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| 1 | Software for automated classification of probe-based confocal laser endomicroscopy videos of colorectal polyps显示文摘AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions was performed on patients under-going screening and surveillance colonoscopies, followed by polypectomies. All resected specimens were reviewed by a reference gastrointestinal pathologist blinded to pCLE information. Histopathology was used as the criterion standard for the differentiation between neoplastic and non-neoplastic lesions. The pCLE video sequences, recorded for each polyp, were analyzed off-line by 2 expert endoscopists who were blinded to the endoscopic characteristics and histopathology. These pCLE videos, along with their histopathology diagnosis, were used to train the automated classification software which is a content-based image retrieval technique followed by k-nearest neighbor classification. The performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists was compared with that of automated pCLE software classification. All evaluations were performed using leave-one-patient- out cross-validation to avoid bias. RESULTS:Colorectal lesions (135) were imaged in 71 patients. Based on histopathology, 93 of these 135 lesions were neoplastic and 42 were non-neoplastic. The study found no statistical significance for the difference between the performance of automated pCLE software classification (accuracy 89.6%, sensitivity 92.5%, specificity 83.3%, using leave-one-patient-out cross-validation) and the performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists (accuracy 89.6%, sensitivity 91.4%, specificity 85.7%). There was very low power (< 6%) to detect the observed differences. The 95% confidence intervals for equivalence testing were:-0.073 to 0.073 for accuracy, -0.068 to 0.089 for sensitivity and -0.18 to 0.13 for specificity. The classification software proposed in this study is not a 'black box' but an informative tool based on the query by example model that produces, as intermediate results, visually similar annotated videos that are directly interpretable by the endoscopist. CONCLUSION:The proposed software for automated classification of pCLE videos of colonic polyps achieves high performance, comparable to that of off-line diagnosis of pCLE videos established by expert endoscopists. | Barbara André Tom Vercauteren Anna M Buchner Murli Krishna Nicholas Ayache Michael B Wallace | 2012 | World Journal of Gastroenterology2012，18，39： | 5 |
| 2 | The peripheral odontngenic keratocyst显示文摘 | Dayan D Buchner A Gorsky M | 1988 | Int J Oral Maxillofac Surg1988，17，2： | 1 |
| 3 | Recombinant human granulocyte-macrophage colony-stimulating factor after chemotherapy in patients with acute myeloid leukemia at higher age or after relapse显示文摘 | Buchner T Hiddemann W Koenigsmann M | 1991 | Blood1991，78，5： | 1 |
| 4 | CD40 ligand is selectively expressed on CD4^+ T cells and platelets:implications for CD40-CD40L signalling in atherosclerosis显示文摘 | Buchner K Henn V Grafe M | 2003 | J Pathol2003，201，2： | 1 |
| 5 | The vitamin E-binding protein afamin increases in maternal serum during pregnancy显示文摘 | Michael Hubalek Hannes Buchner Manfred G. M?rtl Dietmar Schlembach Berthold Huppertz Branka Firulovic Wolfgang K?hler Erich Hafner Benjamin Dieplinger Ludwig Wildt Hans Dieplinger | 2014 | Clinica Chimica Acta2014，，： | 1 |
| 6 | Probing particle size distributions in natural surface waters from 15 nm to 2 μm by a combination of LIBD and single-particle counting显示文摘 | Walther C Buchner S Filella M | 2006 | Colloid and Interface Science2006，301，： | 1 |
| 7 | Induction, binding specificity and function of human ICOS显示文摘 | Beier K C Hutloff A Dittrich A M Heuck C Raucb A Buchner K | 2000 | Eur J Immunol2000，30，： | 1 |
| 8 | Granular cell tumor of the oral cavity updated immunohistochemical profile显示文摘 | Vered M Carpenter WM Buchner A | | 0，，01： | 1 |
| 9 | Carbon nanostructures as multi-functional drug delivery Platforms显示文摘 | Mendes R G Bachmatiuk A Buchner B Cuniberti G Rummeli M H | 2013 | Journal of Materials Chemistry B2013，，1： | 1 |
| 10 | E-cadherin in oral SCC:an analysis of the confusing literature and new insights related to its immunohistochemical expression 显示文摘 | Vered M Allon I Buchner A | 2012 | Histol Histopathol2012，27，2： | 1 |
| 11 | Laser-induced latchup screening and mitiga- tion in CMOS devices显示文摘 | McMORROW D BUCHNER S BAZE M | 2006 | IEEE Trans Nucl Sci2006，53，： | 1 |
| 12 | Clinical outcome of neu- rointerventional emergency treatment of extra-or intracrmdal tandem oc- clusions in acute major stroke :antegrade approach with wallstent and soli- taire stent retriever 显示文摘 | Mpotsaris A Bussmeyer M Buchner H | 2013 | Clin Neuroradio12013，23，3： | 1 |
| 13 | The Jebel Hadid structure (AI Kufrah Basin, SE Lihya)--A possible impact structure and potential hydrocarbon trap? 显示文摘 | Schmieder M Buchner E Le Heron D P | 2009 | Marine and Pc-troleum Geology2009，26，3： | 1 |
| 14 | Variety in vegetable and fruit consumption and the risk of gastric and esophageal cancer in the European Prospective Investigation into Cancer and Nutrition显示文摘 | Jeurnink S M Buchner F L Bueno deMesquita H B | | 0，，06： | 1 |
| 15 | Pain and high sensitivity C reactive protein in patients with chronic low back pain and acute sciatic pain显示文摘 | Sturmer T Raum E Buchner M | 2005 | Ann Rheum Dis2005，64，6： | 1 |
| 16 | Differential effects of short-term ace-and AT1-receptor inhibition onpostischemic injury and leukocyte adherence in vivo and in vitro显示文摘 | Guba M Steinbauer M Buchner M | 2000 | Shock2000，13，3： | 1 |
| 17 | The role of TNF - α in patients with chronic low back pain A prospective comparative longitudinal study显示文摘 | Wang HL Schiltenwolf M Buchner M | 2008 | Clin J Pain2008，24，3： | 1 |
| 18 | Preventing Frail Health显示文摘 | Buchner D M Wagner E | 1992 | Clin Geriatr Med1992，8，1： | 1 |
| 19 | Differential effects of short-term ace- and AT1-reeeptor inhibition on postischemic injury and leukocyte adherence in vivo and in vitro 显示文摘 | Guba M Steinbauer M Buchner M | 2000 | Shock2000，13，3： | 1 |
| 20 | Pinacidil enhances survival of cryopreserved human embryonic stem cells显示文摘 | Barbaric I Jones M Buchner K | 2011 | Cryobiology2011，63，3： | 1 |
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