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| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Hand-assisted laparoscopic splenectomy显示文摘 | Bemelman W A de Wit L T Busch O R | 2000 | Surg Endosc2000，14，11： | 1 |
| 3 | Regulatory elements of the floral homeotie gene AGAMOUS identified by phylogenetic footprinting and shadowing显示文摘 | HONG R L HAMAGUCHI L H BUSCH M A WEIGEL D | 2003 | The Plant Cell2003，15，： | 1 |
| 4 | Complete genome sequence of Streptomyces lividans TK24显示文摘 | Rückert C Albersmeier A Busche T | 2015 | Journal of Biotechnology2015，199，1： | 1 |
| 5 | Evolution of methane sorption capacity of coal seams as a function of burial history - a case study from the Campine Basin, NE Belgium显示文摘 | Hildenbrand A Krooss B M Busch A Gaschnitz R | 2005 | International Journal of Coal Geology2005，19，： | 1 |
| 6 | Lipid peroxidation and the expressional regulation of lhe heat- shock response during ischemia - reperfusion of rat kidney显示文摘 | A kcetin Z Pregla R Busch A | 2000 | Urol lnt2000，65，1： | 1 |
| 7 | Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides 显示文摘 | Pashine A Busch R Belmares MP | 2003 | Immunity2003，19，2： | 1 |
| 8 | Vertical transmission of channel catfish virus显示文摘 | Wise J A Harrell S F Busch R L | 1988 | Am J Vet Res1988，49，9： | 1 |
| 9 | 查看详情显示文摘 | R Busch S Schneider A Peker W L Johnson | | 0，，： | 1 |
| 10 | Functional analysis of the early steps of carotenoid biosynthesis in tobacco 显示文摘 | BUSCH M SEUTER A HAIN R | 2002 | Plant Physiol2002，128，2： | 1 |
| 11 | Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes 显示文摘 | JACKSON R J BUSCH S J CARDIN A D | 1991 | Physiological Reviews1991，71，： | 1 |
| 12 | An amino acid mutation in a potassium channel that prevents inhibition by protein kinase显示文摘 | Vamum M D North R A | 1992 | Science1992，255，5052： | 1 |
| 13 | A molecular link between stem cell regulation and floral patterning in Arabidopsis显示文摘 | Lohmann J U Hong R L Hobe M Busch M A Parcy F Simon R Weigel D | | 0，，： | 1 |
| 14 | Time-Temperature Superposition of Structural Relaxation in a Viscous Metallic Liquid 显示文摘 | Meyer A Busch R Schober H | 1999 | Physical Review Letters1999，83，24： | 1 |
| 15 | Regulation of the endothelial apelin/APJ system by hemodynamic fluid flow显示文摘 | Busch R Strohbach A Pennewitz M | 2015 | Cell Signal2015，27，7： | 1 |
| 16 | Long - term sur- vival in hilar cholangiocarcinoma also possible in unresectable patients显示文摘 | Ruys A T van Haelst S Busch O R | 2012 | World journal of surgery2012，36，9： | 1 |
| 17 | Thermodynamics and kinetics of Zr-Ti-Cu-Ni-Be bulk metallic glass forming liquds 显示文摘 | Jonson W L Busch R Masuhr A | 2006 | Materials Science and Engineering2006，，： | 1 |
| 18 | A reduced scale railway noise bar- rier's insertion loss and absorption coefficeients : comparision of filed measurements and predictions 显示文摘 | Busch T A Nugent R E | 2003 | Journal of Sound and Vibration2003，，11： | 1 |
| 19 | GoumaLong- term Results of a Primary End-to-end Anastomosis in Perop- erative Detected Bile Duct Injury 显示文摘 | Reuver P R Busch O R Rauws E A | 2007 | J Gastrointest Surg2007，11，3： | 1 |
| 20 | Functional analysis of the early steps of carotenoid biosynthesis in tobacco 显示文摘 | Busch M Seuter A Hain R | 2002 | Plant Physiol2002，128，： | 1 |
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