|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of vasculature damage on the outcome of spinal cord injury:a novel collagenase-induced model may give new insights into the mechanisms involved显示文摘The deleterious effect of vasculature damage on the outcome of spinal cord injury has long been recognized,and numerous clinical studies have shown that the presence of hemorrhage into the spinal cord is directly associated with a poorer neurological outcome.Vascular damage leads to decreased blood flow to the cord and the release of potentially toxic blood-borne components.Here we consider the mechanisms that may be contributing to hemorrhage-induced damage and discuss the utility of a new model of spinal cord hemorrhage,which was urgently required as most of our current understanding has been extrapolated from intracerebral hemorrhage studies. | Patrick Losey Daniel C.Anthony | 2014 | Neural Regeneration Research2014，9，20： | 2 |
| 2 | The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT 1A receptor显示文摘 | Shaun Jordan Vuk Koprivica Ruoyan Chen Katsura Tottori Tetsuro Kikuchi C.Anthony Altar | 2002 | European Journal of Pharmacology2002，，3： | 1 |
| 3 | Identification of Global DNA Methylation Signatures in Glioblastoma-Derived Cancer Stem Cells显示文摘Glioblastoma(GBM)is the most common and most aggressive primary brain tumor in adults.The existence of a small population of stem-like tumor cells that efficiently propagate tumors and resist cytotoxic therapy is one proposed mechanism leading to the resilient behavior of tumor cells and poor prognosis.In this study,we performed an in-depth analysis of the DNA methylation landscape in GBMderived cancer stem cells(GSCs).Parallel comparisons of primary tumors and GSC lines derived from these tumors with normal controls(a neural stem cell(NSC)line and normal brain tissue)identified groups of hyper- and hypomethylated genes that display a trend of either increasing or decreasing methylation levels in the order of controls,primary GBMs,and their counterpart GSC lines,respectively.Interestingly,concurrent promoter hypermethylation and gene body hypomethylation were observed in a subset of genes including MGMT,AJAP1 and PTPRN2.These unique DNA methylation signatures were also found in primary GBM-derived xenograft tumors indicating that they are not tissue culture-related epigenetic changes.Integration of GSC-specific epigenetic signatures with gene expression analysis further identified candidate tumor suppressor genes that are frequently down-regulated in GBMs such as SPINT2,NEFM and PENK.Forced re-expression of SPINT2 reduced glioma cell proliferative capacity,anchorage independent growth,cell motility,and tumor sphere formation in vitro.The results from this study demonstrate that GSCs possess unique epigenetic signatures that may play important roles in the pathogenesis of GBM. | Eun-Joon Lee Prakash Rath Jimei Liu Dungsung Ryu Lirong Pei Satish K.Noonepalle Austin Y.Shull Qi Feng N.Scott Litofsky Douglas C.Miller Douglas C.Anthony Mark D.Kirk John Laterra Libin Deng Hong-Bo Xin Xinguo Wang Jeong-Hyeon Choi Huidong Shi | 2015 | Journal of Genetics and Genomics2015，42，7： | 1 |
| 4 | Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain显示文摘 | C.Anthony Altar Richard E. Whitehead Ruoyan Chen Gitta W?rtwein Torsten M. Madsen | 2003 | Biological Psychiatry2003，，7： | 1 |
| 5 | Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor显示文摘 | Takeshi Nakahashi Hironobu Fujimura C.Anthony Altar Jess Li Jun-ichi Kambayashi Narendra N Tandon Bing Sun | 2000 | FEBS Letters2000，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员