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44篇 您的检索式：作者名="Brun MA"

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	题名	作者	年代	出处	被引量
1	Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis.	Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao	2021	Cell Research2021，31，12：	5
2	X-linked retinitis pigmentosa: mutation spectrum of the RPGR and RP2 genes and correlation with visual function显示文摘	Sharon D Bruns GAP McGee TL Sandberg MA Berson EL Dryja TP	2000	Invest Ophthalmol Vis Sci2000，41，9：	1
3	DNA recovery from soils of diverse composition显示文摘	Zhou JZ Bruns MA Tiedje JM		0，，2：	1
4	DNA Recovery from soils of di- verse composition 显示文摘	Zhou JZ Bruns MA Tiedje JM	1996	Applied and Environmental Microbiology1996，62，2：	1
5	DNA Recovery from soils of di- verse composition 显示文摘	Zhou J Bruns MA Tiedje JM	1996	App\| Environ Microbio]1996，62，2：	1
6	Deodorization of swine manure using minced horseradish roots and peroxides 显示文摘	Govere EM Tonegawa M Bruns MA	2005	J Agric Food Chem2005，53，：	1
7	DNA recovery from soils of diverse composition 显示文摘	ZHOU JZ BRUNS MA TIEDJE JM	1996	Appl Environ Mierobiol1996，62，：	1
8	DNA recovery from soils ofdiverse composition显示文摘	Zhou J Bruns MA Tiedje JM	1996	Applied and EnvironmentalMicrobiology1996，62，2：	1
9	DNA recovery from soils of diverse composition显示文摘	Zhou JZ Bruns MA Tiedje JM	1996	Applied and Environmental Microbiology1996，62，2：	1
10	DNA recovery from soils of diverse composition 显示文摘	Zhou JZ Bruns MA Tiedje JM	1996	Applied and Environmental Microbiology1996，62，2：	1
11	DNA recovery from soils of diverse composition显示文摘	Zhou J Bruns MA Tiedje JM	1996	Applied and Environmental Microbiology1996，62，2：	1
12	Terahertz imaging applied to cancer diagnosis 显示文摘	Brun MA Formanek F Yasuda A	2010	Phys Med Biol2010，55，：	1
13	DNA recovery from soils of diverse composition显示文摘	ZHOU JZ BRUNS MA TIEDJE JM	1996	Appl Environ Microbiol1996，62，：	1
14	DNA recovery from soils of di- verse composition显示文摘	Zhou J Z Bruns MA Tiedje J M	1996	Appl Environ Microbiol1996，62，：	1
15	DNA recovery from soils of diverse composition 显示文摘	ZHOU JZ BRUNS MA TIEDJE JM	1996	Appl Environ Microbiol1996，62，2：	1
16	Transcriptomic profil-ing during the post-harvest of heat-treated dixiland Prunus per-sica fruits:common and distinct response to heat and cold显示文摘	Lauxmann MA Brun B Borsani J		0，，12：	1
17	DNA recovery from soils of diverse composition 显示文摘	Zhou J Bruns MA Tiedje JM	1996	Applied Environmental Microbiology1996，62，2：	1
18	DNA recovery from soils of diverse composition 显示文摘	Zhou J Bruns MA Tiedje JM	1996	Appl Environ Microbiol1996，62，：	1
19	DNA recovery from soils of diverse composition显示文摘	Zhou J Bruns MA Tiedje JM	1996	Applied and Environmental Microbiology1996，62，2：	1
20	DNA recovery from soils of diverse composition 显示文摘	Zhou J Bruns MA Tiedje JM	1996	Appl Environ Microbiol1996，62，2：	1

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