|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antibiotics and probiotics in treatment of inflammatory bowel disease显示文摘许多试验性、临床的观察建议肠的微植物群在煽动性的肠疾病(IBD ) 的致病起一个潜在的作用。用抗菌素或职业人员生命学的钠内容的操作代表一种潜在地有效的治疗学的选择。可得到的研究不在 ulcerative (UC ) 支持抗菌素的使用。抗菌素在对待是有效的腐败 Crohn 的疾病(CD ) 的复杂并发症但是他们主要治疗是更争论的使用,尽管这条途径经常并且成功地在临床的实践被采用。有证据关於生命的治疗可以是的那个职业人员在预防和处理有效对中等 UC 温和。相反,成功的学习数据的缺乏目前预防在 CD 的处理的专业版生命学的普遍使用。抗菌素和职业人员生命学看起来在 pouchitis 的处理和预防起一个有益的作用,进一步的审判被保证充分确定他们的临床的功效。 | Paolo Gionchetti Fernando Rizzello Karen M Lammers Claudia Morselli Lucia Sollazzi Samuel Davies Rosy Tambasco Carlo Calabrese Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，21： | 12 |
| 2 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 3 | Lactobacilli,bifi dobacteria and E.coli nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells显示文摘AIM: To investigate whether the stimulation of peripher- al blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specifi c. METHODS: Three strains of bifi dobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centri- fuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 102 to 108 CFU/mL. Cell supernatants were taken and interleukin (IL)-10, IL-1β, and tumor necosis factor (TNF)-α were determined by ELISA. RESULTS: Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bifidobacteriaand lactobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had simi- lar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifi dobacteria and lactobacilli. The cell debris of bifi dobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentra- tions were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION: The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specifi c reactions. High IL-10 response to cell de- bris of bifi dobacteria and E. coli nissle can be found. This corresponds to positive effects of bifi dobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactoba- cilli. | Ulf Helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 4 | Effects of probiotic bacteria on gastrointestinal motility in guinea-pig isolated tissue显示文摘AIM: To evaluate the intestinal motility changes evoked by 8 bacterial strains belonging to Bifidobacterium , Lactobacillus and Streptococcus genera within the probiotic preparation VSL#3. METHODS: Ileum and proximal colon segments isolated from guinea-pigs were used as a study model. Entire cells and cell fractions (cell debris, cell wall fraction, cytoplasmatic fraction, proteinaceous and non- proteinaceous cytoplasmatic components) of VSL#3 strains and, as controls, Escherichia coli, Salmonella aboni and Bacillus licheniformis were tested in this in vitro model. RESULTS: Among the bacterial cell fractions tested, only the cytoplasmatic fraction modified intestinal motility. Lactobacillus strains stimulated the contraction of ileum segment, whereas all probiotic strains tested induced proximal colon relaxation response. The non-proteinaceous cytoplasmatic components were responsible for the colon relaxation. CONCLUSION: The results obtained in this study suggest that the proximal colon relaxation activity showed by the probiotic bacteria could be one of the possible mechanisms of action by which probiotics exert their positive effects in regulating intestinal motility. | Matteo Massi Pierfranco Ioan Roberta Budriesi Alberto Chiarini Beatrice Vitali Karen M Lammers Paolo Gionchetti Massimo Campieri Anthony Lembo Patrizia Brigidi | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 5 | Bacteria as the cause of ulcerativecolitis显示文摘 | Gionchetti P | 2001 | Gut2001，48，： | 1 |
| 6 | Reduction of oxaluria after an oral course of lactic acid bacteria at high concentration显示文摘 | Campieri C Campieri M Bertuzzi V | 2001 | Kidney Int2001，60，3： | 1 |
| 7 | Beclomethasone dipropionate enemas versus prednisolone sodium phosphate enemas in the treatment of distal ulcerative colitis显示文摘 | CAMPIERI M COTTONE M MIGLIO F | 1998 | Alimnet Pharmacol Ther1998，12，4： | 1 |
| 8 | Reduction of oxaluria after an oral course of lactic acid bacteria at high concen- tration显示文摘 | CAMPIERI C CAMPIERI M BERTUZZI V | 2001 | Kidney Int2001，60，3： | 1 |
| 9 | Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease显示文摘 | Belluzzi A Brignola C Campieri M | 1996 | N Engl J Med1996，334，24： | 1 |
| 10 | Reduction of oxaluria after an oral course of lactic acid bacteria at high concentration显示文摘 | Campieri C Campieri M Bertuzzi V | 2001 | Kidney Int2001，60，3： | 1 |
| 11 | Bacteria as the cause of ulcertive colitis显示文摘 | Campieri M Gionehetti P | | 0，，： | 1 |
| 12 | New steroids and new salicylates in inflammatory bowel disease:a critical appraisal显示文摘 | Campieri M | | 0，，3： | 1 |
| 13 | Treatment of ulcerative colitis with high-dose 5-aminosalicyclic acid enemas显示文摘 | Campieri M Lanfranchi GA Bazzocchi G Brignola C Sarti F Franzin G Battocchia A Labo G Dal MontePR | 1981 | Lancet1981，45，8： | 1 |
| 14 | Reduction of oxaluria after an oral course of lactic acid bacteria at high concentration显示文摘 | Campieri C Campieri M Bertuzzi V | 2001 | Kidney Int2001，60，： | 1 |
| 15 | Reduction of oxaluria after an oral course of lactic acid bacteria at high concentration显示文摘 | Campieri C Campieri M Bertuzzi V et aI | 2001 | Kidney Int2001，60，3： | 1 |
| 16 | Optimun dosage of 5-aminoalicyclic acid as rectal enemas in patient with active ulcerative colitis显示文摘 | Campieri M Gionchetti P Benizzi A Brigola C Tampieri M Lannone P Miglioli M Barbara L | 1991 | Gut1991，32，8： | 1 |
| 17 | Beclomethasone dipropionate enemas versus prednisolone sodium phosphate enemas in the treatment of distal ulcerative colitis显示文摘 | Campieri M Cottone M Miglio F | 1998 | Aliment Pharmacol Ther1998，12，4： | 1 |
| 18 | Effect of an enteric- coated fish-oil preparation on relapses in Crohn's disease显示文摘 | Belluzzi A Brignola C Campieri M | 1996 | N Engl J Med1996，334，24： | 1 |
| 19 | Reduction of oxaluria after an oral course of lactic acid bacteria at high concentration 显示文摘 | Campieri C Campieri M Bertuzzi V | 2001 | Kidney international2001，60，3： | 1 |
| 20 | VSL#3 pro-biotic-mixture induces remission in patients with active ulcerative colitis 显示文摘 | Bibiloni R Fedorak RN Tannock GW Madsen KL Gionchetti P Campieri M Simone CD | 2005 | Am J Gastroenterol2005，100，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员