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您的检索式：作者名="Sameer B.Shah"
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| 1 | Peripheral nerve lengthening as a regenerative strategy显示文摘Peripheral nerve injury impairs motor, sensory, and autonomic function, incurring substantial financial costs and diminished quality of life. For large nerve gaps, proximal lesions, or chronic nerve injury, the prognosis for recovery is particularly poor, even with autografts, the current gold standard for treating small to moderate nerve gaps. In vivo elongation of intact proximal stumps towards the injured distal stumps of severed peripheral nerves may offer a promising new strategy to treat nerve injury. This review describes several nerve lengthening strategies, including a novel internal fixator device that enables rapid and distal reconnection of proximal and distal nerve stumps. | Kenneth M.Vaz Justin M.Brown Sameer B.Shah | 2014 | Neural Regeneration Research2014，9，16： | 4 |
| 2 | Redistribution of nerve strain enables end-to-end repair under tension without inhibiting nerve regeneration显示文摘End-to-end repair under no or low tension leads to improved outcomes for transected nerves with short gaps,compared to repairs with a graft.However,grafts are typically used to enable a tension-free repair for moderate to large gaps,as excessive tension can cause repairs to fail and catastrophically impede recovery.In this study,we tested the hypothesis that unloading the repair interface by redistributing tension away from the site of repair is a safe and feasible strategy for end-to-end repair of larger nerve gaps.Further,we tested the hypothesis that such an approach does not adversely affect structural and functional regeneration.In this study,we used a rat sciatic nerve injury model to compare the integrity of repair and several regenerative outcomes following end-to-end repairs of nerve gaps of increasing size.In addition,we proposed the use of a novel implantable device to safely repair end-to-end repair of larger nerve gaps by redistributing tension away from the repair interface.Our data suggest that redistriubution of tension away from the site of repair enables safe end-to-end repair of larger gap sizes.In addition,structural and functional measures of regeneration were equal or enhanced in nerves repaired under tension – with or without a tension redistribution device – compared to tension-free repairs.Provided that repair integrity is maintained,end-to-end repairs under tension should be considered as a reasonable surgical strategy.All animal experiments were performed under the approval of the Institutional Animal Care and Use Committee of University of California,San Diego(Protocol S11274). | Holly M.Howarth Turki Alaziz Brogan Nicolds Shawn O'Connor Sameer B.Shah | 2019 | Neural Regeneration Research2019，14，7： | 2 |
| 3 | Clinical potential of tensionlengthening strategies during nerve repair显示文摘A(very)brief history of tension in nerve repair:Successful nerve repair is achieved by conveying as many axons successfully to their targets as possible.Typically,this is best achieved through a direct end-to-end repair under minimal tension(Millesi,1986).However,this is not feasible in most cases of trauma,where a segment of tissue damage must be excised and overcome.This has most commonly been addressed with the use of nerve grafts to bridge the gap.Autologous nerve grafts are considered the gold standard,with allograft or synthetic substitutes demonstrating some success over shorter distances.Despite their utility,autologous grafts pose challenges of their own.These include functional deficit in the donor distribution(typically sensory),extended operative duration,additional scarring,and a lack of intrinsic blood supply.They are also a poor anatomical match for the stumps being bridged,both internally(disparate neuronal size and composition)as well as externally(often requiring cabled bundles to approximate the caliber of the nerve being repaired).Finally,unlike end-to-end repairs,autologous grafts also require axons to traverse a second repair interface,where a large proportion of axons are lost across the anatomical discontinuity. | Stanley Bazarek Justin M.Brown Sameer B.Shah | 2022 | Neural Regeneration Research2022，17，4： | 0 |
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