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| 1 | Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure显示文摘AIM: To evaluate the effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure (CRF).METHODS: Forty-four patients were enrolled in this study and divided into four groups with respect to their Helicobacter pylori (H pylori) and CRF status. Groups were labeled as follows: 1a: normal renal function, H pylori negative (n = 12), 1b: normal renal function,H pylori positive (n = 11), 2a: CRF, H pylori negative (n = 10), 2b: CRF, H pylori positive (n = 11). Upper gastrointestinal endoscopy was done in all the patients involved in the study. During endoscopical investigation,antral biopsy specimens were taken from each patient.In order to evaluate the cell apoptosis and proliferation in gastric epithelial cells, Bax and proliferating cell nuclear antigen (PCNA) labeling indexes (LI) were assessed with immunohistochemical staining method.RESULTS: For groups 1a, 1b, 2a, and 2b, mean Bax LI was identified as 34.4±13.7, 44.1±16.5, 46.3±20.5,60.7±13.8, respectively and mean PCNA LI was identified as 36.2±17.2, 53.6±25.6, 59.5±25.6, 67.2±22,respectively. When the one-way ANOVA test was applied,statistically significant differences were detected between the groups for both Bax LI (P = 0.004 <0.01) and PCNA LI (P = 0.009 <0.01). When groups were compared further in terms of Bax LI and PCNA LI with Tukey's HSD test for multiple pairwise comparisons, statistically significant difference was observed only between groups 1a and 2b (P = 0.006 <0.01).CONCLUSION: In gastric epithelial cells, expression of both the pre-apoptotic protein Bax and the proliferation marker PCNA increase with H pylori infection. This increase is more evident in patients with uremia. These findings suggest that uremia accelerates apoptosis and proliferation in gastric epithelial cells. | Selim Aydemir Binnaz Handan Ozdemir Gurden Gur Ibrahim Dogan Ugur Yilmaz Sedat Boyacioglu | 2005 | World Journal of Gastroenterology2005，11，45： | 11 |
| 2 | He/icobacter py/ori infection in hemodialysis patients: Susceptibility to amoxicillin and clarithromycin显示文摘AIM: To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls.METHODS: The subjects with dyspeptic complaints were 33 ESRD patients and 46 age- and sex-matched nonuremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched.The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique.RESULTS: None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of the ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant (P<0.05).CONCLUSION: Resistance to amoxicillin does not appear to be an important problem in H pylori-infected ESRD and non-uremic patients in our region. In contrast, the rates of resistance to clarithromycin are high, particularly in the ESRD population. | Selim Aydemir Sedat Boyacioglu Gurden Gur Muge Demirbilek Fusun Kamber Can Murat Korkmaz Ugur Yilmaz | 2005 | World Journal of Gastroenterology2005，11，6： | 5 |
| 3 | Low eradication rate of Helicobacterpyloriwith triple 7-14 days and quadriple therapy in Turkey显示文摘AIM:The eradication rate of Helicobacter pylori (H pylon) shows variation among countries and regimens of treatment.We aimed to study the eradication rates of different regimens in our region and some factors affecting the rate of eradication.METHODS:One hundred and sixty-four Hpylori positivepatients (68 males, 96 females; mean age:48±12 years)with duodenal or gastric ulcer without a smoking history were included in the study. The patients were divided into three groups according to the treatment regimens. Omeprazole 20mg, clarithromycin 500mg, amoxicillin 1g were given twice daily for 1 week (Group I) and 2 weeks (Group Ⅱ).Patients in Group Ⅲ received bismuth subsitrate 300mg,tetracyline 500 mg and metronidazole 500mg four times daily in addition to Omeprazole 20mg twice daily.Two biopsies each before and after treatment were obtained from antrum and corpus, and histopathologically evaluated.Eradication was assumed to be successful if no Hpylorus was detected from four biopsy specimens taken after treatment. The effects of factors like age, sex, Hpyloridensity on antrum and corpus before treatment, the total Hpylori density, and the inflammation scores on the rate of Hpylori eradication were evaluated.RESULTS:The overall eradication rate was 42%. The rates in groups Ⅱ and Ⅲ were statistically higher than that in group I (P<0.05). The rates of eradication were 24.5%,40.7% and 61.5% in groups Ⅰ, Ⅱ and Ⅲ, respectively. The eradication rate was negatively related to either corpus Hpylori density or total Hpyloridensity (P<0.05).The median age was older in the group in which the eradication failed in comparison to that with successful eradication (55yr vs 39yr, P<0.001). No correlation between sex and Hpylori eradication was found.CONCLUSION: Our rates of eradication were significantly lower when compared to those reported in literature.We believe that advanced age and high Hpyloridensity are negative predictive factors for the rate of Hpylorieradication. | Yuksel Gumurdulu Ender Serin Birol zer Fazilet Kayaselcuk Kursat Ozsahin Arif Mansur Cosar Murat Gursoy Gurden Gur Ugur Yilmaz Sedat Boyacioglu | 2004 | World Journal of Gastroenterology2004，10，5： | 4 |
| 4 | Helicobacter pylori eradication lowers serum homocysteine level in patients without gastric atrophy显示文摘AIM: To determine whether Helicobacter pylori ( H pylori)infection caused hyperhomocysteinemia by altering serum vitamin B12, serum folate and erythrocyte folate levels and whether eradication of this organism decreased serum homocysteine level.METHODS: The study involved 73 dyspeptic H pylori-positive patients, none of them had gastric mucosal atrophy based on rapid urease test and histology. Out of 73 patients, 41 (56.2%) showed a successful eradication of Hpylori4 wk after the end of treatment. In these 41 patients, fasting serum vitamin B12, folate and homocysteine levels, and erythrocyte folate levels before and 4 wk after Hpylorieradication therapy were compared.RESULTS: The group with a successful eradication of Hpylori had significantly higher serum vitamin B12 and erythrocyte folate levels in the post-treatment period compared to those in pre-treatment period (210±97 pg/mL vs237±94pg/mL, P<0.O01 and 442±212 ng/mL vs 539±304 ng/mL,P = 0.024, respectively), but showed no significant change in serum folate levels (5.6±2.6 ng/mL vs 6.0±2.4 ng/mL,P= 0.341). Also, the serum homocysteine levels in this group were significantly lower after therapy (13.1±5.2 μmol/L vs 11.9±6.2 μmol/L, P = 0.002). Regression analysis showed that serum homocysteine level was positively correlated with age (P = 0.01) and negatively with serum folate level before therapy (P = 0.003).CONCLUSION: Eradication of H pylori decreases serum homocysteine even in patients who do not exhibit gastric mucosal atrophy. It appears that the level of homocysteine in serum is related to a complex interaction among serum vitamin B12, serum folate and erythrocyte folate levels. | Birol Ozer Ender Serin Yuksel Gumurdulu Fazilet Kayaselcuk Ruksan Anarat Gurden Gur Kemal Kul Mustafa Guclu Sedat Boyacioglu | 2005 | World Journal of Gastroenterology2005，11，18： | 3 |
| 5 | Hepatitis C infection in hemodialysis patients: A review显示文摘Hepatitis C virus(HCV)-related liver disease is a significant cause of morbidity and mortality in patients with end-stage renal disease(ESRD) who is treated with dialysis or kidney transplantation(KT). The survival rate for HCV-infected renal transplant recipients is better than that for HCV-infected hemodialysis patients on transplant waiting lists. Early diagnosis and treatment HCV infection prior to KT prevents complications posttransplantation and reduces mortality. In addition to screening for anti-HCV antibodies and detecting HCV RNA, percutaneous liver biopsy is particularly valuable for assessing the stage of liver damage in HCV-infected patients, because the stage of fibrosis is importantdetermining optimal treatment for HCV. Studies have been demonstrated that with conventional interferon(IFN) monotherapy or pegylated IFN monotherapy are similar efficacy and safety in HCV-infected hemodialysis patients. Sustained viral responses(SVRs) with these monotherapies have ranged approximately 30% to 40%. Limited reports support the use of IFN and ribavirin combination therapy as antiviral treatment for ESRD patients or patients on hemodialysis. Ribavirin can be started at low dose and careful monitoring for side effects. Patients that show SVR after treatment are strong candidates for KT. It is also generally accepted that ESRD patients with decompensated cirrhosis and portal hypertension should be referred to the liver transplant team for consideration of combined liver-KT. | Digdem Ozer Etik Serkan Ocal Ahmet Sedat Boyacioglu | 2015 | World Journal of Hepatology2015，7，6： | 2 |
| 6 | An adaptive network-basedfuzzy inference system (ANFIS) for the prediction ofstock market return: The case of the Istanbul StockExchange 显示文摘 | Boyacioglu M A Avci D | 2010 | Expert Systems with Applications2010，37，12： | 1 |
| 7 | Water pollution sources assessment by multivariate statistical methods in the Tahtali Basin, Turkey显示文摘 | BOYACIOGLU H BOYACIOGLU H | 2008 | Environmental Geology2008，54，： | 1 |
| 8 | Successful living-related heterotopic auxiliary liver transplantation for chronic Budd-Chiari syndrome显示文摘 | Haberal M Karakayali H Boyacioglu S | 1999 | Transplant Proc1999，31，7： | 1 |
| 9 | Helicobacter pylori infection as a possible risk factor for respiratory system disease:a review of the literature显示文摘 | Kanbay M Kanbay A Boyacioglu S | 2007 | Respir Med2007，101，2： | 1 |
| 10 | Predicting direction of stock price index movement using artificial neural networks and support vector machines: The sample of the Istanbnl Stock Exchange显示文摘 | Kara Y Boyacioglu M A Baykan O K | 2011 | Expert Systems with Applications2011，38，： | 1 |
| 11 | Transumbilical multiple-port laparoscopic cholecystectomy using standard laparoscopic instruments显示文摘 | M. Tahir Oruc M. Umit Ugurlu Zehra Boyacioglu | 2012 | Minimally Invasive Therapy & Allied Technologies2012，，6： | 1 |
| 12 | Percutaneous liver biopsy complications in patients with chronic renal failure 显示文摘 | Ozdogan M Ozgur O Boyacioglu S | 1996 | Nephron1996，74，2： | 1 |
| 13 | Predicting Bank Financial Failures Using Neural Networks,Support Vector Machines and Multivariate Statistical Methods:A Comparative Analysis in the Sample of Savings Deposit Insurance Fund (SDIF) Transferred Banks in Turkey显示文摘 | BOYACIOGLU M A KARA Y BAYKAN K | 2009 | Expert Systems with Applications2009，36，2： | 1 |
| 14 | Predicting bank financial failures using neural networks, supportvector machines and multivariate statistical methods: A comparative analysis in the sample of savings deposit insurance fund (SDIF) transferred banks in Turkey 显示文摘 | Boyacioglu M A Kara Y Baykan O K | 2009 | Expert Systems with Applications2009，36，： | 1 |
| 15 | Changes in polyphenol content during production of grape juice concentrate显示文摘 | Esra Capanoglu Ric C.H. de Vos Robert D. Hall Dilek Boyacioglu Jules Beekwilder | 2013 | 2013 (1-4)2013，，1： | 1 |
| 16 | Plasma pharmacokinetics and faecal extraction of ivermectin and doramectin following oral administration in donkeys显示文摘 | Gokbulut C Boyacioglu M Karademir U | 2005 | Res Vet Sci2005，79，： | 1 |
| 17 | A comparison of p21 and p27 immunoexpression in benign glands, prostatic intraepithelial neoplasia and prostate adenocarcinoma 显示文摘 | Doganavsargil B Simsir A Boyacioglu H | 2006 | BJU Intern2006，97，3： | 1 |
| 18 | The effect of silica doping on the microstructure and mechanical properties of c-ZrO2/ SiO2 composites显示文摘 | Tekeli S Boyacioglu T Gtiral A | 2008 | Ceram Int2008，34，8： | 1 |
| 19 | Frozen yogurt with added inulin and isomalt显示文摘 | ISIK U BOYACIOGLU D CAPANOGLU E | 2011 | Journal of DairyScience2011，94，4： | 1 |
| 20 | Recombinant alpha-interferon in renal allograft recipients with chronic hepatitis C显示文摘 | Ozgur O Boyacioglu S Telatar H | 1995 | Nephrol Dial Transplant1995，10，11： | 1 |
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