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| 1 | De novo synthesis of bifunctional conjugated microporous polymers for synergistic coordination mediated uranium entrapment显示文摘This work reports a de novo synthesis of novel bifunctional conjugated microporous polymers(CMPs)exhibiting a synergistic-effect involved coordination behavior to uranium.It is highlighted that the synthetic strategy enables the engineering of the coordination environment within amidoxime functionalized CMP frameworks by specifically introducing ortho-substituted amino functionalities,enhancing the affinity to uranyl ions via forming synergistic complexes.The CMPs exhibit high Brunauer-Emmett-Teller(BET)surface area,well-developed three-dimensional(3D)networks with hierarchical porosity,and favorable chemical and thermal stability because of the covalently cross-linked structure.Compared with the amino-free counterparts,the adsorption capacity of bifunctional CMPs was increased by almost 70%,from 105 to 174 mg/g,indicating evidently enhanced binding ability to uranium.Moreover,new insights into coordination mechanism were obtained by in-depth X-ray photoelectron spectroscopy(XPS)analysis and density functional theory(DFT)calculation,suggesting a dominant role of the oxime ligands forming a 1:1 metal ions/ligands(M/L)coordination model with uranyl ions while demonstrating the synergistic engagement of the amino functionalities via direct binding to uranium center and hydrogen-bonding involved secondary-sphere interaction.This work sheds light on the underlying principles of ortho-substituted functionalities directed synergistic effect to promote the coordination of amidoxime with uranyl ions.And the synthetic strategy established here would enable the task-specific development of more novel CMP-based functional materials for broadened applications. | Boxuan Yu Lei Zhang Gang Ye Qingzhi Liu Jiongli Li Xudong Wang Jing Chen Shengming Xu Shengqian Ma | 2021 | Nano Research2021，14，3： | 2 |
| 2 | Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents显示文摘 | MA Junjie HU Gang XIE Lijun CHEN Lei XU Boxuan GONG Ping | 2015 | Chemical Research in Chinese Universities2015，31，6： | 1 |
| 3 | A fully absorbable biomimetic polymeric micelle loaded with cisplatin as drug carrier for cancer therapy显示文摘cis-dichlorodiammineplatinum(II)(CDDP)-loaded polymeric micelles for cancer therapy have been developed to reduce the serious side effects of cisplatin CDDP.Herein,polymeric micelles incorporated with cisplatin are prepared based on the complexation between CDDP and hydrophilic poly(L-glutamic acid)-b-poly(2-methacryloyloxyethyl phosphorylcholine)(PLG-b-PMPC)diblock copolymers.These CDDP-loaded micelles possess an average size of 91nm with narrow distribution,providing remarkable stability in media containing proteins.The release of CDDP from the micelles is faster at pH 5.0 and pH 6.0 than that at pH 7.4 and in a sustained manner without initial burst release.In addition,there is almost no difference in cellular uptake between these CDDP-loaded micelles and free CDDP.Moreover,in vitro cytotoxicity test shows they possess high efficacy to kill 4T1 cells as compared with free drug.Thus,PLG-b-PMPC copolymer might be a promising carrier for CDDP incorporating in cancer therapy. | Weihua Zhuang Boxuan Ma Gongyan Liu Xiaobing Chen Yunbing Wang | 2018 | Regenerative Biomaterials2018，5，1： | 1 |
| 4 | Design, Synthesis, Biological Activity and Molecular Docking Study of Coumarin Derivatives Bearing 2-MethyIbiphenyl Moiety显示文摘A hybrid pharmacophore approach was used to design and synthesize a series of coumarin derivatives bearing 2-methylbiphenyl moiety, which were evaluated for their in vitro anticancer activities against four cancer cell lines(MCF-75 A549, H460 and HT29) and PD-1/PD-L1 inhibitory activities. Moreover, several compounds with excellent anticancer activities were selected to evaluate the cytotoxicities against one normal cell line(HEK-293). The most promising compound llo showed the best anticancer activities against the four tested cancer cell lines with the IC50 values of 6.45, 8.65, 6,57 and 8.13 gmol/L, respectively, and displayed weak cytotoxicity on the normal cell(HEK-293). Furthermore, screening of PD-1 /PD-L1 inhibitory activity revealed that compound llo could effectively inhibit the binding of PD-1/PD-L1, and the binding interactions of compound llo with PD-L1 protein were explored by molecular docking. All above evidences showed that compound llo might be worthy of further study as a valuable leading compound for the treatment of cancer. | MA Junjie HUANG Kun NI Xin CHEN Roufen XU Boxuan WANG Cuifang | 2019 | Chemical Research in Chinese Universities2019，35，3： | 0 |
| 5 | Isolation of nuclei from transient transfection plants under abiotic stress显示文摘The isolation of nuclei is often the first step to study the processes such as protein–DNA regulation and interactions.Therefore,rapidly obtaining nuclei from woody plants with relatively high purity and minimal contamination is highly desirable.Many methods have been mainly employed in animal tissues because the plant cell wall represents an obstacle for the extraction of nuclei.The knowledge of nuclei of plant is less advanced than that of animals.Nevertheless,with the currently available techniques for nuclear isolation from whole plants,satisfactory yield of intact nuclei cannot be achieved because nuclei and protoplasts are more fragile during liquid nitrogen grinding and they have delicate plasma membranes that are susceptible to bursting when subject to mechanical shock.Therefore,it is very important to develop new methods that have reduced damage to the nuclei. | Lina Wang Miao He Lifang Wang Yafang Lu Bing Yan Qingqi Guo Chuanqiao Tan Boxuan Chen | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 0 |
| 6 | Advances in bismuth-telluride-based thermoelectric devices: Progress and challenges显示文摘By effectively converting waste heat into electricity,thermoelectric materials and devices can provide an alternative approach to tackle the energy crisis.Amongst thermoelectric materials,bismuth telluride(Bi_(2)Te_(3))and its derivatives exhibit high figure of merit ZT values in the near-room-temperature region and show great potential for application in thermoelectric devices.Considering the rapid development of Bi_(2)Te_(3)-based thermoelectric materials and their devices in the last few years,a short and systematic review is much needed.Here,we sum-marize the novel designs,properties,and applications of Bi_(2)Te_(3)-based thermoelectric devices in different contexts,including wearable,portable,implantable,and cross-disciplinary applications.The challenges and outlook for Bi_(2)Te_(3)-based thermoelectric devices are also considered.This work will guide the future development of Bi_(2)Te_(3)-based thermoelectric devices that target broader and more practical applications. | Tianyi Cao Xiao-Lei Shi Meng Li Boxuan Hu Wenyi Chen Wei-Di Liu Wanyu Lyu Jennifer MacLeod Zhi-Gang Chen | 2023 | eScience2023，3，3： | 0 |
| 7 | Nickel-Catalyzed Regiodivergent Asymmetric Cycloadditions of α,β-Unsaturated Carbonyl Compounds显示文摘Regiodivergent asymmetric cycloadditions from the same set of starting materials offer interesting opportunities for rapid construction of optically active cyclic molecules with structural diversity.However,this remains a challenging task due to the difficulty of simultaneously controlling the regio-,diastereo-,and enantioselectivity in the ring formation processes.To address this long-standing problem. | Shi Cao Ziqi Ye Yuehua Chen Yu-Mei Lin Jiahua Fang Yuejiao Wang Boxuan Yang Lei Gong | 2022 | CCS Chemistry2022，4，9： | 0 |
| 8 | Sodium zirconium cyclosilicate pretreatment for formula in vitro reduces potassium intake in infants with chronic kidney disease显示文摘To the Editor:Hyperkalemia is a common life-threatening complication of advanced chronic kidney disease(CKD)in infants.To manage hyperkalemia,dietary potassium intake restrictions is the most convenient,safe,and effective treatment.Kidney Disease Outcomes Quality Initiative(KDOQI)guideline recommends that the general restriction of potassium is 40 to 120 mg·kg^(-1)·day^(-1)for infants and 30 to 40 mg·kg^(-1)·day^(-1)for older children with CKD. | Boxuan Liu Teng Wang Zhi Chen | 2022 | Chinese Medical Journal2022，135，24： | 0 |
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