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| 1 | Risk stratification for ST segment elevation myocardial infarction in the era of primary percutaneous coronary intervention显示文摘Acute coronary syndromes presenting with ST elevation are usually treated with emergency reperfusion/revascularisation therapy. In contrast current evidence and national guidelines recommend risk stratification for non ST segment elevation myocardial infarction(NSTEMI) with the decision on revascularisation dependent on perceived clinical risk. Risk stratification for STEMI has no recommendation. Statistical risk scoring techniques in NSTEMI have been demonstrated to improve outcomes however their uptake has been poor perhaps due to questions over their discrimination and concern for application to individuals who may not have been adequately represented in clinical trials. STEMI is perceived to carry sufficient risk to warrant emergency coronary intervention [by primary percutaneous coronary intervention(PPCI)] even if this results in a delay to reperfusion with immediate thrombolysis. Immediate thrombolysis may be as effective in patients presenting early, or at low risk, but physicians are poor at assessing clinical and procedural risks and currently are not required to consider this. Inadequate data on risk stratification in STEMI inhibits the option of immediate fibrinolysis, which may be cost-effective. Currently the mode of reperfusion for STEMI defaults to emergency angiography and percutaneous coronary intervention ignoring alternative strategies. This review article examines the current risk scores and evidence base for risk stratification for STEMI patients. The requirements for an ideal STEMI risk score are discussed. | Richard A Brogan Christopher J Malkin Philip D Batin Alexander D Simms James M McLenachan Christopher P Gale | 2014 | World Journal of Cardiology2014，6，8： | 6 |
| 2 | Redistribution of nerve strain enables end-to-end repair under tension without inhibiting nerve regeneration显示文摘End-to-end repair under no or low tension leads to improved outcomes for transected nerves with short gaps,compared to repairs with a graft.However,grafts are typically used to enable a tension-free repair for moderate to large gaps,as excessive tension can cause repairs to fail and catastrophically impede recovery.In this study,we tested the hypothesis that unloading the repair interface by redistributing tension away from the site of repair is a safe and feasible strategy for end-to-end repair of larger nerve gaps.Further,we tested the hypothesis that such an approach does not adversely affect structural and functional regeneration.In this study,we used a rat sciatic nerve injury model to compare the integrity of repair and several regenerative outcomes following end-to-end repairs of nerve gaps of increasing size.In addition,we proposed the use of a novel implantable device to safely repair end-to-end repair of larger nerve gaps by redistributing tension away from the repair interface.Our data suggest that redistriubution of tension away from the site of repair enables safe end-to-end repair of larger gap sizes.In addition,structural and functional measures of regeneration were equal or enhanced in nerves repaired under tension – with or without a tension redistribution device – compared to tension-free repairs.Provided that repair integrity is maintained,end-to-end repairs under tension should be considered as a reasonable surgical strategy.All animal experiments were performed under the approval of the Institutional Animal Care and Use Committee of University of California,San Diego(Protocol S11274). | Holly M.Howarth Turki Alaziz Brogan Nicolds Shawn O'Connor Sameer B.Shah | 2019 | Neural Regeneration Research2019，14，7： | 2 |
| 3 | A profile of the immediate endocrine,metabolic and behavioural responses following a dual exposure to endotoxin in early life显示文摘 | Walker FR Brogan A Smith R | 2004 | Physiol Behav2004，83，： | 1 |
| 4 | Vbeta-restricted T cell adherence to endothelial cells a mechanism for superantigendependent vascularinjury显示文摘 | Brogan PA Shah V Klein N | 2004 | Arthritis Rheum2004，5，2： | 1 |
| 5 | Nonpulmonary organ failure and outeome in ehildren treated with high-frequency oseillatory ventilation显示文摘 | Brogan T V Bratton S L Meyer R J | 2000 | J Crit Care2000，15，： | 1 |
| 6 | The effects of the phytoestrogenic isoflavone genistein on the hepatic disposition of preformed and hepatically generated gemfibrozil 1-O-acyl glucuronide in the isolated perfused rat liver显示文摘 | Lucas AN Brogan LR Nation RL | | 0，，10： | 1 |
| 7 | Extracorporeal mem- brane oxygenation in adults with severe respiratory failure: amulti-center database 显示文摘 | Brogan TV Thiagarajan RR Rycus PT | 2009 | Intensive Care Med2009，35，12： | 1 |
| 8 | Vasculitis from the pediatric perspective显示文摘 | Brogan PA lion MJ | 2000 | Curr Rheumatol Reports2000，2，5： | 1 |
| 9 | Measuring the efectiveness of cataract surgery:the reliability and validity of a visual function outcomes instrument显示文摘 | Lawrence D Brogan C Benjamin L | 1999 | Br J Ophthalmol1999，83，1： | 1 |
| 10 | Interventional therapies for the management of cancerpain显示文摘 | Brogan S Junkins S | 2010 | J Support Oncol2010，8，2： | 1 |
| 11 | Beta-restricted T cell adherence to endothelial cells: A mechanism for superantigen dependent vascular injury显示文摘 | Brogan PA Shall V Klein N | 2004 | Arthritis Rheum2004，50，2： | 1 |
| 12 | Science and Narrative Structure in Austen,Hardy,and Woolf显示文摘 | Brogan Howard O | 1957 | Nineteenth-Century Fiction1957，，4： | 1 |
| 13 | Breast cancers among very young premenopausal women (United States)显示文摘 | Althuis MD Brogan DD Coates RJ | 2003 | Cancer Causes Control2003，14，2： | 1 |
| 14 | B lymphocyte depletion therapy in children with refractory systemic lupus erythematosus显示文摘 | Marks SD Patey S Brogan PA | | 0，，10： | 1 |
| 15 | Harmonic analysisof transient currents during sympathetic interaction显示文摘 | Bronzeado H S Brogan P B Yacamini R | 1996 | IEEE Trans on Power Systems1996，11，4： | 1 |
| 16 | Sulphur nutrition in Ireland 显示文摘 | Brogan J C Murphy M D | 1980 | Sulphur Institute Journal1980，，4： | 1 |
| 17 | The disclosure of a diagnosis of an autistic spectrum disorder:Determinants of satisfaction in a sample of Scottish parents显示文摘 | Brogan C A Knussen C | 2003 | Autism2003，7，1： | 1 |
| 18 | Plastic bronchitis in children: a case series and review of the medical literature 显示文摘 | Brogan T V Finn L S Pyskaty D J | 2002 | Pediatr Pulmonol2002，34，6： | 1 |
| 19 | Evaluation of cardiac STATus CK-MB/myoglobin device for rapidly ruling out acute myocardial infarction显示文摘 | Brogan GX Jr Bock J L MeCuskey C F | 1997 | Clin Lab Med1997，17，： | 1 |
| 20 | Vbeta-restricted T cell adherence to endothelial cells:Α mechanism for superantigen-dependent vascular injury显示文摘 | Brogan PA Shan V Klein N | 2004 | Arthritis Rheum2004，50，2： | 1 |
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