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| 1 | Tumor targeted mesoporous silica-coated gold nanorods facilitate detection of pancreatic tumors using Multispectral optoacoustic tomography显示文摘Multispectral optoacoustic 断层摄影术(MSOT ) 是在传统的形式上提供几个优点的一种新兴的成像技术,特别地处于它解决在显微镜的规模上的深度的光对比的能力。当潜在的应用包括临床的阀值由当前的技术设置了的下面的肿瘤的早察觉时,肿瘤特定的对比代理人的缺乏限制 MSOT 成像的使用。因此,我们与 polyacrylic 酸(泛美航空公司) 或 aminefunctionalized mesoporous 硅石(MS ) 由涂层金牌 nanorods (GNR ) 构造了高度稳定的 nano 对比代理人。Syndecan-1,被显示了指向像胰岛素的生长因素 1 受体(IGF1-R )( 在胰腺的肿瘤的 upregulated ) ,在泛美航空公司涂的 GNR (PAA-GNRs ) 或 MS 涂的 GNR (MS-GNRs ) 的表面上被结合创造指向肿瘤的 nanoparticles。在 vitro, nanoparticles 指向的肿瘤与流动 cytometry 被估计。在 S2VP10L 房间(为 IGF1-R 积极) , syndecan-1 MS-GNRs (Syndecan-MS-GNRs ) 在 OA 信号表明了增加, 10x,与 syndecan-1 PAAGNR (Syndecan-PAA-GNRs ) 相比。最小的绑定在 MiaPaca-2 房间被观察(为 IGF1-R 否定) 。在 vivo,肿瘤 Syndecan-MS-GNRs 的特定的指向用鼠科的 orthotopic 被评估胰腺的癌症模型。Syndecan- MS-GNRs 比在象肝那样的离开目标机关在胰腺的肿瘤以内表明了显著地更大的累积。与 IGF1-R 否定 MiaPaca-2 房间植入的老鼠没表明指向的特定的肿瘤。在摘要,我们报导指向的 nano 对比代理人(Syndecan-MS-GNRs ) 能成功地检测 orthotopic 有在用 MSOT 的 vivo 有约束力的最小的离开目标的胰腺的肿瘤。 | Anil Khanal Christopher Ullum Charles W Kimbrough Nichola C. Garbett Joseph A. Burlison Molly W. McNally Phillip Chuong Ayman S. EI-Baz Jacek B. Jasinski Lacey R. McNally | 2015 | Nano Research2015，8，12： | 2 |
| 2 | Correlation of RNA secondary structure and attenuation of Sabin vaccine strains of poliovirus in tissue culture显示文摘 | Macadam A J Ferguson G Burlison J | 1992 | Virology1992，189，2： | 1 |
| 3 | Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of Hsp90显示文摘 | Burlison J A Neckers L Smith A B | 2006 | J Am Chem Soc2006，128，15： | 1 |
| 4 | Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines显示文摘 | Burlison J A Avila C Vielhauer G | 2008 | J Org Chem2008，73，： | 1 |
| 5 | The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity 显示文摘 | Donnelly A C Mays J R Burlison J A | 2008 | J Org Chem2008，73，： | 1 |
| 6 | SPECT/CT localization of oral radioiodine activity: a retrospective study and in-vitro assessment显示文摘 | Jared S. Burlison Michael F. Hartshorne Alan M. Voda Franklin H. Cocks Joanna R. Fair | 2013 | Nuclear Medicine Communications2013，，： | 1 |
| 7 | Ptfl-a determines horizontal and amacrine cell fates during mouse retinal development 显示文摘 | Fujitani Y Fujitani S Luo H Qiu F Burlison J Long Q | 2006 | Development2006，133，22： | 1 |
| 8 | Swsard canopy st ructure and the bite dimensions nd bite weight of grazing sheep显示文摘 | Burlison A J Hodgson J Illius J | | 0，，： | 1 |
| 9 | Anon-toxic HsPgo inhibitor protects neurons from A~-induced toxicity 显示文摘 | ANSAR S BURLISON J A HADDEN M K | 2007 | Bioorganic Med Cbem Lett2007，17，7： | 1 |
| 10 | Deve- lopment of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines 显示文摘 | BURLISON J A AVILA C VIELHAUER G | 2008 | J Org Chem2008，73，6： | 1 |
| 11 | Novobiocin:redesigning a DNA gyrase inhibitor for selective inhibition of Hsp90显示文摘 | BURLISON J A NECKERS L SMITH A B | 2006 | J Am Chem Soc2006，128，15： | 1 |
| 12 | Synthesis and evaluation of coumermycin A1 analogues that inhibit the Hsp90 protein folding machinery 显示文摘 | BURLISON J A BLAGG B S J | 2006 | Org Lett2006，8，21： | 1 |
| 13 | Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines显示文摘 | BURLISON J A AVILA C VIELHAUER G | 2008 | J Org Chem2008，73，6： | 1 |
| 14 | Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells显示文摘 | Burlison JS Long Q Fujitani Y | | 0，，01： | 1 |
| 15 | Hsp90: a novel target for the disruption of multiple signaling cascades显示文摘 | Bishop SC Burlison JA Blagg I38 | 2007 | Curr Cancer Drug Targets2007，7，4： | 1 |
| 16 | Novobiocin: redesigning a DNA gyrase inhibitor for seleetive inhibition of hsp90显示文摘 | BURLISON JA NECKERS L SMITH AB | 2006 | JAm ChemSoc2006，128，15： | 1 |
| 17 | The design, synthesis, and evaluation of cnumarin ring derivatives of the novo- biocin scaffold that exhibit antiproliferative activity 显示文摘 | DONNELLY AC MAYS JR BURLISON JA | 2008 | J Org Chem2008，73，22： | 1 |
| 18 | Development of novobiocin analogues that manifest anti-proliferative activity a- gainst several cancer cell lines显示文摘 | BURLISON JA AVILA C VIELHAUER G | 2008 | J Org Chem2008，73，6： | 1 |
| 19 | Evaluation of the Performance of Tilt Scanning Interferometry for Tomographic Imaging and Profilometry 显示文摘 | Burlison B S H Huntley J M | 2012 | Optics Communications2012，285，7： | 1 |
| 20 | Evaluation of the performance of tilt scanning interferometry for tomographic imaging and profilometry显示文摘 | Burlison B S H Ruiz P D Huntley J M | 2012 | Optics Communications2012，，285： | 1 |
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