(ITT)studies.In uninodular disease,OS in LR was comparable to LT(P=0.13)but DFS remained poorer(HR=2.95;95%CI:2.30-3.79;P<0.01).By region,LR had poorer OS versus LT in North America and Europe(P≤0.01),but not Asia(P=0.25).LR had inferior survival versus LT in studies completed before 2010(P=0.01),but not after 2010(P=0.12).Cohorts that underwent enhanced surveillance had comparable OS after LT and LR(P=0.33),but cohorts undergoing usual surveillance had worse OS after LR(HR=1.95;95%CI:1.24-3.07;P<0.01).Conclusions:Mortality after LR for HCC is nearly 50%higher compared to LT.Survival between LR and LT were similar in uninodular disease.The risk of recurrence after LR is threefold that of LT. | Jin Hean Koh Darren Jun Hao Tan Yuki Ong Wen Hui Lim Cheng Han Ng Phoebe Wen Lin Tay Jie Ning Yong Mark D.Muthiah Eunice X.Tan Ning Qi Pang Beom Kyung Kim Nicholas Syn Alfred Kow Brian K.P.Goh Daniel Q.Huang | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 3 |
| 4 | Extrahepatic complications of nonalcoholic fatty liver disease显示文摘 | Matthew J. Armstrong Leon A. Adams Ali Canbay Wing‐Kin Syn | 2014 | Hepatology2014，，： | 2 |
| 5 | Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease显示文摘 | Wing–Kin Syn Youngmi Jung Alessia Omenetti Manal Abdelmalek Cynthia D. Guy Liu Yang Jiangbo Wang Rafal P. Witek Caitlin M. Fearing Thiago A. Pereira Vanessa Teaberry Steve S. Choi J. Conde–Vancells Gamze F. Karaca Anna Mae Diehl | 2009 | Gastroenterology2009，，4： | 2 |
| 6 | Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice显示文摘 | Bego?a Ochoa Wing‐Kin Syn Igotz Delgado Gamze F. Karaca Youngmi Jung Jiangbo Wang Ana M. Zubiaga Olatz Fresnedo Alessia Omenetti Marzena Zdanowicz Steve S. Choi Anna Mae Diehl | 2010 | Hepatology2010，，： | 2 |
| 7 | Mechanical stability of retained austenite in tempered 9Ni steel 显示文摘 | Syn C K Fultz B Morris J W | 1978 | Metallurgical Transactions A1978，9，11： | 1 |
| 8 | Leptin promotes the myofibroblas- tic phenotype in hepatic stellate cells by activating the hedgehog path- way显示文摘 | Choi SS Syn WK Karaea GF | 2010 | J Biol Chem2010，285，36： | 1 |
| 9 | Modifica- tions in energy demand in urban areas as aresult of climate changes: an assessment for thesoutheast Mediterranean region显示文摘 | CARTALIS C SYN DIN u A PROEDROU M | 2001 | Energy Conversion&Management2001，42，14： | 1 |
| 10 | Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy显示文摘 | SWlDERSKA-SYN M SYN WK XIE G | 2014 | Gut2014，63，8： | 1 |
| 11 | Mechanical stability of retained austenite in tempered 9Ni steel显示文摘 | Syn C K Jin S Morris J W | 1978 | Metallurgical Transactions A1978，，11： | 1 |
| 12 | Hedgehog signaling is criti- cal for normal liver regeneration after partial hepatectomy in mice 显示文摘 | Ochoa B Syn W K Delgado I | 2010 | Hepatol2010，51，5： | 1 |
| 13 | A scalable protocol for the isolation of largesized genomic DNA within an hour from several bacteria显示文摘 | SYN C K C SWARUP S | 2000 | Analytical Biochemistry2000，278，1： | 1 |
| 14 | Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway显示文摘 | CHOI S S SYN W K KARACA G F | 2010 | J Biol Chem2010，285，36： | 1 |
| 15 | Hedgehog-mediated epithe- lial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease显示文摘 | Syn W K Jung Y Omenetti A | 2009 | Gastroenterol2009，137，4： | 1 |
| 16 | Inhibition of Proliferation of Prostate Cancer Cell Line DU-145 in vitro and in vivo Using Salvia miltiorrhiza Bunge显示文摘Objective:To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge.(SM)on the castration-resistant prostate cancer(CRPC)cell line DU-145 in vitro and in vivo.Methods:Prostate cancer cell line(DU-145)and normal prostate cell line(RWPE-1)were treated with SM at different concentrations(3.125,12.5,25 and 50μg/mL)to investigate the antiproliferative effects.DNA laddering analysis was performed to investigate the apoptosis of DU-145 cells.Molecular mechanism was investigated by Western blot analysis of p53,Bcl-2,prostate specific antigen(PSA),and androgen receptor(AR).Six-week-old male BALB/c nude mice were randomly divided into normal control group(n=101)and treated group(n=101)which administered 500 mg/kg SM for 2 weeks.Tumor volumes were measured.Results:Treatment with SM resulted in a dose-dependent decrease in cell number of DU-145 cells in comparison with RWPE-1.DNA laddering analysis indicated the apoptosis of DU-145 cells.Treatment with SM increased the expression of p53 and reduced the expression of Bcl-2 proteins.The levels of PSA were considerably reduced in SM-treated group compared to the controls,and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in PSA.In the tumour xenograft study,SM given once a day for 2 weeks significantly inhibited tumour growth.Conclusion:SM might contribute to the anticancer actions such as induction of apoptosis and inhibition of proliferation of prostate cancer cells. | Woong Jin Bae Jin Bong Choi Kang Sup Kim U Syn Ha Sung Hoo Hong Ji Youl Lee Tae-Kon Hwang Sung Yeoun Hwang WANG Zhi-ping Sae Woong Kim | 2020 | Chinese Journal of Integrative Medicine2020，26，7： | 1 |
| 17 | Leptin promotes the myof- ibroblastic phenotype in hepatic stellate ceils by activating the hedge- hog pathway显示文摘 | Choi SS Syn WK Karaca GF | 2010 | The Journal of biological chemistry2010，，36： | 1 |
| 18 | PerSonal documentation on a social network site: Facebook, a collection of momenls from your tife?显示文摘 | Sinn D Syn S Y | 2014 | Archival Science2014，14，2： | 1 |
| 19 | Personal records on the web: Who's in charge of archiving, Hotmail or archivists? 显示文摘 | Sinn Donghee Syn Sue Yeon Kim Sung-Min | 2011 | Library & Information Science Research2011，33，4： | 1 |
| 20 | Surface morphology effects on high-rate fracture of an aluminum/epoxy interface显示文摘 | Syn C J Chen W W | 2008 | J Compos Mater2008，42，16： | 1 |
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