|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | IL28B polymorphisms associated with therapy response in Chilean chronic hepatitis C patients显示文摘AIM:To analyze the association of three IL28B single nucleotide polymorphisms with response to therapy in Chilean patients infected with hepatitis C virus CV.METHODS:We studied two groups of patients with chronic CV infection genotype 1,under standard combined treatment with pegylated interferon plus ribavirin.One group consisted of 50 patients with sustained virological response,whereas the second group consisted of 49 null responders.In order to analyze the IL28B single nucleotide polymorphisms rs12979860,rs12980275 and rs8099917,samples were used for polymerase chain reaction amplification,and the genotyping was performed by restriction fragment lengthpolymorphism.RESULTS:The IL28B rs12979860 CC,rs12980275 AA and rs8099917 TT genotypes were much more frequently found in patients with sustained virological response compared to null responders 38%,44% and 50% vs 2%,8.2% and 8.2%,respectively.These differences were highly significant in all three cases(P < 0.0001.CONCLUSION:The three IL28B polymorphisms studied are strongly associated with sustained virological response to therapy in Chilean patients with chronic CV genotype 1. | Mauricio Venegas Rodrigo A Villanueva Katherine González Javier Brahm | 2011 | World Journal of Gastroenterology2011，17，31： | 13 |
| 2 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 3 | 如何推行城市和区域规划改革:一位西方规划师的认识显示文摘当前,中国城市社会正处于快速转变之中,迫切改革传统城市规划,以适应发展形势的新变化。文章以温哥华市以及温哥华地区为例,着重介绍了二战以后西方的城市和区域规划改革,包括具体措施和成功经验,并且阐述了作者作为一名西方规划师对中国某些城市和区域规划问题的认识,以期为中国同行提供有益的帮助。 | Brahm Wiesman(韦湘民) 刘健 | 2003 | 国外城市规划2003，，3： | 4 |
| 4 | Luminescence properties of near-UV excitable yellow-orange light emitting warm CaSrAl_2SiO_7:Sm^(3+) phosphors显示文摘Single-phase CaSrAl_2 SiO_7:Sm^(3+) phosphors were synthesized by traditional high temperature solid state reaction method. Formation of samples and phase analysis were confirmed by X-ray diffraction technique. Morphology was done by field emission scanning electron microscopy and elemental compositions were confirmed by energy dispersive X-ray analysis. Present phosphors have tetragonal crystallography with space group P42_1 m. Average crystallite size was calculated by using Scherrer and Williamson-Hall method. Photoluminescence study of CaSrAl_2 SiO_7:Sm^(3+) phosphor was investigated.Under different excitation wavelengths, PL spectra consist of four emission bands at 564, 570, 601 and650 nm. The emission bands located at 564 and 570 nm are associated with the transition ~4 G_(5/2)→~6 H_(5/2)while emission bands at 601 and 650 nm are due to ~4 G_(5/2)→~6 H_(7/2) and ~4 G_(5/2)→~6 H_(9/2),respectively.Intense emission was obtained when phosphor was excited under 404 nm wavelength. Non-radiative energy transfer process involved in concentration quenching, was also discussed. CIE coordinate is found in yellow-orange region, hence CaSrAl_2SiO_7:Sm^(3+) phosphors emit yellow-orange light when efficiently excited by near UV(~400 nm) LED chip. Color purity and CCT of the phosphor were determined; CCT suggests that present phosphor is a good candidate as a warm yellow-orange color emitting phosphor. Effect of different heating rates and different UV exposure time on the TL glow curve of the phosphor was investigated. Activation energies and kinetic parameters for different traps were calculated by using peak shape method. TL emission spectrum was also recorded. Present article explains all the possible mechanisms associated with luminescence process in CaSrAl_2 SiO_7:Sm^(3+) phosphors. | Shweta Sharma Nameeta Brahme D.P.Bisen Pradeep Dewangan | 2019 | Journal of Rare Earths2019，37，4： | 3 |
| 5 | 消除病毒性肝炎的联合宣言显示文摘一、病毒性肝炎给人类健康造成的严重负担
与HIV或者疟疾这些众所周知的感染性疾病相比,病毒性肝炎常被称作"沉默的杀手"。 | Javier Brahm Laurent Castera 侯金林 Keith Lindor 张新(译) 李用国(译) | 2016 | 肝脏2016，21，12： | 3 |
| 6 | PreS1 antigen in different forms of hepatitis B virus infection显示文摘 | Brahm J Hurtado C Elgueta S | 1995 | Rew Med chil1995，123，5： | 1 |
| 7 | Clinical and radiobiological advantages of single-dose stereotactic light-ion radiation therapy for large intracranial arteriovenous malformations 显示文摘 | Andisheh B Brahme A Bitaraf MA | 2009 | Neurosurg2009，24，： | 1 |
| 8 | Artifacts, anatomical and physiological variants, and unrelated diseases that might cause false-positive whole-body 131-I scans in patients with thyroid cancer显示文摘 | Brahm Shapiro Vittoria Rufini Ayman Jarwan Onelio Geatti Kimberlee J. Kearfott Lorraine M. Fig Ian D. Kirkwood Milton D. Gross | 2000 | Seminars in Nuclear Medicine2000，，： | 1 |
| 9 | Correlates and Trend of H1V Prevalence Among Female Sex Workers Attending Sexually Transmitted Disease Clinics in Pune, India (1993-2002)显示文摘 | Brahme R Mehta S Salay S | 2006 | J Acquir Immune Defic Syndr2006，41，1： | 1 |
| 10 | Pre S1 antigon in different forms of hepatitis B virus infection显示文摘 | Brahm J Hurtado C Elgueta S | 1995 | Rev Med Chi11995，123，5： | 1 |
| 11 | Strategy Implementation:a Comparison of Face-to-face Negotiations in the People's Republic of China and the United States显示文摘 | Brahm R Graham J L | 1992 | Strategic Management Journal1992，13，： | 1 |
| 12 | Dynamic MR imaging of carpal tunnel syndrome显示文摘 | Brahme SK Hodler J Braun RM | 1997 | Skeletal Radiol1997，26，： | 1 |
| 13 | 原发性免疫缺陷病患者肿瘤发生情况:美国免疫缺陷网络注册患者肿瘤发病率分析显示文摘研究背景评估了在美国免疫缺陷网络(USIDNET)注册的原发性免疫缺陷病(PIDDs)患者的总体和器官特异性肿瘤发病率,并与监测、流行病学和最终结果项目(SEER)数据库中经年龄校正的人群的肿瘤发病率进行比较。目的假设PIDD患者由于免疫功能受损,肿瘤发病率会增加。方法将2003年至2015年在USIDNET注册中心注册的PIDD (n=3658)患者的总体和器官特异性肿瘤发病率进行评估,并与SEER数据库中经年龄校正的人群发病率进行比较。结果与年龄相匹配的SEER人群相比,观察到PIDD患者罹患肿瘤的相对危险率为1. 42倍(P<0. 001)。PIDD的男性患癌症的风险是年龄校正的男性人群的1. 91倍(P<0. 001),而PIDD女性患者的总体肿瘤发病率与经年龄校正的女性人群相比并无差异。对SEER数据库中最常见的4个恶性肿瘤——肺癌、结肠癌、乳腺癌和前列腺癌的发病率进行分析,PIDD患者中这些肿瘤的发病没有显著增加。男性和女性PIDD患者的淋巴瘤发病率均显著增加(男性10倍,P<0. 001;女性8. 34倍,P<0. 001)。结论 PIDD患者的肿瘤发病率较高。在特定的PIDD人群中淋巴瘤发病率的增高是导致总体肿瘤发病率提高的主要原因,而常见的实体肿瘤的风险没有增加。这些数据表明免疫系统在预防特定肿瘤方面有一定的作用。 | Paul C.Mayor Kevin H.Eng Kelly L.Singel Scott I.Abrams Kunle Odunsi Kirsten B.Moysich Ramsay Fuleihan Elizabeth Garabedian Patricia Lugar Hans D.Ochs Francisco A.Bonilla Rebecca H.Buckley Kathleen E.Sullivan Zuhair K.Ballas Charlotte Cunningham-Rundles Brahm H.Segal 白炜 曾小峰 | 2018 | 中华临床免疫和变态反应杂志2018，12，2： | 1 |
| 14 | Pre S1 antigen in differert forms of hepatitis B virus infection显示文摘 | Hurtado C Elgueta S | 1995 | Rew Med Chil1995，123，5： | 1 |
| 15 | Cardiac allograft vasculopathy:a review显示文摘 | Ramzy D Rao V Brahm J | 2005 | Can J Surg2005，48，4： | 1 |
| 16 | Terminal end of the human odontoblast process显示文摘 | Grotz KA AI-Nawas B Brahm R | 2000 | Clin Oral Invest2000，4，3： | 1 |
| 17 | Biologically optimized 3-dimensional in vivo predictive assay-based radiation therapy using positron emission tomography-computerized tomography imaging显示文摘 | Brahme A | 2003 | Acta Oncol2003，42，2： | 1 |
| 18 | Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts显示文摘 | Brahm H Segal Nikolaos G Almyroudis | 2007 | CID2007，44，： | 1 |
| 19 | Hepatitis B virus vaccine:early and lateresponse in Chileans with high risk of infection显示文摘 | Hurtado C Brahm J Chesta J | 1993 | Rev Med Chil1993，121，5： | 1 |
| 20 | Bacteriuria in patients with primary biliary cirrhosis显示文摘 | Brahm J Chesta J | 1993 | Rev Med Chil1993，121，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员