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| 1 | Cyclooxygenase-2 and the inflammogenesis of breast cancer显示文摘Cohesive scientific evidence from molecular, animal, and human investigations supports the hypothesis that constitutive overexpression of cyclooxygenase-2(COX-2) is a ubiquitous driver of mammary carcinogenesis, and reciprocally, that COX-2 blockade has strong potential for breast cancer prevention and therapy. Key findings include the following:(1) COX-2 is constitutively expressed throughout breast cancer development and expression intensifies with stage at detection, cancer progression and metastasis;(2) essential features of mammary carcinogenesis(mutagenesis, mitogenesis, angiogenesis, reduced apoptosis, metastasis and immunosuppression) are linked to COX-2-driven prostaglandin E2(PGE-2) biosynthesis;(3) upregulation of COX-2 and PGE-2 expression induces transcription of CYP-19 and aromatase-catalyzed estrogen biosynthesis which stimulates unbridled mitogenesis;(4) extrahe-patic CYP-1B1 in mammary adipose tissue converts paracrine estrogen to carcinogenic quinones with mutagenic impact; and(5) agents that inhibit COX-2 reduce the risk of breast cancer in women without disease and reduce recurrence risk and mortality in women with breast cancer. Recent sharp increases in global breast cancer incidence and mortality are likely driven by chronic inflammation of mammary adipose and upregulation of COX-2 associated with the obesity pandemic. The totality of evidence clearly supports the supposition that mammary carcinogenesis often evolves as a progressive series of highly specific cellular and molecular changes in response to induction of constitutive overexpression of COX-2 and the prostaglandin cascade in the 'inflammogenesis of breast cancer'. | Randall E Harris Bruce C Casto Zachary M Harris | 2014 | World Journal of Clinical Oncology2014，5，4： | 15 |
| 2 | Nicotine-induced upregulation of antioxidant protein Prx 1 in oral squamous cell carcinoma显示文摘Nicotine is a source of exogenous oxidative stress, which is associated with the pathogenesis of numerous diseases including oral squamous cell carcinoma (OSCC), whereas an antioxidant protein, peroxiredoxin 1 (Prx 1), plays an important role in the modulation of this condition. This study was to investigate the association between Prx 1 and tobacco-induced oxidative stress. The expression of Prx 1 and GST in OSCC Tca8113 cells, which were pre-treated with nicotine, was determined. In the present study, MTT assay, reactive oxygen species (ROS) assay, RT-PCR and Western blot analyses, respectively, were conducted to assess cell viability, ROS level, and expression level of Prx 1 and GST in nicotine-treated Tca8113 cells. Nuclear factor kappa B (NF- B) expression was detected by immuno-fluorescence. Our results showed the growth of Tca8113 cells was increased in a dose-dependent manner when cells were treated with nicotine at concentrations from 0.1 to 10 mol/L, but the proliferation of the cells decreased at 100 mol/L. ROS levels increased in all groups treated with nicotine at concentrations of 0.1, 1, 10, or 100 mol/L for 24h. Prx 1 and GST mRNA and protein expression were up-regulated in cells treated with nicotine for the same time at different concentrations or at the same concentration for different times (P<0.05). NF-B was translocated from cytoplasm to nucleus, the expression of NF- B was increased in nucleus. These results suggest that up-regulation of Prx1 expression appears to be associated with tobacco-induced oxidative stress, which may play an important role in the pathogenesis of OSCC. | ZHAO YanHua ZHANG Min YAN Fei CASTO Bruce C TANG XiaoFei | 2013 | Chinese Science Bulletin2013，58，16： | 7 |
| 3 | The MAPK signalling pathways and colorectal cancer显示文摘 | Jing Yuan Fang Bruce C Richardson | 2005 | Lancet Oncology2005，，5： | 3 |
| 4 | Field N 2 O, CO 2 and CH 4 fluxes in relation to tillage, compaction and soil quality in Scotland显示文摘 | Bruce C Ball Albert Scott John P Parker | 1999 | Soil & Tillage Research1999，，1： | 2 |
| 5 | Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China. | Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 2 |
| 6 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 7 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 8 | Elicitation of lignin biosynthesis and iso peroxidase activity by pectic fragnents insuspension cultures caster bean显示文摘 | Bruce R J West C A | 1989 | PlantPhysiol1989，91，： | 1 |
| 9 | Marketing Productivity, Marketing Audits and Systems for Marketing Performance Assessment显示文摘 | NEIL A M BRUCE H C | 2002 | Journal of Business Research2002，，55： | 1 |
| 10 | Multiple scattering from random rough surfaces using the kirchhoff approximation显示文摘 | Bruce N C Dainty J C | 1991 | Journal of Modern Optics1991，38，3： | 1 |
| 11 | Biotransformation of alkaoids显示文摘 | RAKALOIDS D A LISTER D L BRUCE N C | 2002 | Alkaloids chem Biol2002，，58： | 1 |
| 12 | The lightning discharge显示文摘 | Bruce C E R Golde R H | 1941 | J Inst Elect1941，，88： | 1 |
| 13 | Observational study of maternal anthropometry and fetal insulin显示文摘 | Soltani-K H Bruce C Fraser RB | 1999 | Arch Dis Child fetal Neonatal ED1999，81，2： | 1 |
| 14 | The lithium intercalation compound Li2CoSiO4 and its behaviour as a positive electrode for lithium batteries 显示文摘 | NESS C DELOBEL B ARMSTRONG A R BRUCE P G | 2007 | Chem Commun (Camb)2007，46，： | 1 |
| 15 | Absorption of a- mino acids from the intestine and their netflux across the mesenteric -and portal -drained viscera of lambs显示文摘 | MACRAE J C BRUCE L A BROWN D S | 1997 | J Anim Sci1997，75，12： | 1 |
| 16 | Write back-aware partitioning and replacement for last-level caches in phase change main memory systems显示文摘 | Miao Zhou Yu Du Bruce C el al | 2012 | ACM Transactions on Architecture and Code Optimi- zation2012，8，4： | 1 |
| 17 | Paleoshoreline evidence for postglacial tilting in Southern Manitoba显示文摘 | Gary E T Donald R C Bruce G B | 1998 | Journal of Paleolin- nology1998，19，： | 1 |
| 18 | Dynamic chan- ges of left ventricular performance and left atrial volume in- duced by the mueller maneuver in healthy young adults and implications for obstructive sleep apnea, atrial fibrillation, and heart failure显示文摘 | Orban M Bruce C J Pressman GS | 2008 | Am J Cardiol2008，102，11： | 1 |
| 19 | Evidence-based practice and social work 显示文摘 | AARON C BRUCE A | 2004 | J Evidence Based Social Work2004，1，1： | 1 |
| 20 | Critical flux determination by the flux-step method in a submerged membrane bioreactor 显示文摘 | Pierre L C Bruce J Chang I S | 2003 | Journal of Membrane Science2003，227，： | 1 |
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