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| 1 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 2 | Evolutionary origins,diversification,and biogeography of liver flukes(Digenea,Fasciolidae)显示文摘 | LOTFY W M BRANT S V DEJONG R J | 2008 | Am J Trop Med Hyg2008，79，2： | 1 |
| 3 | Plasma ignition in a 30 mm cannon显示文摘 | Beyer R A Brant A L | 2007 | IEEE Transactions on Magnetics2007，43，1： | 1 |
| 4 | A multi - interface level measurement system using a segmented capacitance sensor for oil separators显示文摘 | Yang W Q Brant M R M S Beck | 1994 | Meas Sci Technol1994，5，： | 1 |
| 5 | Atrial flutter and the risk of thromboembolism: a systematic review and meta- analysis 显示文摘 | Ghali WA Wasil BI Brant R | 2005 | Am J Med2005，118，2： | 1 |
| 6 | Kaplan-Meier methods yielded misleading results in competing risk scenarios显示文摘 | Southern DA Faris PD Brant R | 2006 | J C/in Epidemiol2006，59，10： | 1 |
| 7 | Kelco microbial polysaccharides S- 130 (welan) and S-657 display similar dilute aqueous solution behavior显示文摘 | URBANI R BRANT D A | 1989 | Carbohydrate Polymers1989，12，： | 1 |
| 8 | Nonlinear absorption study of a C60-toluene solution显示文摘 | McLean D G Sutherland R L Brant M C | 1993 | Opt Lett1993，18，11： | 1 |
| 9 | Nonrespiratory predictor of mechanical ventilation dependency in intensive care unit patients 显示文摘 | Sapi jaszko MJA Brant R Sandharm D | 1996 | Crit Care Med1996，24，： | 1 |
| 10 | Sulfur hexafluoride and the electric power industry显示文摘 | Christophorou L G OlthoffJ K Van Brant R J | 1997 | IEEE Transactions on Electrical Insulation1997，13，5： | 1 |
| 11 | Brief report : maternal kangaroo care for neonatal pain relief: a systematic narrative review显示文摘 | Warnock FF Castral TC Brant R | 2010 | J Pediatr Psycho2010，35，9： | 1 |
| 12 | A prospective cohort study on antioxidant and folate intake and male lung cancer risk显示文摘 | Voorrips L E Goldbohm R A Brant H A M | 1998 | Cancer Epidemiol Biomark Prev1998，9，： | 1 |
| 13 | Assessing proportionality in the proportionalodds model for ordinal logistic regression显示文摘 | Brant R | 1990 | Biometrics1990，46，4： | 1 |
| 14 | Prevalence of gastroesophageal reflux symptoms in asthma 显示文摘 | Field S K Underwood M Brant R | 1996 | Chest1996，109，2： | 1 |
| 15 | A decision rule for diagnostic testing in obstructive sleep apnea显示文摘 | Tsai WH Returners JE Brant R | 2003 | Am J Respir Crit Care Med2003，167，10： | 1 |
| 16 | Use of Micellar-Enhanced Ultrafiltration at low Surfactant Concentrations and with Anionic-Nonionic Surfaction Mixtrues 显示文摘 | Bita R Fillipi Loriw Brant John F Scamehom | 1999 | Journal of Colloid and Interface Science1999，213，： | 1 |
| 17 | Impact of urethral injury management on the treatment and outcome of concurrent pelvic fractures显示文摘 | Brant E Mayher James L Guyton Jeffrey R Gingrich | 2001 | Urology2001，，3： | 1 |
| 18 | A randomized, controlled, crossover study of a non- customized tongue retaining device for sleep disordered breathing 显示文摘 | Dort L Brant R | 2008 | Sleep Breath2008，12，： | 1 |
| 19 | A decision rule for diagnos- tic testing in obstructive sleep apnea 显示文摘 | Tsai WH Remmers JE Brant R | 2003 | Am J Respir Crit Care Med2003，167，10： | 1 |
| 20 | 显示文摘 | Brant J Lecoanet H Wiesner M R | 2005 | J Nanopart Res2005，7，12： | 1 |
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