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| 1 | Evaluating patients' perception of service quality at hospitals in nine Chinese cities by use of the ServQual scale显示文摘Objective: To investigate patients' perception of service quality at hospitals in nine Chinese cities and propose some measures for improvement. Methods: The ServQ ual scale method was used in a survey involving patients at out-patient and in-patient facilities in Shanghai, Chongqing, Chengdu, Nanning, Guilin and Laibin of Guangxi, Honghezhou of Yunnan, Wulumuqi of Xinjiang and Zhongshan of Guangdong. The data collected were entered and analyzed using SPSS 20.0. Statistical analyses included descriptive statistics, factor analyses, reliability analyses, product-moment correlations, independent-sample t-tests, One-way ANOVA and regression analyses. Results: The Kaiser-Meyer-Olkin value for the factor analysis of the scale was 0.979. The Cronbach's α for the reliability analysis was 0.978. All the Pearson correlation coei cients were positive and statistically signii cant. Visitors to out-patient facilities reported more positive perception tacilities on tangibles(t = 4.168, P(t = 1.979, P | Min Li Douglas Bruce Lowrie Cheng-Yu Huang Xiang-Chan Lu Ying-Chu Zhu Xing-Hua Wu Mayila Shayiti Qiong-Zhen Tan Hua-Ling Yang Si-Yuan Chen Pan Zhao Sheng-Hua He Xiu-Rong Wang Hong-Zhou Lu | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，6： | 4 |
| 2 | Monteggia fractures显示文摘 | Bruce HE Harvey JP Wilson JC Jr | 1974 | J Bone Joint Surg Am1974，56，： | 1 |
| 3 | p14ARF inhibits the growth of p53 deficient cells in a cell-specific manner显示文摘 | Li Y He L Bruce A | 2006 | Biochim Biophys Acta2006，1763，8： | 1 |
| 4 | Cationic lipids enhance siRNA-mediated interferon response in mice显示文摘 | Zheng Ma Jiang Li Fengtian He Annette Wilson Bruce Pitt Song Li | 2005 | Biochemical and Biophysical Research Communications2005，，： | 1 |
| 5 | The occurrence of selected antibiotics in Hong Kong coastal waters显示文摘 | A. Gulkowska Yuhe He M.K. So Leo W.Y. Yeung H.W. Leung J.P. Giesy Paul K.S. Lam Michael Martin Bruce J. Richardson | 2007 | Marine Pollution Bulletin2007，，8： | 1 |
| 6 | Lymph Node Macrophages Re- strict Murine Cytomegalovirus Dissemination 显示文摘 | FarrelL HE Davis-Poynter N Bruce K | 2015 | J Virol2015，89，14： | 1 |
| 7 | Genetic and Physical Mapping of the Lps Locus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region显示文摘 | Alexander Poltorak Irina Smirnova Xiaolong He Mu-Ya Liu Christophe Van Huffel Dale Birdwell Erica Alejos Maria Silva Xin Du Patricia Thompson Edward K.L. Chan Jessica Ledesma Bruce Roe Sandra Clifton Stefanie N. Vogel Bruce Beutler | 1998 | Blood Cells Molecules and Diseases1998，，3： | 1 |
| 8 | Antibody-Enhanced Binding of Dengue-2 Virus to Human Platelets显示文摘 | Songli Wang Runtao He Jintana Patarapotikul Bruce L. Innis Robert Anderson | 1995 | Virology1995，，1： | 1 |
| 9 | Biodegradable magnesium materials regulate ROS-RNS balance in pro-inflammatory macrophage environment显示文摘The relationship between reactive oxygen and nitrogen species(ROS-RNS)secretion and the concomitant biocorrosion of degradable magnesium(Mg)materials is poorly understood.We found that Mg foils implanted short term in vivo(24 h)displayed large amounts of proinflammatory F4/80+/iNOS+macrophages at the interface.We sought to investigate the interplay between biodegrading Mg materials(98.6%Mg,AZ31&AZ61)and macrophages(RAW 264.7)stimulated with lipopolysaccharide(RAW 264.7^(LPS))to induce ROS-RNS secretion.To test how these proinflammatory ROS-RNS secreting cells interact with Mg corrosion in vitro,Mg and AZ61 discs were suspended approximately 2 mm above a monolayer of RAW 264.7 cells,either with or without ^(LPS).The surfaces of both materials showed acute(24 h)changes when incubated in the proinflammatory RAW 264.7^(LPS) environment.Mg discs incubated with RAW 264.7^(LPS) macrophages showed greater corrosion pitting,while AZ61 showed morphological and elemental bulk product changes via scanning electron microscopy-energy dispersive X-ray spectroscopy(SEM-EDX).X-ray photoelectron spectroscopy(XPS)analysis showed a reduction in the Ca/P ratio of the surface products for AZ61 disc incubated with RAW 264.7^(LPS),but not the Mg discs.Moreover,RAW 264.7^(LPS) macrophages were found to be more viable in the acute biodegradative environment generated by Mg materials,as demonstrated by calcein-AM and cleaved(active)caspase-3 staining(CC3).^(LPS) stimulation caused an increase in ROS-RNS,and a decrease in antioxidant peroxidase activity.Mg and AZ61 were found to change this ROS-RNS balance,independently of physiological antioxidant mechanisms.The findings highlight the complexity of the cellular driven acute inflammatory responses to different biodegradable Mg,and how it can potentially affect performance of these materials. | Maria P.Kwesiga Amani A.Gillette Fatemeh Razaviamri Margaret E.Plank Alexia L.Canull Zachary Alesch Weilue He Bruce P.Lee Roger J.Guillory II | 2023 | Bioactive Materials2023，，5： | 0 |
| 10 | Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA显示文摘To ensure proper dosage of a drug,analytical quantification of it in biofluid is necessary.Liquid chromatography mass spectrometry(LC-MS)is the conventional method of choice as it permits accurate identification and quantification.However,it requires expensive instrumentation and is not appropriate for bedside use.Using soluble epoxide hydrolase(sEH)inhibitors(EC5026 and TPPU)as examples,we report development of a nanobody-based enzyme-linked immunosorbent assay(ELISA)for such small molecules and its use to accurately quantify the drug chemicals in human samples.Under optimized conditions,two nanobody-based ELISAs were successfully established for EC5026 and TPPU with low limits of detection of 0.085 ng/mL and 0.31 ng/mL,respectively,and two order of magnitude linear ranges with high precision and accuracy.The assay was designed to detect parent and two biologically active metabolites in the investigation of a new drug candidate EC5026.In addition,the ELISAs displayed excellent correlation with LC-MS analysis and evaluation of inhibitory potency.The results indicate that nanobody-based ELISA methods can efficiently analyze drug like compounds.These methods could be easily implemented by the bedside,in the field in remote areas or in veterinary practice.This work illustrates that nanobody based assays offer alternative and supplementary analytical tools to mass spectrometry for monitoring small molecule medicines during clinical development and therapy.Attributes of nanobody based pharmaceutical assays are discussed. | Huiyi Yang Meng Qi Qiyi He Sung Hee Hwang Jun Yang Mark McCoy Christophe Morisseau Suqing Zhao Bruce D.Hammock | 2023 | Journal of Pharmaceutical Analysis2023，13，9： | 0 |
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