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| 1 | 延胡索酸水合酶缺陷型肾细胞癌32例临床病理和分子分析显示文摘延胡索酸水合酶缺陷型肾细胞癌属于罕见的、新近发现的与遗传性平滑肌瘤病和肾细胞癌综合征相关的肿瘤实体。延胡索酸水合酶缺陷型肾细胞癌可表现出多种临床和病理学表现,但通常表现为局部进展和转移性疾病,预后较差。作者通过延胡索酸水合酶免疫组化和(或)延胡索酸水合酶突变分析确定32例延胡索酸水合酶缺陷型肾细胞癌,并对其临床和病理特征进行回顾性分析。 | Lau H D Chan E Fan A C 魏建国(摘译) 方三高(审校) | 2020 | 临床与实验病理学杂志2020，36，3： | 19 |
| 2 | 绕正方形排列的顺排的四个圆柱的流动研究显示文摘本文通过采用激光诱导荧关技术(LIF),对按正方形排列、边长间距比为4的顺排的四个圆柱的层流绕流进行了流动可视化研究;同时,在Re=200的情况下,对该流场进行了PIV流场测量,两种实验结果吻合良好,显示的都是只在下游圆柱的后面才有漩涡脱落。可是,采用两维有限体积法离散N-S方程计算该流场与实验结果完全不符合,原因尚不清楚。 | 李景银 K Lam K T Chan R M C So | 2004 | 工程热物理学报2004，25，1： | 14 |
| 3 | Inflammatory bowel disease in Asia: A systematic review显示文摘 | Lani Prideaux Michael A Kamm Peter P De Cruz Francis K L Chan Siew C Ng | 2012 | Journal of Gastroenterology and Hepatology2012，，8： | 5 |
| 4 | Epidemiology of Alzheimer’s disease and other forms of dementia in China, 1990–2010: a systematic review and analysis显示文摘 | Kit Yee Chan Wei Wang Jing Jing Wu Li Liu Evropi Theodoratou Josip Car Lefkos Middleton Tom C Russ Ian J Deary Harry Campbell Wei Wang Igor Rudan | 2013 | The Lancet . 2013 (9882)2013，，9882： | 5 |
| 5 | Current application of proteomics in biomarker discoveryfor inflammatory bowel disease显示文摘Recently, the field of proteomics has rapidly expanded in its application towards clinical research with objectives ranging from elucidating disease pathogenesis to discovering clinical biomarkers. As proteins govern and/or reflect underlying cellular processes, the study of proteomics provides an attractive avenue for research as it allows for the rapid identification of protein profiles in a biological sample. Inflammatory bowel disease(IBD) encompasses several heterogeneous and chronic conditions of the gastrointestinal tract. Proteomic technology provides a powerful means of addressing major challenges in IBD today, especially for identifying biomarkers to improve its diagnosis and management. This review will examine the current state of IBD proteomics research and its use in biomarker research. Furthermore, we also discuss the challenges of translating proteomic research into clinically relevant tools. The potential application of this growing field is enormous and is likely to provide significant insights towards improving our future understanding and management of IBD. | Patrick PY Chan Valerie C Wasinger Rupert W Leong | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 5 |
| 6 | Anti-rods/rings autoantibody generation in hepatitis Cpatients during interferon-α/ribavirin therapy显示文摘Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effective and less toxic therapeutic options, in most parts of the world the standard treatment consists of a weekly injection of pegylated interferon α(IFN-α) together with a daily dose of ribavirin. HCV patients frequently present circulating non-organ-specific autoantibodies demonstrating a variety of staining patterns in the indirect immunofluorescence assay for antinuclear antibodies(ANA). Between 20% to 40% of HCV patients treated with IFN-α and ribavirin develop autoantibodies showing a peculiar ANA pattern characterized as rods and rings(RR) structures. The aim of this article is to review the recent reports regarding RR structures and anti-rods/rings(antiRR) autoantibody production by HCV patients after IFN-α/ribavirin treatment. Anti-RR autoantibodies first appear around the sixth month of treatment and reach a plateau around the twelfth month. After treatment completion, anti-RR titers decrease/disappear in half the patients and remain steady in the other half. Some studies have observed a higher frequency of anti-RR antibodies in relapsers, i.e., patients in which circulating virus reappears after initially successful therapy. The main target of anti-RR autoantibodies in HCV patients is inosine-5'-monophosphate dehydrogenase 2(IMPDH2), the rate-limiting enzyme involved in the guanosine triphosphate biosynthesis pathway. Ribavirin is a direct IMPDH2 inhibitor and is able to induce the formation of RR structures in vitro and in vivo. In conclusion, these observations led to the hypothesis that anti-RR autoantibody production is a human model of immunologic tolerance breakdown that allows us to explore the humoral autoimmune response from the beginning of the putative triggering event: exposure to ribavirin and interferon. | Gerson Dierley Keppeke S John Calise Edward KL Chan Luis Eduardo C Andrade | 2016 | World Journal of Gastroenterology2016，22，6： | 4 |
| 7 | Consolidation and dynamics of 3D unsaturated porous seabed under rigid caisson breakwater loaded by hydrostatic pressure and wave显示文摘In this study,based on the dynamic Biot's theory 'u-p' approximation,a 3D finite element method(FEM) numerical soil model is developed,in which the Generalized Newmark-β method is adopted to determine the time integration.The developed 3D FEM soil model is a part of the coupled model PORO-WSSI 3D for 3D wave-seabed-marine structures interaction problem,and is validated by the analytical solution proposed by Wang(2000) for a laterally infinite seabed loaded by a uniform force.By adopting the developed 3D soil model,the consolidation of seabed under a caisson breakwater and hydrostatic pressure is investigated.The numerical results show that the caisson breakwater built on seabed has very significant effect on the stresses/displacements fields in the seabed foundation after the transient deformation and primary consolidation are completed.The parametric study indicates that the Young's modulus E of seabed is the most important parameter to affect the settlement of breakwater,and the displacement fields in seabed foundation.Taking the consolidation status as the initial condition,the interaction between ocean wave,caisson breakwater and seabed foundation is briefly investigated.The 3D ocean wave is determined by solving the Navier-Stokes equations with finite volume method(FVM).The numerical results indicate that there is intensive interaction between | YE JianHong JENG DongSheng CHAN A H C | 2012 | Science China(Technological Sciences)2012，55，8： | 4 |
| 8 | 皮肤病患者预防新型冠状病毒肺炎个人防护专家共识(第一版)显示文摘2019年12月以来,湖北省武汉市陆续出现新型冠状病毒感染引起的以肺部病变为主的新发呼吸道传染病,即新型冠状病毒肺炎(COVID-19),之后呈现快速蔓延.该病具有发病迅速、传染性强、病程变化快等特点,因此采取甲类传染病的预防、控制措施.当前全国正处于新型冠状病毒肺炎防控工作的紧张阶段,皮肤病患者多存在皮肤屏障功能受损情况,会增加易感性.因此,皮肤病患者的个人防护工作亦极为迫切.针对上述问题,我们组织美国、英国、澳大利亚,中国香港、中国澳门、中国台湾及中国多省市著名专家、教授联合编写了皮肤病患者个人防护专家共识,内容较为翔实,以满足当前抗击新型冠状病毒肺炎疫情工作的需要,帮助皮肤病患者更好地做好个人防护. | 无 邓列华 孙乐栋 曾凡钦 赵华 王宏伟 姜群 林泽 | 2020 | 暨南大学学报(自然科学与医学版)2020，41，2： | 4 |
| 9 | Consortium for the Human Information and Neurocognitive Endophenotype (CHINE) in China's Mainland: An example from neurological soft signs for neuropsychiatric disorders显示文摘Increasing efforts to identify alternate expressions of neuropsychiatric disorders that are broader than the DSM or ICD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional expressions of neuropsychiatric disorders may advance the search for underlying etiological or modulatory factors. Endophenotypic research can be considered to be one of the most promising strategies to bridge the gap between genomic complexity and the phenotypic heterogeneity observed in neuropsychiatric disorders. However, the majority of endophenotype studies were limited to our western counterparts, very little has been done and initiated by scholars in China's Mainland. In this paper, we urge the need to establish a potential central consortium for endophenotypes to study neuropsychiatric disorders in China's Mainland. In particular, we illustrate a potential example of neurological soft signs in following the steps for building the consortium. | CHAN Raymond C K | 2011 | Chinese Science Bulletin2011，56，32： | 3 |
| 10 | Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage显示文摘Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH. | Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 11 | 伴有浆细胞分化的套细胞淋巴瘤显示文摘 | Young K H Chan W C Fu K 黄文斌(摘译) | 2006 | 临床与实验病理学杂志2006，22，5： | 2 |
| 12 | A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings显示文摘The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011. | LUI Simon S Y SHAM Pak CHAN Raymond C K CHEUNG Eric F C | 2011 | Chinese Science Bulletin2011，56，32： | 2 |
| 13 | 一种模拟堆石料的二维多边形离散单元法及程序显示文摘在考虑堆石料真实颗粒形状的基础上,将每个颗粒用一个多边形离散单元表示,基于一种线性搜索算法对多边形-多边形之间的接触详情进行检索计算,引入基于势能原理的法向多边形-多边形接触模型及切向库仑摩擦模型,形成了一种多边形离散元计算方法,并开发了相应的PDEM程序。可以从颗粒尺度层面展示颗粒之间的相互作用以及每个颗粒的位移和转动,帮助进一步揭示颗粒的细观特性(形状、大小、材料特性等)对堆石料的宏观强度和变形的影响。最后采用PDEM程序对某粗粒料的二维模型试验进行了数值模拟,得到了与室内试验一致的应力变形规律,展现了其方法和程序用于研究堆石料的有效性。 | 罗滔 OOI E T CHAN A H C 傅少君 | 2017 | 岩土力学2017，38，3： | 2 |
| 14 | 基于二阶矩燃烧模型的液雾燃烧大涡模拟显示文摘采用亚网格动能(k方程)应力模型、二阶矩(SOM)燃烧模型和欧拉拉氏两相流模型,对乙醇-空气液雾燃烧进行了大涡模拟(LES)。瞬态结果显示:在火焰的高温区域,旋涡强度较大;在高温区边缘附近存在的拟序结构有脱落的趋势。在燃烧装置的燃料进口附近,近喷嘴中心区域,大量液滴聚集在条状湍流拟序结构的周围。LES模拟的统计结果给出的温度分布与实验结果吻合较好。说明SOM燃烧模型适用于液雾两相湍流燃烧研究,计算结果经过和实验数据对比发现,LES-SOM燃烧模型优于RANS-PDF及LES-FA计算结果。数值计算结果与实验结果的误差主要是由于采用统观一步反应机理引起的,表明燃烧模型还有待进一步改进。 | 李科 周力行 CHAN C K | 2012 | 工程热物理学报2012，33，3： | 2 |
| 15 | Effect of fiber pretreatment condition on the interfacial strength and mechanical properties of wood fiber/PP composites显示文摘 | Wu J S Yu D M Chan C M | 2000 | J Appl Polym Sci2000，76，7： | 2 |
| 16 | Clay strength under earthquake loading conditions显示文摘 | Seed H B Chan C K | 1966 | Journal of the soil mechanics and foundations division1966，2，： | 2 |
| 17 | Origin and therapy for hypertriglyceridaemia in type 2 diabetes显示文摘Hypertriglyceridaemia(HTG) is a risk factor for cardiovascular disease(CVD) in type 2 diabetes and is caused by the interaction of genes and non-genetic factors, specifically poor glycaemic control and obesity. In spite of statin treatment, residual risk of CVD remains high in type 2 diabetes, and this may relate to HTG and atherogenic dyslipidemia. Treatment of HTG emphasises correcting secondary factors and adverse lifestyles, in particular, diet and exercise. Pharmacotherapy is also required in most type 2 diabetic patients. Statins are the first-line therapy to achieve recommended therapeutic targets of plasma low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol. Fibrates, ezetimibe and n-3 fatty acids are adjunctive treatment options for residual and persistent HTG. Evidence for the use of niacin has been challenged by non-significant CVD outcomes in two recent large clinical trials. Further investigation is required to clarify the use of incretin-based therapies for HTG in type 2 diabetes. Extreme HTG, with risk of pancreatitis, may require insulin infusion therapy or apheresis.New therapies targeting HTG in diabetes need to be tested in clinical endpoint trials. The purpose of this review is to examine the current evidence and provide practical guidance on the management of HTG in type 2 diabetes. | Jing Pang Dick C Chan Gerald F Watts | 2014 | World Journal of Diabetes2014，5，2： | 2 |
| 18 | Uncondi-tionally stable staggered solution procedure for soil-pore fluid interaction problems显示文摘 | Zienkiewicz O C Paul D K Chan A H | 1988 | Int J for Numerical Methods in Engineering1988，26，： | 2 |
| 19 | Nanotoxicity: the growing need for in vivo study显示文摘 | Hans C Fischer Warren CW Chan | 2007 | Current Opinion in Biotechnology2007，，6： | 2 |
| 20 | An overview of energy sources for electric vehicles显示文摘 | Chau K T Wong Y S Chan C C | 1999 | Energy Conversion and Management1999，40，10： | 2 |
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