|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 依前列醇长期治疗原发性肺动脉高压的临床资料分析显示文摘目的 观察依前列醇长期治疗原发性肺动脉高压 (PPH)的疗效。方法 临床诊断为PPH且心功能为Ⅲ~Ⅳ级的慢性充血性心力衰竭患者 69例 ,均接受依前列醇长期静脉连续注入治疗(起始剂量在 2~ 62ng·kg- 1 ·min- 1 范围内。在长期治疗中 ,药物剂量应根据患者的反应进行调整 ,剂量通常随治疗时间每 2个月增加 1次 ,每次增加 1~ 2ng·kg- 1 ·min- 1 )并观察其疗效。用右心导管法和超声心动图检查法对所有患者测量三尖瓣跨瓣压 (ΔP)和心输出量 (CO)。随访期间每 4个月用超声心动图检查法复查上述指标 1次。结果 PPH患者长期用依前列醇治疗后 ,ΔP由 (84 1± 2 4 1 )mmHg (1mmHg=0 1 33kPa)降至 (62 7± 1 8 2 )mmHg(P <0 0 1 ) ,CO由 (4 0 0± 1 2 2 )L/min升至 (4 70± 1 2 7)L/min(P <0 0 2 ) ,ΔP/CO由 2 2 8± 9 4降至 1 4 9± 6 5(P <0 0 1 )。结论 长期静脉连续注入依前列醇治疗PPH ,可使患者右室压力逐渐下降 ,CO增加 。 | 曹铁生 袁丽君 段云友 王作军 庄磊 Shelley M Shapiro Bruce H Brundage | 2003 | 中华内科杂志2003，42，2： | 16 |
| 2 | 改进医疗服务质量、确保病人安全的教学方法显示文摘提高医疗服务质量、确保病人安全是当前医学教育及培训面临的巨大挑战。今天的医生及医务工作者应具备良好的沟通能力,掌握如何在临床实践中鉴别、预防和处理不良事件及接近过失事件(nearmisses),如何使用当前获得的证据及相关信息,如何安全有效地在团队中工作,如何在实践中教授和学习病人安全知识,如何根据认可的伦理原则服务公众。 | Merrilyn M Walton Bruce H Barraclough Samantha A Van Staalduinen Susan L Elliott 段玉蓉(译) 张鸣明(审校) | 2009 | 中国循证医学杂志2009，9，9： | 7 |
| 3 | Modeling Climate Change Impacts on the US Agricultural Exports显示文摘Climate change is expected to have substantial effects on agricultural productivity worldwide. However, these impacts will differ across commodities, locations and time periods. As a result, landowners will see changes in relative returns that are likely to induce modifications in production practices and land allocation. In addition, regional variations in impacts can alter relative competitiveness across countries and lead to adjustments in international trade patterns. Thus in climate change impact studies it is likely useful to account for worldwide productivity effects. In this study, we investigate the implications of considering rest of world climate impacts on projections of the US agricultural exports. We chose to focus on the US because it is one of the largest agricultural exporters. To conduct our analyses, we consider four alternative climate scenarios, both with and without rest of world climate change impacts. Our results show that considering/ignoring rest of world climate impacts causes signifi cant changes in the US production and exports projections. Thus we feel climate change impact studies should account not only for climate impacts in the country of focus but also on productivity in the rest of the world in order to capture effects on commodity markets and trade potential. | ZHANG Yu-quan CAI Yong-xia Beach Robert H McCARL Bruce A | 2014 | Journal of Integrative Agriculture2014，13，4： | 3 |
| 4 | Nephropathy in dietary hyperoxaluria:A potentially preventable acute or chronic kidney disease显示文摘Hyperoxaluria can cause not only nephrolithiasis and nephrocalcinosis,but also renal parenchymal disease histologically characterized by deposition of calcium oxalate crystals throughout the renal parenchyma,profound tubular damage and interstitial inflammation and fibrosis.Hyperoxaluric nephropathy presents clinically as acute or chronic renal failure that may progress to endstage renal disease(ESRD).This sequence of events,well recognized in the past in primary and enteric hyperoxalurias,has also been documented in a few cases of dietary hyperoxaluria.Estimates of oxalate intake in patients with chronic dietary hyperoxaluria who developed chronic kidney disease or ESRD were comparable to the reported average oxalate content of the diets of certain populations worldwide,thus raising the question whether dietary hyperoxaluria is a primary cause of ESRD in these regions.Studies addressing this question have the potential of improving population health and should be undertaken,alongside ongoing studies which are yielding fresh insights into the mechanisms of intestinal absorption and renal excretion of oxalate,and into the mechanisms of development of oxalate-induced renal parenchymal disease.Novel preventive and therapeutic strategies for treating all types of hyperoxaluria are expected to develop from these studies. | Robert H Glew Yijuan Sun Bruce L Horowitz Konstantin N Konstantinov Marc Barry Joanna R Fair Larry Massie Antonios H Tzamaloukas | 2014 | World Journal of Nephrology2014，3，4： | 3 |
| 5 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 6 | Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China. | Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 2 |
| 7 | Glucocorticoids and prostate cancer treatment: friend or foe?显示文摘Glucocorticoids 在前列腺癌症的治疗被使用了减缓疾病前进,改进疼痛控制并且抵消 chemo- 和神经质的治疗的副作用。然而,他们可以也有潜力经由变异的雄激素受体或 glucocorticoid 受体(GR ) 驾驶前列腺癌症生长。在这评论,我们在前列腺癌症的治疗检验 glucocorticoids 的历史、当代的使用,考察他们可以由禁止或开车前列腺癌症生长的潜在的机制,并且描述定义他们对前列腺癌症的生物学的贡献的潜在的工具。 | Bruce Montgomery Heather H Cheng James Drechsler Elahe A Mostaghel | 2014 | Asian Journal of Andrology2014，16，3： | 2 |
| 8 | IFNr and lymphocytes prevent primary tumor development and shape tumor immunogenicity显示文摘 | SHANKARAN V IKEDA H BRUCE AT | 2001 | Nature2001，410，6832： | 2 |
| 9 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 10 | Marketing Productivity, Marketing Audits and Systems for Marketing Performance Assessment显示文摘 | NEIL A M BRUCE H C | 2002 | Journal of Business Research2002，，55： | 1 |
| 11 | Determinants of success in endoscopic cerebrospinal fluid leak repair显示文摘 | DEVRAJ BASU BRUCE H HAUGHEY | 2006 | Otolaryngology-Head and Neck Surgery2006，135，5： | 1 |
| 12 | Hierarchical adaptive dynamic power management 显示文摘 | Ren Zhiyuan BRUCE H K RADU M | 2005 | IEEE Transactions on Computers2005，54，4： | 1 |
| 13 | Cancer immunoediting:from immunosurveillance to tumor escape显示文摘 | Dunn GP Bruce AT Ikeda H | 2002 | Nature Immunol2002，3，11： | 1 |
| 14 | The lightning discharge显示文摘 | Bruce C E R Golde R H | 1941 | J Inst Elect1941，，88： | 1 |
| 15 | Observational study of maternal anthropometry and fetal insulin显示文摘 | Soltani-K H Bruce C Fraser RB | 1999 | Arch Dis Child fetal Neonatal ED1999，81，2： | 1 |
| 16 | The Evolution of Debt and Equi- ty Markets in Economic Development显示文摘 | JOHN H B BRUCE D S | 1998 | Economic Theo- ry1998，12，3： | 1 |
| 17 | Surfactant properties and biodegradation of polyethoxylates from phenolic lipids 显示文摘 | TYMAN J H P BRUCE I E | 2004 | Journal of Surfactants and Detergents2004，7，2： | 1 |
| 18 | Hot-cor- rosion Resistance of Ni-Cr-A1-Y and Ni-18 % Si SI- loys in Sulfate Eutectic and Sulfate Plus Vanadate Melts at 973 K 显示文摘 | BRUCE M W FRED S P GERALD H M | 2002 | Oxidation of Metals2002，58，56： | 1 |
| 19 | Diet-induced maternalobesity alters ovarian morphology and gene expression in the adultmouse offspring显示文摘 | Cheong Y Sadek K H Bruce K D | 2014 | Fertil Steril2014，102，3： | 1 |
| 20 | Atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus 显示文摘 | Haque S Mirjafari H Bruce IN | 2008 | Curr Opin Lipidol2008，19，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员