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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | The effects of Spirulina on anemia and immune function in senior citizens显示文摘Anemia and immunological dysfunction(i.e.immunosenescence)are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena.Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects.We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia.We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases.Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study.Complete cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of supplementation.Thirty study participants completed the entire study and the data obtained were analyzed.Over the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes.In addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants.Older women appeared to benefit more rapidly from Spirulina supplements.Similarly,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation.Spirulina may ameliorate anemia and immunosenescence in older subjects.We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials. | Carlo Selmi Patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 3 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 4 | Development of broodstock diets for the European sea bass (Dicentrarchus labrax)with special emphasis on the importance of n-3 and n-6 HUFA to reproductive performance 显示文摘 | Bruce M P Oyen F Bell J G | 1999 | Aquaculture1999，177，： | 1 |
| 5 | Hot-cor- rosion Resistance of Ni-Cr-A1-Y and Ni-18 % Si SI- loys in Sulfate Eutectic and Sulfate Plus Vanadate Melts at 973 K 显示文摘 | BRUCE M W FRED S P GERALD H M | 2002 | Oxidation of Metals2002，58，56： | 1 |
| 6 | Lithium insertion into manganese spinels 显示文摘 | Thackeray M M David W I F Bruce P G | 1983 | Mater Res Bull1983，18，4： | 1 |
| 7 | A model of the thermal balance for cat- tle in hot conditions 显示文摘 | McGoven P E Bruce J M | 2000 | Animal Production Technology2000，77，1： | 1 |
| 8 | 显示文摘 | Shaju K M Bruce P G | 2006 | Adv Mater2006，18，17： | 1 |
| 9 | Cognitive progression in epilepsy 显示文摘 | Seidenberg M Da Bruce H | 2007 | Neuropsyehol Rev2007，17，4： | 1 |
| 10 | 查看详情显示文摘 | Bruce D A Wikinson A P White M G | | 0，，： | 1 |
| 11 | 查看详情显示文摘 | H L Nguyen P N Horton M B Hursthouse C Legon D W Bruce | | 0，，： | 1 |
| 12 | Lithium insertion into manganese spinels显示文摘 | Thackeray M M David W I F Bruce P G | 1983 | Materials Research Bulletin1983，18，4： | 1 |
| 13 | DNA extraction from several cacti显示文摘 | Candelario M J Natalia D Bruce P B | 2000 | Hort Science2000，35，6： | 1 |
| 14 | Design and realization of a millimeter-wave Si/SiGe HBT frequency multiplier 显示文摘 | BRUCES P O RYDBERG A KIM M | 1998 | IEEE Trans Microwave Theory Tech1998，46，11： | 1 |
| 15 | Iron and cobalt ethylene polymerization catalys bearing 2,6-bis (imino) pyridyl ligands: synthesis, structures,and polymerization studies 显示文摘 | BRITOVSEK G J P BRUCE M GIBSON V C | 1999 | Journal of American Chemical Society1999，121，38： | 1 |
| 16 | Traditional fertilizion and its effect on corn insect populations in the Guatemalan highlands显示文摘 | Helda M Ivette P Bruce F | 2001 | Agriculture Ecosystems & Environment2001，84，： | 1 |
| 17 | Propylene Polymerization with Unbridge Metallocenes:Ligarid Effects in the Selectivity for Elastomeric Polypropylene显示文摘 | Maciejewsk J L Bruce P M D Waymouth R M | 1997 | Organometallics1997，16，： | 1 |
| 18 | Lithium Insertion into Manganese Spinels显示文摘 | Thackeray M M David W I F Bruce P G | 1983 | Mater Res Bull1983，18，： | 1 |
| 19 | Theoretical Studies on the Photochemistry of the Cis-to-Trans Conversion in Dinuclear Gold Halide Bis(diphenylphosphino) ethylene Complexes 显示文摘 | Schwerdtfeger P Bruce A E Bruce M R M | 1998 | J Am Chem Soc1998，120，： | 1 |
| 20 | Response of oral lichen plarms to topical tacrolimus in 37 patients 显示文摘 | Byrd J A Davis M D P Bruce A J' | 2004 | Arch Dermatol2004，140，12： | 1 |
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